DE69700561T2 - Verfahren zur Entfernung von N-Terminalem Methionin - Google Patents

Verfahren zur Entfernung von N-Terminalem Methionin

Info

Publication number
DE69700561T2
DE69700561T2 DE69700561T DE69700561T DE69700561T2 DE 69700561 T2 DE69700561 T2 DE 69700561T2 DE 69700561 T DE69700561 T DE 69700561T DE 69700561 T DE69700561 T DE 69700561T DE 69700561 T2 DE69700561 T2 DE 69700561T2
Authority
DE
Germany
Prior art keywords
terminal
removal
terminal methionine
methionine residue
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69700561T
Other languages
English (en)
Other versions
DE69700561D1 (de
Inventor
Osamu Nishimura
Masato Suenaga
Mae Hiroaki Oh
Shinji Tsuji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE69700561D1 publication Critical patent/DE69700561D1/de
Publication of DE69700561T2 publication Critical patent/DE69700561T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/246—IL-2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Forging (AREA)
DE69700561T 1996-06-14 1997-06-05 Verfahren zur Entfernung von N-Terminalem Methionin Expired - Lifetime DE69700561T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15463496 1996-06-14

Publications (2)

Publication Number Publication Date
DE69700561D1 DE69700561D1 (de) 1999-11-04
DE69700561T2 true DE69700561T2 (de) 2000-05-04

Family

ID=15588495

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69700561T Expired - Lifetime DE69700561T2 (de) 1996-06-14 1997-06-05 Verfahren zur Entfernung von N-Terminalem Methionin

Country Status (11)

Country Link
US (2) US6066470A (de)
EP (1) EP0812856B1 (de)
KR (1) KR100478747B1 (de)
CN (1) CN1158303C (de)
AT (1) ATE185146T1 (de)
CA (1) CA2207723C (de)
DE (1) DE69700561T2 (de)
DK (1) DK0812856T3 (de)
ES (1) ES2136458T3 (de)
GR (1) GR3032139T3 (de)
IL (1) IL121053A (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2768743B1 (fr) * 1997-09-23 2001-09-14 Bio Merieux Procede de lyse de micro-organisme
DE69941337D1 (de) * 1998-10-05 2009-10-08 Takeda Pharmaceutical Verfahren zum eliminieren von n-terminalem methionin
EP1138772A4 (de) * 1998-12-11 2005-04-06 Takeda Chemical Industries Ltd Verfahren zur herstellung von apelin
US20040029215A1 (en) * 2000-12-07 2004-02-12 Masato Suenaga Process for producing rfrp
WO2002052027A1 (fr) * 2000-12-22 2002-07-04 Nippon Soda Co., Ltd. Procede de production d'une substance a l'aide d'un catalyseur microbien
KR20050090430A (ko) * 2002-12-31 2005-09-13 알투스 파마슈티컬스 인코포레이티드 인간 성장 호르몬 결정 및 이것의 제조 방법
DE10353973B4 (de) * 2003-11-19 2006-08-17 Beru Ag Verfahren zum Herstellen eines keramischen Glühstiftes für eine keramische Glühkerze
WO2007076131A2 (en) * 2005-12-23 2007-07-05 Altus Pharmaceuticals Inc. Compositions comprising polycation-complexed protein crystals and methods of treatment using them
PT2118123E (pt) 2007-01-31 2016-02-10 Harvard College Péptidos de p53 estabilizados e suas utilizações
KR20160061439A (ko) 2007-03-28 2016-05-31 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
CN108570097A (zh) 2010-08-13 2018-09-25 爱勒让治疗公司 拟肽大环化合物
AU2012326026B2 (en) 2011-10-18 2017-04-13 Aileron Therapeutics, Inc. Peptidomimetic macrocyles
NZ627528A (en) 2012-02-15 2016-05-27 Aileron Therapeutics Inc Peptidomimetic macrocycles
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
CA2919604A1 (en) * 2013-08-21 2015-02-26 Cadila Healthcare Limited Purification process for pth
CA2961258A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
JP2018516844A (ja) 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986007380A1 (en) 1985-06-04 1986-12-18 Takeda Chemical Industries, Ltd. Process for preparing polypeptide
IT1219454B (it) * 1988-02-17 1990-05-18 Serono Cesare Ist Ricerca Metodo di rottura alla metionina di polipeptidi contenenti pontidisolfuro
JPH06316557A (ja) * 1993-03-06 1994-11-15 Fuji Kagaku Kogyo Kk アルキルチオ脂肪酸誘導体、製造法及びその肝臓疾患、腎臓疾患、膵臓疾患及び脳疾患用剤

