KR100553641B1 - 아미노알킬 글루코스아민 인산염 화합물 및 이를아쥬반트와 면역작동체로 사용하는 방법 - Google Patents
아미노알킬 글루코스아민 인산염 화합물 및 이를아쥬반트와 면역작동체로 사용하는 방법 Download PDFInfo
- Publication number
- KR100553641B1 KR100553641B1 KR1019997010285A KR19997010285A KR100553641B1 KR 100553641 B1 KR100553641 B1 KR 100553641B1 KR 1019997010285 A KR1019997010285 A KR 1019997010285A KR 19997010285 A KR19997010285 A KR 19997010285A KR 100553641 B1 KR100553641 B1 KR 100553641B1
- Authority
- KR
- South Korea
- Prior art keywords
- mmol
- compound
- delete delete
- stereogen
- configuration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/853,826 | 1997-05-08 | ||
| US08/853,826 US6113918A (en) | 1997-05-08 | 1997-05-08 | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US8/853,826 | 1997-05-08 | ||
| PCT/US1998/009385 WO1998050399A1 (en) | 1997-05-08 | 1998-05-07 | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20010012333A KR20010012333A (ko) | 2001-02-15 |
| KR100553641B1 true KR100553641B1 (ko) | 2006-02-22 |
Family
ID=25317008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019997010285A Expired - Lifetime KR100553641B1 (ko) | 1997-05-08 | 1998-05-07 | 아미노알킬 글루코스아민 인산염 화합물 및 이를아쥬반트와 면역작동체로 사용하는 방법 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6113918A (enExample) |
| EP (1) | EP0983286B1 (enExample) |
| JP (2) | JP4485608B2 (enExample) |
| KR (1) | KR100553641B1 (enExample) |
| CN (1) | CN1181086C (enExample) |
| AP (1) | AP1181A (enExample) |
| AT (1) | ATE272067T1 (enExample) |
| AU (1) | AU740663B2 (enExample) |
| BR (1) | BRPI9809791B8 (enExample) |
| CA (1) | CA2288601C (enExample) |
| DE (1) | DE69825271T2 (enExample) |
| DK (1) | DK0983286T3 (enExample) |
| ES (1) | ES2224397T3 (enExample) |
| HU (1) | HU228667B1 (enExample) |
| ID (1) | ID22994A (enExample) |
| IL (2) | IL132739A0 (enExample) |
| NZ (1) | NZ500938A (enExample) |
| OA (1) | OA11214A (enExample) |
| PL (1) | PL188046B1 (enExample) |
| PT (1) | PT983286E (enExample) |
| WO (1) | WO1998050399A1 (enExample) |
Families Citing this family (340)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458366B1 (en) | 1995-09-01 | 2002-10-01 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
| US6592877B1 (en) * | 1995-09-01 | 2003-07-15 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
| US6290969B1 (en) * | 1995-09-01 | 2001-09-18 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
| US6764840B2 (en) | 1997-05-08 | 2004-07-20 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| AU773921B2 (en) * | 1997-05-08 | 2004-06-10 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US7541020B2 (en) * | 1997-05-08 | 2009-06-02 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US7063967B2 (en) | 1997-05-08 | 2006-06-20 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US6303347B1 (en) * | 1997-05-08 | 2001-10-16 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US20030235557A1 (en) | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US8143386B2 (en) * | 1999-04-07 | 2012-03-27 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis antigens and their uses |
| KR100863367B1 (ko) | 1999-05-13 | 2008-10-13 | 와이어쓰 홀딩스 코포레이션 | 보조제 배합 제형물 |
| JP2003510370A (ja) | 1999-10-07 | 2003-03-18 | コリクサ コーポレイション | Mycobacteriumtuberculosisの融合タンパク質 |
| PL209127B1 (pl) | 2000-02-23 | 2011-07-29 | Smithkline Beecham Biolog | Środek farmaceutyczny do stosowania w immunoterapeutycznym leczeniu raka i sposób diagnozowania u pacjenta obecności lub podatności na raka |
| AU2001241738A1 (en) | 2000-02-25 | 2001-09-03 | Corixa Corporation | Compounds and methods for diagnosis and immunotherapy of tuberculosis |
| US20040002068A1 (en) | 2000-03-01 | 2004-01-01 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
| US6699846B2 (en) * | 2000-03-17 | 2004-03-02 | Corixa Corporation | Mono- and disaccharides for the treatment of nitric oxide related disorders |
| EP1385541B1 (en) * | 2000-04-13 | 2008-06-18 | Corixa Corporation | Immunostimulant compositions comprising an aminoalkyl glucosaminide phosphate and qs-21 |
| BR0110975A (pt) * | 2000-05-19 | 2004-03-23 | Corixa Corp | Tratamento profilático e terapêutico de doenças infecciosas ou outras doenças com compostos à base de mono- e disacarìdeos |
| US20030139356A1 (en) * | 2001-05-18 | 2003-07-24 | Persing David H. | Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds |
| US20030105032A1 (en) * | 2000-05-19 | 2003-06-05 | Persing David H. | Phophylactic and therapeutic treatment of infectious and other diseases with mono-and disaccharide-based compounds |
| EP1542732B1 (en) | 2000-06-20 | 2009-09-16 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis |
| EP1311522B1 (en) | 2000-08-04 | 2006-03-22 | Corixa Corporation | New immunoeffector compounds |
| PL366031A1 (en) | 2000-11-10 | 2005-01-24 | Wyeth Holdings Corporation | Adjuvant combination formulations |
| JP2008531580A (ja) * | 2000-12-08 | 2008-08-14 | スリーエム イノベイティブ プロパティズ カンパニー | 免疫応答修飾因子の標的化送達のための組成物および方法 |
| EP2402359A1 (en) | 2000-12-28 | 2012-01-04 | Wyeth LLC | Recombinant protective protein from streptococcus pneumoniae |
| US20070128229A1 (en) * | 2002-04-12 | 2007-06-07 | Wyeth | Surface proteins of Streptococcus pyogenes |
| JP2004533236A (ja) * | 2001-04-13 | 2004-11-04 | ワイエス | 化膿性連鎖球菌(Streptococcuspyogenes)の表面タンパク質 |
| EP2258842A1 (en) | 2001-04-16 | 2010-12-08 | Wyeth Holdings Corporation | Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof |
| JP2005504513A (ja) | 2001-05-09 | 2005-02-17 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
| US7361352B2 (en) | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| MX339524B (es) * | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| RU2288723C2 (ru) * | 2002-02-04 | 2006-12-10 | Корикса Корпорейшн | Профилактическое и терапевтическое лечение инфекционных и других заболеваний с помощью иммуноэффективных соединений |
| NZ534592A (en) | 2002-02-04 | 2006-06-30 | Corixa Corp | Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds |
| EP1482795B1 (en) * | 2002-02-04 | 2009-11-11 | Corixa Corporation | New immunoeffector compounds |
| US6911434B2 (en) * | 2002-02-04 | 2005-06-28 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds |
| US20030190333A1 (en) * | 2002-02-04 | 2003-10-09 | Corixa Corporation | Immunostimulant compositions comprising aminoalkyl glucosaminide phosphates and saponins |
| US7030094B2 (en) * | 2002-02-04 | 2006-04-18 | Corixa Corporation | Immunostimulant compositions comprising an aminoalkyl glucosaminide phosphate and QS-21 |
| RU2289585C2 (ru) * | 2002-02-04 | 2006-12-20 | Корикса Корпорейшн | Новые аминоалкилглюкозаминидфосфатные соединения, иммуностимулирующая фармацевтическая композиция, их содержащая, и способ индуцирования иммунного ответа |
| WO2003070187A2 (en) | 2002-02-15 | 2003-08-28 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis |
| US7351413B2 (en) * | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
| WO2003072026A2 (en) * | 2002-02-22 | 2003-09-04 | 3M Innovative Properties Company | Method of reducing and treating uvb-induced immunosuppression |
| AU2003213640A1 (en) * | 2002-02-28 | 2003-09-16 | Corixa Corporation | Methods of modulating dendritic cells using adjuvants |
| NZ535754A (en) * | 2002-03-15 | 2007-01-26 | Wyeth Corp | Mutants of the P4 protein of nontypable haemophilus influenzae with reduced enzymatic activity |
| JP5014573B2 (ja) * | 2002-05-09 | 2012-08-29 | オンコサイレオン インコーポレーテッド | 脂質aおよび他の炭水化物リガンド類似体 |
| US7288640B2 (en) * | 2002-07-08 | 2007-10-30 | Corixa Corporation | Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor |
| MXPA05000407A (es) | 2002-07-08 | 2005-04-19 | Corixa Corp | Procedimientos para la produccion de fosfato de aminoalquilglucosaminida e inmunoefectores de disacarido, e intermediarios para los mismos. |
| US7785608B2 (en) * | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
| US7301554B2 (en) * | 2002-09-20 | 2007-11-27 | Ricoh Company, Ltd. | Light scanning device, scanning line adjusting method, scanning line adjusting control method, image forming apparatus, and image forming method |
| WO2004060319A2 (en) | 2002-12-30 | 2004-07-22 | 3M Innovative Properties Company | Immunostimulatory combinations |
| CN101080234A (zh) * | 2003-01-06 | 2007-11-28 | 科里克萨有限公司 | 一些氨烷基氨基葡糖苷磷酸酯化合物和它们的用途 |
| US7960522B2 (en) * | 2003-01-06 | 2011-06-14 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
| US7375180B2 (en) * | 2003-02-13 | 2008-05-20 | 3M Innovative Properties Company | Methods and compositions related to IRM compounds and Toll-like receptor 8 |
| US7485432B2 (en) * | 2003-02-27 | 2009-02-03 | 3M Innovative Properties Company | Selective modulation of TLR-mediated biological activity |
| JP2006519866A (ja) | 2003-03-04 | 2006-08-31 | スリーエム イノベイティブ プロパティズ カンパニー | Uv誘発性の表皮の新形成の予防的治療 |
| US7179253B2 (en) | 2003-03-13 | 2007-02-20 | 3M Innovative Properties Company | Method of tattoo removal |
| ATE556711T1 (de) * | 2003-03-13 | 2012-05-15 | 3M Innovative Properties Co | Verfahren zur verbesserung der hautqualität |
| US20040192585A1 (en) | 2003-03-25 | 2004-09-30 | 3M Innovative Properties Company | Treatment for basal cell carcinoma |
| US20040265351A1 (en) * | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| WO2004108072A2 (en) * | 2003-04-10 | 2004-12-16 | 3M Innovative Properties Company | Delivery of immune response modifier compounds using metal-containing particulate support materials |
| WO2005016275A2 (en) * | 2003-08-05 | 2005-02-24 | 3M Innovative Properties Company | Formulations containing an immune response modifier |
| WO2005018551A2 (en) | 2003-08-12 | 2005-03-03 | 3M Innovative Properties Company | Oxime substituted imidazo-containing compounds |
| WO2005018574A2 (en) * | 2003-08-25 | 2005-03-03 | 3M Innovative Properties Company | Immunostimulatory combinations and treatments |
| CA2536136C (en) | 2003-08-27 | 2012-10-30 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted imidazoquinolines |
| WO2005023190A2 (en) | 2003-09-05 | 2005-03-17 | 3M Innovative Properties Company | Treatment for cd5+ b cell lymphoma |
| US8871782B2 (en) | 2003-10-03 | 2014-10-28 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| US20050096259A1 (en) * | 2003-10-31 | 2005-05-05 | 3M Innovative Properties Company | Neutrophil activation by immune response modifier compounds |
| EP1685129A4 (en) | 2003-11-14 | 2008-10-22 | 3M Innovative Properties Co | OXIMSUBSTITUTED IMIDAZORING CONNECTIONS |
| CA2545825A1 (en) | 2003-11-14 | 2005-06-02 | 3M Innovative Properties Company | Hydroxylamine substituted imidazo ring compounds |
| MY161812A (en) | 2003-11-25 | 2017-05-15 | 3M Innovative Properties Co | Substituted imidazo ring systems and methods |
| WO2005055932A2 (en) * | 2003-12-02 | 2005-06-23 | 3M Innovative Properties Company | Therapeutic combinations and methods including irm compounds |
| US20050226878A1 (en) * | 2003-12-02 | 2005-10-13 | 3M Innovative Properties Company | Therapeutic combinations and methods including IRM compounds |
| AR047062A1 (es) | 2003-12-17 | 2006-01-04 | Wyeth Corp | Conjugados portadores de peptidos inmunogenicos a beta y metodos para producirlos |
| AU2004299501B2 (en) | 2003-12-17 | 2010-12-23 | Wyeth Llc | Immunogenic peptide carrier conjugates and methods of producing same |
| JP2007517035A (ja) | 2003-12-29 | 2007-06-28 | スリーエム イノベイティブ プロパティズ カンパニー | アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン |
| JP2007517044A (ja) | 2003-12-30 | 2007-06-28 | スリーエム イノベイティブ プロパティズ カンパニー | イミダゾキノリニル、イミダゾピリジニル、およびイミダゾナフチリジニルスルホンアミド |
| JP2007517055A (ja) * | 2003-12-30 | 2007-06-28 | スリーエム イノベイティブ プロパティズ カンパニー | 免疫応答の増強 |
| TW200612932A (en) | 2004-03-24 | 2006-05-01 | 3M Innovative Properties Co | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
| WO2006126981A2 (en) * | 2004-04-28 | 2006-11-30 | 3M Innovative Properties Company | Compositions and methods for mucosal vaccination |
| GB0410220D0 (en) | 2004-05-07 | 2004-06-09 | Kirkham Lea Ann | Mutant pneumolysin proteins |
| MXPA06013448A (es) | 2004-05-21 | 2007-01-23 | Wyeth Corp | Proteina alterada que liga a la fibronectina en staphylococcus aureus. |
| US20050267145A1 (en) * | 2004-05-28 | 2005-12-01 | Merrill Bryon A | Treatment for lung cancer |
| US8017779B2 (en) | 2004-06-15 | 2011-09-13 | 3M Innovative Properties Company | Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
| TW200613554A (en) | 2004-06-17 | 2006-05-01 | Wyeth Corp | Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV |
| US7897609B2 (en) | 2004-06-18 | 2011-03-01 | 3M Innovative Properties Company | Aryl substituted imidazonaphthyridines |
| WO2006009826A1 (en) | 2004-06-18 | 2006-01-26 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
| US7915281B2 (en) | 2004-06-18 | 2011-03-29 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method |
| EP1786450A4 (en) * | 2004-08-27 | 2009-11-11 | 3M Innovative Properties Co | HIV IMMUNOSTIMATORY COMPOSITIONS |
| WO2006042254A2 (en) * | 2004-10-08 | 2006-04-20 | 3M Innovative Properties Company | Adjuvant for dna vaccines |
| WO2007001423A2 (en) | 2004-10-21 | 2007-01-04 | Wyeth | Immunogenic compositions of staphylococcus epidermidis polypeptide and polynucleotide antigens |
| US8461174B2 (en) | 2004-12-30 | 2013-06-11 | 3M Innovative Properties Company | Treatment for cutaneous metastases |
| JP5313502B2 (ja) | 2004-12-30 | 2013-10-09 | スリーエム イノベイティブ プロパティズ カンパニー | 置換キラル縮合[1,2]イミダゾ[4,5−c]環状化合物 |
| CA2592904C (en) | 2004-12-30 | 2015-04-07 | 3M Innovative Properties Company | Chiral fused [1,2]imidazo[4,5-c] ring compounds |
| AU2006210392A1 (en) | 2005-02-04 | 2006-08-10 | Coley Pharmaceutical Group, Inc. | Aqueous gel formulations containing immune response modifiers |
| WO2006086634A2 (en) | 2005-02-11 | 2006-08-17 | Coley Pharmaceutical Group, Inc. | Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods |
| EP1863814A1 (en) | 2005-04-01 | 2007-12-12 | Coley Pharmaceutical Group, Inc. | 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases |
| WO2006107853A2 (en) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridine-1,4-diamines and analogs thereof |
| US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| EP2425856A1 (en) | 2005-04-08 | 2012-03-07 | Wyeth LLC | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| AU2006241166A1 (en) * | 2005-04-25 | 2006-11-02 | 3M Innovative Properties Company | Immunostimulatory compositions |
| US20080213318A1 (en) * | 2005-07-05 | 2008-09-04 | Hawaii Biotech, Inc. | Malaria MSP-1 C-terminal enhanced subunit vaccine |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| DK2384765T3 (en) | 2005-12-22 | 2017-01-09 | Glaxosmithkline Biologicals Sa | Vaccine against Streptococcus pneumoniae. |
| US8951528B2 (en) * | 2006-02-22 | 2015-02-10 | 3M Innovative Properties Company | Immune response modifier conjugates |
| WO2007113222A2 (en) | 2006-03-30 | 2007-10-11 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| KR20090017655A (ko) | 2006-06-02 | 2009-02-18 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 환자가 면역치료제에 대한 반응자일지의 여부를 확인하는 방법 |
| WO2008008432A2 (en) | 2006-07-12 | 2008-01-17 | Coley Pharmaceutical Group, Inc. | Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods |
| ES2525732T3 (es) | 2006-07-18 | 2014-12-29 | Glaxosmithkline Biologicals S.A. | Vacunas contra el paludismo |
| WO2008012538A2 (en) | 2006-07-25 | 2008-01-31 | The Secretary Of State For Defence | Live vaccine strains of francisella |
| EP2433648A3 (en) | 2006-10-12 | 2012-04-04 | GlaxoSmithKline Biologicals S.A. | Vaccine comprising an oil in water emulsion adjuvant |
| ES2528166T3 (es) * | 2006-11-15 | 2015-02-04 | Eli Lilly And Company | Métodos y composiciones para tratar la gripe |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| US20080149123A1 (en) * | 2006-12-22 | 2008-06-26 | Mckay William D | Particulate material dispensing hairbrush with combination bristles |
| CL2008000611A1 (es) | 2007-03-02 | 2008-09-05 | Glaxosmithkline Biolog Sa | Procedimiento para fomentar respuesta inmunitaria frente a un patogeno que comprende administrar i) uno o mas polipeptidos inmunogenicos derivados del patogeno, ii) uno o mas vectores adenoviricos que comprenden uno o mas polinucleotidos que codifica |
| PL2136836T3 (pl) | 2007-04-04 | 2017-07-31 | Infectious Disease Research Institute | Kompozycje immunogenne zawierające polipeptydy prątka gruźlicy i produkty ich fuzji |
| US9452209B2 (en) | 2007-04-20 | 2016-09-27 | Glaxosmithkline Biologicals Sa | Influenza vaccine |
| EP2687228B1 (en) | 2007-06-26 | 2017-07-19 | GlaxoSmithKline Biologicals S.A. | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
| MX2010001284A (es) | 2007-08-02 | 2010-08-31 | Biondvax Pharmaceuticals Ltd | Vacunas contra la influenza con multiepitope multimerico. |
| JP5406839B2 (ja) | 2007-09-17 | 2014-02-05 | オンコメチローム サイエンシズ ソシエテ アノニム | Mage−a発現の改良された検出 |
| US20090215710A1 (en) * | 2007-09-24 | 2009-08-27 | Reliance Life Sciences Pvt. Ltd. | Carbohydrate based toll-like receptor (tlr) antagonists |
| PT2227483T (pt) | 2007-12-19 | 2017-06-21 | Henry M Jackson Found Advancement Military Medicine Inc | Formas solúveis da glicoproteína f de vírus hendra e nipah e suas utilizações |
| AU2008340319A1 (en) * | 2007-12-21 | 2009-07-02 | Wyeth Llc | Genetically modified attenuated vesicular stomatitis virus, compositions and methods of use thereof |
| SI2222710T1 (sl) | 2007-12-24 | 2016-11-30 | Id Biomedical Corporation Of Quebec | Rekombinatni RSV antigeni |
| WO2009126822A2 (en) | 2008-04-09 | 2009-10-15 | The University Of North Carolina At Chapel Hill | Methods of regulating actin cytoskeletal rearrangement and intercellular gap formation |
| ES2678694T3 (es) | 2008-04-16 | 2018-08-16 | Glaxosmithkline Biologicals Sa | Vacuna |
| WO2009155484A2 (en) | 2008-06-20 | 2009-12-23 | Wyeth | Compositions and methods of use of orf1358 from beta-hemolytic streptococcal strains |
| EP2356135B1 (en) * | 2008-11-05 | 2017-10-25 | Wyeth LLC | Multicomponent immunogenic composition for the prevention of beta-hemolytic streptococcal (bhs) disease |
| CA2745205A1 (en) | 2008-12-03 | 2010-06-10 | Protea Vaccine Technologies Ltd. | Glutamyl trna synthetase (gts) fragments |
| ES2552243T3 (es) * | 2008-12-23 | 2015-11-26 | Glaxosmithkline Biologicals S.A. | Miméticos del lípido A para su uso en la inducción de una respuesta inmunitaria |
| WO2010079081A1 (en) | 2009-01-07 | 2010-07-15 | Glaxosmithkline Biologicals S.A. | Methods for recovering a virus or a viral antigen produced by cell culture |
| GB0901423D0 (en) | 2009-01-29 | 2009-03-11 | Secr Defence | Treatment |
| GB0901411D0 (en) | 2009-01-29 | 2009-03-11 | Secr Defence | Treatment |
