KR102104762B1 - 펩티도미메틱 거대고리 - Google Patents

펩티도미메틱 거대고리 Download PDF

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KR102104762B1
KR102104762B1 KR1020197016502A KR20197016502A KR102104762B1 KR 102104762 B1 KR102104762 B1 KR 102104762B1 KR 1020197016502 A KR1020197016502 A KR 1020197016502A KR 20197016502 A KR20197016502 A KR 20197016502A KR 102104762 B1 KR102104762 B1 KR 102104762B1
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KR20190069603A (ko
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빈센트 겔라바
노리유키 가와하타
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에일러론 테라퓨틱스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020197016502A 2010-08-13 2011-08-13 펩티도미메틱 거대고리 Expired - Fee Related KR102104762B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US37370110P 2010-08-13 2010-08-13
US37363810P 2010-08-13 2010-08-13
US61/373,701 2010-08-13
US61/373,638 2010-08-13
US37416310P 2010-08-16 2010-08-16
US61/374,163 2010-08-16
PCT/US2011/047692 WO2012021876A2 (en) 2010-08-13 2011-08-13 Peptidomimetic macrocycles

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020187014674A Division KR20180058866A (ko) 2010-08-13 2011-08-13 펩티도미메틱 거대고리

Publications (2)

Publication Number Publication Date
KR20190069603A KR20190069603A (ko) 2019-06-19
KR102104762B1 true KR102104762B1 (ko) 2020-04-24

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KR1020187014674A Ceased KR20180058866A (ko) 2010-08-13 2011-08-13 펩티도미메틱 거대고리
KR1020177013069A Ceased KR20170058446A (ko) 2010-08-13 2011-08-13 펩티도미메틱 거대고리
KR1020197016502A Expired - Fee Related KR102104762B1 (ko) 2010-08-13 2011-08-13 펩티도미메틱 거대고리
KR1020137006479A Ceased KR20130099938A (ko) 2010-08-13 2011-08-13 펩티도미메틱 거대고리

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KR1020187014674A Ceased KR20180058866A (ko) 2010-08-13 2011-08-13 펩티도미메틱 거대고리
KR1020177013069A Ceased KR20170058446A (ko) 2010-08-13 2011-08-13 펩티도미메틱 거대고리

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US (5) US8859723B2 (enExample)
EP (1) EP2603600B1 (enExample)
JP (3) JP2013535514A (enExample)
KR (4) KR20180058866A (enExample)
CN (2) CN108570097A (enExample)
BR (1) BR112013003248A2 (enExample)
CA (1) CA2807685C (enExample)
DK (1) DK2603600T3 (enExample)
ES (1) ES2711526T3 (enExample)
MX (2) MX355543B (enExample)
PL (1) PL2603600T3 (enExample)
PT (1) PT2603600T (enExample)
RU (2) RU2582678C2 (enExample)
SI (1) SI2603600T1 (enExample)
WO (3) WO2012021875A1 (enExample)

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CN109627287A (zh) 2007-02-23 2019-04-16 爱勒让治疗公司 三唑大环系统
JP5631201B2 (ja) 2007-03-28 2014-11-26 プレジデント アンド フェローズ オブ ハーバード カレッジ ステッチングされたポリペプチド
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US20170114098A1 (en) * 2015-09-03 2017-04-27 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
JP2018528217A (ja) 2015-09-10 2018-09-27 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子
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