BR112017019653A2 - derivados heteroaril bicíclicos fundidos tendo atividade como inibidores de phd - Google Patents
derivados heteroaril bicíclicos fundidos tendo atividade como inibidores de phdInfo
- Publication number
- BR112017019653A2 BR112017019653A2 BR112017019653-0A BR112017019653A BR112017019653A2 BR 112017019653 A2 BR112017019653 A2 BR 112017019653A2 BR 112017019653 A BR112017019653 A BR 112017019653A BR 112017019653 A2 BR112017019653 A2 BR 112017019653A2
- Authority
- BR
- Brazil
- Prior art keywords
- activity
- bicyclic heteroaryl
- fused bicyclic
- heteroaryl derivatives
- phd inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
a presente invenção fornece compostos de fórmula (i) e sais farmaceuticamente aceitável dos mesmos (i) em que x1, x2, x3, y1, y2, r1, r2 e r3 são como definidos no relatório descritivo, processos para sua preparação, composições farmacêuticas que os contêm e seu uso em terapia.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1504565.1A GB201504565D0 (en) | 2015-03-18 | 2015-03-18 | Novel compounds |
| GB1504565.1 | 2015-03-18 | ||
| PCT/JP2016/059782 WO2016148306A1 (en) | 2015-03-18 | 2016-03-17 | Fused bicyclic heteroaryl derivatives having activity as phd inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112017019653A2 true BR112017019653A2 (pt) | 2018-05-15 |
| BR112017019653B1 BR112017019653B1 (pt) | 2023-10-03 |
Family
ID=53051992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017019653-0A BR112017019653B1 (pt) | 2015-03-18 | 2016-03-17 | Composto de formula i e composição farmaceutica |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US10287286B2 (pt) |
| EP (1) | EP3271357B1 (pt) |
| JP (1) | JP6726681B2 (pt) |
| KR (1) | KR102609431B1 (pt) |
| CN (1) | CN107531698A (pt) |
| AU (1) | AU2016234209B2 (pt) |
| BR (1) | BR112017019653B1 (pt) |
| CA (1) | CA2979024C (pt) |
| CL (1) | CL2017002354A1 (pt) |
| CO (1) | CO2017009353A2 (pt) |
| CR (1) | CR20170468A (pt) |
| DK (1) | DK3271357T3 (pt) |
| DO (1) | DOP2017000209A (pt) |
| EA (1) | EA035739B1 (pt) |
| EC (1) | ECSP17069696A (pt) |
| ES (1) | ES2774052T3 (pt) |
| GB (1) | GB201504565D0 (pt) |
| GE (1) | GEP20207095B (pt) |
| HK (1) | HK1249512A1 (pt) |
| HU (1) | HUE047918T2 (pt) |
| IL (1) | IL254277B (pt) |
| MX (1) | MX2017011902A (pt) |
| MY (1) | MY194873A (pt) |
| NZ (1) | NZ735631A (pt) |
| PE (1) | PE20180656A1 (pt) |
| PH (1) | PH12017501699A1 (pt) |
| PT (1) | PT3271357T (pt) |
| SG (1) | SG11201707280VA (pt) |
| TN (1) | TN2017000384A1 (pt) |
| UA (1) | UA123668C2 (pt) |
| WO (1) | WO2016148306A1 (pt) |
| ZA (1) | ZA201706612B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ744349A (en) | 2016-02-24 | 2023-06-30 | Pfizer | Pyrazolo[1,5-a]pyrazin-4-yl derivatives as jak-inhibitors |
| WO2019034973A1 (en) | 2017-08-14 | 2019-02-21 | Pfizer Inc. | PYRAZOLO [1,5-A] PYRAZIN-4-YL AND RELATED DERIVATIVES |
| CA3106385A1 (en) * | 2018-09-13 | 2020-03-19 | Kissei Pharmaceutical Co., Ltd. | Imidazopyridinone compound |
| CN110950806A (zh) * | 2019-11-14 | 2020-04-03 | 安庆博曼生物技术有限公司 | 四乙基氯化铵催化嘧啶环羟基氯代制备方法 |
| US11718622B2 (en) | 2020-03-16 | 2023-08-08 | Exelixis Inc. | Heterocyclic adenosine receptor antagonists |
| UY39477A (es) * | 2020-10-20 | 2022-05-31 | Amgen Inc | Compuestos espiro heterocíclicos y métodos de uso |
| CA3235718A1 (en) | 2021-10-28 | 2023-05-04 | Insilico Medicine Ip Limited | Prolyl hydroxylase domain-containing protein (phd) inhibitors and uses thereof |
| WO2023111990A1 (en) * | 2021-12-17 | 2023-06-22 | Akebia Therapeutics, Inc. | Selective phd1 inhibitor compounds, compositions, and methods of use |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4209621A (en) | 1979-04-27 | 1980-06-24 | American Cyanamid Company | (Substituted-phenyl)-1,2,4-triazolo[4,3-a]-pyrimidines and (substituted-phenyl)-1,2,4-triazolo[1,5-a]pyrimidines |
| DK135184A (da) | 1983-03-03 | 1984-10-10 | Riker Laboratories Inc | Triazol(4,3-c)- og triazol(1,5-c)pyrimidiner |
| US4572910A (en) * | 1983-03-03 | 1986-02-25 | Riker Laboratories, Inc. | Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings |
| AU7306201A (en) | 2000-06-30 | 2002-01-14 | American Home Prod | Substituted-triazolopyrimidines as anticancer agents |
| JP2010065026A (ja) | 2008-08-13 | 2010-03-25 | Ishihara Sangyo Kaisha Ltd | ピリジル−トリアゾロピリミジン誘導体又はその塩、並びにそれらを含有する有害生物防除剤 |
| JP2010065024A (ja) | 2008-08-14 | 2010-03-25 | Ishihara Sangyo Kaisha Ltd | トリアゾロピリミジン誘導体又はその塩を含有する有害生物防除剤 |
| AU2010271732B2 (en) * | 2009-07-17 | 2016-08-25 | Japan Tobacco Inc. | Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer |
| JP2011168582A (ja) * | 2010-01-21 | 2011-09-01 | Ishihara Sangyo Kaisha Ltd | トリアゾロピリジン誘導体又はその塩、それらの製造方法及びそれらを含有する有害生物防除剤 |
| BR112015003380A2 (pt) * | 2012-08-23 | 2017-07-04 | Mitsubishi Tanabe Pharma Corp | composto de pirazolopirimidina |
-
2015
- 2015-03-18 GB GBGB1504565.1A patent/GB201504565D0/en not_active Ceased
-
2016
- 2016-03-17 PE PE2018000126A patent/PE20180656A1/es unknown
- 2016-03-17 MX MX2017011902A patent/MX2017011902A/es active IP Right Grant
- 2016-03-17 EP EP16715122.4A patent/EP3271357B1/en active Active
- 2016-03-17 CR CR20170468A patent/CR20170468A/es unknown
- 2016-03-17 WO PCT/JP2016/059782 patent/WO2016148306A1/en active Application Filing
- 2016-03-17 ES ES16715122T patent/ES2774052T3/es active Active
- 2016-03-17 NZ NZ735631A patent/NZ735631A/en unknown
- 2016-03-17 EA EA201792057A patent/EA035739B1/ru unknown
- 2016-03-17 PT PT167151224T patent/PT3271357T/pt unknown
- 2016-03-17 SG SG11201707280VA patent/SG11201707280VA/en unknown
- 2016-03-17 HU HUE16715122A patent/HUE047918T2/hu unknown
- 2016-03-17 US US15/558,824 patent/US10287286B2/en active Active
- 2016-03-17 BR BR112017019653-0A patent/BR112017019653B1/pt active IP Right Grant
- 2016-03-17 GE GEAP201614608A patent/GEP20207095B/en unknown
- 2016-03-17 KR KR1020177030091A patent/KR102609431B1/ko active IP Right Grant
- 2016-03-17 MY MYPI2017703420A patent/MY194873A/en unknown
- 2016-03-17 JP JP2017549107A patent/JP6726681B2/ja active Active
- 2016-03-17 AU AU2016234209A patent/AU2016234209B2/en active Active
- 2016-03-17 TN TNP/2017/000384A patent/TN2017000384A1/en unknown
- 2016-03-17 DK DK16715122.4T patent/DK3271357T3/da active
- 2016-03-17 UA UAA201708877A patent/UA123668C2/uk unknown
- 2016-03-17 CA CA2979024A patent/CA2979024C/en active Active
- 2016-03-17 CN CN201680022416.0A patent/CN107531698A/zh active Pending
-
2017
- 2017-09-03 IL IL254277A patent/IL254277B/en active IP Right Grant
- 2017-09-14 CO CONC2017/0009353A patent/CO2017009353A2/es unknown
- 2017-09-15 PH PH12017501699A patent/PH12017501699A1/en unknown
- 2017-09-15 CL CL2017002354A patent/CL2017002354A1/es unknown
- 2017-09-18 DO DO2017000209A patent/DOP2017000209A/es unknown
- 2017-10-02 ZA ZA2017/06612A patent/ZA201706612B/en unknown
- 2017-10-18 EC ECIEPI201769696A patent/ECSP17069696A/es unknown
-
2018
- 2018-07-13 HK HK18109089.3A patent/HK1249512A1/zh unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B09W | Correction of the decision to grant [chapter 9.1.4 patent gazette] |
Free format text: RETIFIQUE-SE, POR INCORRECAO NO QUADRO 1 |
|
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/03/2016, OBSERVADAS AS CONDICOES LEGAIS |