BR112012032234A2 - "derivados de heteroaril imidazolona como inibidores de jak". - Google Patents

"derivados de heteroaril imidazolona como inibidores de jak".

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Publication number
BR112012032234A2
BR112012032234A2 BR112012032234A BR112012032234A BR112012032234A2 BR 112012032234 A2 BR112012032234 A2 BR 112012032234A2 BR 112012032234 A BR112012032234 A BR 112012032234A BR 112012032234 A BR112012032234 A BR 112012032234A BR 112012032234 A2 BR112012032234 A2 BR 112012032234A2
Authority
BR
Brazil
Prior art keywords
imidazolone derivatives
jak inhibitors
heteroaryl imidazolone
heteroaryl
jak
Prior art date
Application number
BR112012032234A
Other languages
English (en)
Inventor
Elena Gomez Castillo
Jacob Gonzalez Rodriguez
Jordi Bach Tana
Paul Robert Eastwood
Original Assignee
Almirall Sa
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43028230&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012032234(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of BR112012032234A2 publication Critical patent/BR112012032234A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

derivados de heteroaril imidazolona como inibidores de jak. novos derivados de heteroaril imidazolona tendo a estrutura química de fórmula (i) são revelados; bem como o processo para a sua preparação, composições farmacêuticas compreendendo os mesmos e o seu uso em terapia como inibidores de janus quinases (jak).
BR112012032234A 2010-06-15 2011-06-14 "derivados de heteroaril imidazolona como inibidores de jak". BR112012032234A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10382174A EP2397482A1 (en) 2010-06-15 2010-06-15 Heteroaryl imidazolone derivatives as jak inhibitors
US36505910P 2010-07-16 2010-07-16
PCT/EP2011/002917 WO2011157397A1 (en) 2010-06-15 2011-06-14 Heteroaryl imidazolone derivatives as jak inhibitors

Publications (1)

Publication Number Publication Date
BR112012032234A2 true BR112012032234A2 (pt) 2016-11-29

Family

ID=43028230

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012032234A BR112012032234A2 (pt) 2010-06-15 2011-06-14 "derivados de heteroaril imidazolona como inibidores de jak".

Country Status (21)

Country Link
US (1) US20130089512A1 (pt)
EP (2) EP2397482A1 (pt)
JP (1) JP2013528630A (pt)
KR (1) KR20130113331A (pt)
CN (1) CN102933583A (pt)
AR (1) AR081932A1 (pt)
AU (1) AU2011267385A1 (pt)
BR (1) BR112012032234A2 (pt)
CA (1) CA2802588A1 (pt)
CL (1) CL2012003564A1 (pt)
CO (1) CO6640257A2 (pt)
CR (1) CR20120634A (pt)
EA (1) EA201201677A1 (pt)
GT (1) GT201200321A (pt)
MX (1) MX2012014017A (pt)
PE (1) PE20130234A1 (pt)
SG (1) SG186163A1 (pt)
TW (1) TW201201811A (pt)
UY (1) UY33454A (pt)
WO (1) WO2011157397A1 (pt)
ZA (1) ZA201207636B (pt)

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WO2019034973A1 (en) 2017-08-14 2019-02-21 Pfizer Inc. PYRAZOLO [1,5-A] PYRAZIN-4-YL AND RELATED DERIVATIVES
GB201809102D0 (en) 2018-06-04 2018-07-18 Univ Oxford Innovation Ltd Compounds
CN109376887A (zh) * 2018-09-30 2019-02-22 广州翼云科技有限公司 基于福利平台精准客户预约活动的信息采集系统和方法
EP3632908A1 (en) 2018-10-02 2020-04-08 Inventiva Inhibitors of the yap/taz-tead interaction and their use in the treatment of cancer
WO2020092015A1 (en) 2018-11-02 2020-05-07 University Of Rochester Therapeutic mitigation of epithelial infection
CN111454214B (zh) * 2020-05-27 2023-04-07 龙曦宁（上海）医药科技有限公司 一种2-甲氧基1-嘧啶乙胺盐酸盐的合成方法
KR102409595B1 (ko) 2020-06-29 2022-06-17 한국과학기술연구원 단백질 카이네이즈 csf-1r 억제제로서의 신규 퓨리논 유도체
JP7023026B1 (ja) 2021-05-18 2022-02-21 株式会社アイビー化粧品 Ｊａｋ阻害剤
WO2022242768A1 (zh) * 2021-05-21 2022-11-24 广州嘉越医药科技有限公司 一种吡咯并嘧啶类化合物的应用
CN115417869B (zh) * 2022-09-19 2024-06-11 安徽大学 一种6-溴咪唑[1.2a]吡啶-3-甲酰胺的合成方法

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