DE69935929D1 - Verfahren zur reinigung von blutbestandteilen - Google Patents

Verfahren zur reinigung von blutbestandteilen

Info

Publication number
DE69935929D1
DE69935929D1 DE69935929T DE69935929T DE69935929D1 DE 69935929 D1 DE69935929 D1 DE 69935929D1 DE 69935929 T DE69935929 T DE 69935929T DE 69935929 T DE69935929 T DE 69935929T DE 69935929 D1 DE69935929 D1 DE 69935929D1
Authority
DE
Germany
Prior art keywords
blood components
cleaning blood
cleaning
components
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69935929T
Other languages
English (en)
Other versions
DE69935929T2 (de
Inventor
Michael T Trese
George A Williams
Michael Hartzer
Wendelin A Dailey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NUVUE TECHNOLOGIES, INC., GILSUM, N.H., US
Original Assignee
NUVUE TECHNOLOGIES Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NUVUE TECHNOLOGIES Inc filed Critical NUVUE TECHNOLOGIES Inc
Application granted granted Critical
Publication of DE69935929D1 publication Critical patent/DE69935929D1/de
Publication of DE69935929T2 publication Critical patent/DE69935929T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6091—Cartridges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
DE69935929T 1998-10-26 1999-10-19 Verfahren zur reinigung von blutbestandteilen Expired - Lifetime DE69935929T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/178,970 US6207066B1 (en) 1996-07-23 1998-10-26 Method for purification of a blood component
PCT/US1999/024273 WO2000024492A1 (en) 1998-10-26 1999-10-19 Method for purification of a blood component
US178970 2002-06-25

Publications (2)

Publication Number Publication Date
DE69935929D1 true DE69935929D1 (de) 2007-06-06
DE69935929T2 DE69935929T2 (de) 2008-01-10

Family

ID=22654666

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69935929T Expired - Lifetime DE69935929T2 (de) 1998-10-26 1999-10-19 Verfahren zur reinigung von blutbestandteilen

Country Status (6)

Country Link
US (2) US6207066B1 (de)
EP (1) EP1137465B1 (de)
JP (1) JP2002528200A (de)
AU (1) AU1316300A (de)
DE (1) DE69935929T2 (de)
WO (1) WO2000024492A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355243B1 (en) * 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
US7544500B2 (en) * 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
US6964764B2 (en) 1999-11-13 2005-11-15 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
US6969515B2 (en) * 1999-11-13 2005-11-29 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
US20020086431A1 (en) * 2000-08-21 2002-07-04 Markham Walter Bruce Sample preparation and slide plating apparatus and method
JP4996791B2 (ja) * 2001-03-14 2012-08-08 Ｊｎｃ株式会社 エンドトキシン吸着体、及びそれを用いたエンドトキシンの除去方法
US6787135B2 (en) 2002-03-13 2004-09-07 William Beaumont Hospital Modification of vitreal matrix metalloproteinase activity
US6855263B2 (en) * 2002-07-23 2005-02-15 Nuvue Technologies, Inc. Rapid process for purification and concentration of plasmin
GB0228409D0 (en) 2002-12-06 2003-01-08 Thromb X Nv Pharmacological vitreolysis
US7354515B2 (en) 2004-02-23 2008-04-08 Millennium Medical Technologies, Inc. Fluid concentrator
JP4608286B2 (ja) * 2004-11-11 2011-01-12 クラレメディカル株式会社 血液成分回収用吸着材
JP2007068497A (ja) * 2005-09-09 2007-03-22 Nihon Pharmaceutical Co Ltd プラスミンの精製法
KR20110017903A (ko) * 2008-06-04 2011-02-22 테일크리스 바이오쎄러퓨틱스 아이엔씨. 플라스민의 제조를 위한 조성물, 방법 및 키트
EP2329257B1 (de) * 2008-08-01 2018-03-07 BioVentures, Inc., Vorrichtung und verfahren zur reinigung, isolierung, entsalzung oder zum puffer-/lösungsmittelaustausch von substanzen
JP5789521B2 (ja) * 2009-03-03 2015-10-07 グリフオルス・セラピユーテイクス・インコーポレーテツドＧｒｉｆｏｌｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． プラスミノーゲンを製造するための組成物、方法およびキット；ならびにそれから製造されるプラスミン
US9011684B2 (en) 2011-03-07 2015-04-21 Spinesmith Holdings, Llc Fluid concentrator with removable cartridge
JP2016512889A (ja) * 2013-03-15 2016-05-09 セラノス， インコーポレイテッド サンプルの収集およびサンプル分離の方法と機器
AU2022288369A1 (en) * 2021-06-08 2024-01-04 Csl Behring Ag Process for isolating plasminogen from a blood plasma fraction