Also Published As

Publication number Publication date
EP0812856B1 (de) 1999-09-29
ATE185146T1 (de) 1999-10-15
US6309859B1 (en) 2001-10-30
KR100478747B1 (ko) 2005-09-08
US6066470A (en) 2000-05-23
CN1158303C (zh) 2004-07-21
IL121053A (en) 2000-12-06
IL121053A0 (en) 1997-11-20
DE69700561D1 (de) 1999-11-04
GR3032139T3 (en) 2000-04-27
EP0812856A1 (de) 1997-12-17
CA2207723A1 (en) 1997-12-14
ES2136458T3 (es) 1999-11-16
KR980002062A (ko) 1998-03-30
CA2207723C (en) 2006-12-12
DK0812856T3 (da) 2000-01-03
CN1178798A (zh) 1998-04-15

Similar Documents

Publication Publication Date Title
DE69700561D1 (de) Verfahren zur Entfernung von N-Terminalem Methionin
DE69523695T2 (de) Verfahren zur Reinigung von Kohlendioxyd
DE69914773D1 (de) Verfahren zur reinigung von 1,3-propandiol
DE59800221D1 (de) Verfahren zur Stabilisierung von Retinol bzw. Retinol-Derivaten
DE69503937T2 (de) Verfahren zur Entfernung von Kohlendioxid aus Verbrennungsabgasen
DE69714911D1 (de) Verfahren zur Entfernung von Merkaptanen aus LNG
DE69715234D1 (de) Verfahren zur reinigung von 1,1-difluorethan
DE69017587D1 (de) Verfahren zur Entfernung von Dimeren von Chloropren aus Polychloropren.
ATE220558T1 (de) Verbessertes verfahren zur stabilisierung von proteinen
DE69935929D1 (de) Verfahren zur reinigung von blutbestandteilen
DE69710078D1 (de) Verfahren zur reinigung von 1,1,1,3,3-pentafluorpropan
DE69931418D1 (de) Verfahren zur Entfernung von Kohlendioxid aus Gasen
DE69713258T2 (de) Verfahren zur Reinigung von Milchsäure
DE69104274T2 (de) Verfahren zur Beseitigung von Kohlendioxid.
DE59807142D1 (de) Verfahren zur reinigung von anlagenteilen
DE69738323D1 (de) Verfahren zur verringerung der abbaubarkeit von futterprotein
DE58903414D1 (de) Verfahren zur entfernung von chlor aus abgasen.
DE69809209T2 (de) Verfahren zur rückgewinnung von fluorwasserstoff
DE59603664D1 (de) Verfahren zur Reinigung von Gasen
DE69418320D1 (de) Verfahren zur rückgewinnung von fluorwasserstoff
DE69941337D1 (de) Verfahren zum eliminieren von n-terminalem methionin
DE69426837T2 (de) Verfahren zur reinigung von 1,1,1,3,3-pentafluoro-2,3-dichloropropan
DE69732252D1 (de) Verfahren zur Vakuumbedampfung von Metallen
DE59203759D1 (de) Verfahren zur Entfernung von H2S aus Gasen.
DE29601518U1 (de) Vorrichtung zur Vermittlung von Informationen über den Bewegungsablauf von Fahrzeugen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP