|
CA2632630C
(en)
|
2005-12-13 |
2016-12-06 |
President And Fellows Of Harvard College |
Scaffolds for cell transplantation
|
|
ES2773858T3
(es)
|
2010-10-06 |
2020-07-15 |
Harvard College |
Hidrogeles formadores de poros inyectables para terapias celulares basadas en materiales
|
|
US9675561B2
(en)
|
2011-04-28 |
2017-06-13 |
President And Fellows Of Harvard College |
Injectable cryogel vaccine devices and methods of use thereof
|
|
CN104244929B
(zh)
|
2012-04-16 |
2017-04-05 |
哈佛学院董事会 |
用于调节免疫反应的介孔二氧化硅组合物
|
|
WO2013185052A1
(en)
|
2012-06-08 |
2013-12-12 |
Aduro Biotech |
Compostions and methods for cancer immunotherapy
|
|
EA201590396A1
(ru)
|
2012-12-13 |
2015-12-30 |
Адуро Биотек, Инк. |
Композиция, содержащая циклические пуриновые динуклеотиды с определенной стереохимией, и способ ее получения и применения
|
|
CA2908154C
(en)
|
2013-04-29 |
2023-11-28 |
Memorial Sloan Kettering Cancer Center |
Compositions and methods for altering second messenger signaling
|
|
WO2014179760A1
(en)
|
2013-05-03 |
2014-11-06 |
The Regents Of The University Of California |
Cyclic di-nucleotide induction of type i interferon
|
|
US9549944B2
(en)
|
2013-05-18 |
2017-01-24 |
Aduro Biotech, Inc. |
Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling
|
|
RS59500B1
(sr)
|
2013-05-18 |
2019-12-31 |
Aduro Biotech Inc |
Sastavi i metode za aktiviranje signaliziranja koje je zavisno od „stimulatora gena za interferon“
|
|
WO2015017652A1
(en)
|
2013-07-31 |
2015-02-05 |
Memorial Sloan-Kettering Cancer Center |
Sting crystals and modulators
|
|
EP3049442A4
(en)
|
2013-09-26 |
2017-06-28 |
Costim Pharmaceuticals Inc. |
Methods for treating hematologic cancers
|
|
JP2016538344A
(ja)
*
|
2013-11-19 |
2016-12-08 |
ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago |
癌処置としてのstingアゴニストの使用
|
|
WO2015109391A1
(en)
|
2014-01-24 |
2015-07-30 |
Children's Hospital Of Eastern Ontario Research Institute Inc. |
Smc combination therapy for the treatment of cancer
|
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
|
CA2936962C
(en)
|
2014-03-14 |
2024-03-05 |
Novartis Ag |
Antibody molecules to lag-3 and uses thereof
|
|
CN107073090A
(zh)
|
2014-04-30 |
2017-08-18 |
哈佛学院董事会 |
结合的疫苗装置和杀死癌细胞的方法
|
|
ES2692226T3
(es)
|
2014-06-04 |
2018-11-30 |
Glaxosmithkline Intellectual Property Development Limited |
Dinucleótidos cíclicos como moduladores de STING
|
|
CA2960824A1
(en)
|
2014-09-13 |
2016-03-17 |
Novartis Ag |
Combination therapies of alk inhibitors
|
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|
|
CA2964367C
(en)
|
2014-10-14 |
2024-01-30 |
Novartis Ag |
Antibody molecules to pd-l1 and uses thereof
|
|
US11058758B2
(en)
*
|
2014-11-20 |
2021-07-13 |
National Institutes Of Biomedical Innovation, Health And Nutrition |
TH1-inducing adjuvant comprising combination of different nucleic acid adjuvants, and use of same
|
|
ES2764178T3
(es)
|
2014-12-16 |
2020-06-02 |
Kayla Therapeutics |
Dinucleótidos cíclicos fluorados para inducción de citocinas
|
|
GB201501462D0
(en)
*
|
2015-01-29 |
2015-03-18 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
EP3250250A4
(en)
*
|
2015-01-30 |
2019-05-22 |
President and Fellows of Harvard College |
PERITUMORAL AND INTRATUMORAL MATERIALS FOR CANCER THERAPY
|
|
SG11201806623VA
(en)
|
2015-02-11 |
2018-09-27 |
Univ Johns Hopkins |
Bacteria over-expressing c-di-amp and therapeutic methods
|
|
HK1247089A1
(zh)
|
2015-03-10 |
2018-09-21 |
Aduro Biotech, Inc. |
用於活化“干扰素基因刺激物”依赖性信号传导的组合物和方法
|
|
CN114099793A
(zh)
|
2015-04-10 |
2022-03-01 |
哈佛学院院长等 |
免疫细胞捕获装置及其制备和使用方法
|
|
CN108064176A
(zh)
|
2015-04-22 |
2018-05-22 |
库瑞瓦格股份公司 |
用于治疗肿瘤疾病的含有rna的组合物
|
|
WO2017019896A1
(en)
*
|
2015-07-29 |
2017-02-02 |
Novartis Ag |
Combination therapies comprising antibody molecules to pd-1
|
|
DK3317301T3
(da)
|
2015-07-29 |
2021-06-28 |
Immutep Sas |
Kombinationsterapier omfattende antistofmolekyler mod lag-3
|
|
US20180207273A1
(en)
|
2015-07-29 |
2018-07-26 |
Novartis Ag |
Combination therapies comprising antibody molecules to tim-3
|
|
CN106692967A
(zh)
*
|
2015-08-12 |
2017-05-24 |
聊城市奥润生物医药科技有限公司 |
环二核苷酸cGAMP联合PD1的抗体(Nivolumab)在制备抗肿瘤药物中的应用
|
|
GEP20207182B
(en)
|
2015-08-13 |
2020-11-25 |
Merck Sharp & Dohme |
Cyclic di-nucleotide compounds as sting agonists
|
|
US11453697B1
(en)
|
2015-08-13 |
2022-09-27 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
CN106540255A
(zh)
*
|
2015-09-18 |
2017-03-29 |
聊城市奥润生物医药科技有限公司 |
环二核苷酸cGAMP联合贝伐珠单抗在抗肿瘤中的应用
|
|
UY36969A
(es)
|
2015-10-28 |
2017-05-31 |
Novartis Ag |
Composiciones y métodos para activar la señalización dependiente del estimulador del gen de interferon
|
|
MA44334A
(fr)
|
2015-10-29 |
2018-09-05 |
Novartis Ag |
Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
|
|
MX363780B
(es)
|
2015-12-03 |
2019-04-03 |
Glaxosmithkline Ip Dev Ltd |
Dinucleótidos de purina cíclica como moduladores del estimulador de los genes de interferón.
|
|
US20170199961A1
(en)
|
2015-12-16 |
2017-07-13 |
Gritstone Oncology, Inc. |
Neoantigen Identification, Manufacture, and Use
|
|
WO2017106740A1
(en)
*
|
2015-12-16 |
2017-06-22 |
Aduro Biotech, Inc. |
Methods for identifying inhibitors of "stimulator of interferon gene"-dependent interferon production
|
|
WO2017106656A1
(en)
|
2015-12-17 |
2017-06-22 |
Novartis Ag |
Antibody molecules to pd-1 and uses thereof
|
|
MX2018008592A
(es)
|
2016-01-11 |
2018-12-10 |
Novartis Ag |
Anticuerpos monoclonales humanizados inmunoestimulantes contra interleucina-2 humana, y proteinas de fusion de los mismos.
|
|
WO2017123657A1
(en)
|
2016-01-11 |
2017-07-20 |
Gary Glick |
Cyclic dinucleotides for treating conditions associated with sting activity such as cancer
|
|
SMT202500412T1
(it)
|
2016-01-11 |
2025-11-10 |
Innate Tumor Immunity Inc |
Dinucleotidi ciclici per il trattamento di condizioni associate all’attività di sting quali il cancro
|
|
CN106544319A
(zh)
*
|
2016-01-24 |
2017-03-29 |
聊城市奥润生物医药科技有限公司 |
一种用于刺激树突状细胞成熟的组合物及其用于刺激树突状细胞成熟的方法
|
|
CN115487351A
(zh)
|
2016-02-06 |
2022-12-20 |
哈佛学院校长同事会 |
重塑造血巢以重建免疫
|
|
CN114751950B
(zh)
*
|
2016-03-18 |
2025-04-18 |
免疫传感器公司 |
环二核苷酸化合物及使用方法
|
|
CN106540256A
(zh)
*
|
2016-03-27 |
2017-03-29 |
聊城市奥润生物医药科技有限公司 |
环二核苷酸-脂质体偶联单克隆抗体在抗肿瘤中的应用
|
|
WO2017175156A1
(en)
|
2016-04-07 |
2017-10-12 |
Glaxosmithkline Intellectual Property Development Limited |
Heterocyclic amides useful as protein modulators
|
|
JOP20170083B1
(ar)
|
2016-04-07 |
2022-03-14 |
Glaxosmithkline Ip Dev Ltd |
أميدات هتيروسيكلية مفيدة كمعدلات بروتين
|
|
US10533007B2
(en)
|
2016-04-19 |
2020-01-14 |
Innate Tumor Immunity, Inc. |
NLRP3 modulators
|
|
EP3445761A1
(en)
|
2016-04-19 |
2019-02-27 |
Innate Tumor Immunity, Inc. |
Nlrp3 modulators
|
|
US10696985B1
(en)
|
2016-06-06 |
2020-06-30 |
Vanderbilt University |
Reversibly crosslinked endosomolytic polymer vesicles for cytosolic drug delivery
|
|
US11098077B2
(en)
|
2016-07-05 |
2021-08-24 |
Chinook Therapeutics, Inc. |
Locked nucleic acid cyclic dinucleotide compounds and uses thereof
|
|
EP3481402A4
(en)
*
|
2016-07-06 |
2020-01-22 |
Sperovie Biosciences, Inc. |
CONNECTIONS, COMPOSITIONS AND METHODS FOR TREATING A DISEASE
|
|
WO2018009652A1
(en)
*
|
2016-07-06 |
2018-01-11 |
Sperovie Biosciences, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
CA3030427A1
(en)
|
2016-07-13 |
2018-01-18 |
President And Fellows Of Harvard College |
Antigen-presenting cell-mimetic scaffolds and methods for making and using the same
|
|
NL2017267B1
(en)
|
2016-07-29 |
2018-02-01 |
Aduro Biotech Holdings Europe B V |
Anti-pd-1 antibodies
|
|
NL2017270B1
(en)
|
2016-08-02 |
2018-02-09 |
Aduro Biotech Holdings Europe B V |
New anti-hCTLA-4 antibodies
|
|
JP7274214B2
(ja)
|
2016-08-02 |
2023-05-16 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
免疫応答を調節するための生体材料
|
|
US11725035B2
(en)
|
2016-08-09 |
2023-08-15 |