| WO2010089339A1 (en) | 2009-02-06 | 2010-08-12 | Glaxosmithkline Biologicals S.A. | Purification of virus or viral antigens by density gradient ultracentrifugation |
| AR075437A1 (es) | 2009-02-17 | 2011-03-30 | Glaxosmithkline Biolog Sa | Composicion inmunogenica que comprende al menos un antigeno del virus del dengue inactivado y un adyuvante sin aluminio, metodo para producir dicha vacuna y su uso para preparar un medicamento |
| SG174877A1 (en) | 2009-03-17 | 2011-11-28 | Mdxhealth Sa | Improved detection of gene expression |
| CA2757998A1 (en) * | 2009-04-09 | 2010-10-14 | The University Of North Carolina At Chapel Hill | Methods of treating edema related to ischemia-reperfusion |
| GB0906234D0 (en) | 2009-04-14 | 2009-05-20 | Secr Defence | Vaccine |
| SI2445522T1 (sl) | 2009-06-22 | 2017-10-30 | Wyeth Llc | Imunogeni sestavki antigenov Staphylococcusa aureusa |
| WO2011041003A2 (en) | 2009-06-22 | 2011-04-07 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
| MX2012000036A (es) | 2009-06-24 | 2012-02-28 | Glaxosmithkline Biolog Sa | Vacuna. |
| JP6062245B2 (ja) | 2009-06-24 | 2017-01-18 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 組換えrsv抗原 |
| CA2803282C (en) | 2009-07-06 | 2018-05-01 | David E. Anderson | Methods for preparing vesicles and formulations produced therefrom |
| WO2011005769A1 (en) | 2009-07-06 | 2011-01-13 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| SG178026A1 (en) | 2009-07-15 | 2012-03-29 | Novartis Ag | Rsv f protein compositions and methods for making same |
| GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB0917457D0 (en) | 2009-10-06 | 2009-11-18 | Glaxosmithkline Biolog Sa | Method |
| ES2538474T3 (es) | 2009-09-25 | 2015-06-22 | Glaxosmithkline Biologicals S.A. | Ensayo de inmunodifusión para el virus de la gripe |
| GB0919117D0 (en) | 2009-10-30 | 2009-12-16 | Glaxosmithkline Biolog Sa | Process |
| WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
| CN102858961A (zh) | 2010-05-03 | 2013-01-02 | 葛兰素史密丝克莱恩生物有限公司 | 新方法 |
| GB201009273D0 (en) | 2010-06-03 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel vaccine |
| AU2011262346B2 (en) | 2010-06-04 | 2014-12-11 | Wyeth Llc | Streptococcus pneumoniae vaccine formulations |
| CA2840079C (en) | 2010-07-06 | 2018-07-03 | Variation Biotechnologies Inc. | Compositions and methods for treating influenza |
| DK2608805T4 (da) | 2010-08-23 | 2025-06-30 | Wyeth Llc | STABILE FORMULERINGER AF NEISSERIA MENINGITIDIS rLP2086 ANTIGENER |
| RU2546873C2 (ru) | 2010-09-10 | 2015-04-10 | УАЙТ ЭлЭлСи | Нелипидизированные варианты антигенов neisseria meningitidis orf2086 |
| GB201101331D0 (en) | 2011-01-26 | 2011-03-09 | Glaxosmithkline Biolog Sa | Compositions and uses |
| SG190731A1 (en) | 2010-12-14 | 2013-07-31 | Glaxosmithkline Biolog Sa | Mycobacterium antigenic composition |
| ES2769425T3 (es) | 2010-12-22 | 2020-06-25 | Wyeth Llc | Composiciones inmunogénicas estables de antígenos de Staphylococcus aureus |
| MX359103B (es) | 2011-01-13 | 2018-09-14 | Variation Biotechnologies Inc | Composiciones y sus usos en el tratamiento de infecciones virales. |
| CA2828068C (en) | 2011-02-22 | 2019-03-19 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
| BR112013021779A2 (pt) | 2011-02-24 | 2017-09-19 | Oncothyreon Inc | vacina de glicolipopeptídeo baseada em muc1 com adjuvante. |
| BR112013029169B1 (pt) | 2011-05-13 | 2021-09-28 | Novartis Ag | Polipeptídeo f pré-fusão do vírus sincicial respiratório (rsv), composição imunogênica e uso da mesma |
| WO2012156391A1 (en) | 2011-05-17 | 2012-11-22 | Glaxosmithkline Biologicals S.A. | Vaccine against streptococcus pneumoniae |
| JP6460789B2 (ja) | 2011-06-03 | 2019-01-30 | スリーエム イノベイティブ プロパティズ カンパニー | ポリエチレングリコールセグメントを有するヘテロ2官能性リンカー及び該リンカーから調製された免疫反応調節複合体 |
| JP6415979B2 (ja) | 2011-06-03 | 2018-10-31 | スリーエム イノベイティブ プロパティズ カンパニー | ヒドラジノ1h−イミダゾキノリン−4−アミン及びこれから調製された複合体 |
| ITMI20111182A1 (it) | 2011-06-28 | 2012-12-29 | Canio Buonavoglia | Vaccino per coronavirus canino |
| GB201113570D0 (en) | 2011-08-05 | 2011-09-21 | Glaxosmithkline Biolog Sa | Vaccine |
| GB201116248D0 (en) | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
| GB201119999D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
| GB201120000D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
| US20140356399A1 (en) | 2012-01-12 | 2014-12-04 | Variation Biotechnologies, Inc. | Compositions and methods for treating viral infections |
| WO2013111012A2 (en) | 2012-01-27 | 2013-08-01 | Variation Biotechnologies, Inc. | Methods and compositions for therapeutic agents |
| PE20190458A1 (es) | 2012-03-09 | 2019-04-01 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| US20150110824A1 (en) | 2012-03-18 | 2015-04-23 | Glaxosmithkline Biologicals, Sa | Method of vaccination against human papillomavirus |
| EP3492095A1 (en) | 2012-04-01 | 2019-06-05 | Technion Research & Development Foundation Limited | Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies |
| KR102057217B1 (ko) | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| EP2875041A2 (en) | 2012-07-19 | 2015-05-27 | Zoetis LLC | Bovine influenza c virus compositions |
| WO2014018724A1 (en) | 2012-07-27 | 2014-01-30 | Zoetis Llc | Tick toxin compositions |
| CA2879939A1 (en) | 2012-08-06 | 2014-02-13 | Glaxosmithkline Biologicals S.A. | Novel method |
| US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
| EP3421051B1 (en) | 2012-08-16 | 2020-05-13 | Pfizer Inc | Glycoconjugation processes and compositions |
| KR20140075196A (ko) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| SI2935299T1 (sl) | 2012-12-20 | 2019-12-31 | Pfizer Inc. | Postopek glikokonjugacije |
| JP6440360B2 (ja) | 2013-02-05 | 2018-12-19 | 日東電工株式会社 | 経皮投与用ワクチン組成物 |
| JP6512568B2 (ja) | 2013-02-05 | 2019-05-15 | 日東電工株式会社 | 経皮投与用wt1ペプチド癌ワクチン組成物 |
| CA2840988A1 (en) | 2013-02-05 | 2014-08-05 | Nitto Denko Corporation | Wt1 peptide cancer vaccine composition for mucosal administration |
| JP2014169278A (ja) | 2013-02-05 | 2014-09-18 | Nitto Denko Corp | 経皮投与用ワクチン組成物 |
| EP2762161A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | E75-vaccine composition for mucosal administration |
| EP2762157A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Vaccine composition for transdermal or mucosal administration |
