ES8708229A1 - Un procedimiento para la obtencion de 1,3-dihidro-2h-imidazo (4,5-b)-quinolin-2-onas. - Google Patents

Un procedimiento para la obtencion de 1,3-dihidro-2h-imidazo (4,5-b)-quinolin-2-onas.

Info

Publication number
ES8708229A1
ES8708229A1 ES554336A ES554336A ES8708229A1 ES 8708229 A1 ES8708229 A1 ES 8708229A1 ES 554336 A ES554336 A ES 554336A ES 554336 A ES554336 A ES 554336A ES 8708229 A1 ES8708229 A1 ES 8708229A1
Authority
ES
Spain
Prior art keywords
quinolin
imidazo
dihydro
onas
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554336A
Other languages
English (en)
Spanish (es)
Other versions
ES554336A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES554336A0 publication Critical patent/ES554336A0/es
Publication of ES8708229A1 publication Critical patent/ES8708229A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES554336A 1985-04-25 1986-04-24 Un procedimiento para la obtencion de 1,3-dihidro-2h-imidazo (4,5-b)-quinolin-2-onas. Expired ES8708229A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents

Publications (2)

Publication Number Publication Date
ES554336A0 ES554336A0 (es) 1987-10-01
ES8708229A1 true ES8708229A1 (es) 1987-10-01

Family

ID=27111398

Family Applications (3)

Application Number Title Priority Date Filing Date
ES554336A Expired ES8708229A1 (es) 1985-04-25 1986-04-24 Un procedimiento para la obtencion de 1,3-dihidro-2h-imidazo (4,5-b)-quinolin-2-onas.
ES557552A Expired ES8802521A1 (es) 1985-04-25 1987-05-14 Un procedimiento para la obtencion de 1,3-dihidro-2h-imidazo (4,5-b)-quinolin-2-onas
ES557551A Expired ES8801829A1 (es) 1985-04-25 1987-05-14 Un procedimiento para la obtencion de 1,3-dihidro-2h-imidazo (4,5-b)-quinolin-2-onas

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557552A Expired ES8802521A1 (es) 1985-04-25 1987-05-14 Un procedimiento para la obtencion de 1,3-dihidro-2h-imidazo (4,5-b)-quinolin-2-onas
ES557551A Expired ES8801829A1 (es) 1985-04-25 1987-05-14 Un procedimiento para la obtencion de 1,3-dihidro-2h-imidazo (4,5-b)-quinolin-2-onas

Country Status (32)

Country Link
US (1) US4668686A (enExample)
KR (1) KR940000828B1 (enExample)
CN (1) CN1016175B (enExample)
AT (1) AT390257B (enExample)
AU (1) AU592983B2 (enExample)
BE (1) BE904671A (enExample)
CA (1) CA1298836C (enExample)
CH (1) CH675722A5 (enExample)
CY (1) CY1641A (enExample)
DE (1) DE3614132A1 (enExample)
DK (3) DK164868C (enExample)
EG (1) EG18104A (enExample)
ES (3) ES8708229A1 (enExample)
FI (1) FI83316C (enExample)
FR (1) FR2581065B1 (enExample)
GB (1) GB2174987B (enExample)
GR (1) GR861086B (enExample)
HK (1) HK64492A (enExample)
HU (1) HU195813B (enExample)
IL (1) IL78581A0 (enExample)
IT (1) IT1215651B (enExample)
LU (1) LU86406A1 (enExample)
MY (1) MY102086A (enExample)
NL (1) NL8601053A (enExample)
NO (1) NO163406C (enExample)
NZ (1) NZ215885A (enExample)
OA (1) OA08242A (enExample)
PT (1) PT82460B (enExample)
SE (1) SE461468B (enExample)
SG (1) SG29092G (enExample)
SU (3) SU1450746A3 (enExample)
YU (1) YU46054B (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
TW593317B (en) * 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
CA2166721C (en) * 1993-07-06 1999-07-27 Allen Jacob Duplantier Bicyclic tetrahydro pyrazolopyridines
TW574214B (en) * 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US6664264B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
AU2004266658A1 (en) 2003-08-12 2005-03-03 3M Innovative Properties Company Hydroxylamine substituted imidazo-containing compounds
RU2006105101A (ru) 2003-08-27 2007-10-10 3М Инновейтив Пропертиз Компани (US) Арилокси и арилалкиленокси замещенные имидазохинолины
AU2004270201A1 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
RU2412942C2 (ru) 2003-10-03 2011-02-27 3М Инновейтив Пропертиз Компани Оксизамещенные имидазохинолины, способные модулировать биосинтез цитокинов
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
WO2005048945A2 (en) * 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
EP1685129A4 (en) 2003-11-14 2008-10-22 3M Innovative Properties Co OXIMSUBSTITUTED IMIDAZORING CONNECTIONS
CA2547020C (en) 2003-11-25 2014-03-25 3M Innovative Properties Company 1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier
JP2007517035A (ja) 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
CA2551399A1 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
TW200612932A (en) 2004-03-24 2006-05-01 3M Innovative Properties Co Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en) 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
WO2006009826A1 (en) 2004-06-18 2006-01-26 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
CN101824034A (zh) * 2004-09-14 2010-09-08 诺华疫苗和诊断公司 咪唑并喹啉化合物
CA2592904C (en) 2004-12-30 2015-04-07 3M Innovative Properties Company Chiral fused [1,2]imidazo[4,5-c] ring compounds
EP1831221B1 (en) 2004-12-30 2012-08-08 3M Innovative Properties Company Substituted chiral fused 1,2 imidazo 4,5-c ring compounds
EP1844201B1 (en) 2005-02-04 2016-08-24 3M Innovative Properties Company Aqueous gel formulations containing immune response modifiers
CA2597587A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
CA2602590A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
AU2006232377A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
US7906506B2 (en) 2006-07-12 2011-03-15 3M Innovative Properties Company Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
EP2995619B1 (en) 2006-08-02 2019-09-25 Cytokinetics, Inc. Certain chemical entities comprising imidazopyrimidines, compositions and methods
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
WO2008121333A1 (en) * 2007-03-30 2008-10-09 Cytokinetics, Incorporated Certain chemical entities, compositions and methods
US10272082B2 (en) 2011-07-13 2019-04-30 Cytokinetics, Inc. Combination ALS therapy
CN120265631A (zh) * 2023-01-13 2025-07-04 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
YU116787A (en) 1988-04-30
SU1450746A3 (ru) 1989-01-07
US4668686A (en) 1987-05-26
SG29092G (en) 1992-05-15
NO163406B (no) 1990-02-12
NO163406C (no) 1990-05-23
HU195813B (en) 1988-07-28
OA08242A (en) 1987-10-30
BE904671A (fr) 1986-10-24
DK80291D0 (da) 1991-04-30
LU86406A1 (fr) 1986-11-05
EG18104A (en) 1992-09-30
FI861684A0 (fi) 1986-04-22
CA1298836C (en) 1992-04-14
SE8601907L (sv) 1986-10-26
ES554336A0 (es) 1987-10-01
CN86102747A (zh) 1987-02-04
GB8610037D0 (en) 1986-05-29
IT1215651B (it) 1990-02-22
YU46054B (sh) 1992-12-21
SU1470192A3 (ru) 1989-03-30
DK80291A (da) 1991-04-30
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
NZ215885A (en) 1989-04-26
GR861086B (en) 1986-09-01
DK81091D0 (da) 1991-05-01
CY1641A (en) 1992-11-06
ES8802521A1 (es) 1988-07-16
IT8620206A0 (it) 1986-04-24
HUT42089A (en) 1987-06-29
PT82460B (pt) 1988-11-30
ES557551A0 (es) 1988-02-16
SU1560056A3 (ru) 1990-04-23
PT82460A (en) 1986-05-01
FR2581065A1 (fr) 1986-10-31
IL78581A0 (en) 1986-08-31
DK190986A (da) 1986-10-26
GB2174987B (en) 1989-08-02
NL8601053A (nl) 1986-11-17
FI861684L (fi) 1986-10-26
CN1016175B (zh) 1992-04-08
GB2174987A (en) 1986-11-19
AT390257B (de) 1990-04-10
SE8601907D0 (sv) 1986-04-24
ES8801829A1 (es) 1988-02-16
DK164868B (da) 1992-08-31
MY102086A (en) 1992-03-31
DK165249C (da) 1993-03-22
KR860008177A (ko) 1986-11-12
CH675722A5 (enExample) 1990-10-31
ES557552A0 (es) 1988-07-16
FR2581065B1 (fr) 1990-02-02
FI83316B (fi) 1991-03-15
NO861617L (no) 1986-10-27
AU5641386A (en) 1986-10-30
DK190986D0 (da) 1986-04-24
AU592983B2 (en) 1990-02-01
FI83316C (fi) 1991-06-25
ATA112186A (de) 1989-09-15
DK164868C (da) 1993-01-11
SE461468B (sv) 1990-02-19
DK165249B (da) 1992-10-26
DE3614132A1 (de) 1986-11-27
DK165248B (da) 1992-10-26
HK64492A (en) 1992-09-04
KR940000828B1 (ko) 1994-02-02

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401