BR112017025781A2 - derivados de 2-(pirazolopiridin-3-il)pirimidina como inibidores de jak - Google Patents

derivados de 2-(pirazolopiridin-3-il)pirimidina como inibidores de jak

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Publication number
BR112017025781A2
BR112017025781A2 BR112017025781-5A BR112017025781A BR112017025781A2 BR 112017025781 A2 BR112017025781 A2 BR 112017025781A2 BR 112017025781 A BR112017025781 A BR 112017025781A BR 112017025781 A2 BR112017025781 A2 BR 112017025781A2
Authority
BR
Brazil
Prior art keywords
pyrazolopyridin
pyrimidine derivatives
jak inhibitors
jak
inhibitors
Prior art date
Application number
BR112017025781-5A
Other languages
English (en)
Inventor
Esteve Trias Cristina
Taltavull Moll Joan
Gonzalez Rodriguez Jacob
Vidal Juan Bernat
Original Assignee
Almirall, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall, S.A. filed Critical Almirall, S.A.
Publication of BR112017025781A2 publication Critical patent/BR112017025781A2/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members

Abstract

são descritos novos derivados de 2-(pirazolopiridin-3-il)pirimidina; bem como processos para sua preparação, composições farmacêuticas que compreende os mesmos e seu uso em terapia como inibidores de quinases janus (jak).
BR112017025781-5A 2015-06-11 2016-06-10 derivados de 2-(pirazolopiridin-3-il)pirimidina como inibidores de jak BR112017025781A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15382305.9 2015-06-11
EP15382305 2015-06-11
PCT/EP2016/063391 WO2016198663A1 (en) 2015-06-11 2016-06-10 2-(pyrazolopyridin-3-yl)pyrimidine derivatives as jak inhibitors

Publications (1)

Publication Number Publication Date
BR112017025781A2 true BR112017025781A2 (pt) 2018-08-14

Family

ID=53476802

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017025781-5A BR112017025781A2 (pt) 2015-06-11 2016-06-10 derivados de 2-(pirazolopiridin-3-il)pirimidina como inibidores de jak

Country Status (22)

Country Link
US (1) US10759793B2 (pt)
EP (1) EP3307272A1 (pt)
JP (1) JP2018516954A (pt)
KR (1) KR20180012854A (pt)
CN (1) CN107667106A (pt)
AR (1) AR104963A1 (pt)
AU (1) AU2016275716C1 (pt)
BR (1) BR112017025781A2 (pt)
CA (1) CA2987328A1 (pt)
CL (1) CL2017003107A1 (pt)
CO (1) CO2017011996A2 (pt)
CR (1) CR20170557A (pt)
EA (1) EA035312B1 (pt)
HK (1) HK1246667A1 (pt)
IL (1) IL255668A (pt)
MA (1) MA42592A (pt)
MX (1) MX2017015029A (pt)
PE (1) PE20180279A1 (pt)
PH (1) PH12017502236A1 (pt)
SG (1) SG10201911926UA (pt)
TW (1) TW201705961A (pt)
WO (1) WO2016198663A1 (pt)

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BR112018003741A2 (pt) 2015-08-24 2018-09-25 Glaxosmithkline Ip No 2 Ltd composições biofarmacêuticas
US20190029987A1 (en) * 2016-02-12 2019-01-31 Universitat Zurich Dimethyl fumarate (dmf) for prevention or treatment of gout, acne, diabetes, vitiligo and/or pyoderma gangrenosum
US11020396B2 (en) 2016-11-08 2021-06-01 Cancer Research Technology Limited Pyrimidinone derivatives as Cdc7 inhibitors
WO2018136554A1 (en) * 2017-01-17 2018-07-26 Menlo Therapeutics Inc. Use of neurokinin-1 antagonists as antitussives
US11311548B2 (en) 2017-03-02 2022-04-26 Aslan Pharmaceuticals Pte. Ltd. Cancer therapy
TW201834649A (zh) * 2017-03-02 2018-10-01 新加坡商亞獅康私人有限公司 癌症療法
US11957931B2 (en) * 2017-04-26 2024-04-16 Yale University Compositions and methods for treating vitiligo
CN108514637A (zh) * 2018-05-07 2018-09-11 山东省眼科研究所 Stat3抑制剂s31-201在治疗干眼症中的应用
CN109810991B (zh) * 2019-03-02 2021-11-12 昆明理工大学 二氢蝶酸合酶基因folP的用途
CA3177477A1 (en) * 2020-06-02 2021-12-09 Nerre Therapeutics Limited Neurokinin (nk)-1 receptor antagonists for use in the treatment of pulmonary fibrosis conditions promoted by mechanical injury to the lungs
CA3219092A1 (en) * 2021-05-03 2022-11-10 Incyte Corporation Jak1 pathway inhibitors for the treatment of prurigo nodularis

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
JPS54128591A (en) 1978-03-25 1979-10-05 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
EP2338888A1 (en) 2009-12-24 2011-06-29 Almirall, S.A. Imidazopyridine derivatives as JAK inhibitors
UY33213A (es) * 2010-02-18 2011-09-30 Almirall Sa Derivados de pirazol como inhibidores de jak
EP2397482A1 (en) 2010-06-15 2011-12-21 Almirall, S.A. Heteroaryl imidazolone derivatives as jak inhibitors
AR086042A1 (es) * 2011-04-28 2013-11-13 Galapagos Nv Compuesto util para el tratamiento de enfermedades degenerativas e inflamatorias y composicion farmaceutica
WO2013025628A1 (en) * 2011-08-15 2013-02-21 Ligand Pharmaceuticals Incorporated Janus kinase inhibitor compounds and methods
EP2758377B1 (en) * 2011-09-22 2017-08-02 Merck Sharp & Dohme Corp. Cycloalkylnitrile pyrazole carboxamides as janus kinase inhibitors
TW201605811A (zh) * 2013-12-11 2016-02-16 阿爾米雷爾有限公司 作為jak抑制劑之吡唑并嘧啶-2基衍生物

Also Published As

Publication number Publication date
AU2016275716B2 (en) 2020-01-23
EP3307272A1 (en) 2018-04-18
CR20170557A (es) 2018-02-06
WO2016198663A1 (en) 2016-12-15
US20180162856A1 (en) 2018-06-14
KR20180012854A (ko) 2018-02-06
JP2018516954A (ja) 2018-06-28
MA42592A (fr) 2018-06-20
IL255668A (en) 2018-01-31
EA201792689A1 (ru) 2018-07-31
SG10201911926UA (en) 2020-01-30
PE20180279A1 (es) 2018-02-07
MX2017015029A (es) 2018-04-13
TW201705961A (zh) 2017-02-16
PH12017502236A1 (en) 2018-06-11
AR104963A1 (es) 2017-08-30
AU2016275716C1 (en) 2020-10-15
CL2017003107A1 (es) 2018-04-02
US10759793B2 (en) 2020-09-01
HK1246667A1 (zh) 2018-09-14
NZ737314A (en) 2021-02-26
CN107667106A (zh) 2018-02-06
CO2017011996A2 (es) 2018-03-28
CA2987328A1 (en) 2016-12-15
EA035312B1 (ru) 2020-05-27
AU2016275716A1 (en) 2017-12-07

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