ES2136458T3 - Metodo para separar la metionina n-terminal. - Google Patents

Metodo para separar la metionina n-terminal.

Info

Publication number
ES2136458T3
ES2136458T3 ES97303856T ES97303856T ES2136458T3 ES 2136458 T3 ES2136458 T3 ES 2136458T3 ES 97303856 T ES97303856 T ES 97303856T ES 97303856 T ES97303856 T ES 97303856T ES 2136458 T3 ES2136458 T3 ES 2136458T3
Authority
ES
Spain
Prior art keywords
terminal
metionin
separating
methionine residue
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97303856T
Other languages
English (en)
Inventor
Osamu Nishimura
Masato Suenaga
Mae Hiroaki Oh
Shinji Tsuji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2136458T3 publication Critical patent/ES2136458T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/246—IL-2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
  • Forging (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA UN METODO PARA ELIMINAR QUIMICAMENTE UN RESIDUO DE METIONINA N TERMINAL SELECTIVAMENTE, ESPECIFICAMENTE Y EFICAZMENTE A PARTIR DE UN PEPTIDO O UNA SAL DEL MISMO QUE TIENE UN RESIDUO DE METIONINA OPCIONALMENTE OXIDADO EN SU EXTREMO N TERMINAL. EN EL METODO REACCIONA UN PEPTIDO O UNA SAL DEL MISMO QUE TIENE UN RESIDUO DE METIONINA OPCIONALMENTE OXIDADO EN SU EXTREMO N TERMINAL CON UN DERIVADO {AL} - DICETONA, SEGUIDO DE HIDROLISIS.
ES97303856T 1996-06-14 1997-06-05 Metodo para separar la metionina n-terminal. Expired - Lifetime ES2136458T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15463496 1996-06-14

Publications (1)

Publication Number Publication Date
ES2136458T3 true ES2136458T3 (es) 1999-11-16

Family

ID=15588495

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97303856T Expired - Lifetime ES2136458T3 (es) 1996-06-14 1997-06-05 Metodo para separar la metionina n-terminal.

Country Status (11)

Country Link
US (2) US6066470A (es)
EP (1) EP0812856B1 (es)
KR (1) KR100478747B1 (es)
CN (1) CN1158303C (es)
AT (1) ATE185146T1 (es)
CA (1) CA2207723C (es)
DE (1) DE69700561T2 (es)
DK (1) DK0812856T3 (es)
ES (1) ES2136458T3 (es)
GR (1) GR3032139T3 (es)
IL (1) IL121053A (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2768743B1 (fr) * 1997-09-23 2001-09-14 Bio Merieux Procede de lyse de micro-organisme
CA2346064A1 (en) * 1998-10-05 2000-04-13 Takeda Chemical Industries, Ltd. Method for removing n-terminal methionine
EP1138772A4 (en) * 1998-12-11 2005-04-06 Takeda Chemical Industries Ltd PROCESS FOR THE PRODUCTION OF APELINE
AU2002221067A1 (en) * 2000-12-07 2002-06-18 Takeda Chemical Industries Ltd. Process for producing rfrp
EP1352964A4 (en) * 2000-12-22 2005-02-16 Nippon Soda Co PROCESS FOR PRODUCING A SUBSTANCE USING A MICROBIAL CATALYST
CA2512052C (en) * 2002-12-31 2016-06-21 Altus Pharmaceuticals Inc. Human growth hormone crystals and methods for preparing them
DE10353973B4 (de) * 2003-11-19 2006-08-17 Beru Ag Verfahren zum Herstellen eines keramischen Glühstiftes für eine keramische Glühkerze
WO2007076131A2 (en) * 2005-12-23 2007-07-05 Altus Pharmaceuticals Inc. Compositions comprising polycation-complexed protein crystals and methods of treatment using them
PL2118123T3 (pl) 2007-01-31 2016-06-30 Dana Farber Cancer Inst Inc Stabilizowane peptydy p53 i ich zastosowania
JP5631201B2 (ja) 2007-03-28 2014-11-26 プレジデント アンド フェローズ オブ ハーバード カレッジ ステッチングされたポリペプチド
KR102104762B1 (ko) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
EP2768518A4 (en) 2011-10-18 2015-05-27 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES
RU2642299C2 (ru) 2012-02-15 2018-01-24 Эйлерон Терапьютикс, Инк. P53 пептидомиметические макроциклы
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
JP6046862B2 (ja) * 2013-08-21 2016-12-21 カディラ ヘルスケア リミテッド Ｐｔｈの精製方法
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
JP2018516844A (ja) 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用
CN115806946B (zh) * 2022-12-20 2025-09-16 深圳瑞德林生物技术有限公司 京都啡肽及其衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986007380A1 (fr) 1985-06-04 1986-12-18 Takeda Chemical Industries, Ltd. Procede de preparation de polypeptides
IT1219454B (it) * 1988-02-17 1990-05-18 Serono Cesare Ist Ricerca Metodo di rottura alla metionina di polipeptidi contenenti pontidisolfuro
JPH06316557A (ja) * 1993-03-06 1994-11-15 Fuji Kagaku Kogyo Kk アルキルチオ脂肪酸誘導体、製造法及びその肝臓疾患、腎臓疾患、膵臓疾患及び脳疾患用剤

Also Published As

Publication number Publication date
IL121053A0 (en) 1997-11-20
ATE185146T1 (de) 1999-10-15
CN1158303C (zh) 2004-07-21
DE69700561D1 (de) 1999-11-04
KR980002062A (ko) 1998-03-30
US6066470A (en) 2000-05-23
EP0812856A1 (en) 1997-12-17
CA2207723C (en) 2006-12-12
DE69700561T2 (de) 2000-05-04
CA2207723A1 (en) 1997-12-14
GR3032139T3 (en) 2000-04-27
US6309859B1 (en) 2001-10-30
KR100478747B1 (ko) 2005-09-08
CN1178798A (zh) 1998-04-15
IL121053A (en) 2000-12-06
EP0812856B1 (en) 1999-09-29
DK0812856T3 (da) 2000-01-03

Similar Documents

Publication Publication Date Title
DK0812856T3 (da) Fremgangsmåde til fjernelse af N-terminalt methionin
ATE353956T1 (de) Methoden zur virus-reinigung
DZ2285A1 (fr) Inhibiteurs de protéase de la cystéine.
BR9807020B1 (pt) método para purificar um derivado de aspartame n-alquilado.
FI970680L (fi) Menetelmä polyhydroksilakaanihapon talteenottamiseksi
DE69938395D1 (de) Rkennung welche diesen scanner verwendet
TR199700451A3 (tr) LNG'den Merkaptanlari ayirmak için metod.
ITTO971003A0 (it) Metodo di sequenziazione di oggetti postale.
BR9800538A (pt) Aparelho para purificar um composto e método para eliminar pelo menos uma impureza de um composto.3
NL1002931C1 (nl) Carrosseriesamenstel.
DE69941337D1 (de) Verfahren zum eliminieren von n-terminalem methionin
FI955952L (fi) Menetelmä fenolin talteenottamiseksi Na2S04 sisältävästä vesivirrasta
FI960568L (fi) Menetelmä metallien talteenottamiseksi
FI943467A7 (fi) Menetelmä bakteeriperäisten lipopolysakkaridien erottamiseksi proteiinipitoisista liuoksista
NL1012028A1 (nl) Aminozuursequentie.
ATA130396A (de) Schere bzw. zange
ES1029259Y (es) Util para el borrado manuel de escritura.
ES1029317Y (es) Alicates para la fijacion de precintos.
ES1035211Y (es) Util para limpieza.
ES1036906Y (es) Claraboya con apertura perfeccionada para la extraccion de humos.
IT1297655B1 (it) Autoregolatore pneumatico per motocompressore.
FR2713533B1 (fr) Pince semi automatique pose anneaux de marque truarc.
ES1028742Y (es) Mecanismo para el accionamiento de cortinas.
ITNA960013V0 (it) Biodepuratrice biologico per imbarcazioni oscillante.
ES1034155Y (es) Dispositivo para el ensamblaje de piezas.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 812856

Country of ref document: ES