Stipe Therapeutics Aps |
Methods of treating a disorder associated with with insufficient stimulator of interferon genes (STING) activity
|
|
BR112019004042A2
(pt)
|
2016-08-30 |
2019-05-28 |
Dana-Farber Cancer Institute, Inc. |
composições de liberação de fármaco e usos das mesmas
|
|
US11052149B2
(en)
|
2016-09-19 |
2021-07-06 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for inducing an immune response
|
|
US10537590B2
(en)
|
2016-09-30 |
2020-01-21 |
Boehringer Ingelheim International Gmbh |
Cyclic dinucleotide compounds
|
|
TN2020000158A1
(en)
|
2016-10-04 |
2022-04-04 |
Merck Sharp & Dohme |
BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS
|
|
WO2018065360A1
(de)
|
2016-10-07 |
2018-04-12 |
Biolog Life Science Institute Forschungslabor Und Biochemica-Vertrieb Gmbh |
Benzimidazolhaltige cyclische dinukleotide, verfahren zu deren herstellung und ihre verwendung zur aktivierung von stimulator von interferongenen (sting)-abhängigen signalwegen
|
|
EP3525817A4
(en)
|
2016-10-11 |
2020-09-16 |
The Governors of the University of Alberta |
HEPATITIS C VIRUS-BASED IMMUNOGENIC COMPOSITIONS INCLUDING AS ADJUSTING A CYCLIC DINULEOTIDE OR ARCHAEOSOME AND THEIR METHODS OF USE
|
|
JOP20170188A1
(ar)
*
|
2016-11-25 |
2019-01-30 |
Janssen Biotech Inc |
ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting)
|
|
JP2018090562A
(ja)
*
|
2016-12-01 |
2018-06-14 |
武田薬品工業株式会社 |
環状ジヌクレオチド
|
|
JOP20170192A1
(ar)
*
|
2016-12-01 |
2019-01-30 |
Takeda Pharmaceuticals Co |
داي نوكليوتيد حلقي
|
|
AU2017378782A1
(en)
*
|
2016-12-20 |
2019-07-04 |
Merck Sharp & Dohme Corp. |
Combinations of PD-1 antagonists and cyclic dinucleotide sting agonists for cancer treatment
|
|
AU2017378783A1
(en)
*
|
2016-12-20 |
2019-07-04 |
Merck Sharp & Dohme Corp. |
Cyclic dinucleotide sting agonists for cancer treatment
|
|
ES2924186T3
(es)
|
2017-01-27 |
2022-10-05 |
Janssen Biotech Inc |
Dinucleótidos cíclicos como agonistas de STING
|
|
AU2018212787B2
(en)
|
2017-01-27 |
2023-10-26 |
Janssen Biotech, Inc. |
Cyclic dinucleotides as sting agonists
|
|
EA201991804A1
(ru)
|
2017-02-01 |
2020-02-07 |
МОДЕРНАТиЭкс, ИНК. |
ИММУНОМОДУЛИРУЮЩИЕ ТЕРАПЕВТИЧЕСКИЕ КОМПОЗИЦИИ мРНК, КОДИРУЮЩЕЙ ПЕПТИДЫ С АКТИВИРУЮЩЕЙ ОНКОГЕННОЙ МУТАЦИЕЙ
|
|
TWI674261B
(zh)
|
2017-02-17 |
2019-10-11 |
美商英能腫瘤免疫股份有限公司 |
Nlrp3 調節劑
|
|
JP2018131427A
(ja)
*
|
2017-02-17 |
2018-08-23 |
国立研究開発法人理化学研究所 |
免疫細胞の制御技術
|
|
US20200055883A1
(en)
|
2017-02-17 |
2020-02-20 |
Eisai R&D Management Co., Ltd. |
Cyclic di-nucleotides derivative for the treatment of cancer
|
|
US10933078B2
(en)
|
2017-02-21 |
2021-03-02 |
Board Of Regents, The University Of Texas System |
Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling
|
|
CN106727331B
(zh)
*
|
2017-03-13 |
2022-02-01 |
杭州星鳌生物科技有限公司 |
免疫脂质体-环二核苷酸的组成、制备方法及其在抗肿瘤中的应用
|
|
MX2019011148A
(es)
|
2017-03-20 |
2019-10-17 |
Genocea Biosciences Inc |
Metodos de tratamiento.
|
|
JOP20190218A1
(ar)
|
2017-03-22 |
2019-09-22 |
Boehringer Ingelheim Int |
مركبات ثنائية النيوكليوتيدات حلقية معدلة
|
|
CN118267470A
(zh)
|
2017-04-13 |
2024-07-02 |
赛罗帕私人有限公司 |
抗SIRPα抗体
|
|
CA3058966A1
(en)
|
2017-04-14 |
2018-10-18 |
Tollnine, Inc. |
Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use
|
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
|
AR113224A1
(es)
*
|
2017-04-28 |
2020-02-19 |
Novartis Ag |
Conjugados de anticuerpo que comprenden un agonista de sting
|
|
AR111651A1
(es)
|
2017-04-28 |
2019-08-07 |
Novartis Ag |
Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación
|
|
WO2018208667A1
(en)
*
|
2017-05-12 |
2018-11-15 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
|
CN108853144A
(zh)
*
|
2017-05-16 |
2018-11-23 |
科济生物医药(上海)有限公司 |
Toll样受体激动剂与免疫效应细胞的联用
|
|
WO2018229715A1
(en)
|
2017-06-16 |
2018-12-20 |
Novartis Ag |
Compositions comprising anti-cd32b antibodies and methods of use thereof
|
|
MY204117A
(en)
|
2017-06-22 |
2024-08-08 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
US20200172628A1
(en)
|
2017-06-22 |
2020-06-04 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
CA3069524A1
(en)
|
2017-07-14 |
2019-01-17 |
Innate Tumor Immunity, Inc. |
Nlrp3 modulators
|
|
EP3431484A1
(en)
*
|
2017-07-21 |
2019-01-23 |
Ludwig-Maximilians-Universität München |
A fluorescent cyclic dinucleotide and its use in methods of identifying substances having an ability to modulate the cgas/sting pathway
|
|
EP3658565B1
(en)
*
|
2017-07-28 |
2022-11-09 |
Bristol-Myers Squibb Company |
Cyclic dinucleotides as anticancer agents
|
|
CA3071538A1
(en)
|
2017-08-04 |
2019-02-07 |
Merck Sharp & Dohme Corp. |
Benzo[b]thiophene sting agonists for cancer treatment
|
|
JP2020529421A
(ja)
|
2017-08-04 |
2020-10-08 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
がんの処置のためのPD−1アンタゴニストおよびベンゾ[b]チオフェンSTINGアゴニストの組み合わせ
|
|
MX2020002303A
(es)
|
2017-08-30 |
2020-09-10 |
Beijing Xuanyi Pharmasciences Co Ltd |
Dinucleotidos ciclicos como moduladores del estimulador de genes de interferon.
|
|
ES2945140T3
(es)
*
|
2017-08-31 |
2023-06-28 |
Bristol Myers Squibb Co |
Dinucleótidos cíclicos como agentes anticancerosos
|
|
ES2904317T3
(es)
*
|
2017-08-31 |
2022-04-04 |
Bristol Myers Squibb Co |
Dinucleótidos cíclicos como agentes anticancerosos
|
|
WO2019046511A1
(en)
|
2017-08-31 |
2019-03-07 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE
|
|
HUE066413T2
(hu)
|
2017-09-08 |
2024-08-28 |
Univ Leland Stanford Junior |
ENPP1 inhibitorok és alkalmazásuk rák kezelésére
|
|
WO2019051489A1
(en)
|
2017-09-11 |
2019-03-14 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
|
|
WO2019051488A1
(en)
|
2017-09-11 |
2019-03-14 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
|
|
BR112020006780A2
(pt)
|
2017-10-05 |
2020-10-06 |
Glaxosmithkline Intellectual Property Development Limited |
moduladores do estimulador de genes do interferon (sting)
|
|
TW201927771A
(zh)
|
2017-10-05 |
2019-07-16 |
英商葛蘭素史密斯克藍智慧財產發展有限公司 |
可作為蛋白質調節劑之雜環醯胺及其使用方法
|
|
CN118888004A
(zh)
|
2017-10-10 |
2024-11-01 |
磨石生物公司 |
使用热点进行的新抗原鉴别
|
|
US20210040205A1
(en)
|
2017-10-25 |
2021-02-11 |
Novartis Ag |
Antibodies targeting cd32b and methods of use thereof
|
|
PE20210156A1
(es)
|
2017-11-10 |
2021-01-26 |
Takeda Pharmaceuticals Co |
Compuestos moduladores de sting y metodos de elaboracion y uso
|
|
EA038805B1
(ru)
*
|
2017-11-21 |
2021-10-21 |
Такеда Фармасьютикал Компани Лимитед |
Циклические динуклеотиды в качестве агонистов sting (стимулятор генов интерферона)
|
|
US11885815B2
(en)
|
2017-11-22 |
2024-01-30 |
Gritstone Bio, Inc. |
Reducing junction epitope presentation for neoantigens
|
|
WO2019104353A1
(en)
*
|
2017-11-27 |
2019-05-31 |
Children's Medical Center Corporation |
Stimulator of interferon genes (sting) ligands and uses thereof
|
|
CA3085337A1
(en)
*
|
2017-12-15 |
2019-06-20 |
Janssen Biotech, Inc. |
Cyclic dinucleotides as sting agonists
|
|
US11685761B2
(en)
|
2017-12-20 |
2023-06-27 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
WO2019123339A1
(en)
|
2017-12-20 |
2019-06-27 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
|
WO2019123340A1
(en)
|
2017-12-20 |
2019-06-27 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
|
WO2019136118A2
(en)
*
|
2018-01-04 |
2019-07-11 |
Academia Sinica |
Cell-associating immunologic adjuvants for treatment enhancement
|
|
JP2021512144A
(ja)
*
|
2018-01-26 |
2021-05-13 |
ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニアThe Regents of the University of California |
環状ジヌクレオチドアジュバント含有結核ワクチンの鼻腔内送達
|
|
CN111936156A
(zh)
|
2018-02-02 |
2020-11-13 |
诺华股份有限公司 |
用于治疗癌症的STING激动剂和IL-15/IL15-Ra的组合
|
|
EP3749681A1
(en)
*
|
2018-02-06 |
2020-12-16 |
STipe Therapeutics ApS |
Modulation of p62 and sting activity
|
|
US12220462B1
(en)
|
2018-02-13 |
2025-02-11 |
Abionyx Pharma Sa |
Complexes for delivery of cyclic dinucleotides
|
|
US20190275135A1
(en)
|
2018-03-12 |
2019-09-12 |
Janssen Pharmaceuticals, Inc |
Vaccines against intra-abdominal infections
|
|
CN110272462B
(zh)
*
|
2018-03-15 |
2023-03-10 |
南开大学 |
制备化合物的方法
|
|
CN112118866A
(zh)
|
2018-03-23 |
2020-12-22 |
科迪亚克生物科学公司 |
包含sting激动剂的细胞外囊泡
|
|
US20210009627A1
(en)
|
2018-03-27 |
2021-01-14 |
Boehringer Ingelheim International Gmbh |
Cyclic dinucleotide compounds containing 2-aza-hypoxanthine or 6h-pytazolo[1,5-d][1,2,4]trizain-7-one as string agonists
|
|
JP2021519279A
(ja)
|
2018-03-27 |
2021-08-10 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
修飾環式ジヌクレオチド化合物
|
|
US10793557B2
(en)
|
2018-04-03 |
2020-10-06 |
Merck Sharp & Dohme Corp. |
Sting agonist compounds
|
|
US11702430B2
(en)
|
2018-04-03 |
2023-07-18 |
Merck Sharp & Dohme Llc |
Aza-benzothiophene compounds as STING agonists
|
|
WO2019195658A1
(en)
|
2018-04-05 |
2019-10-10 |
Dana-Farber Cancer Institute, Inc. |
Sting levels as a biomarker for cancer immunotherapy
|
|
TW202005654A
(zh)
|
2018-04-06 |
2020-02-01 |
捷克科學院有機化學與生物化學研究所 |
2,2,─環二核苷酸
|
|
TWI818007B
(zh)
|
2018-04-06 |
2023-10-11 |
捷克科學院有機化學與生物化學研究所 |
2'3'-環二核苷酸
|
|
TWI833744B
(zh)
*
|
2018-04-06 |
2024-03-01 |
捷克科學院有機化學與生物化學研究所 |
3'3'-環二核苷酸
|
|
KR102711180B1
(ko)
|
2018-04-25 |
2024-09-26 |
인네이트 튜머 이뮤니티, 인코포레이티드 |
Nlrp3 조정제
|
|
CN108310378A
(zh)
*
|
2018-04-28 |
2018-07-24 |
杭州星鳌生物科技有限公司 |
一类新型免疫联体抗肿瘤创新药物的制备及其应用
|
|
TW202014193A
(zh)
|
2018-05-03 |
2020-04-16 |
捷克科學院有機化學與生物化學研究所 |
包含碳環核苷酸之2’3’-環二核苷酸
|
|
GB201807924D0
(en)
|
2018-05-16 |
2018-06-27 |
Ctxt Pty Ltd |
Compounds
|
|
US20210214459A1
(en)
|
2018-05-31 |
2021-07-15 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
KR20210015937A
(ko)
|
2018-06-01 |
2021-02-10 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
방광암을 치료하기 위한 방법
|
|
JP2021529173A
(ja)
*
|
2018-06-20 |
2021-10-28 |
イエール ユニバーシティ |
Rig−iアゴニストおよびそれを使用した処置
|
|
EP3817820A1
(en)
|
2018-07-03 |
2021-05-12 |
IFM Due, Inc. |
Compounds and compositions for treating conditions associated with sting activity
|
|
MA53096A
(fr)
|
2018-07-03 |
2021-05-12 |
Ifm Due Inc |
Composés et compositions destinés au traitement d'états pathologiques associés à une activité de sting
|
|
EP3820477A4
(en)
|
2018-07-10 |
2022-07-13 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES
|
|
SG11202100023XA
(en)
*
|
2018-07-11 |
2021-01-28 |
Actym Therapeutics Inc |
Engineered immunostimulatory bacterial strains and uses thereof
|
|
KR102783784B1
(ko)
|
2018-08-16 |
2025-03-21 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
화합물의 염 및 이의 결정
|
|
US12201627B2
(en)
|
2018-08-16 |
2025-01-21 |
Innate Tumor Immunity, Inc. |
NLRP3 modulators
|
|
US11572360B2
(en)
|
2018-08-16 |
2023-02-07 |
Innate Tumor Immunity, Inc. |
Substituted 4-amino-1H-imidazo[4,5-c]quinoline compounds and improved methods for their preparation
|
|
EP3837015B1
(en)
|
2018-08-16 |
2024-02-14 |
Innate Tumor Immunity, Inc. |
Imidazo[4,5-c]quinoline derived nlrp3-modulators
|
|
MA53438A
(fr)
|
2018-08-24 |
2021-09-15 |
Codiak Biosciences Inc |
Vésicules extracellulaires ciblant des cellules dendritiques et utilisations associées
|
|
SMT202500141T1
(it)
|
2018-09-06 |
2025-05-12 |
Daiichi Sankyo Co Ltd |
Coniugati farmaco-anticorpo di derivati dinucleotidici ciclici
|
|
WO2020049534A1
(en)
|
2018-09-07 |
2020-03-12 |
Novartis Ag |
Sting agonist and combination therapy thereof for the treatment of cancer
|
|
US20220031825A1
(en)
*
|
2018-09-17 |
2022-02-03 |
Quratis Inc. |
Immunological adjuvant and vaccine composition including sting agonist
|
|
WO2020061129A1
(en)
|
2018-09-19 |
2020-03-26 |
President And Fellows Of Harvard College |
Compositions and methods for labeling and modulation of cells in vitro and in vivo
|
|
MX2021003207A
(es)
*
|
2018-09-21 |
2021-06-23 |
Shanghai De Novo Pharmatech Co Ltd |
Analogo de dinucleotido ciclico. composicion farmaceutica del mismo y su aplicacion.
|
|
AU2019373241A1
(en)
|
2018-10-29 |
2021-06-10 |
Genocea Biosciences, Inc. |
Treatment methods
|
|
US11110106B2
(en)
|
2018-10-29 |
2021-09-07 |
Venenum Biodesign, LLC |
Sting agonists for treating bladder cancer and solid tumors
|
|
AU2019371206A1
(en)
|
2018-10-29 |
2021-05-27 |
Venenum Biodesign, LLC |
Novel sting agonists
|
|
US20220008346A1
(en)
|
2018-10-30 |
2022-01-13 |
Vanderbilt University |
Graft copolymers, methods of forming graft copolymers, and methods of use thereof
|
|
EP3873938A1
(en)
|
2018-10-31 |
2021-09-08 |
Novartis AG |
Dc-sign antibody conjugates comprising sting agonists
|
|
US11596692B1
(en)
|
2018-11-21 |
2023-03-07 |
Incyte Corporation |
PD-L1/STING conjugates and methods of use
|
|
WO2020117623A1
(en)
*
|
2018-12-07 |
2020-06-11 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
|
WO2020117624A1
(en)
*
|
2018-12-07 |
2020-06-11 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
|
EP3891164A4
(en)
*
|
2018-12-07 |
2022-08-24 |
Merck Sharp & Dohme Corp. |
CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
|
|
WO2020143740A1
(zh)
*
|
2019-01-10 |
2020-07-16 |
南开大学 |
环二核苷酸前药分子及其制备方法和应用
|
|
KR20210114983A
(ko)
|
2019-01-14 |
2021-09-24 |
인네이트 튜머 이뮤니티, 인코포레이티드 |
Nlrp3 조정제
|
|
JP7373571B2
(ja)
|
2019-01-14 |
2023-11-02 |
イネイト・テューマー・イミュニティ・インコーポレイテッド |
がん治療に用いるためのnlrp3モジュレーターとしての置換キナゾリン
|
|
JP7335341B2
(ja)
|
2019-01-14 |
2023-08-29 |
イネイト・テューマー・イミュニティ・インコーポレイテッド |
Nlrp3モジュレーター
|
|
EP3911417B1
(en)
|
2019-01-14 |
2022-10-26 |
Innate Tumor Immunity, Inc. |
Heterocyclic nlrp3 modulators , for use in the treatment of cancer
|
|
TW202043198A
(zh)
|
2019-01-17 |
2020-12-01 |
美商Ifm Due有限公司 |
用於治療與sting活性相關之病況的化合物及組合物
|
|
US10998091B2
(en)
|
2019-02-07 |
2021-05-04 |
Sandeep Patil |
Systems for monitoring compliance with a patch dosage regimen and methods of using the same
|
|
US12024709B2
(en)
|
2019-02-27 |
2024-07-02 |
Actym Therapeutics, Inc. |
Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
|
|
CN113543851B
(zh)
*
|
2019-03-07 |
2025-03-18 |
捷克共和国有机化学与生物化学研究所 |
2’3’-环二核苷酸及其前药
|
|
US20220143061A1
(en)
|
2019-03-07 |
2022-05-12 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3'3'-cyclic dinucleotides and prodrugs thereof
|
|
WO2020178768A1
(en)
|
2019-03-07 |
2020-09-10 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
|
|
IL286467B1
(en)
|
2019-03-18 |
2025-10-01 |
Janssen Pharmaceuticals Inc |
Methods for producing bioconjugates of E. COLI O-antigen polysaccharides, preparations thereof and methods for using them
|
|
PE20212265A1
(es)
|
2019-03-18 |
2021-11-30 |
Janssen Pharmaceuticals Inc |
Bioconjugados de antigenos-polisacaridos de e. coli, metodos de produccion y metodos de utilizacion de los mismos
|
|
JP2022525924A
(ja)
|
2019-03-21 |
2022-05-20 |
コディアック バイオサイエンシーズ, インコーポレイテッド |
細胞外小胞コンジュゲート及びその使用
|
|
US12233356B2
(en)
|
2019-03-21 |
2025-02-25 |
Lonza Sales Ag |
Process for preparing extracellular vesicles
|
|
SG11202109702QA
(en)
|
2019-03-21 |
2021-10-28 |
Codiak Biosciences Inc |
Extracellular vesicles for vaccine delivery
|
|
EP3946324B1
(en)
|
2019-04-04 |
2025-07-30 |
Merck Sharp & Dohme LLC |
Inhibitors of histone deacetylase-3 useful for the treatment of cancer, inflammation, neurodegeneration diseases and diabetes
|
|
TW202104214A
(zh)
|
2019-04-05 |
2021-02-01 |
英商葛蘭素史密斯克藍智慧財產發展有限公司 |
化合物
|
|
EP3962493A2
(en)
|
2019-05-03 |
2022-03-09 |
Flagship Pioneering Innovations V, Inc. |
Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor
|
|
WO2020227421A1
(en)
*
|
2019-05-09 |
2020-11-12 |
Aligos Therapeutics, Inc. |
Modified cyclic dinucleoside compounds as sting modulators
|
|
CN119770674A
(zh)
|
2019-05-10 |
2025-04-08 |
武田药品工业株式会社 |
抗体药物缀合物
|
|
EP3976584A1
(en)
|
2019-05-29 |
2022-04-06 |
IFM Due, Inc. |
Compounds and compositions for treating conditions associated with sting activity
|
|
US20220251200A1
(en)
|
2019-07-03 |
2022-08-11 |
Codiak Biosciences, Inc. |
Extracellular vesicles targeting t cells and uses thereof
|
|
WO2021007160A1
(en)
|
2019-07-05 |
2021-01-14 |
Tambo, Inc. |
Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
|
|
GB201910304D0
(en)
|
2019-07-18 |
2019-09-04 |
Ctxt Pty Ltd |
Compounds
|
|
GB201910305D0
(en)
|
2019-07-18 |
2019-09-04 |
Ctxt Pty Ltd |
Compounds
|
|
TW202114710A
(zh)
|
2019-07-25 |
2021-04-16 |
英屬開曼群島商百濟神州有限公司 |
作為sting促效劑之環狀二核苷酸
|
|
US11155567B2
(en)
|
2019-08-02 |
2021-10-26 |
Mersana Therapeutics, Inc. |
Sting agonist compounds and methods of use
|
|
US12098212B2
(en)
|
2019-08-12 |
2024-09-24 |
Purinomia Biotech, Inc. |
Methods and compositions for promoting and potentiating T-cell mediated immune responses through ADCC targeting of CD39 expressing cells
|
|
WO2021041532A1
(en)
|
2019-08-26 |
2021-03-04 |
Dana-Farber Cancer Institute, Inc. |
Use of heparin to promote type 1 interferon signaling
|
|
EP3785719A1
(en)
*
|
2019-08-28 |
2021-03-03 |
Helmholtz-Zentrum für Infektionsforschung GmbH |
New use of cyclic dinucleotides
|
|
US20230241089A1
(en)
|
2019-09-25 |
2023-08-03 |
Codiak Biosciences, Inc. |
Sting agonist comprising exosomes for treating neuroimmunological disorders
|
|
EP4034276A1
(en)
|
2019-09-25 |
2022-08-03 |
Codiak BioSciences, Inc. |
Methods of producing extracellular vesicles
|
|
EP4034150A1
(en)
|
2019-09-25 |
2022-08-03 |
Codiak BioSciences, Inc. |
Sting agonist comprising exosomes combined with il-12 displaying exosomes for treating a tumour
|
|
US20240099973A1
(en)
|
2019-09-25 |
2024-03-28 |
Lonza Sales Ag |
Extracellular vesicle compositions
|
|
IL291821A
(en)
|
2019-10-02 |
2022-06-01 |
Janssen Vaccines & Prevention Bv |
Staphylococcus peptides and methods of use
|
|
TW202128775A
(zh)
|
2019-10-16 |
2021-08-01 |
英商阿法克塔生命科學有限公司 |
PD-L1抑制劑-TGFβ抑制劑雙特異性藥物部分
|
|
US20230074558A1
(en)
|
2019-12-06 |
2023-03-09 |
Mersana Therapeutics, Inc. |
Dimeric compounds as sting agonists
|
|
JP7662644B2
(ja)
|
2019-12-18 |
2025-04-15 |
シーティーエックスティー・ピーティーワイ・リミテッド |
化合物
|
|
JP7573622B2
(ja)
|
2020-01-10 |
2024-10-25 |
イネイト・テューマー・イミュニティ・インコーポレイテッド |
Nlrp3モジュレーター
|
|
CN115038461A
(zh)
|
2020-01-16 |
2022-09-09 |
杨森制药公司 |
FimH突变体、其组合物及其用途
|
|
CN115427458A
(zh)
|
2020-02-28 |
2022-12-02 |
塔拉克治疗公司 |
转谷氨酰胺酶介导的缀合
|
|
EP4115909A4
(en)
|
2020-03-06 |
2024-10-30 |
Daiichi Sankyo Company, Limited |
ANTIBODY-DRUG CONJUGATE WITH NOVEL CYCLIC DINUCLEOTIDE DERIVATIVE
|
|
WO2021184017A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Extracellular vesicles for treating neurological disorders
|
|
AU2021236763A1
(en)
|
2020-03-20 |
2022-10-06 |
Lonza Sales Ag |
Extracellular vesicles for therapy
|
|
BR112022019919A2
(pt)
|
2020-04-02 |
2023-02-14 |
Mersana Therapeutics Inc |
Conjugado de anticorpo-fármaco compreendendo agonistas de sting
|
|
EP4134098A4
(en)
|
2020-04-10 |
2024-05-15 |
ONO Pharmaceutical Co., Ltd. |
Method of cancer therapy
|
|
US11857618B2
(en)
|
2020-04-17 |
2024-01-02 |
Emory University |
Boosting immunogenicity of vaccines using saponins and agonists of the intracellular stimulator of interferon genes pathway
|
|
JP7776145B2
(ja)
|
2020-05-13 |
2025-11-26 |
マサチューセッツ インスティテュート オブ テクノロジー |
ポリマーマイクロデバイスの組成物およびがん免疫療法におけるその使用
|
|
WO2021237100A1
(en)
|
2020-05-21 |
2021-11-25 |
Codiak Biosciences, Inc. |
Methods of targeting extracellular vesicles to lung
|
|
JP2023537066A
(ja)
|
2020-08-07 |
2023-08-30 |
タンボ・インコーポレイテッド |
トランス-シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用
|
|
TW202227479A