| CA2841014A1 (en) | 2013-02-05 | 2014-08-05 | Nitto Denko Corporation | Tape preparation of wt1 peptide cancer vaccine for transdermal administration |
| US10071051B2 (en) | 2013-02-05 | 2018-09-11 | Nitto Denko Corporation | WT1 peptide cancer vaccine composition for transdermal administration |
| US20140234377A1 (en) | 2013-02-05 | 2014-08-21 | Nitto Denko Corporation | Vaccine composition for mucosal administration |
| CA2840959A1 (en) | 2013-02-05 | 2014-08-05 | Nitto Denko Corporation | Vaccine composition |
| WO2014136064A2 (en) | 2013-03-08 | 2014-09-12 | Pfizer Inc. | Immunogenic fusion polypeptides |
| AU2014243756B2 (en) | 2013-03-13 | 2018-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| EP2983703A1 (en) | 2013-03-15 | 2016-02-17 | Zoetis Services LLC | Cross-protection of bovines against b. trehalosi infection by a multi-valent vaccine |
| CA2905162A1 (en) | 2013-03-15 | 2014-09-18 | Glaxosmithkline Biologicals S.A. | Composition containing buffered aminoalkyl glucosaminide phosphate derivatives and its use for enhancing an immune response |
| US10058603B2 (en) | 2013-03-15 | 2018-08-28 | Glaxosmithkline Biologicals S.A. | Vaccine |
| US9909114B2 (en) | 2013-03-28 | 2018-03-06 | Infectious Disease Research Institute | Vaccines comprising leishmania polypeptides for the treatment and diagnosis of leishmaniasis |
| JP6603209B2 (ja) | 2013-05-10 | 2019-11-06 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | ソルターゼ(Sortase)を用いた生存細胞のタンパク質修飾 |
| JP6564367B2 (ja) | 2013-08-05 | 2019-08-21 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 併用免疫原性組成物 |
| BR112016004136B1 (pt) | 2013-08-30 | 2023-04-11 | Km Biologics Co., Ltd. | Métodos para produzir um vírus em uma cultura celular e para a preparação de uma vacina |
| CA2923129C (en) | 2013-09-08 | 2020-06-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| JP2015059577A (ja) | 2013-09-17 | 2015-03-30 | Ntn株式会社 | チェーン伝動装置 |
| CN104436157A (zh) | 2013-09-23 | 2015-03-25 | 恩金生物有限公司 | 流感疫苗和治疗 |
| WO2015092710A1 (en) | 2013-12-19 | 2015-06-25 | Glaxosmithkline Biologicals, S.A. | Contralateral co-administration of vaccines |
| US11708411B2 (en) | 2013-12-20 | 2023-07-25 | Wake Forest University Health Sciences | Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines |
| HRP20211288T1 (hr) | 2014-01-21 | 2021-11-26 | Pfizer Inc. | Kapsularni polisaharidi bakterije streptococcus pneumoniae i njihovi konjugati |
| PT3096783T (pt) | 2014-01-21 | 2021-08-16 | Pfizer | Polissacáridos capsulares de streptococcus pneumoniae e conjugados dos mesmos |
| WO2016130569A1 (en) | 2015-02-09 | 2016-08-18 | Mj Biologics, Inc. | A composition comprising pedv antigens and methods for making and using the composition |
| EP3443983B1 (en) | 2014-02-14 | 2022-07-20 | Pfizer Inc. | Immunogenic glycoprotein conjugates |
| EP3556353A3 (en) | 2014-02-25 | 2020-03-18 | Merck Sharp & Dohme Corp. | Lipid nanoparticle vaccine adjuvants and antigen delivery systems |
| CN106535930A (zh) | 2014-03-11 | 2017-03-22 | 明尼苏达大学董事会 | 猪流行性腹泻病毒疫苗及其使用方法 |
| BE1022346A9 (fr) | 2014-03-12 | 2016-10-07 | Glaxosmithkline Biologicals Sa | Compositions liposomales pour une administration mucosale |
| AU2015228387A1 (en) | 2014-03-12 | 2016-10-27 | Glaxosmithkline Biologicals S.A. | Immunogenic liposomal formulation |
| CA2944768C (en) | 2014-04-03 | 2022-08-30 | Biondvax Pharmaceuticals Ltd. | Compositions of multimeric-multiepitope influenza polypeptides and their production |
| EP3888676A1 (en) | 2014-06-13 | 2021-10-06 | GlaxoSmithKline Biologicals S.A. | Immunogenic combinations |
| WO2016012385A1 (en) | 2014-07-21 | 2016-01-28 | Sanofi Pasteur | Vaccine composition comprising ipv and cyclodextrins |
| AR102547A1 (es) | 2014-11-07 | 2017-03-08 | Takeda Vaccines Inc | Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y su uso |
| AU2015252119A1 (en) | 2014-11-07 | 2016-05-26 | Takeda Vaccines, Inc. | Hand, foot, and mouth vaccines and methods of manufacture and use thereof |
| JP2018509384A (ja) | 2015-01-06 | 2018-04-05 | イミューノヴァクシーン テクノロジーズ インコーポレイテッドImmunovaccine Technologies Inc. | リピドa模倣体、調製方法、及びその使用 |
| MA41414A (fr) | 2015-01-28 | 2017-12-05 | Centre Nat Rech Scient | Protéines de liaison agonistes d' icos |
| MX391027B (es) | 2015-02-19 | 2025-03-21 | Pfizer | Composiciones de neisseria meningitidis y metodos de la misma. |
| WO2016140702A1 (en) | 2015-03-03 | 2016-09-09 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Serivces | Display platform from bacterial spore coat proteins |
| EP3268380B1 (en) | 2015-03-12 | 2018-12-26 | Zoetis Services LLC | Pyolysin methods and compositions |
| RU2692923C2 (ru) | 2015-05-04 | 2019-06-28 | Пфайзер Инк. | Конъюгаты полисахарида стрептококка группы В и белка, способы получения конъюгатов, иммуногенные композиции, содержащие конъюгаты, и их применения |
| US10682314B2 (en) | 2015-05-26 | 2020-06-16 | Ohio State Innovation Foundation | Nanoparticle based vaccine strategy against swine influenza virus |
| BR112018002520A2 (pt) | 2015-08-06 | 2018-09-18 | Glaxosmithkline Ip Dev Ltd | Agonistas de tlr4 e composições dos mesmos e seuuso no tratamento de câncer |
| WO2017021912A1 (en) | 2015-08-06 | 2017-02-09 | Glaxosmithkline Intellectual Property Development Limited | Combined tlrs modulators with anti ox40 antibodies |
| TW201716084A (zh) | 2015-08-06 | 2017-05-16 | 葛蘭素史克智慧財產發展有限公司 | 組合物及其用途與治療 |
| WO2017030901A1 (en) | 2015-08-14 | 2017-02-23 | Zoetis Services Llc | Mycoplasma bovis compositions |
| US10526309B2 (en) | 2015-10-02 | 2020-01-07 | The University Of North Carolina At Chapel Hill | Pan-TAM inhibitors and Mer/Axl dual inhibitors |
| CN108367062B (zh) | 2015-10-13 | 2022-05-06 | 赛诺菲巴斯德有限公司 | 抗金黄色葡萄球菌的免疫原性组合物 |
| MA44334A (fr) | 2015-10-29 | 2018-09-05 | Novartis Ag | Conjugués d'anticorps comprenant un agoniste du récepteur de type toll |
| NZ738202A (en) | 2015-12-03 | 2019-07-26 | Glaxosmithkline Ip Dev Ltd | Cyclic purine dinucleotides as modulators of sting |
| US20180318415A1 (en) | 2015-12-08 | 2018-11-08 | Glaxosmithkline Biologicals, Sa | Novel adjuvant formulations |
| WO2017098421A1 (en) | 2015-12-08 | 2017-06-15 | Glaxosmithkline Intellectual Property Development Limited | Benzothiadiazine compounds |
