PE20190458A1 - Composiciones de neisseria meningitidis y metodos de las mismas - Google Patents

Composiciones de neisseria meningitidis y metodos de las mismas

Info

Publication number
PE20190458A1
PE20190458A1 PE2019000328A PE2019000328A PE20190458A1 PE 20190458 A1 PE20190458 A1 PE 20190458A1 PE 2019000328 A PE2019000328 A PE 2019000328A PE 2019000328 A PE2019000328 A PE 2019000328A PE 20190458 A1 PE20190458 A1 PE 20190458A1
Authority
PE
Peru
Prior art keywords
neisseria meningitidis
methods
same
amino acid
refers
Prior art date
Application number
PE2019000328A
Other languages
English (en)
Inventor
Annaliesa Sybil Anderson
Susan Kay Hoiseth
Kathrin Ute Jansen
Justin Keith Moran
Mark E Ruppen
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20190458A1 publication Critical patent/PE20190458A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1031—Mutagenizing nucleic acids mutagenesis by gene assembly, e.g. assembly by oligonucleotide extension PCR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/36—Neisseria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se refiere a un polipeptido aislado que comprende una determinada secuencia de aminoacidos, la cual puede presentar algunas modificaciones (en la secuencia, ausencia de cisteina en algunos residuos de aminoacidos, entre otras), y a un polipeptido ORF2086 aislado no piruvilado y no lipidado de Neisseria meningitidis serogrupo B, el cual forma parte de composiciones inmunogenicas junto con al menos un conjugado de un sacarido capsular de un serogrupo de Neisseria meningitidis, pudiendo anadirse uno o mas adyuvantes (citoquinas, linfocinas, entre otros), un diluyente o portador, un tampon, entre otros. Tambien se refiere a metodos de preparacion de los compuestos y composiciones inmunogenicas. La presente invencion es util para el tratamiento de enfermedades causadas por Neisseria meningitidis, meningitis meningococica en especial.
PE2019000328A 2012-03-09 2013-03-06 Composiciones de neisseria meningitidis y metodos de las mismas PE20190458A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261609257P 2012-03-09 2012-03-09

Publications (1)

Publication Number Publication Date
PE20190458A1 true PE20190458A1 (es) 2019-04-01

Family

ID=48182966

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2014001352A PE20142115A1 (es) 2012-03-09 2013-03-06 Composiciones de neisseria meningitidis y metodos de las mismas
PE2019000328A PE20190458A1 (es) 2012-03-09 2013-03-06 Composiciones de neisseria meningitidis y metodos de las mismas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2014001352A PE20142115A1 (es) 2012-03-09 2013-03-06 Composiciones de neisseria meningitidis y metodos de las mismas

Country Status (21)

Country Link
US (3) US8986710B2 (es)
EP (3) EP4043029A1 (es)
JP (2) JP5925342B2 (es)
KR (5) KR101763625B1 (es)
CN (3) CN105693830B (es)
AR (3) AR090294A1 (es)
AU (5) AU2013229063B2 (es)
BR (2) BR112014021658A2 (es)
CA (4) CA2865745C (es)
CO (1) CO7061042A2 (es)
HK (1) HK1206625A1 (es)
IL (4) IL234555B (es)
MX (3) MX2018011291A (es)
MY (2) MY198910A (es)
NZ (2) NZ628449A (es)
PE (2) PE20142115A1 (es)
PH (2) PH12014501887A1 (es)
RU (2) RU2665841C2 (es)
SG (3) SG11201404730XA (es)
TW (5) TWI616455B (es)
WO (1) WO2013132452A2 (es)

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NZ607224A (en) 2010-09-10 2014-11-28 Wyeth Llc Non-lipidated variants of neisseria meningitidis orf2086 antigens
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
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BR112017001417B1 (pt) * 2014-07-23 2023-11-07 Children's Hospital & Research Center At Oakland Variantes da proteína de ligação ao fator h (fhbp), composição imunogênica e uso de uma fhbp variante referência cruzada
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CA2995454A1 (en) * 2015-08-11 2017-02-16 Orbis Health Solutions Llc Bacterial and viral vaccine strategy
US20180228885A1 (en) * 2016-03-04 2018-08-16 Orbis Health Solutions Llc Bacterial and viral vaccine strategy
DK3506935T3 (en) 2016-09-02 2024-04-02 Sanofi Pasteur Inc Neisseria meningitidis-vaccine
CN118021947A (zh) * 2017-01-31 2024-05-14 辉瑞大药厂 脑膜炎奈瑟菌组合物及其使用方法
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