KR100572171B1 - 투여량 계측 흡입기용 안정화 제제 - Google Patents
투여량 계측 흡입기용 안정화 제제 Download PDFInfo
- Publication number
- KR100572171B1 KR100572171B1 KR1020007003416A KR20007003416A KR100572171B1 KR 100572171 B1 KR100572171 B1 KR 100572171B1 KR 1020007003416 A KR1020007003416 A KR 1020007003416A KR 20007003416 A KR20007003416 A KR 20007003416A KR 100572171 B1 KR100572171 B1 KR 100572171B1
- Authority
- KR
- South Korea
- Prior art keywords
- agent
- dispersion
- perforated microstructures
- surfactant
- perforated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A61K9/1682—Processes
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S977/902—Specified use of nanostructure
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- Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nanotechnology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Dispersion Chemistry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Optics & Photonics (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6033797P | 1997-09-29 | 1997-09-29 | |
| US60/060,337 | 1997-09-29 | ||
| US10693298A | 1998-06-29 | 1998-06-29 | |
| US9/106,932 | 1998-06-29 | ||
| US09/106,932 | 1998-06-29 | ||
| US13384898A | 1998-08-14 | 1998-08-14 | |
| US09/133,848 | 1998-08-14 | ||
| US9/133,848 | 1998-08-14 | ||
| PCT/US1998/020615 WO1999016422A1 (en) | 1997-09-29 | 1998-09-29 | Stabilized preparations for use in metered dose inhalers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20010030810A KR20010030810A (ko) | 2001-04-16 |
| KR100572171B1 true KR100572171B1 (ko) | 2006-04-19 |
Family
ID=27369827
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020007003416A Expired - Lifetime KR100572171B1 (ko) | 1997-09-29 | 1998-09-29 | 투여량 계측 흡입기용 안정화 제제 |
| KR1020007003401A Expired - Fee Related KR100575070B1 (ko) | 1997-09-29 | 1998-09-29 | 안정화된 생활성 제제 및 이의 사용 방법 |
| KR1020007003367A Expired - Lifetime KR100589926B1 (ko) | 1997-09-29 | 1998-09-29 | 천공된 미립자 및 사용 방법 |
| KR1020007003368A Expired - Fee Related KR100599634B1 (ko) | 1997-09-29 | 1998-09-29 | 분무기 내에 사용하기 위한 안정화된 제제 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020007003401A Expired - Fee Related KR100575070B1 (ko) | 1997-09-29 | 1998-09-29 | 안정화된 생활성 제제 및 이의 사용 방법 |
| KR1020007003367A Expired - Lifetime KR100589926B1 (ko) | 1997-09-29 | 1998-09-29 | 천공된 미립자 및 사용 방법 |
| KR1020007003368A Expired - Fee Related KR100599634B1 (ko) | 1997-09-29 | 1998-09-29 | 분무기 내에 사용하기 위한 안정화된 제제 |
Country Status (27)
| Country | Link |
|---|---|
| EP (4) | EP1019022B2 (enExample) |
| JP (9) | JP4526702B2 (enExample) |
| KR (4) | KR100572171B1 (enExample) |
| CN (1) | CN1169520C (enExample) |
| AT (3) | ATE248583T1 (enExample) |
| AU (4) | AU757337C (enExample) |
| BG (1) | BG64816B1 (enExample) |
| BR (1) | BR9812693A (enExample) |
| CA (4) | CA2304819C (enExample) |
| CZ (1) | CZ300758B6 (enExample) |
| DE (2) | DE69814428T2 (enExample) |
| DK (2) | DK1019022T4 (enExample) |
| EA (2) | EA002562B1 (enExample) |
| EE (1) | EE04628B1 (enExample) |
| ES (3) | ES2205560T5 (enExample) |
| HR (1) | HRP20000175B1 (enExample) |
| IL (2) | IL135126A0 (enExample) |
| IS (1) | IS2154B (enExample) |
| ME (1) | MEP4108A (enExample) |
| NO (1) | NO340149B1 (enExample) |
| NZ (1) | NZ503464A (enExample) |
| PL (1) | PL195212B1 (enExample) |
| PT (1) | PT1019022E (enExample) |
| RS (1) | RS50182B (enExample) |
| SK (1) | SK285068B6 (enExample) |
| TR (1) | TR200000819T2 (enExample) |
| WO (3) | WO1999016421A1 (enExample) |
Families Citing this family (273)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US20020052310A1 (en) | 1997-09-15 | 2002-05-02 | Massachusetts Institute Of Technology The Penn State Research Foundation | Particles for inhalation having sustained release properties |
| US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
| US6503480B1 (en) | 1997-05-23 | 2003-01-07 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US7052678B2 (en) | 1997-09-15 | 2006-05-30 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
| US6433040B1 (en) | 1997-09-29 | 2002-08-13 | Inhale Therapeutic Systems, Inc. | Stabilized bioactive preparations and methods of use |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6946117B1 (en) | 1997-09-29 | 2005-09-20 | Nektar Therapeutics | Stabilized preparations for use in nebulizers |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| ATE248583T1 (de) * | 1997-09-29 | 2003-09-15 | Nektar Therapeutics | In dosierinhalatoren verwendbare, stabilisierte zubereitungen |
| GB9727102D0 (en) * | 1997-12-22 | 1998-02-25 | Andaris Ltd | Microparticles and their therapeutic use |
| WO2000000215A1 (en) * | 1998-06-29 | 2000-01-06 | Inhale Therapeutic Systems, Inc. | Particulate delivery systems and methods of use |
| KR100796220B1 (ko) * | 1998-06-29 | 2008-01-21 | 넥타르 테라퓨틱스 | 미립자 전달 시스템 및 사용 방법 |
| US6956021B1 (en) | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
| US6630169B1 (en) | 1999-03-31 | 2003-10-07 | Nektar Therapeutics | Particulate delivery systems and methods of use |
| US6223455B1 (en) † | 1999-05-03 | 2001-05-01 | Acusphere, Inc. | Spray drying apparatus and methods of use |
| HK1048956B (zh) * | 1999-05-27 | 2006-07-28 | 阿库斯菲尔公司 | 多孔药物基质及其制造方法 |
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1998
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| EP0372777A2 (en) * | 1988-12-06 | 1990-06-13 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
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