| EP3402878A1 (en) | 2016-01-11 | 2018-11-21 | Zoetis Services LLC | Novel cross protective vaccine compositions for porcine epidemic diarrhea virus |
| WO2017137085A1 (en) | 2016-02-11 | 2017-08-17 | Sanofi Pasteur | Meningitidis vaccines comprising subtilinases |
| WO2017153952A1 (en) | 2016-03-10 | 2017-09-14 | Glaxosmithkline Intellectual Property Development Limited | 5-sulfamoyl-2-hydroxybenzamide derivatives |
| CN109563081A (zh) | 2016-04-07 | 2019-04-02 | 葛兰素史克知识产权开发有限公司 | 可用作蛋白调节剂的杂环酰胺类 |
| SI3440076T1 (sl) | 2016-04-07 | 2022-09-30 | Glaxosmithkline Intellectual Property Development Limited | Heterociklični amidi uporabni kot proteinski modulatorji |
| ES2801423T3 (es) | 2016-05-05 | 2021-01-11 | Glaxosmithkline Ip No 2 Ltd | Potenciador de inhibidores del homólogo Zeste 2 |
| US11033615B2 (en) | 2016-05-31 | 2021-06-15 | The Government of the United States, As Represented by the Secretary of the Army Fort Detrick, Maryland | Zika virus vaccine and methods of production |
| EP3474890A1 (en) | 2016-06-22 | 2019-05-01 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften E. V. | Pneumococcal polysaccharide-protein conjugate composition |
| EP3269385A1 (en) | 2016-07-12 | 2018-01-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Pneumococcal polysaccharide-protein conjugate composition |
| US20190241573A1 (en) | 2016-07-20 | 2019-08-08 | Glaxosmithkline Intellectual Property Development Limited | Isoquinoline derivatives as perk inhibitors |
| MX2019002178A (es) | 2016-08-23 | 2019-09-18 | Glaxosmithkline Biologicals Sa | Peptidos de fusion con antigenos enlazados a fragmentos cortos de cadena invariante (cd74). |
| CA3036218A1 (en) | 2016-09-16 | 2018-03-22 | Infectious Disease Research Institute | Vaccines comprising mycobacterium leprae polypeptides for the prevention, treatment, and diagnosis of leprosy |
| WO2018060288A1 (en) | 2016-09-29 | 2018-04-05 | Glaxosmithkline Biologicals S.A. | Compositions and methods of treatment of persistent hpv infection |
| GB201616904D0 (en) | 2016-10-05 | 2016-11-16 | Glaxosmithkline Biologicals Sa | Vaccine |
| US10751402B2 (en) | 2016-11-09 | 2020-08-25 | Pfizer Inc. | Immunogenic compositions and uses thereof |
| WO2018100536A1 (en) | 2016-12-01 | 2018-06-07 | Glaxosmithkline Intellectual Property Development Limited | Methods of treating cancer |
| JP7136777B2 (ja) | 2016-12-07 | 2022-09-13 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 新規プロセス |
| GB201620968D0 (en) | 2016-12-09 | 2017-01-25 | Glaxosmithkline Biologicals Sa | Adenovirus polynucleotides and polypeptides |
| WO2018109220A2 (en) | 2016-12-16 | 2018-06-21 | Institute For Research In Biomedicine | Novel recombinant prefusion rsv f proteins and uses thereof |
| GB201621686D0 (en) | 2016-12-20 | 2017-02-01 | Glaxosmithkline Biologicals Sa | Novel methods for inducing an immune response |
| KR102650073B1 (ko) | 2017-01-31 | 2024-03-20 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코커스 뉴모니아 혈청형 19f 유래의 협막 다당류 단백질 접합체의 제조 방법 |
| EP4656208A2 (en) | 2017-01-31 | 2025-12-03 | Merck Sharp & Dohme LLC | Methods for making polysaccharide-protein conjugates |
| PE20191107A1 (es) | 2017-01-31 | 2019-08-26 | Pfizer | Composiciones de neisseria meningitidis y metodos respectivos |
| CN110392690B (zh) | 2017-02-24 | 2024-01-30 | 默沙东有限责任公司 | 肺炎球菌缀合物疫苗制剂 |
| GB201703529D0 (en) | 2017-03-06 | 2017-04-19 | Cambridge Entpr Ltd | Vaccine composition |
| US10525119B2 (en) | 2017-03-31 | 2020-01-07 | Boston Medical Center Corporation | Methods and compositions using highly conserved pneumococcal surface proteins |
| CN118085055A (zh) | 2017-04-19 | 2024-05-28 | 生物医学研究所 | 作为疫苗及新疟疾疫苗和抗体结合靶标的疟原虫子孢子npdp肽 |
| EP3615061A1 (en) | 2017-04-28 | 2020-03-04 | GlaxoSmithKline Biologicals S.A. | Vaccination |
| US11389465B2 (en) | 2017-05-01 | 2022-07-19 | Vanderbilt University | Phosphorylated hexaacyl disaccharides (PHADs) for treating or preventing infections |
| GB201707700D0 (en) | 2017-05-12 | 2017-06-28 | Glaxosmithkline Biologicals Sa | Dried composition |
| GB2600652B (en) | 2017-05-30 | 2022-11-02 | Glaxosmithkline Biologicals Sa | Novel compositions |
| BR112019027387A8 (pt) | 2017-06-23 | 2022-12-06 | Univ Maryland | Composições imunogênicas |
| WO2019021208A1 (en) | 2017-07-27 | 2019-01-31 | Glaxosmithkline Intellectual Property Development Limited | USEFUL INDAZOLE DERIVATIVES AS PERK INHIBITORS |
| CA3074708A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| WO2019053617A1 (en) | 2017-09-12 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | CHEMICAL COMPOUNDS |
| AU2018331874B2 (en) | 2017-09-13 | 2022-06-02 | Sanofi Pasteur | Human cytomegalovirus immunogenic composition |
| JP2020536106A (ja) | 2017-10-05 | 2020-12-10 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Hivの処置に有用なインターフェロン遺伝子の刺激物質(sting)の調節物質 |
| WO2019069270A1 (en) | 2017-10-05 | 2019-04-11 | Glaxosmithkline Intellectual Property Development Limited | GENERATOR STIMULATOR MODULATORS (STING) INTERFERON |
| JP7197880B2 (ja) * | 2017-10-19 | 2022-12-28 | 学校法人 名城大学 | エステル化剤及びその利用 |
| KR102686858B1 (ko) | 2017-12-06 | 2024-07-19 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코쿠스 뉴모니아에 폴리사카라이드-단백질 접합체를 포함하는 조성물 및 그의 사용 방법 |
| CA3090271A1 (en) | 2018-02-12 | 2019-08-15 | Inimmune Corporation | Toll-like receptor ligands |
| US11912736B2 (en) | 2018-02-21 | 2024-02-27 | The University Of Montana | Diaryl trehalose compounds and uses thereof |
| CA3034912A1 (en) | 2018-02-28 | 2019-08-28 | Pfizer Inc. | Il-15 variants and uses thereof |
| US11572381B2 (en) | 2018-03-02 | 2023-02-07 | The University Of Montana | Immunogenic trehalose compounds and uses thereof |
| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| US11525010B2 (en) | 2018-05-23 | 2022-12-13 | Pfizer Inc. | Antibodies specific for GUCY2c and uses thereof |
| BR112020022897A2 (pt) | 2018-05-23 | 2021-02-23 | Pfizer Inc. | anticorpos específicos para cd3 e usos dos mesmos |
| EP3574915A1 (en) | 2018-05-29 | 2019-12-04 | Neovacs | Immunogenic product comprising il-4 and/or il-13 for treating disorders associated with aberrant il-4 and/or il 13 expression or activity |
