DOP2017000209A - Derivados de heteroarilo bicíclico fusionados con actividad como inhibidores de phd - Google Patents
Derivados de heteroarilo bicíclico fusionados con actividad como inhibidores de phdInfo
- Publication number
- DOP2017000209A DOP2017000209A DO2017000209A DO2017000209A DOP2017000209A DO P2017000209 A DOP2017000209 A DO P2017000209A DO 2017000209 A DO2017000209 A DO 2017000209A DO 2017000209 A DO2017000209 A DO 2017000209A DO P2017000209 A DOP2017000209 A DO P2017000209A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- heteroaril
- bicyclic
- fused
- derivatives
- activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención proporciona compuestos de la fórmula (I) y sales farmacéuticamente aceptables de estos, en la que X1, X2, X3, Y1, Y2, R1, R2 y R3 son tal como se define en la memoria descriptiva, procesos para su preparación, composiciones farmacéuticas que los contienen y su uso en terapia.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1504565.1A GB201504565D0 (en) | 2015-03-18 | 2015-03-18 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2017000209A true DOP2017000209A (es) | 2017-10-15 |
Family
ID=53051992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2017000209A DOP2017000209A (es) | 2015-03-18 | 2017-09-18 | Derivados de heteroarilo bicíclico fusionados con actividad como inhibidores de phd |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US10287286B2 (es) |
| EP (1) | EP3271357B1 (es) |
| JP (1) | JP6726681B2 (es) |
| KR (1) | KR102609431B1 (es) |
| CN (1) | CN107531698A (es) |
| AU (1) | AU2016234209B2 (es) |
| BR (1) | BR112017019653B1 (es) |
| CA (1) | CA2979024C (es) |
| CL (1) | CL2017002354A1 (es) |
| CO (1) | CO2017009353A2 (es) |
| CR (1) | CR20170468A (es) |
| DK (1) | DK3271357T3 (es) |
| DO (1) | DOP2017000209A (es) |
| EA (1) | EA035739B1 (es) |
| EC (1) | ECSP17069696A (es) |
| ES (1) | ES2774052T3 (es) |
| GB (1) | GB201504565D0 (es) |
| GE (1) | GEP20207095B (es) |
| HK (1) | HK1249512A1 (es) |
| HU (1) | HUE047918T2 (es) |
| IL (1) | IL254277B (es) |
| MX (1) | MX2017011902A (es) |
| MY (1) | MY194873A (es) |
| NZ (1) | NZ735631A (es) |
| PE (1) | PE20180656A1 (es) |
| PH (1) | PH12017501699A1 (es) |
| PT (1) | PT3271357T (es) |
| SG (1) | SG11201707280VA (es) |
| TN (1) | TN2017000384A1 (es) |
| UA (1) | UA123668C2 (es) |
| WO (1) | WO2016148306A1 (es) |
| ZA (1) | ZA201706612B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3419978B1 (en) | 2016-02-24 | 2020-04-15 | Pfizer Inc | Pyrazolo[1,5-a]pyrazin-4-yl derivatives as jak-inhibitors |
| WO2019034973A1 (en) | 2017-08-14 | 2019-02-21 | Pfizer Inc. | PYRAZOLO [1,5-A] PYRAZIN-4-YL AND RELATED DERIVATIVES |
| KR20210057014A (ko) * | 2018-09-13 | 2021-05-20 | 깃세이 야쿠힌 고교 가부시키가이샤 | 이미다조피리디논 화합물 |
| CN110950806A (zh) * | 2019-11-14 | 2020-04-03 | 安庆博曼生物技术有限公司 | 四乙基氯化铵催化嘧啶环羟基氯代制备方法 |
| US11718622B2 (en) | 2020-03-16 | 2023-08-08 | Exelixis Inc. | Heterocyclic adenosine receptor antagonists |
| TW202233629A (zh) * | 2020-10-20 | 2022-09-01 | 美商安進公司 | 雜環螺環化合物及使用方法 |
| AR127501A1 (es) | 2021-10-28 | 2024-01-31 | Insilico Medicine Ip Ltd | Inhibidores de la proteína que contiene el dominio de prolil hidroxilasa (phd) y usos de los mismos |
| WO2023111990A1 (en) * | 2021-12-17 | 2023-06-22 | Akebia Therapeutics, Inc. | Selective phd1 inhibitor compounds, compositions, and methods of use |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4209621A (en) | 1979-04-27 | 1980-06-24 | American Cyanamid Company | (Substituted-phenyl)-1,2,4-triazolo[4,3-a]-pyrimidines and (substituted-phenyl)-1,2,4-triazolo[1,5-a]pyrimidines |
| US4572910A (en) * | 1983-03-03 | 1986-02-25 | Riker Laboratories, Inc. | Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings |
| DK135184A (da) * | 1983-03-03 | 1984-10-10 | Riker Laboratories Inc | Triazol(4,3-c)- og triazol(1,5-c)pyrimidiner |
| PL360027A1 (en) | 2000-06-30 | 2004-09-06 | Wyeth | Substituted-triazolopyrimidines as anticancer agents |
| JP2010065026A (ja) | 2008-08-13 | 2010-03-25 | Ishihara Sangyo Kaisha Ltd | ピリジル−トリアゾロピリミジン誘導体又はその塩、並びにそれらを含有する有害生物防除剤 |
| JP2010065024A (ja) | 2008-08-14 | 2010-03-25 | Ishihara Sangyo Kaisha Ltd | トリアゾロピリミジン誘導体又はその塩を含有する有害生物防除剤 |
| EP2746282A1 (en) * | 2009-07-17 | 2014-06-25 | Japan Tobacco Inc. | Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer |
| JP2011168582A (ja) | 2010-01-21 | 2011-09-01 | Ishihara Sangyo Kaisha Ltd | トリアゾロピリジン誘導体又はその塩、それらの製造方法及びそれらを含有する有害生物防除剤 |
| CA2881806A1 (en) * | 2012-08-23 | 2014-02-27 | Mitsubishi Tanabe Pharma Corporation | Pyrazolopyrimidine compound |
-
2015
- 2015-03-18 GB GBGB1504565.1A patent/GB201504565D0/en not_active Ceased
-
2016
- 2016-03-17 GE GEAP201614608A patent/GEP20207095B/en unknown
- 2016-03-17 TN TNP/2017/000384A patent/TN2017000384A1/en unknown
- 2016-03-17 WO PCT/JP2016/059782 patent/WO2016148306A1/en active Application Filing
- 2016-03-17 KR KR1020177030091A patent/KR102609431B1/ko active IP Right Grant
- 2016-03-17 CN CN201680022416.0A patent/CN107531698A/zh active Pending
- 2016-03-17 PE PE2018000126A patent/PE20180656A1/es unknown
- 2016-03-17 UA UAA201708877A patent/UA123668C2/uk unknown
- 2016-03-17 EA EA201792057A patent/EA035739B1/ru unknown
- 2016-03-17 ES ES16715122T patent/ES2774052T3/es active Active
- 2016-03-17 EP EP16715122.4A patent/EP3271357B1/en active Active
- 2016-03-17 NZ NZ735631A patent/NZ735631A/en unknown
- 2016-03-17 HU HUE16715122A patent/HUE047918T2/hu unknown
- 2016-03-17 MY MYPI2017703420A patent/MY194873A/en unknown
- 2016-03-17 MX MX2017011902A patent/MX2017011902A/es active IP Right Grant
- 2016-03-17 DK DK16715122.4T patent/DK3271357T3/da active
- 2016-03-17 CR CR20170468A patent/CR20170468A/es unknown
- 2016-03-17 SG SG11201707280VA patent/SG11201707280VA/en unknown
- 2016-03-17 CA CA2979024A patent/CA2979024C/en active Active
- 2016-03-17 PT PT167151224T patent/PT3271357T/pt unknown
- 2016-03-17 US US15/558,824 patent/US10287286B2/en active Active
- 2016-03-17 AU AU2016234209A patent/AU2016234209B2/en active Active
- 2016-03-17 BR BR112017019653-0A patent/BR112017019653B1/pt active IP Right Grant
- 2016-03-17 JP JP2017549107A patent/JP6726681B2/ja active Active
-
2017
- 2017-09-03 IL IL254277A patent/IL254277B/en active IP Right Grant
- 2017-09-14 CO CONC2017/0009353A patent/CO2017009353A2/es unknown
- 2017-09-15 CL CL2017002354A patent/CL2017002354A1/es unknown
- 2017-09-15 PH PH12017501699A patent/PH12017501699A1/en unknown
- 2017-09-18 DO DO2017000209A patent/DOP2017000209A/es unknown
- 2017-10-02 ZA ZA2017/06612A patent/ZA201706612B/en unknown
- 2017-10-18 EC ECIEPI201769696A patent/ECSP17069696A/es unknown
-
2018
- 2018-07-13 HK HK18109089.3A patent/HK1249512A1/zh unknown
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