KR101208480B1 - 말산 효소 활성이 감쇠된 에스케리키아 세균을 사용하는ｌ-라이신 또는 ｌ-트레오닌의 생산방법 - Google Patents

말산 효소 활성이 감쇠된 에스케리키아 세균을 사용하는ｌ-라이신 또는 ｌ-트레오닌의 생산방법 Download PDF

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KR101208480B1
KR101208480B1 KR1020057024543A KR20057024543A KR101208480B1 KR 101208480 B1 KR101208480 B1 KR 101208480B1 KR 1020057024543 A KR1020057024543 A KR 1020057024543A KR 20057024543 A KR20057024543 A KR 20057024543A KR 101208480 B1 KR101208480 B1 KR 101208480B1
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val
glu
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KR20060026436A (ko
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디엔 스티븐 반
신타로 이와타니
요시히로 우스다
가즈히코 마쓰이
유타 나카이
도모코 스즈키
미카 모리야
유치로 쓰지
다쿠지 우에다
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아지노모토 가부시키가이샤
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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KR1020057024543A 2003-07-29 2004-07-29 말산 효소 활성이 감쇠된 에스케리키아 세균을 사용하는ｌ-라이신 또는 ｌ-트레오닌의 생산방법 Expired - Lifetime KR101208480B1 (ko)

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Application Number Priority Date Filing Date Title
JPJP-P-2003-00202842 2003-07-29
JP2003202842 2003-07-29
PCT/JP2004/011220 WO2005010175A1 (en) 2003-07-29 2004-07-29 Method for producing l-lysine or l-threonine using escherichia bacteria having attnuated malic enzyme activity

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KR20060026436A KR20060026436A (ko) 2006-03-23
KR101208480B1 true KR101208480B1 (ko) 2012-12-05

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KR1020057024543A Expired - Lifetime KR101208480B1 (ko) 2003-07-29 2004-07-29 말산 효소 활성이 감쇠된 에스케리키아 세균을 사용하는ｌ-라이신 또는 ｌ-트레오닌의 생산방법
KR1020067002048A Expired - Fee Related KR101073370B1 (ko) 2003-07-29 2004-07-29 물질 생산에 영향을 미치는 대사 흐름을 결정하는 방법

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US (3) US7306933B2 (enExample)
EP (2) EP1649403A2 (enExample)
JP (2) JP4894134B2 (enExample)
KR (2) KR101208480B1 (enExample)
CN (2) CN100520793C (enExample)
AT (1) ATE397059T1 (enExample)
BR (2) BRPI0413030A (enExample)
DE (1) DE602004014158D1 (enExample)
DK (1) DK1651758T3 (enExample)
ES (1) ES2305849T3 (enExample)
PL (1) PL1651758T3 (enExample)
RU (1) RU2337140C2 (enExample)
WO (2) WO2005010794A2 (enExample)
ZA (1) ZA200510144B (enExample)

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WO2019190193A1 (ko) 2018-03-27 2019-10-03 씨제이제일제당 (주) 글라이신 생산능이 증가된 미생물 및 이를 이용한 발효 조성물 생산 방법
WO2020166831A1 (ko) 2019-02-15 2020-08-20 씨제이제일제당 (주) 생물반응기의 운전 조건을 결정하는 장치 및 방법
WO2020226341A1 (ko) 2019-05-09 2020-11-12 씨제이제일제당 (주) L-아미노산을 생산하는 미생물 및 이를 이용한 l-아미노산을 생산하는 방법
US11180784B2 (en) 2018-01-25 2021-11-23 Cj Cheiljedang Corporation Microorganism of the genus Corynebacterium producing L-amino acids and a method for producing L-amino acids using the same
WO2022191467A1 (ko) 2021-03-08 2022-09-15 씨제이제일제당 (주) L-아미노산을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-아미노산의 생산방법
WO2022234880A1 (ko) 2021-05-07 2022-11-10 씨제이제일제당 (주) 신규 프로모터 및 이의 용도
WO2022234881A1 (ko) 2021-05-07 2022-11-10 씨제이제일제당 (주) 신규 프로모터 및 이의 용도
WO2024128795A1 (ko) 2022-12-13 2024-06-20 씨제이제일제당 (주) 신규한 망간 의존성 전사 조절자 변이체 및 이를 이용한 l-글루탐산 생산 방법
WO2024144060A1 (ko) 2022-12-28 2024-07-04 씨제이제일제당 (주) 신규한 아세토락테이트 합성효소 활성을 갖는 변이체 폴리펩티드 및 이를 이용한 l-글루탐산 생산 방법
WO2024144057A1 (ko) 2022-12-27 2024-07-04 씨제이제일제당 (주) 신규한 텔루륨 저항성 막단백질 운송자 변이체 및 이를 이용한 l-글루탐산 생산 방법
WO2024181764A1 (ko) 2023-02-27 2024-09-06 씨제이제일제당 (주) 변이체 폴리펩티드 및 이를 이용한 l-글루탐산 생산 방법

