AR075437A1 - Composicion inmunogenica que comprende al menos un antigeno del virus del dengue inactivado y un adyuvante sin aluminio, metodo para producir dicha vacuna y su uso para preparar un medicamento - Google Patents
Composicion inmunogenica que comprende al menos un antigeno del virus del dengue inactivado y un adyuvante sin aluminio, metodo para producir dicha vacuna y su uso para preparar un medicamentoInfo
- Publication number
- AR075437A1 AR075437A1 ARP100100442A ARP100100442A AR075437A1 AR 075437 A1 AR075437 A1 AR 075437A1 AR P100100442 A ARP100100442 A AR P100100442A AR P100100442 A ARP100100442 A AR P100100442A AR 075437 A1 AR075437 A1 AR 075437A1
- Authority
- AR
- Argentina
- Prior art keywords
- immunogenic composition
- adjuvant
- dengue
- virus
- vaccine
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Composicion inmunogénica que comprende al menos un antígeno del virus del dengue inactivado que se selecciona entre el grupo consistente en antígenos del virus Dengue-1, Dengue-2, Dengue- 3 y Dengue-4 y un adyuvante sin aluminio. Método para producir dicha vacuna. Su uso para preparar un medicamento util para prevenir, mejorar o tratar una enfermedad producida por el virus del dengue. Reivindicacion 4: La composicion inmunogénica de cualquiera de las reivindicaciones 1 a 3, caracterizada porque el adyuvante comprende una emulsion de aceite en agua. Reivindicacion 5: La composicion inmunogénica de cualquiera de las reivindicaciones 1 a 4, caracterizada porque el adyuvante comprende un vehículo de emulsion de aceite en agua que comprende un aceite metabolizable, un tocol y un emulsionante. Reivindicacion 6: La composicion inmunogénica de la reivindicacion 4 o 5, caracterizada porque el aceite metabolizable es escualeno. Reivindicacion 7: La composicion inmunogénica de cualquiera de las reivindicaciones 5 o 6, caracterizada porque el tocol es alfa-tocoferol. Reivindicacion 8: La composicion inmunogénica de cualquiera de las reivindicaciones 4 a 7, caracterizada porque la emulsion comprende un emulsionante tensioactivo no ionico. Reivindicacion 9: La composicion inmunogénica de reivindicacion 8, caracterizada porque el tensioactivo no ionico es monooleato de polioxietileno sorbitano. Reivindicacion 17: La composicion inmunogénica de la reivindicacion 15, caracterizada porque el adyuvante comprende además colesterol. Reivindicacion 18: La composicion inmunogénica de cualquiera de las reivindicaciones 15 a 17, caracterizada porque el adyuvante comprende además 1,2-dioleoil-sn-glicero-3-fosfocolina (DOPC).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15306009P | 2009-02-17 | 2009-02-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR075437A1 true AR075437A1 (es) | 2011-03-30 |
Family
ID=42174405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100100442A AR075437A1 (es) | 2009-02-17 | 2010-02-16 | Composicion inmunogenica que comprende al menos un antigeno del virus del dengue inactivado y un adyuvante sin aluminio, metodo para producir dicha vacuna y su uso para preparar un medicamento |
Country Status (23)
Country | Link |
---|---|
US (2) | US9265821B2 (es) |
EP (1) | EP2398821B1 (es) |
JP (2) | JP6058266B2 (es) |
KR (1) | KR101738704B1 (es) |
CN (1) | CN102395600B (es) |
AR (1) | AR075437A1 (es) |
AU (1) | AU2010215595A1 (es) |
BR (1) | BRPI1011224A2 (es) |
CA (1) | CA2752809A1 (es) |
CL (1) | CL2011001993A1 (es) |
CO (1) | CO6551750A2 (es) |
DO (1) | DOP2011000268A (es) |
ES (1) | ES2649020T3 (es) |
IL (1) | IL214385A (es) |
MX (1) | MX338898B (es) |
NZ (1) | NZ700477A (es) |
PE (2) | PE20110992A1 (es) |
PH (1) | PH12015501637A1 (es) |
SG (2) | SG2014014385A (es) |
TW (2) | TWI528972B (es) |
UY (1) | UY32457A (es) |
WO (1) | WO2010094663A1 (es) |
ZA (1) | ZA201105656B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2459216T3 (da) | 2009-09-02 | 2013-12-09 | Novartis Ag | Immunogene sammensætninger omfattende tlr-aktivitetsmodulatorer |
WO2012031140A1 (en) | 2010-09-01 | 2012-03-08 | Novartis Ag | Adsorption of immunopotentiators to insoluble metal salts |