| WO2019239311A1 (en) | 2018-06-12 | 2019-12-19 | Glaxosmithkline Biologicals Sa | Adenovirus polynucleotides and polypeptides |
| EP3581201A1 (en) | 2018-06-15 | 2019-12-18 | GlaxoSmithKline Biologicals S.A. | Escherichia coli o157:h7 proteins and uses thereof |
| EP3829618B1 (en) | 2018-07-31 | 2025-07-16 | GlaxoSmithKline Biologicals SA | Antigen purification method |
| WO2020030570A1 (en) | 2018-08-06 | 2020-02-13 | Glaxosmithkline Intellectual Property Development Limited | Combinations of an ox40 antibody and a tlr4 modulator and uses thereof |
| WO2020030571A1 (en) | 2018-08-06 | 2020-02-13 | Glaxosmithkline Intellectual Property Development Limited | Combinations of a pd-1 antibody and a tlr4 modulator and uses thereof |
| WO2020031087A1 (en) | 2018-08-06 | 2020-02-13 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy |
| CN111315407B (zh) | 2018-09-11 | 2023-05-02 | 上海市公共卫生临床中心 | 一种广谱抗流感疫苗免疫原及其应用 |
| WO2020109365A1 (en) | 2018-11-29 | 2020-06-04 | Glaxosmithkline Biologicals Sa | Methods for manufacturing an adjuvant |
| WO2020131763A2 (en) | 2018-12-19 | 2020-06-25 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| WO2020128893A1 (en) | 2018-12-21 | 2020-06-25 | Pfizer Inc. | Combination treatments of cancer comprising a tlr agonist |
| EP3897846A1 (en) | 2018-12-21 | 2021-10-27 | GlaxoSmithKline Biologicals SA | Methods of inducing an immune response |
| WO2020237164A1 (en) | 2019-05-23 | 2020-11-26 | The University Of Montana | Vaccine adjuvants based on tlr receptor ligands |
| US20230295313A1 (en) | 2019-06-26 | 2023-09-21 | Glaxosmithkline Intellectual Property Development Limited | Il1rap binding proteins |
| GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| US20220280636A1 (en) | 2019-07-19 | 2022-09-08 | Merck Sharp & Dohme Corp. | Antigenic glycoprotein e polypeptides, compositions, and methods of use thereof |
| JP2022542032A (ja) | 2019-07-21 | 2022-09-29 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 治療用ウイルスワクチン |
| US20220265803A1 (en) | 2019-07-31 | 2022-08-25 | Sanofi Pasteur Inc. | Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same |
| WO2021018941A1 (en) | 2019-07-31 | 2021-02-04 | Glaxosmithkline Intellectual Property Development Limited | Methods of treating cancer |
| WO2021043961A1 (en) | 2019-09-06 | 2021-03-11 | Glaxosmithkline Intellectual Property Development Limited | Dosing regimen for the treatment of cancer with an anti icos agonistic antibody and chemotherapy |
| EP4028051A1 (en) | 2019-09-09 | 2022-07-20 | GlaxoSmithKline Biologicals S.A. | Immunotherapeutic compositions |
| CN115605222A (zh) | 2019-09-27 | 2023-01-13 | 辉瑞公司(Us) | 脑膜炎奈瑟氏菌组合物及其方法 |
| CA3155173A1 (en) | 2019-09-27 | 2021-04-01 | Glaxosmithkline Intellectual Property Development Limited | Antigen binding proteins |
| JP2023503086A (ja) | 2019-11-22 | 2023-01-26 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 細菌サッカリド複合糖質ワクチンの用法及び用量 |
| US11702474B2 (en) | 2019-12-17 | 2023-07-18 | Pfizer Inc. | Antibodies specific for CD47, PD-L1, and uses thereof |
| JP7662644B2 (ja) | 2019-12-18 | 2025-04-15 | シーティーエックスティー・ピーティーワイ・リミテッド | 化合物 |
| CN115209916A (zh) | 2020-02-13 | 2022-10-18 | 伊利诺伊大学理事会 | 用于检测和预防丝虫病的疫苗和方法 |
| CA3175521A1 (en) | 2020-04-16 | 2021-10-21 | Par'immune Sas | 28 kda gst proteins from schistosoma for the treatment of vasculitis |
| US20230146256A1 (en) | 2020-04-17 | 2023-05-11 | Regents Of The University Of Minnesota | SARS-CoV-2 SPIKE RECEPTOR BINDING DOMAIN AND COMPOSITIONS AND METHODS THEREOF |
| EP3900739A1 (en) | 2020-04-21 | 2021-10-27 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Synthetic streptococcus pneumoniae saccharide conjugates to conserved membrane protein |
| CA3181627A1 (en) | 2020-05-05 | 2021-11-11 | Glaxosmithkline Biologicals Sa | Microfluidic mixing device and methods of use |
| US20230236205A1 (en) | 2020-06-01 | 2023-07-27 | Loop Diagnostics, S.L. | Method and kit for the early detection of sepsis |
| WO2021245611A1 (en) | 2020-06-05 | 2021-12-09 | Glaxosmithkline Biologicals Sa | Modified betacoronavirus spike proteins |
| BR112022025969A2 (pt) | 2020-06-22 | 2023-01-17 | Sumitomo Pharma Co Ltd | Adjuvante com atividade agonista de tlr4 |
| JP2023533793A (ja) | 2020-07-17 | 2023-08-04 | ファイザー・インク | 治療用抗体およびそれらの使用 |
| EP4203995A1 (en) | 2020-08-26 | 2023-07-05 | Pfizer Inc. | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
| JP2023542141A (ja) | 2020-09-15 | 2023-10-05 | ザ ユニバーシティー オブ モンタナ | 繊維状バクテリオファージを標的化する組成物および方法 |
| US20230364232A1 (en) | 2020-09-17 | 2023-11-16 | Neovacs | IMMUNOGENIC PRODUCT COMPRISING AN IgE FRAGMENT FOR TREATING IgE-MEDIATED INFLAMMATORY DISORDERS |
| CN116457364A (zh) * | 2020-11-11 | 2023-07-18 | 第一三共株式会社 | 新型氨基烷基氨基葡糖苷4-磷酸酯衍生物 |
| EP4255919A2 (en) | 2020-12-02 | 2023-10-11 | GlaxoSmithKline Biologicals S.A. | Donor strand complemented fimh |
| EP4032547A1 (en) | 2021-01-20 | 2022-07-27 | GlaxoSmithKline Biologicals S.A. | Hsv1 fce derived fragements for the treatment of hsv |
| AU2022218139A1 (en) | 2021-02-03 | 2023-09-21 | Pai Life Sciences Inc. | Vaccine and methods for preventing filariasis and dirofilariasis |
| CN117222428A (zh) | 2021-02-11 | 2023-12-12 | 葛兰素史克生物有限公司 | Hpv疫苗生产 |
| JP2024509529A (ja) | 2021-03-02 | 2024-03-04 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | Dnmt1阻害剤としての置換ピリジン |
| JP2024511831A (ja) | 2021-03-31 | 2024-03-15 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | 抗原結合タンパク質およびそれらの組み合わせ |
| WO2023020994A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| WO2023020993A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| WO2023020992A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
| EP4448548B8 (en) | 2021-12-13 | 2025-12-03 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Bacteriophage lambda-vaccine system |
| CN114318353B (zh) * | 2021-12-27 | 2023-12-05 | 广东红日星实业有限公司 | 一种除灰剂及其制备方法和应用 |
| WO2024069420A2 (en) | 2022-09-29 | 2024-04-04 | Pfizer Inc. | Immunogenic compositions comprising an rsv f protein trimer |
| US20250161420A1 (en) | 2023-11-16 | 2025-05-22 | Merck Sharp & Dohme Llc | Peptide conjugate vaccine compositions and methods for the treatment of alzheimer's disease |