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943245A (en) 1974-02-14 1976-03-09 Armour Pharmaceutical Company Purification of plasminogen
US4356958A (en) * 1977-07-19 1982-11-02 The United States Of America As Represented By The Secretary Of Health And Human Services Blood cell separator
US4604358A (en) 1983-04-14 1986-08-05 Armour Pharmaceutical Company Preparation of pasteurized human plasminogen
US4724207A (en) * 1984-02-02 1988-02-09 Cuno Incorporated Modified siliceous chromatographic supports
AT390801B (de) 1988-07-28 1990-07-10 Immuno Ag Verfahren zur herstellung von lys-plasminogen
US5304118A (en) 1992-12-16 1994-04-19 Trese Michael T Method for performing a vitrectomy on an eye

Also Published As

Publication number Publication date
DE69935929T2 (de) 2008-01-10
AU1316300A (en) 2000-05-15
JP2002528200A (ja) 2002-09-03
WO2000024492A1 (en) 2000-05-04
US6183692B1 (en) 2001-02-06
EP1137465A1 (de) 2001-10-04
EP1137465A4 (de) 2003-01-29
US6207066B1 (en) 2001-03-27
EP1137465B1 (de) 2007-04-25

Similar Documents

Publication Publication Date Title
DE69519832T2 (de) Verfahren zur Polyetherreinigung
ATE296915T1 (de) Verfahren zur textilbehandlung
DE69914773D1 (de) Verfahren zur reinigung von 1,3-propandiol
DE69910557D1 (de) Verfahren zur reinigung von aminonitrilen
DE50010474D1 (de) Verfahren zur verkapselung von bauelementen
DE60138046D1 (de) Verfahren zur reinigung von methanhaltigem abgas
DE69935929D1 (de) Verfahren zur reinigung von blutbestandteilen
DE60038975D1 (de) Verfahren zur reinigung von bishydroxyalkylterephthalaten
DE69916400D1 (de) Verfahren zur selektiven Entfernung von Nitrilen
DE69830758D1 (de) Verfahren zur Oberflächenbehandlung
DE60014506D1 (de) Verfahren zur Entfernung von Organohalogenverbindungen
DE60001867D1 (de) Verfahren zur Reinigung von Acrylsäure
DE69713258D1 (de) Verfahren zur Reinigung von Milchsäure
DE69807562T2 (de) Verfahren zur Reinigung von schädlichen Gasen
DE59905958D1 (de) Verfahren zur reinigung von triethanolamin
DE59807142D1 (de) Verfahren zur reinigung von anlagenteilen
DE69904787T2 (de) Verfahren zur Entfernung von Verschmierungen
DE60143947D1 (de) Verfahren zur reinigung von fluorierten alkansäuren
DE60013246D1 (de) Verfahren zur trennung von hämoglobin
DE69731891D1 (de) Verfahren zur reinigung von gbs-toxin/cm101
DE69830899D1 (de) Verfahren zur reinigung von siloxan
DE60133691D1 (de) Verfahren zur reinigung von amiden
DE69932857D1 (de) Verfahren zur reinigung von phosphorsäure
DE69824283D1 (de) Verfahren zur reinigung von caprolactam
ATA96197A (de) Verfahren zur reinigung von schadstoffbelasteten gasen

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: NUVUE TECHNOLOGIES, INC., GILSUM, N.H., US

8364 No opposition during term of opposition