KR940000828B1 - 항혈전성 강심제 이미다조 퀴놀린의 제조방법 - Google Patents

항혈전성 강심제 이미다조 퀴놀린의 제조방법 Download PDF

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Publication number
KR940000828B1
KR940000828B1 KR1019860003204A KR860003204A KR940000828B1 KR 940000828 B1 KR940000828 B1 KR 940000828B1 KR 1019860003204 A KR1019860003204 A KR 1019860003204A KR 860003204 A KR860003204 A KR 860003204A KR 940000828 B1 KR940000828 B1 KR 940000828B1
Authority
KR
South Korea
Prior art keywords
compound
imidazo
quinolin
dihydro
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1019860003204A
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English (en)
Korean (ko)
Other versions
KR860008177A (ko
Inventor
에이.민웰 니콜라스
제이.라이트 죤
Original Assignee
브리스톨-마이어스 스퀴브 캄파니
이삭 쟈코브스키
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 브리스톨-마이어스 스퀴브 캄파니, 이삭 쟈코브스키 filed Critical 브리스톨-마이어스 스퀴브 캄파니
Publication of KR860008177A publication Critical patent/KR860008177A/ko
Application granted granted Critical
Publication of KR940000828B1 publication Critical patent/KR940000828B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1019860003204A 1985-04-25 1986-04-25 항혈전성 강심제 이미다조 퀴놀린의 제조방법 Expired - Lifetime KR940000828B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US726869 1985-04-25
US726,869 1985-04-25
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents
US832,212 1986-02-26

Publications (2)

Publication Number Publication Date
KR860008177A KR860008177A (ko) 1986-11-12
KR940000828B1 true KR940000828B1 (ko) 1994-02-02

Family

ID=27111398

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860003204A Expired - Lifetime KR940000828B1 (ko) 1985-04-25 1986-04-25 항혈전성 강심제 이미다조 퀴놀린의 제조방법

Country Status (32)

Country Link
US (1) US4668686A (enExample)
KR (1) KR940000828B1 (enExample)
CN (1) CN1016175B (enExample)
AT (1) AT390257B (enExample)
AU (1) AU592983B2 (enExample)
BE (1) BE904671A (enExample)
CA (1) CA1298836C (enExample)
CH (1) CH675722A5 (enExample)
CY (1) CY1641A (enExample)
DE (1) DE3614132A1 (enExample)
DK (3) DK164868C (enExample)
EG (1) EG18104A (enExample)
ES (3) ES8708229A1 (enExample)
FI (1) FI83316C (enExample)
FR (1) FR2581065B1 (enExample)
GB (1) GB2174987B (enExample)
GR (1) GR861086B (enExample)
HK (1) HK64492A (enExample)
HU (1) HU195813B (enExample)
IL (1) IL78581A0 (enExample)
IT (1) IT1215651B (enExample)
LU (1) LU86406A1 (enExample)
MY (1) MY102086A (enExample)
NL (1) NL8601053A (enExample)
NO (1) NO163406C (enExample)
NZ (1) NZ215885A (enExample)
OA (1) OA08242A (enExample)
PT (1) PT82460B (enExample)
SE (1) SE461468B (enExample)
SG (1) SG29092G (enExample)
SU (3) SU1450746A3 (enExample)
YU (1) YU46054B (enExample)

