CN1272058A - 多孔微粒及其使用方法 - Google Patents
多孔微粒及其使用方法 Download PDFInfo
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- CN1272058A CN1272058A CN98809603A CN98809603A CN1272058A CN 1272058 A CN1272058 A CN 1272058A CN 98809603 A CN98809603 A CN 98809603A CN 98809603 A CN98809603 A CN 98809603A CN 1272058 A CN1272058 A CN 1272058A
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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Abstract
Description
化合物 | 折光指数 |
HFA-134aHFA-227CFC-12CFC-114PFOB甘露醇乙醇正辛烷DMPCPluronic F-68蔗糖羟乙基淀粉氯化钠 | 1.1721.2231.2871.2881.3051.3331.3611.3971.431.431.5381.541.544 |
色甘酸钠MDI | ||||
MMAD(GSD) | 喉部沉积μg | 微小颗粒分数% | 微小颗粒剂量g | |
Intal*,CFC(n=4)(Rhone-Poulenc Rorer)800μg剂量 | 4.7±0.5(1.9±0.06) | 629 | 24.3±2.1 | 202±27 |
喷雾干燥空心多孔粉末,HFA(Alliance)(n=3)300μg剂量 | 3.4±0.2(2.0±0.3) | 97 | 67.3±5.5 | 200±11 |
样品 | 平均尺寸(微米) | 5.4微米下的% | 95%下(微米) |
纯粉末 | 1.2 | 100 | 2.0 |
MDI | 2.4 | 96.0 | 5.1 |
DPI | 1.1 | 100 | 1.8 |
样品 | 平均尺寸(微米) | 5.4微米下的% | 95%下(微米) |
纯粉末 | 1.3 | 100 | 2.1 |
MDI | 2.2 | 98.1 | 4.6 |
DPI | 1.2 | 99.8 | 2.2 |
样品 | MMAD(GSD) | 微小颗粒分数% | 微小颗粒剂量mcg/剂量 |
VentolinRotacaps(n=2) | 7.869(1.6064) | 20 | 15 |
舒喘宁硫酸盐微球(n=3) | 4.822(1.9082) | 63 | 60 |
Claims (61)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6033797P | 1997-09-29 | 1997-09-29 | |
US60/060,337 | 1997-09-29 | ||
US10693298A | 1998-06-29 | 1998-06-29 | |
US09/106,932 | 1998-06-29 | ||
US13384898A | 1998-08-14 | 1998-08-14 | |
US09/133,848 | 1998-08-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1272058A true CN1272058A (zh) | 2000-11-01 |
CN1169520C CN1169520C (zh) | 2004-10-06 |
Family
ID=27369827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB98809603XA Expired - Lifetime CN1169520C (zh) | 1997-09-29 | 1998-09-29 | 多孔微粒及其使用方法 |
Country Status (28)
Country | Link |
---|---|
EP (4) | EP1019022B2 (zh) |
JP (9) | JP2001517692A (zh) |
KR (4) | KR100589926B1 (zh) |
CN (1) | CN1169520C (zh) |
AT (3) | ATE239447T1 (zh) |
AU (4) | AU757337C (zh) |
BG (1) | BG64816B1 (zh) |
BR (1) | BR9812693A (zh) |
CA (4) | CA2304820C (zh) |
CZ (1) | CZ300758B6 (zh) |
DE (2) | DE69814428T2 (zh) |
DK (2) | DK1019022T4 (zh) |
EA (2) | EA003665B1 (zh) |
EE (1) | EE04628B1 (zh) |
ES (3) | ES2205560T5 (zh) |
HK (1) | HK1031680A1 (zh) |
HR (1) | HRP20000175B1 (zh) |
IL (2) | IL135126A0 (zh) |
IS (1) | IS2154B (zh) |
ME (1) | MEP4108A (zh) |
NO (1) | NO340149B1 (zh) |
NZ (1) | NZ503464A (zh) |
PL (1) | PL195212B1 (zh) |
PT (1) | PT1019022E (zh) |
RS (1) | RS50182B (zh) |
SK (1) | SK285068B6 (zh) |
TR (1) | TR200000819T2 (zh) |
WO (3) | WO1999016419A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104161731A (zh) * | 2013-05-15 | 2014-11-26 | Cj医药健康株式会社 | 连续工艺的微球制备方法及由此制备的微球 |
CN105193773A (zh) * | 2009-05-29 | 2015-12-30 | 珍珠治疗公司 | 活性剂的呼吸递送 |
CN111700883A (zh) * | 2020-07-23 | 2020-09-25 | 深圳大佛药业股份有限公司 | 一种硫酸沙丁胺醇缓释型吸入制剂及其生产工艺 |
CN115144310A (zh) * | 2022-07-01 | 2022-10-04 | 重庆交通大学 | 一种旋桨式絮凝沉降试验装置及方法 |
Families Citing this family (231)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6503480B1 (en) | 1997-05-23 | 2003-01-07 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
DE69814428T2 (de) * | 1997-09-29 | 2004-05-13 | Nektar Therapeutics, San Carlos | In verneblern verwendbare, stabilisierte zubereitungen |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US6433040B1 (en) | 1997-09-29 | 2002-08-13 | Inhale Therapeutic Systems, Inc. | Stabilized bioactive preparations and methods of use |
US6946117B1 (en) * | 1997-09-29 | 2005-09-20 | Nektar Therapeutics | Stabilized preparations for use in nebulizers |
GB9727102D0 (en) * | 1997-12-22 | 1998-02-25 | Andaris Ltd | Microparticles and their therapeutic use |
WO2000000215A1 (en) * | 1998-06-29 | 2000-01-06 | Inhale Therapeutic Systems, Inc. | Particulate delivery systems and methods of use |
JP2003535017A (ja) * | 1998-06-29 | 2003-11-25 | ネクター セラピューティクス | 微粒子デリバリーシステムおよび使用の方法 |
US6630169B1 (en) | 1999-03-31 | 2003-10-07 | Nektar Therapeutics | Particulate delivery systems and methods of use |
US6223455B1 (en) * | 1999-05-03 | 2001-05-01 | Acusphere, Inc. | Spray drying apparatus and methods of use |
KR100752000B1 (ko) * | 1999-05-27 | 2007-08-28 | 아쿠스피어 인코포레이티드. | 다공성 약물 매트릭스의 제조방법 |
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