AU592983B2 - Imidazoquinoline antithrombogenic cardiotonicagents - Google Patents

Imidazoquinoline antithrombogenic cardiotonicagents Download PDF

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Publication number
AU592983B2
AU592983B2 AU56413/86A AU5641386A AU592983B2 AU 592983 B2 AU592983 B2 AU 592983B2 AU 56413/86 A AU56413/86 A AU 56413/86A AU 5641386 A AU5641386 A AU 5641386A AU 592983 B2 AU592983 B2 AU 592983B2
Authority
AU
Australia
Prior art keywords
compound
formula
imidazo
dihydro
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU56413/86A
Other languages
English (en)
Other versions
AU5641386A (en
Inventor
Nicholas A. Meanwell
John J. Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of AU5641386A publication Critical patent/AU5641386A/en
Application granted granted Critical
Publication of AU592983B2 publication Critical patent/AU592983B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU56413/86A 1985-04-25 1986-04-21 Imidazoquinoline antithrombogenic cardiotonicagents Ceased AU592983B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US726869 1985-04-25
US832212 1986-02-26
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents

Publications (2)

Publication Number Publication Date
AU5641386A AU5641386A (en) 1986-10-30
AU592983B2 true AU592983B2 (en) 1990-02-01

Family

ID=27111398

Family Applications (1)

Application Number Title Priority Date Filing Date
AU56413/86A Ceased AU592983B2 (en) 1985-04-25 1986-04-21 Imidazoquinoline antithrombogenic cardiotonicagents

Country Status (32)

Country Link
US (1) US4668686A (enExample)
KR (1) KR940000828B1 (enExample)
CN (1) CN1016175B (enExample)
AT (1) AT390257B (enExample)
AU (1) AU592983B2 (enExample)
BE (1) BE904671A (enExample)
CA (1) CA1298836C (enExample)
CH (1) CH675722A5 (enExample)
CY (1) CY1641A (enExample)
DE (1) DE3614132A1 (enExample)
DK (3) DK164868C (enExample)
EG (1) EG18104A (enExample)
ES (3) ES8708229A1 (enExample)
FI (1) FI83316C (enExample)
FR (1) FR2581065B1 (enExample)
GB (1) GB2174987B (enExample)
GR (1) GR861086B (enExample)
HK (1) HK64492A (enExample)
HU (1) HU195813B (enExample)
IL (1) IL78581A0 (enExample)
IT (1) IT1215651B (enExample)
LU (1) LU86406A1 (enExample)
MY (1) MY102086A (enExample)
NL (1) NL8601053A (enExample)
NO (1) NO163406C (enExample)
NZ (1) NZ215885A (enExample)
OA (1) OA08242A (enExample)
PT (1) PT82460B (enExample)
SE (1) SE461468B (enExample)
SG (1) SG29092G (enExample)
SU (3) SU1450746A3 (enExample)
YU (1) YU46054B (enExample)

Families Citing this family (45)

