BR112022001931A2 - Derivados de bis-[n-((5-carbamoil)-1h-benzo[d]imidazol-2-il)-pirazol-5-carboxamida e compostos relacionados como agonistas de sting (estimulador de genes de interferon) para o tratamento de câncer - Google Patents

Derivados de bis-[n-((5-carbamoil)-1h-benzo[d]imidazol-2-il)-pirazol-5-carboxamida e compostos relacionados como agonistas de sting (estimulador de genes de interferon) para o tratamento de câncer

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Publication number
BR112022001931A2
BR112022001931A2 BR112022001931A BR112022001931A BR112022001931A2 BR 112022001931 A2 BR112022001931 A2 BR 112022001931A2 BR 112022001931 A BR112022001931 A BR 112022001931A BR 112022001931 A BR112022001931 A BR 112022001931A BR 112022001931 A2 BR112022001931 A2 BR 112022001931A2
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Prior art keywords
imidazol
carbamoyl
benzo
treatment
pyrazol
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BR112022001931A
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English (en)
Inventor
D Jones Brian
Dorin Toader
W Kelleher Eugene
R Duvall Jeremy
D Thomas Joshua
W Bentley Keith
S Ray Soumya
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Mersana Therapeutics Inc
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Application filed by Mersana Therapeutics Inc filed Critical Mersana Therapeutics Inc
Publication of BR112022001931A2 publication Critical patent/BR112022001931A2/pt

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Abstract

a presente invenção refere-se a compostos de fórmula (ia') como agonistas de sting (estimulador de genes de interferon), para uso no tratamento de, por exemplo, doenças infecciosas, incluindo, mas não limitadas a, obesidade, lesão hepática, metabolismo açúcar-lipídico e infecção por vírus. a presente descrição descreve a síntese e caracterização de compostos exemplares, bem como dados farmacológicos dos mesmos (por exemplo, páginas 128 a 286; exemplos 1 a 54, tabelas 1, 2a, 2b e 3). um complosto exemplar é, por exemplo 1: (e)-n-(5-carbamoil-1-(4-(5-carbamoil-2-(4-etil-2-metiloxazol-5-carboxamido)-7-(3-hidroxipropóxi)-1h-benzo[d]imidazol-1-il)-7-metóxi-1h-benzo[d]imidazol-2-il)-4-etil-2-metiloxazol-5-carboxamida (composto 9). (composto 9)
BR112022001931A 2019-08-02 2020-07-31 Derivados de bis-[n-((5-carbamoil)-1h-benzo[d]imidazol-2-il)-pirazol-5-carboxamida e compostos relacionados como agonistas de sting (estimulador de genes de interferon) para o tratamento de câncer BR112022001931A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962882081P 2019-08-02 2019-08-02
US201962944643P 2019-12-06 2019-12-06
US202062982935P 2020-02-28 2020-02-28
PCT/US2020/044538 WO2021026009A1 (en) 2019-08-02 2020-07-31 Bis-[n-((5-carbamoyl)-1h-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as sting (stimulator of interferon genes) agonists for the treatment of cancer

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BR112022001931A2 true BR112022001931A2 (pt) 2022-06-21

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US (2) US11155567B2 (pt)
EP (1) EP4007758A1 (pt)
JP (1) JP2022543086A (pt)
KR (1) KR20220056176A (pt)
CN (1) CN114585623A (pt)
AU (1) AU2020324388A1 (pt)
BR (1) BR112022001931A2 (pt)
CA (1) CA3149482A1 (pt)
IL (1) IL290212A (pt)
MX (1) MX2022001407A (pt)
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BR112022001931A2 (pt) 2019-08-02 2022-06-21 Mersana Therapeutics Inc Derivados de bis-[n-((5-carbamoil)-1h-benzo[d]imidazol-2-il)-pirazol-5-carboxamida e compostos relacionados como agonistas de sting (estimulador de genes de interferon) para o tratamento de câncer
MX2022012304A (es) * 2020-04-02 2022-11-30 Mersana Therapeutics Inc Conjugados de anticuerpo-farmaco que comprenden agonistas de sting.
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