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US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
TW593317B (en) * 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
EP0707585A1 (en) * 1993-07-06 1996-04-24 Pfizer Inc. Bicyclic tetrahydro pyrazolopyridines
TW530047B (en) * 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
US6664264B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
AU2004266658A1 (en) 2003-08-12 2005-03-03 3M Innovative Properties Company Hydroxylamine substituted imidazo-containing compounds
BRPI0413998A (pt) 2003-08-27 2006-11-07 3M Innovative Properties Co imidazoquinolinas arilóxi e arilalquilenóxi substituìdas
US20050054665A1 (en) 2003-09-05 2005-03-10 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
BRPI0414856A (pt) 2003-10-03 2006-11-21 3M Innovative Properties Co imidazoquinolinas alcóxi-substituìdas
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
WO2005048933A2 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
CA2545825A1 (en) * 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
CA2547020C (en) 2003-11-25 2014-03-25 3M Innovative Properties Company 1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier
WO2005066170A1 (en) 2003-12-29 2005-07-21 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
AU2004312508A1 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
TW200612932A (en) 2004-03-24 2006-05-01 3M Innovative Properties Co Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en) 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
WO2006009826A1 (en) 2004-06-18 2006-01-26 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
CA2580343A1 (en) * 2004-09-14 2006-03-23 Novartis Vaccines And Diagnostics, Inc. Imidazoquinoline compounds
US8034938B2 (en) 2004-12-30 2011-10-11 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
AU2005322898B2 (en) 2004-12-30 2011-11-24 3M Innovative Properties Company Chiral fused (1,2)imidazo(4,5-c) ring compounds
US9248127B2 (en) 2005-02-04 2016-02-02 3M Innovative Properties Company Aqueous gel formulations containing immune response modifiers
US7968563B2 (en) 2005-02-11 2011-06-28 3M Innovative Properties Company Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
CA2602683A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
WO2006107851A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
PT2583970E (pt) 2006-08-02 2016-02-08 Cytokinetics Inc Certas entidades químicas, composições e métodos compreendendo imidazopirimidinas
EP2139478A4 (en) * 2007-03-30 2010-05-05 Cytokinetics Inc CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
EA201791043A1 (ru) 2011-07-13 2017-09-29 Сайтокинетикс, Инк. Комбинированная терапия бокового амиотрофического склероза
CN120265631A (zh) * 2023-01-13 2025-07-04 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
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US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
CN1016175B (zh) 1992-04-08
HK64492A (en) 1992-09-04
IT8620206A0 (it) 1986-04-24
GB2174987A (en) 1986-11-19
AT390257B (de) 1990-04-10
ES557552A0 (es) 1988-07-16
FI861684A0 (fi) 1986-04-22
ATA112186A (de) 1989-09-15
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
NO163406C (no) 1990-05-23
NZ215885A (en) 1989-04-26
SU1450746A3 (ru) 1989-01-07
SE461468B (sv) 1990-02-19
AU5641386A (en) 1986-10-30
YU46054B (sh) 1992-12-21
ES554336A0 (es) 1987-10-01
GR861086B (en) 1986-09-01
DK190986D0 (da) 1986-04-24
GB2174987B (en) 1989-08-02
CH675722A5 (enExample) 1990-10-31
SU1560056A3 (ru) 1990-04-23
ES557551A0 (es) 1988-02-16
DK190986A (da) 1986-10-26
NO861617L (no) 1986-10-27
BE904671A (fr) 1986-10-24
NO163406B (no) 1990-02-12
OA08242A (en) 1987-10-30
DK165249B (da) 1992-10-26
SG29092G (en) 1992-05-15
AU592983B2 (en) 1990-02-01
ES8802521A1 (es) 1988-07-16
ES8708229A1 (es) 1987-10-01
FR2581065B1 (fr) 1990-02-02
SE8601907D0 (sv) 1986-04-24
CY1641A (en) 1992-11-06
DK165248B (da) 1992-10-26
SE8601907L (sv) 1986-10-26
IT1215651B (it) 1990-02-22
FI861684L (fi) 1986-10-26
FR2581065A1 (fr) 1986-10-31
CN86102747A (zh) 1987-02-04
PT82460B (pt) 1988-11-30
FI83316B (fi) 1991-03-15
DK80291A (da) 1991-04-30
PT82460A (en) 1986-05-01
HUT42089A (en) 1987-06-29
KR860008177A (ko) 1986-11-12
FI83316C (fi) 1991-06-25
EG18104A (en) 1992-09-30
DK164868B (da) 1992-08-31
DK80291D0 (da) 1991-04-30
US4668686A (en) 1987-05-26
GB8610037D0 (en) 1986-05-29
MY102086A (en) 1992-03-31
ES8801829A1 (es) 1988-02-16
IL78581A0 (en) 1986-08-31
DK164868C (da) 1993-01-11
DE3614132A1 (de) 1986-11-27
NL8601053A (nl) 1986-11-17
LU86406A1 (fr) 1986-11-05
SU1470192A3 (ru) 1989-03-30
DK165249C (da) 1993-03-22
DK81091D0 (da) 1991-05-01
YU116787A (en) 1988-04-30
HU195813B (en) 1988-07-28
CA1298836C (en) 1992-04-14

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