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AU2000230762A1 (en) 2000-01-21 2001-07-31 Ajinomoto Co. Inc. Process for producing l-lysine
BR0304860A (pt) * 2002-11-11 2004-08-31 Ajinomoto Kk Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia
CN101243177B (zh) 2004-01-30 2012-12-05 味之素株式会社 生产l-氨基酸的微生物和生产l-氨基酸的方法
US8510054B2 (en) * 2004-02-05 2013-08-13 Ajinomoto Co., Inc. Intracellular metabolic flux analysis method using substrate labeled with isotope
JP4802507B2 (ja) * 2004-02-05 2011-10-26 味の素株式会社 同位体で標識された基質を用いた細胞内代謝フラックスの解析方法
JP4654592B2 (ja) * 2004-04-02 2011-03-23 味の素株式会社 代謝フラックスの決定方法
ES2941685T3 (es) 2004-10-07 2023-05-24 Ajinomoto Kk Método para producción de una substancia básica
US7915018B2 (en) * 2004-10-22 2011-03-29 Ajinomoto Co., Inc. Method for producing L-amino acids using bacteria of the Enterobacteriaceae family
WO2007013639A1 (en) 2005-07-25 2007-02-01 Ajinomoto Co., Inc. A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE cpxR GENE
WO2007017710A1 (en) * 2005-08-11 2007-02-15 Metabolic Explorer Process for the preparation of aspartate and derived amino acids like lysine, threonine, isoleucine, methionine, homoserine, or valine employing a microorganism with enhanced isocitrate lyase and/or malate synthase expression
DE112005003358T5 (de) 2005-09-15 2008-03-13 Korea Advanced Institute Of Science & Technology Verfahren zur Verbesserung von Organismen unter Verwendung von Flussabtastung, basierend auf verstärktem objektiven Fluss
EP1929029A1 (en) 2005-09-27 2008-06-11 Ajinomoto Co., Inc. An l-amino acid-producing bacterium and a method for producing l-amino acids
WO2007037459A1 (en) 2005-09-27 2007-04-05 Ajinomoto Co., Inc. An l-amino acid-producing bacterium and a method for producing l-amino acids
JP2007117082A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2007185184A (ja) * 2005-12-16 2007-07-26 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
WO2007086618A1 (en) 2006-01-30 2007-08-02 Ajinomoto Co., Inc. L-amino acid producing bacterium and method of producing l-amino acid
JP2009095237A (ja) * 2006-02-02 2009-05-07 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2009118740A (ja) 2006-03-03 2009-06-04 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
EP2004803A2 (en) 2006-03-23 2008-12-24 Ajinomoto Co., Inc. A method for producing an l-amino acid using bacterium of theenterobacteriaceae family with attenuated expression of a gene coding for small rna
RU2338784C2 (ru) * 2006-03-24 2008-11-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Новая альдолаза, днк, кодирующая альдолазу, клетки, трансформированные днк, способ получения альдолазы и способ получения 4-гидрокси-l-изолейцина (варианты)
JP2009060791A (ja) * 2006-03-30 2009-03-26 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
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KR100727053B1 (ko) * 2006-05-04 2007-06-12 한국과학기술원 대사산물들의 플럭스 섬 프로파일링을 이용한 생물개량방법
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WO2005010794A3 (en) 2005-12-01
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US7306933B2 (en) 2007-12-11
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