BR112017025781A2 - derivados de 2-(pirazolopiridin-3-il)pirimidina como inibidores de jak - Google Patents

derivados de 2-(pirazolopiridin-3-il)pirimidina como inibidores de jak

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Publication number
BR112017025781A2
BR112017025781A2 BR112017025781-5A BR112017025781A BR112017025781A2 BR 112017025781 A2 BR112017025781 A2 BR 112017025781A2 BR 112017025781 A BR112017025781 A BR 112017025781A BR 112017025781 A2 BR112017025781 A2 BR 112017025781A2
Authority
BR
Brazil
Prior art keywords
pyrazolopyridin
pyrimidine derivatives
jak inhibitors
jak
inhibitors
Prior art date
Application number
BR112017025781-5A
Other languages
English (en)
Inventor
Esteve Trias Cristina
Taltavull Moll Joan
Gonzalez Rodriguez Jacob
Vidal Juan Bernat
Original Assignee
Almirall, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall, S.A. filed Critical Almirall, S.A.
Publication of BR112017025781A2 publication Critical patent/BR112017025781A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members

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  • Health & Medical Sciences (AREA)
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  • Pulmonology (AREA)
  • Hematology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
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  • Obesity (AREA)
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  • Biomedical Technology (AREA)
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  • Rheumatology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

são descritos novos derivados de 2-(pirazolopiridin-3-il)pirimidina; bem como processos para sua preparação, composições farmacêuticas que compreende os mesmos e seu uso em terapia como inibidores de quinases janus (jak).
BR112017025781-5A 2015-06-11 2016-06-10 derivados de 2-(pirazolopiridin-3-il)pirimidina como inibidores de jak BR112017025781A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15382305.9 2015-06-11
EP15382305 2015-06-11
PCT/EP2016/063391 WO2016198663A1 (en) 2015-06-11 2016-06-10 2-(pyrazolopyridin-3-yl)pyrimidine derivatives as jak inhibitors

Publications (1)

Publication Number Publication Date
BR112017025781A2 true BR112017025781A2 (pt) 2018-08-14

Family

ID=53476802

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017025781-5A BR112017025781A2 (pt) 2015-06-11 2016-06-10 derivados de 2-(pirazolopiridin-3-il)pirimidina como inibidores de jak

Country Status (22)

Country Link
US (1) US10759793B2 (pt)
EP (1) EP3307272A1 (pt)
JP (1) JP2018516954A (pt)
KR (1) KR20180012854A (pt)
CN (1) CN107667106A (pt)
AR (1) AR104963A1 (pt)
AU (1) AU2016275716C1 (pt)
BR (1) BR112017025781A2 (pt)
CA (1) CA2987328A1 (pt)
CL (1) CL2017003107A1 (pt)
CO (1) CO2017011996A2 (pt)
CR (1) CR20170557A (pt)
EA (1) EA035312B1 (pt)
HK (1) HK1246667A1 (pt)
IL (1) IL255668A (pt)
MA (1) MA42592A (pt)
MX (1) MX2017015029A (pt)
PE (1) PE20180279A1 (pt)
PH (1) PH12017502236A1 (pt)
SG (1) SG10201911926UA (pt)
TW (1) TW201705961A (pt)
WO (1) WO2016198663A1 (pt)

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AU2016311385C1 (en) 2015-08-24 2019-08-22 Glaxosmithkline Intellectual Property (No. 2) Limited Biopharmaceutical compositions
WO2017137576A1 (en) * 2016-02-12 2017-08-17 Universität Zürich Dimethyl fumarate (dmf) for prevention or treatment of gout, acne, diabetes, vitiligo and/or pyoderma gangrenosum
EP3538523B1 (en) 2016-11-08 2021-05-19 Cancer Research Technology Limited Pyrimidinone derivatives as cdc7 inhibitors
US20180235931A1 (en) * 2017-01-17 2018-08-23 Menlo Therapeutics Inc. Use of neurokinin-1 antagonists as antitussives
TW201834649A (zh) 2017-03-02 2018-10-01 新加坡商亞獅康私人有限公司 癌症療法
US11311548B2 (en) 2017-03-02 2022-04-26 Aslan Pharmaceuticals Pte. Ltd. Cancer therapy
WO2018200786A1 (en) * 2017-04-26 2018-11-01 Yale University Compositions and methods for treating vitiligo
CN108514637A (zh) * 2018-05-07 2018-09-11 山东省眼科研究所 Stat3抑制剂s31-201在治疗干眼症中的应用
CN109810991B (zh) * 2019-03-02 2021-11-12 昆明理工大学 二氢蝶酸合酶基因folP的用途
CN115697332A (zh) * 2020-06-02 2023-02-03 尼尔医疗有限公司 用于治疗由肺的机械损伤促进的肺纤维化状况的神经激肽(nk)-1受体拮抗剂
MX2023009682A (es) 2021-02-19 2023-10-30 Sudo Biosciences Ltd Inhibidores de tyk2 y sus usos.
CA3219092A1 (en) * 2021-05-03 2022-11-10 Incyte Corporation Jak1 pathway inhibitors for the treatment of prurigo nodularis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54128591A (en) 1978-03-25 1979-10-05 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
EP2338888A1 (en) * 2009-12-24 2011-06-29 Almirall, S.A. Imidazopyridine derivatives as JAK inhibitors
UY33213A (es) * 2010-02-18 2011-09-30 Almirall Sa Derivados de pirazol como inhibidores de jak
EP2397482A1 (en) 2010-06-15 2011-12-21 Almirall, S.A. Heteroaryl imidazolone derivatives as jak inhibitors
AR086042A1 (es) * 2011-04-28 2013-11-13 Galapagos Nv Compuesto util para el tratamiento de enfermedades degenerativas e inflamatorias y composicion farmaceutica
WO2013025628A1 (en) * 2011-08-15 2013-02-21 Ligand Pharmaceuticals Incorporated Janus kinase inhibitor compounds and methods
AU2012312303B2 (en) * 2011-09-22 2016-09-15 Merck Sharp & Dohme Corp. Cyanomethylpyrazole carboxamides as janus kinase inhibitors
TW201605811A (zh) 2013-12-11 2016-02-16 阿爾米雷爾有限公司 作為jak抑制劑之吡唑并嘧啶-2基衍生物

Also Published As

Publication number Publication date
EP3307272A1 (en) 2018-04-18
HK1246667A1 (zh) 2018-09-14
IL255668A (en) 2018-01-31
WO2016198663A1 (en) 2016-12-15
EA035312B1 (ru) 2020-05-27
CN107667106A (zh) 2018-02-06
MA42592A (fr) 2018-06-20
MX2017015029A (es) 2018-04-13
TW201705961A (zh) 2017-02-16
AU2016275716C1 (en) 2020-10-15
JP2018516954A (ja) 2018-06-28
CA2987328A1 (en) 2016-12-15
US10759793B2 (en) 2020-09-01
AU2016275716B2 (en) 2020-01-23
US20180162856A1 (en) 2018-06-14
SG10201911926UA (en) 2020-01-30
CO2017011996A2 (es) 2018-03-28
PE20180279A1 (es) 2018-02-07
CR20170557A (es) 2018-02-06
AU2016275716A1 (en) 2017-12-07
KR20180012854A (ko) 2018-02-06
CL2017003107A1 (es) 2018-04-02
PH12017502236A1 (en) 2018-06-11
EA201792689A1 (ru) 2018-07-31
NZ737314A (en) 2021-02-26
AR104963A1 (es) 2017-08-30

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]