KR101682494B1 - 뉴클레오시드 사이클릭포스페이트 - Google Patents

뉴클레오시드 사이클릭포스페이트 Download PDF

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KR101682494B1
KR101682494B1 KR1020117000655A KR20117000655A KR101682494B1 KR 101682494 B1 KR101682494 B1 KR 101682494B1 KR 1020117000655 A KR1020117000655 A KR 1020117000655A KR 20117000655 A KR20117000655 A KR 20117000655A KR 101682494 B1 KR101682494 B1 KR 101682494B1
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optionally substituted
alkyl
purin
dioxaphosphinin
tetrahydro
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KR20110016501A (ko
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진파 두
다나팔란 나가라스남
가나파티 레디 파무라파티
브루스 에스. 로스
마이클 조셉 소피아
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길리애드 파마셋 엘엘씨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1020117000655A 2008-06-11 2009-06-08 뉴클레오시드 사이클릭포스페이트 Expired - Fee Related KR101682494B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US6068308P 2008-06-11 2008-06-11
US61/060,683 2008-06-11
US14036908P 2008-12-23 2008-12-23
US61/140,369 2008-12-23
US12/479,075 2009-06-05
US12/479,075 US8173621B2 (en) 2008-06-11 2009-06-05 Nucleoside cyclicphosphates
PCT/US2009/046619 WO2009152095A2 (en) 2008-06-11 2009-06-08 Nucleoside cyclicphosphates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020167033252A Division KR20160139060A (ko) 2008-06-11 2009-06-08 뉴클레오시드 사이클릭포스페이트

Publications (2)

Publication Number Publication Date
KR20110016501A KR20110016501A (ko) 2011-02-17
KR101682494B1 true KR101682494B1 (ko) 2016-12-05

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KR1020167033252A Ceased KR20160139060A (ko) 2008-06-11 2009-06-08 뉴클레오시드 사이클릭포스페이트
KR1020117000655A Expired - Fee Related KR101682494B1 (ko) 2008-06-11 2009-06-08 뉴클레오시드 사이클릭포스페이트

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Country Status (19)

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US (2) US8173621B2 (enExample)
EP (1) EP2313422B1 (enExample)
JP (2) JP5749160B2 (enExample)
KR (2) KR20160139060A (enExample)
CN (1) CN102119167A (enExample)
AR (1) AR072104A1 (enExample)
AU (1) AU2009257647C1 (enExample)
BR (1) BRPI0915484A2 (enExample)
CA (1) CA2727495C (enExample)
CL (1) CL2010001407A1 (enExample)
CO (1) CO6321272A2 (enExample)
ES (1) ES2536727T3 (enExample)
IL (1) IL209916A (enExample)
MX (1) MX2010013768A (enExample)
PT (1) PT2313422E (enExample)
TW (1) TW201002733A (enExample)
UY (1) UY31892A (enExample)
WO (1) WO2009152095A2 (enExample)
ZA (1) ZA201008829B (enExample)

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KR20160139060A (ko) 2016-12-06
AU2009257647C1 (en) 2014-10-23
BRPI0915484A2 (pt) 2019-09-17
ZA201008829B (en) 2011-09-28
UY31892A (es) 2010-01-05
US8173621B2 (en) 2012-05-08
CA2727495A1 (en) 2009-12-17
AU2009257647B2 (en) 2014-04-10
KR20110016501A (ko) 2011-02-17
US8759510B2 (en) 2014-06-24
CA2727495C (en) 2017-08-29
IL209916A0 (en) 2011-02-28
TW201002733A (en) 2010-01-16
US20100081628A1 (en) 2010-04-01
ES2536727T3 (es) 2015-05-28
CL2010001407A1 (es) 2011-05-06
JP2015180655A (ja) 2015-10-15
AU2009257647A1 (en) 2009-12-17

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