| EP4656648A1 (en) | 2024-05-31 | 2025-12-03 | Consejo Superior De Investigaciones Científicas | Immunomodulatory thiourea and urea carbohydrate compounds and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62129292A (ja) * | 1985-11-28 | 1987-06-11 | Toho Yakuhin Kogyo Kk | 生物活性を発現するリピドa単糖類縁体 |
| JPS6344588A (ja) * | 1986-08-11 | 1988-02-25 | Toho Yakuhin Kogyo Kk | リピドa単糖類縁体のレクタス型異性体 |
| US4746742A (en) * | 1985-11-28 | 1988-05-24 | Toho Yakuhin Kogyo Kabushiki Kaisha | Analogs of nonreducing monosaccharide moiety of lipid A |
| JPS6330495A (ja) * | 1986-07-24 | 1988-02-09 | Toho Yakuhin Kogyo Kk | リピドa単糖類縁体の立体異性体 |
-
1997
- 1997-05-08 US US08/853,826 patent/US6113918A/en not_active Expired - Lifetime
-
1998
- 1998-05-07 DK DK98922138T patent/DK0983286T3/da active
- 1998-05-07 AP APAP/P/1999/001693A patent/AP1181A/en active
- 1998-05-07 JP JP54851298A patent/JP4485608B2/ja not_active Expired - Lifetime
- 1998-05-07 BR BRPI9809791A patent/BRPI9809791B8/pt not_active IP Right Cessation
- 1998-05-07 KR KR1019997010285A patent/KR100553641B1/ko not_active Expired - Lifetime
- 1998-05-07 EP EP98922138A patent/EP0983286B1/en not_active Expired - Lifetime
- 1998-05-07 IL IL13273998A patent/IL132739A0/xx unknown
- 1998-05-07 WO PCT/US1998/009385 patent/WO1998050399A1/en not_active Ceased
- 1998-05-07 NZ NZ500938A patent/NZ500938A/en not_active IP Right Cessation
- 1998-05-07 CN CNB988061694A patent/CN1181086C/zh not_active Expired - Lifetime
- 1998-05-07 ES ES98922138T patent/ES2224397T3/es not_active Expired - Lifetime
- 1998-05-07 AT AT98922138T patent/ATE272067T1/de active
- 1998-05-07 AU AU74747/98A patent/AU740663B2/en not_active Expired
- 1998-05-07 DE DE69825271T patent/DE69825271T2/de not_active Expired - Lifetime
- 1998-05-07 PT PT98922138T patent/PT983286E/pt unknown
- 1998-05-07 PL PL34320598A patent/PL188046B1/pl unknown
- 1998-05-07 CA CA002288601A patent/CA2288601C/en not_active Expired - Lifetime
- 1998-05-07 ID IDW991539A patent/ID22994A/id unknown
- 1998-05-07 HU HU0004147A patent/HU228667B1/hu unknown
-
1999
- 1999-11-04 IL IL132739A patent/IL132739A/en not_active IP Right Cessation
- 1999-11-05 OA OA9900244A patent/OA11214A/en unknown
-
2009
- 2009-12-04 JP JP2009276135A patent/JP5266192B2/ja not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100553641B1 (ko) | 아미노알킬 글루코스아민 인산염 화합물 및 이를아쥬반트와 면역작동체로 사용하는 방법 | |
| US6355257B1 (en) | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors | |
| US6764840B2 (en) | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors | |
| US6303347B1 (en) | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors | |
| CN105131051B (zh) | 合成的吡喃葡萄糖脂佐剂 | |
| EP3197907B1 (en) | Vaccines against streptococcus pneumoniae serotype 8 | |
| JP2003514824A (ja) | 合成脂質−a類似体およびその使用 | |
| US7063967B2 (en) | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors | |
| EP0038750A1 (en) | Immunologically active dipeptidyl 4-0-, 6-0-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation | |
| EP3274358B1 (en) | Vaccine against carbapenem-resistantklebsiella pneumoniae | |
| US7541020B2 (en) | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors | |
| HK1029120B (en) | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors | |
| AU773921B2 (en) | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors | |
| EP3000820A1 (en) | Synthetic vaccines against Streptococcus pneumoniae serotype 8 | |
| MXPA99010262A (en) | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors | |
| HK1242329B (en) | Vaccines against streptococcus pneumoniae serotype 8 | |
| HK1242329A1 (en) | Vaccines against streptococcus pneumoniae serotype 8 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 19991106 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| N231 | Notification of change of applicant | ||
| PN2301 | Change of applicant |
Patent event date: 19991227 Comment text: Notification of Change of Applicant Patent event code: PN23011R01D |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20030428 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20050205 Patent event code: PE09021S01D |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20050609 Patent event code: PE09021S01D |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20050914 Patent event code: PE09021S01D |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20051220 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 20060213 Patent event code: PR07011E01D |
|
| PR1002 | Payment of registration fee |
Payment date: 20060214 End annual number: 3 Start annual number: 1 |
|
| PG1601 | Publication of registration | ||
| PR1001 | Payment of annual fee |
Payment date: 20090114 Start annual number: 4 End annual number: 4 |
|
| PR1001 | Payment of annual fee |
Payment date: 20100113 Start annual number: 5 End annual number: 5 |
|
| PR1001 | Payment of annual fee |
Payment date: 20110201 Start annual number: 6 End annual number: 6 |
|
| PR1001 | Payment of annual fee |
Payment date: 20120131 Start annual number: 7 End annual number: 7 |
|
| FPAY | Annual fee payment |
Payment date: 20130130 Year of fee payment: 8 |
|
| PR1001 | Payment of annual fee |
Payment date: 20130130 Start annual number: 8 End annual number: 8 |
|
| FPAY | Annual fee payment |
Payment date: 20140129 Year of fee payment: 9 |
|
| PR1001 | Payment of annual fee |
Payment date: 20140129 Start annual number: 9 End annual number: 9 |
|
| FPAY | Annual fee payment |
Payment date: 20150129 Year of fee payment: 10 |
|
| PR1001 | Payment of annual fee |
Payment date: 20150129 Start annual number: 10 End annual number: 10 |
|
| FPAY | Annual fee payment |
Payment date: 20151230 Year of fee payment: 11 |
|
| PR1001 | Payment of annual fee |
Payment date: 20151230 Start annual number: 11 End annual number: 11 |
|
| FPAY | Annual fee payment |
Payment date: 20161229 Year of fee payment: 12 |
|
| PR1001 | Payment of annual fee |
Payment date: 20161229 Start annual number: 12 End annual number: 12 |
|
| FPAY | Annual fee payment |
Payment date: 20171228 Year of fee payment: 13 |
|
| PR1001 | Payment of annual fee |
Payment date: 20171228 Start annual number: 13 End annual number: 13 |
|
| EXPY | Expiration of term | ||
| PC1801 | Expiration of term |
Termination date: 20181107 Termination category: Expiration of duration |