HU195813B - Process for preparing 1,2-dihydro-2h-imidazo/4,5-b/quinolin-2-one derivatives i medical compositions containing them as active substance - Google Patents

Process for preparing 1,2-dihydro-2h-imidazo/4,5-b/quinolin-2-one derivatives i medical compositions containing them as active substance Download PDF

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Publication number
HU195813B
HU195813B HU861723A HU172386A HU195813B HU 195813 B HU195813 B HU 195813B HU 861723 A HU861723 A HU 861723A HU 172386 A HU172386 A HU 172386A HU 195813 B HU195813 B HU 195813B
Authority
HU
Hungary
Prior art keywords
imidazo
dihydro
quinolin
formula
compound
Prior art date
Application number
HU861723A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT42089A (en
Inventor
A N Meanwell
J J Wright
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of HUT42089A publication Critical patent/HUT42089A/hu
Publication of HU195813B publication Critical patent/HU195813B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU861723A 1985-04-25 1986-04-25 Process for preparing 1,2-dihydro-2h-imidazo/4,5-b/quinolin-2-one derivatives i medical compositions containing them as active substance HU195813B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents

Publications (2)

Publication Number Publication Date
HUT42089A HUT42089A (en) 1987-06-29
HU195813B true HU195813B (en) 1988-07-28

Family

ID=27111398

Family Applications (1)

Application Number Title Priority Date Filing Date
HU861723A HU195813B (en) 1985-04-25 1986-04-25 Process for preparing 1,2-dihydro-2h-imidazo/4,5-b/quinolin-2-one derivatives i medical compositions containing them as active substance

Country Status (32)

