MX9303713A - Proceso estereoselectivo para preparar un derivadoribofuranosilo enriquecido con alfa anomero. - Google Patents

Proceso estereoselectivo para preparar un derivadoribofuranosilo enriquecido con alfa anomero.

Info

Publication number
MX9303713A
MX9303713A MX9303713A MX9303713A MX9303713A MX 9303713 A MX9303713 A MX 9303713A MX 9303713 A MX9303713 A MX 9303713A MX 9303713 A MX9303713 A MX 9303713A MX 9303713 A MX9303713 A MX 9303713A
Authority
MX
Mexico
Prior art keywords
alpha
enriched
ibofuranosilo
anomerous
derivator
Prior art date
Application number
MX9303713A
Other languages
English (en)
Inventor
Ta-Sen Chou
Charles David Jones
Thomas Edward Mabry
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX9303713A publication Critical patent/MX9303713A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un proceso esteroselectivo para preparar derivados de 1-alfa-halo-2-deoxi-2, 2-difluro-D-robofuranosilo enriquecidos con alfa-anómero que comprende poner en contacto un 2-deoxi-2, 2-difluoro-D-ribofuranosilo-1-(beta)-sulfonato protegido con 3, 5-hidroxi con una fuente de haluro en un disolvente inerte.
MX9303713A 1992-06-22 1993-06-21 Proceso estereoselectivo para preparar un derivadoribofuranosilo enriquecido con alfa anomero. MX9303713A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90230692A 1992-06-22 1992-06-22

Publications (1)

Publication Number Publication Date
MX9303713A true MX9303713A (es) 1994-05-31

Family

ID=25415658

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9303713A MX9303713A (es) 1992-06-22 1993-06-21 Proceso estereoselectivo para preparar un derivadoribofuranosilo enriquecido con alfa anomero.

Country Status (15)

Country Link
US (1) US5453499A (es)
EP (1) EP0576231B1 (es)
JP (1) JP3291071B2 (es)
KR (1) KR940000475A (es)
AT (1) ATE153669T1 (es)
BR (1) BR9302427A (es)
CA (1) CA2098887C (es)
DE (1) DE69311000T2 (es)
DK (1) DK0576231T3 (es)
ES (1) ES2103433T3 (es)
GR (1) GR3023911T3 (es)
HU (1) HU214030B (es)
IL (1) IL106075A (es)
MX (1) MX9303713A (es)
TW (1) TW224102B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100449618B1 (ko) * 1998-03-27 2004-11-16 부광약품 주식회사 2'-플루오로-5-메틸-β-L-아라비노푸라노실유리딘의 제조방법
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
KR100578616B1 (ko) * 2004-07-23 2006-05-10 한미약품 주식회사 Ｄ-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법
KR100699099B1 (ko) * 2004-07-29 2007-03-22 한미약품 주식회사 1-α-할로-2,2-다이플루오로-2-데옥시-Ｄ-라이보퓨라노스유도체 및 이의 제조방법
BRPI0513783A (pt) * 2004-07-29 2008-05-13 Hanmi Pharm Ind Co Ltd derivados 1-(alfa)-halo-2, 2-diflúor-2-desóxi-d-ribofuranose e processo para a sua preparação
SI3109244T1 (sl) * 2004-09-14 2019-06-28 Gilead Pharmasset Llc Priprava 2'fluoro-2'-alkil-substituiranih ali drugih neobvezno substituiranih ribofuranozil pirimidinov in purinov in njihovih derivatov
CN101437524B (zh) * 2004-09-14 2012-01-11 法莫赛特股份有限公司 2＇-氟-2＇-烷基-取代的或其它任选取代的呋喃核糖基嘧啶和嘌呤及其衍生物的制备
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
KR100858842B1 (ko) 2007-03-23 2008-09-22 동우신테크 주식회사 키랄아민을 이용한 광학활성 옥소라이보스유도체의제조방법
US7994310B2 (en) * 2007-03-23 2011-08-09 Dongwoo Syntech Co., Ltd. Process for preparing 2′-deoxy-2′, 2′-difluorocytidine
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
SG172363A1 (en) * 2008-12-23 2011-07-28 Pharmasset Inc Synthesis of purine nucleosides
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI583692B (zh) 2009-05-20 2017-05-21 基利法瑪席特有限責任公司 核苷磷醯胺
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
AP3515A (en) 2010-03-31 2016-01-11 Gilead Pharmasset Llc Nucleoside phosphoramidates
JP6069215B2 (ja) 2010-11-30 2017-02-01 ギリアド ファーマセット エルエルシー 化合物
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
ES2900570T3 (es) 2013-08-27 2022-03-17 Gilead Pharmasset Llc Formulación de combinación de dos compuestos antivirales
CN106317147B (zh) * 2015-07-06 2018-11-27 扬州硒瑞恩生物医药科技有限公司 核苷类化合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3277077A (en) * 1964-06-03 1966-10-04 Merck & Co Inc 3-deoxy ribofuranosyl halides
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US5256798A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
US5256797A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers
US5252756A (en) * 1992-06-22 1993-10-12 Eli Lilly And Company Process for preparing beta-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-arylsulfonates

Also Published As

Publication number Publication date
ES2103433T3 (es) 1997-09-16
KR940000475A (ko) 1994-01-03
ATE153669T1 (de) 1997-06-15
TW224102B (es) 1994-05-21
HUT64550A (en) 1994-01-28
HU214030B (en) 1997-12-29
US5453499A (en) 1995-09-26
CA2098887A1 (en) 1993-12-23
BR9302427A (pt) 1994-01-11
DE69311000T2 (de) 1997-11-27
JP3291071B2 (ja) 2002-06-10
JPH0656863A (ja) 1994-03-01
DK0576231T3 (da) 1997-08-25
DE69311000D1 (de) 1997-07-03
CA2098887C (en) 2003-10-28
EP0576231B1 (en) 1997-05-28
IL106075A (en) 2000-12-06
IL106075A0 (en) 1993-10-20
GR3023911T3 (en) 1997-09-30
HU9301828D0 (en) 1993-09-28
EP0576231A1 (en) 1993-12-29

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Legal Events

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FG Grant or registration
MM Annulment or lapse due to non-payment of fees