(zh)
|
2020-09-02 |
2022-07-16 |
日商第一三共股份有限公司 |
新穎內-β-N-乙醯葡萄糖胺苷酶
|
|
JP2023546316A
(ja)
|
2020-09-08 |
2023-11-02 |
ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム |
多価sting活性化組成物およびその使用法
|
|
EP4213870A1
(en)
|
2020-09-17 |
2023-07-26 |
Janssen Pharmaceuticals, Inc. |
Multivalent vaccine compositions and uses thereof
|
|
WO2022066883A1
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Extracellular vesicles comprising kras antigens and uses thereof
|
|
CA3192470A1
(en)
|
2020-09-23 |
2022-03-31 |
Tim SOOS |
Methods of producing extracellular vesicles
|
|
US20240241020A1
(en)
|
2020-09-23 |
2024-07-18 |
Lonza Sales Ag |
Process for preparing extracellular vesicles
|
|
EP4217087A2
(en)
|
2020-09-23 |
2023-08-02 |
Codiak BioSciences, Inc. |
Process for preparing extracellular vesicles
|
|
JP2023545178A
(ja)
|
2020-10-14 |
2023-10-26 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Stingアゴニストと、細胞透過性ペプチド、カーゴ、及びtlrペプチドアゴニストを含む複合体との組合せ
|
|
EP3984535A1
(en)
|
2020-10-16 |
2022-04-20 |
Albert-Ludwigs-Universität Freiburg |
Nlrp3 activators for use in the treatment of infectious diseases or cancer by activating nlrp3 inflammasome
|
|
CN115160392A
(zh)
*
|
2020-10-20 |
2022-10-11 |
泰励生物科技(上海)有限公司 |
多功能环二核苷酸及其用途
|
|
KR20230107586A
(ko)
|
2020-10-20 |
2023-07-17 |
타이리간드 바이오사이언스 (상하이) 리미티드 |
다기능성 사이클릭 디뉴클레오티드 및 이의 용도
|
|
JP2023548310A
(ja)
|
2020-10-30 |
2023-11-16 |
アバクタ・ライフ・サイエンシーズ・リミテッド |
Fap活性化血清半減期延長型治療用コンジュゲート
|
|
EP4240488A1
(en)
|
2020-11-09 |
2023-09-13 |
Takeda Pharmaceutical Company Limited |
Antibody drug conjugates
|
|
TW202241516A
(zh)
|
2020-12-17 |
2022-11-01 |
美商杜夫特學院信託管理公司 |
經fap活化之放射性治療診斷(radiotheranostics),與其相關用途
|
|
US12152018B2
(en)
|
2021-01-08 |
2024-11-26 |
Ifm Due, Inc. |
Compounds and compositions for treating conditions associated with STING activity
|
|
WO2022153166A1
(en)
|
2021-01-12 |
2022-07-21 |
Janssen Pharmaceuticals, Inc. |
Fimh mutants, compositions therewith and use thereof
|
|
TW202241454A
(zh)
|
2021-02-01 |
2022-11-01 |
日商第一三共股份有限公司 |
抗體-免疫賦活化劑共軛物之新穎製造方法
|
|
JP2024514074A
(ja)
|
2021-04-01 |
2024-03-28 |
ヤンセン ファーマシューティカルズ,インコーポレーテッド |
E.coli o18バイオコンジュゲートの産生
|
|
US20240423927A1
(en)
|
2021-04-20 |
2024-12-26 |
Institut Curie |
Compositions and methods for use in immunotherapy
|
|
EP4326321A1
(en)
|
2021-04-20 |
2024-02-28 |
Institut Curie |
Compositions and methods for use in immunotherapy
|
|
WO2022234003A1
(en)
|
2021-05-07 |
2022-11-10 |
Avacta Life Sciences Limited |
Cd33 binding polypeptides with stefin a protein
|
|
US20220313724A1
(en)
*
|
2021-05-17 |
2022-10-06 |
Highlight Therapeutics, S.L. |
Compositions for intratumoral administration and related methods
|
|
EP4359544A4
(en)
*
|
2021-06-24 |
2025-08-13 |
Univ Miami |
STING-DEPENDENT ADJUVANTS
|
|
WO2023056468A1
(en)
|
2021-09-30 |
2023-04-06 |
Codiak Biosciences, Inc. |
Extracellular vesicle comprising cholesterol tagged sting-agonist
|
|
WO2023057567A1
(en)
|
2021-10-07 |
2023-04-13 |
Avacta Life Sciences Limited |
Pd-l1 binding affimers
|
|
CN114106140A
(zh)
*
|
2021-11-23 |
2022-03-01 |
哈尔滨医科大学附属肿瘤医院 |
一种表达特定sting异构体、细胞系、制备方法、用途
|
|
WO2023154799A1
(en)
|
2022-02-14 |
2023-08-17 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Combination immunotherapy for treating cancer
|
|
KR20240155298A
(ko)
|
2022-03-02 |
2024-10-28 |
다이이찌 산쿄 가부시키가이샤 |
Fc 함유 분자의 제조 방법
|
|
WO2023218243A1
(en)
|
2022-05-12 |
2023-11-16 |
Avacta Life Sciences Limited |
Lag-3/pd-l1 binding fusion proteins
|
|
WO2024048490A1
(ja)
|
2022-08-29 |
2024-03-07 |
第一三共株式会社 |
変異Fc領域を含む抗体薬物コンジュゲート
|
|
WO2024211577A1
(en)
|
2023-04-05 |
2024-10-10 |
Massachusetts Institute Of Technology |
Hybrid polymeric systems and methods of use thereof
|