ES2681698T3 (es) * | 2011-03-02 | 2018-09-14 | Glaxosmithkline Biologicals Sa | Vacunas de combinación con menores dosis de antígeno y/o adyuvante |
BR112013030236A2 (pt) * | 2011-05-26 | 2016-12-06 | Glaxosmithkline Biolog Sa | preparação em massa de vírus da dengue inativado ou uma composição imunogênica, e, preparação liofilizada de vírus da dengue inativado |
CA2866406A1 (en) | 2012-03-08 | 2013-09-12 | Novartis Ag | Adjuvanted formulations of booster vaccines |
WO2017109698A1 (en) | 2015-12-22 | 2017-06-29 | Glaxosmithkline Biologicals Sa | Immunogenic formulation |
WO2017197034A1 (en) * | 2016-05-10 | 2017-11-16 | Najit Technologies, Inc. | Inorganic polyatomic oxyanions for protecting against antigenic damage during pathogen inactivation for vaccine production |
JP7195147B2 (ja) * | 2016-05-16 | 2022-12-23 | アクセス ツー アドバンスト ヘルス インスティチュート | Peg化リポソームおよび使用方法 |
PL3558351T3 (pl) * | 2016-12-23 | 2022-03-21 | Intervet International B.V. | Szczepionka skojarzona dla świń |
US20200276299A1 (en) * | 2017-09-08 | 2020-09-03 | Infectious Disease Research Institute | Liposomal formulations comprising saponin and methods of use |
CN112601815A (zh) * | 2018-08-27 | 2021-04-02 | 迈凯恩技术有限公司 | 使用永生化单核细胞和诱导细胞的抗感染药物、疫苗等的评价方法 |
CN111150849A (zh) * | 2020-04-02 | 2020-05-15 | 广州隽沐生物科技股份有限公司 | 一种组合物及其制备方法及其应用 |
CN114377122B (zh) * | 2022-01-18 | 2023-04-07 | 四川大学 | 一种基于四面体框架核酸的复合佐剂、mRNA疫苗及其制备方法和用途 |
WO2023147337A2 (en) * | 2022-01-25 | 2023-08-03 | Takeda Vaccines, Inc. | Large-scale flaviviral vaccine production and manufacture |
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US4372945A (en) | 1979-11-13 | 1983-02-08 | Likhite Vilas V | Antigen compounds |
IL61904A (en) | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
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2010
- 2010-02-16 PE PE2011001431A patent/PE20110992A1/es not_active Application Discontinuation
- 2010-02-16 US US13/148,741 patent/US9265821B2/en not_active Expired - Fee Related
- 2010-02-16 KR KR1020117021610A patent/KR101738704B1/ko active IP Right Grant
- 2010-02-16 SG SG2014014385A patent/SG2014014385A/en unknown
- 2010-02-16 JP JP2011549593A patent/JP6058266B2/ja not_active Expired - Fee Related
- 2010-02-16 BR BRPI1011224A patent/BRPI1011224A2/pt not_active IP Right Cessation
- 2010-02-16 EP EP10709443.5A patent/EP2398821B1/en active Active
- 2010-02-16 PE PE2015001630A patent/PE20151588A1/es not_active Application Discontinuation
- 2010-02-16 NZ NZ700477A patent/NZ700477A/en not_active IP Right Cessation
- 2010-02-16 WO PCT/EP2010/051882 patent/WO2010094663A1/en active Application Filing
- 2010-02-16 AU AU2010215595A patent/AU2010215595A1/en not_active Abandoned
- 2010-02-16 AR ARP100100442A patent/AR075437A1/es unknown
- 2010-02-16 CN CN201080016827.1A patent/CN102395600B/zh not_active Expired - Fee Related
- 2010-02-16 CA CA2752809A patent/CA2752809A1/en not_active Abandoned
- 2010-02-16 MX MX2011008649A patent/MX338898B/es active IP Right Grant
- 2010-02-16 ES ES10709443.5T patent/ES2649020T3/es active Active
- 2010-02-16 SG SG2011055068A patent/SG173194A1/en unknown
- 2010-02-17 UY UY0001032457A patent/UY32457A/es not_active Application Discontinuation
- 2010-02-22 TW TW099104980A patent/TWI528972B/zh active
- 2010-02-22 TW TW103135137A patent/TW201517915A/zh unknown
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2011
- 2011-08-01 ZA ZA2011/05656A patent/ZA201105656B/en unknown
- 2011-08-01 IL IL214385A patent/IL214385A/en not_active IP Right Cessation
- 2011-08-16 CL CL2011001993A patent/CL2011001993A1/es unknown
- 2011-08-19 DO DO2011000268A patent/DOP2011000268A/es unknown
- 2011-08-30 CO CO11111072A patent/CO6551750A2/es not_active Application Discontinuation
-
2015
- 2015-06-22 JP JP2015125077A patent/JP6104988B2/ja not_active Expired - Fee Related
- 2015-07-23 PH PH12015501637A patent/PH12015501637A1/en unknown
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2016
- 2016-01-11 US US14/992,354 patent/US20160120972A1/en not_active Abandoned
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