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US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
TW593317B (en) * 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
CN1048015C (zh) * 1993-07-06 2000-01-05 美国辉瑞有限公司 双环四氢吡唑并吡啶类化合物
TW574214B (en) * 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US6664264B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
WO2005018556A2 (en) 2003-08-12 2005-03-03 3M Innovative Properties Company Hydroxylamine substituted imidazo-containing compounds
RU2006105101A (ru) 2003-08-27 2007-10-10 3М Инновейтив Пропертиз Компани (US) Арилокси и арилалкиленокси замещенные имидазохинолины
WO2005023190A2 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for cd5+ b cell lymphoma
US8871782B2 (en) * 2003-10-03 2014-10-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
US8598192B2 (en) * 2003-11-14 2013-12-03 3M Innovative Properties Company Hydroxylamine substituted imidazoquinolines
CA2545774A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
AR046781A1 (es) 2003-11-25 2005-12-21 3M Innovative Properties Co Derivados de imidazoquinolinas. composiciones farmaceuticas.
WO2005066170A1 (en) 2003-12-29 2005-07-21 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
CA2551399A1 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
AU2005228150A1 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en) 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
AU2005284835A1 (en) * 2004-09-14 2006-03-23 Novartis Vaccines And Diagnostics Inc. Imidazoquinoline compounds
EP1831226B1 (en) 2004-12-30 2012-08-08 3M Innovative Properties Company Chiral tetracyclic compounds inducing interferon biosynthesis
AU2005326708C1 (en) 2004-12-30 2012-08-30 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
AU2006210392A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune response modifiers
CA2597587A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
US7943636B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company 1-substituted pyrazolo (3,4-C) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
WO2006107853A2 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
US7906506B2 (en) 2006-07-12 2011-03-15 3M Innovative Properties Company Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
BRPI0714725B1 (pt) 2006-08-02 2021-05-25 Cytokinetics, Inc Entidade química, composição farmaceuticamente aceitável, e, uso de uma entidade química
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
US7851484B2 (en) 2007-03-30 2010-12-14 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
CN109316480A (zh) 2011-07-13 2019-02-12 赛特凯恩蒂克公司 组合als疗法
EP4678641A1 (en) * 2023-01-13 2026-01-14 Shanghai Helioson Pharmaceutical Co., Ltd. Quinolinone compound and naphthyridinone compound and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
CH675722A5 (enExample) 1990-10-31
NO861617L (no) 1986-10-27
SE461468B (sv) 1990-02-19
PT82460A (en) 1986-05-01
SU1470192A3 (ru) 1989-03-30
HK64492A (en) 1992-09-04
FI83316B (fi) 1991-03-15
IT8620206A0 (it) 1986-04-24
NZ215885A (en) 1989-04-26
NL8601053A (nl) 1986-11-17
YU116787A (en) 1988-04-30
DK80291A (da) 1991-04-30
DK165248B (da) 1992-10-26
ES557551A0 (es) 1988-02-16
ES8708229A1 (es) 1987-10-01
DK164868C (da) 1993-01-11
ES554336A0 (es) 1987-10-01
DK80291D0 (da) 1991-04-30
AT390257B (de) 1990-04-10
IL78581A0 (en) 1986-08-31
ES557552A0 (es) 1988-07-16
US4668686A (en) 1987-05-26
ES8801829A1 (es) 1988-02-16
MY102086A (en) 1992-03-31
DE3614132A1 (de) 1986-11-27
AU5641386A (en) 1986-10-30
GR861086B (en) 1986-09-01
DK164868B (da) 1992-08-31
YU46054B (sh) 1992-12-21
GB2174987A (en) 1986-11-19
IT1215651B (it) 1990-02-22
NO163406B (no) 1990-02-12
CY1641A (en) 1992-11-06
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
SG29092G (en) 1992-05-15
FI861684A0 (fi) 1986-04-22
DK165249C (da) 1993-03-22
NO163406C (no) 1990-05-23
PT82460B (pt) 1988-11-30
EG18104A (en) 1992-09-30
CN1016175B (zh) 1992-04-08
CA1298836C (en) 1992-04-14
SU1450746A3 (ru) 1989-01-07
GB8610037D0 (en) 1986-05-29
HUT42089A (en) 1987-06-29
SE8601907D0 (sv) 1986-04-24
DK190986A (da) 1986-10-26
KR860008177A (ko) 1986-11-12
ATA112186A (de) 1989-09-15
OA08242A (en) 1987-10-30
DK165249B (da) 1992-10-26
LU86406A1 (fr) 1986-11-05
FI861684L (fi) 1986-10-26
FR2581065A1 (fr) 1986-10-31
FI83316C (fi) 1991-06-25
ES8802521A1 (es) 1988-07-16
SE8601907L (sv) 1986-10-26
KR940000828B1 (ko) 1994-02-02
BE904671A (fr) 1986-10-24
SU1560056A3 (ru) 1990-04-23
DK190986D0 (da) 1986-04-24
HU195813B (en) 1988-07-28
CN86102747A (zh) 1987-02-04
GB2174987B (en) 1989-08-02
DK81091D0 (da) 1991-05-01
FR2581065B1 (fr) 1990-02-02

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