Country Link
US (1) US4668686A (enExample)
KR (1) KR940000828B1 (enExample)
CN (1) CN1016175B (enExample)
AT (1) AT390257B (enExample)
AU (1) AU592983B2 (enExample)
BE (1) BE904671A (enExample)
CA (1) CA1298836C (enExample)
CH (1) CH675722A5 (enExample)
CY (1) CY1641A (enExample)
DE (1) DE3614132A1 (enExample)
DK (3) DK164868C (enExample)
EG (1) EG18104A (enExample)
ES (3) ES8708229A1 (enExample)
FI (1) FI83316C (enExample)
FR (1) FR2581065B1 (enExample)
GB (1) GB2174987B (enExample)
GR (1) GR861086B (enExample)
HK (1) HK64492A (enExample)
HU (1) HU195813B (enExample)
IL (1) IL78581A0 (enExample)
IT (1) IT1215651B (enExample)
LU (1) LU86406A1 (enExample)
MY (1) MY102086A (enExample)
NL (1) NL8601053A (enExample)
NO (1) NO163406C (enExample)
NZ (1) NZ215885A (enExample)
OA (1) OA08242A (enExample)
PT (1) PT82460B (enExample)
SE (1) SE461468B (enExample)
SG (1) SG29092G (enExample)
SU (3) SU1450746A3 (enExample)
YU (1) YU46054B (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
TW593317B (en) * 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
HUT74170A (en) * 1993-07-06 1996-11-28 Pfizer Bicyclic tetrahydro pyrazolopyridines
TW574214B (en) * 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US6664264B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
AR045261A1 (es) 2003-08-12 2005-10-19 3M Innovative Properties Co Compuestos que contienen imidazo quinolina o imidazo piridina sustituidos; composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos inmunomoduladores
ES2406730T3 (es) 2003-08-27 2013-06-07 3M Innovative Properties Company Imidazoquinolinas sustituidas con ariloxi y arilalquilenoxi
AU2004270201A1 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
AR046046A1 (es) 2003-10-03 2005-11-23 3M Innovative Properties Co Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas.
US7897767B2 (en) 2003-11-14 2011-03-01 3M Innovative Properties Company Oxime substituted imidazoquinolines
CA2545825A1 (en) * 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
MXPA06005910A (es) 2003-11-25 2006-08-23 3M Innovative Properties Co Sistemas de anillo imidazo sustituido y metodos.
EP1701955A1 (en) 2003-12-29 2006-09-20 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
WO2005066169A2 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
CA2559863A1 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en) 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
EP1797091A2 (en) * 2004-09-14 2007-06-20 Novartis Vaccines and Diagnostics, Inc. Imidazoquinoline compounds
JP5543068B2 (ja) 2004-12-30 2014-07-09 スリーエム イノベイティブ プロパティズ カンパニー キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
ES2392648T3 (es) 2004-12-30 2012-12-12 3M Innovative Properties Company Compuestos quirales sustituidos que contienen un núcleo 1,2-imidazo-4,5-c condensado
CA2597092A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
CA2597587A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
US7943610B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company Pyrazolopyridine-1,4-diamines and analogs thereof
JP2008538550A (ja) 2005-04-01 2008-10-30 コーリー ファーマシューティカル グループ，インコーポレイテッド ウイルス感染および腫瘍性疾患を処置するためのサイトカイン生合成の調節因子としての１−置換ピラゾロ（３，４−ｃ）環状化合物
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
EP2666777A1 (en) 2006-08-02 2013-11-27 Cytokinetics, Inc. Certain chemical entities having an imidazo<4,5-b>pyrazin-2(3H)-one core, compositions and methods
EP2139478A4 (en) * 2007-03-30 2010-05-05 Cytokinetics Inc CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
WO2013010015A2 (en) 2011-07-13 2013-01-17 Cytokinetics, Inc. Combination als therapy
CN120265631A (zh) * 2023-01-13 2025-07-04 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
SU1470192A3 (ru) 1989-03-30
SU1450746A3 (ru) 1989-01-07
SE461468B (sv) 1990-02-19
AU5641386A (en) 1986-10-30
ES8802521A1 (es) 1988-07-16
EG18104A (en) 1992-09-30
ES554336A0 (es) 1987-10-01
ATA112186A (de) 1989-09-15
ES557551A0 (es) 1988-02-16
FI861684A0 (fi) 1986-04-22
DK164868C (da) 1993-01-11
CA1298836C (en) 1992-04-14
HK64492A (en) 1992-09-04
NL8601053A (nl) 1986-11-17
DK81091D0 (da) 1991-05-01
LU86406A1 (fr) 1986-11-05
DK165248B (da) 1992-10-26
SG29092G (en) 1992-05-15
GB2174987B (en) 1989-08-02
CN86102747A (zh) 1987-02-04
DK190986D0 (da) 1986-04-24
DK80291A (da) 1991-04-30
ES557552A0 (es) 1988-07-16
NO861617L (no) 1986-10-27
MY102086A (en) 1992-03-31
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
FI861684L (fi) 1986-10-26
NO163406C (no) 1990-05-23
ES8708229A1 (es) 1987-10-01
CY1641A (en) 1992-11-06
NO163406B (no) 1990-02-12
IT1215651B (it) 1990-02-22
DK190986A (da) 1986-10-26
SE8601907L (sv) 1986-10-26
AU592983B2 (en) 1990-02-01
DK164868B (da) 1992-08-31
YU46054B (sh) 1992-12-21
IL78581A0 (en) 1986-08-31
PT82460B (pt) 1988-11-30
FR2581065A1 (fr) 1986-10-31
DK165249B (da) 1992-10-26
SE8601907D0 (sv) 1986-04-24
AT390257B (de) 1990-04-10
DE3614132A1 (de) 1986-11-27
YU116787A (en) 1988-04-30
HUT42089A (en) 1987-06-29
KR860008177A (ko) 1986-11-12
SU1560056A3 (ru) 1990-04-23
FI83316B (fi) 1991-03-15
CH675722A5 (enExample) 1990-10-31
US4668686A (en) 1987-05-26
CN1016175B (zh) 1992-04-08
FR2581065B1 (fr) 1990-02-02
NZ215885A (en) 1989-04-26
BE904671A (fr) 1986-10-24
FI83316C (fi) 1991-06-25
GB8610037D0 (en) 1986-05-29
KR940000828B1 (ko) 1994-02-02
IT8620206A0 (it) 1986-04-24
GR861086B (en) 1986-09-01
PT82460A (en) 1986-05-01
DK165249C (da) 1993-03-22
ES8801829A1 (es) 1988-02-16
DK80291D0 (da) 1991-04-30
GB2174987A (en) 1986-11-19
OA08242A (en) 1987-10-30

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee