MX360448B - Adyuvantes sinteticos de glucopiranosil-lipido. - Google Patents

Adyuvantes sinteticos de glucopiranosil-lipido.

Info

Publication number
MX360448B
MX360448B MX2014009221A MX2014009221A MX360448B MX 360448 B MX360448 B MX 360448B MX 2014009221 A MX2014009221 A MX 2014009221A MX 2014009221 A MX2014009221 A MX 2014009221A MX 360448 B MX360448 B MX 360448B
Authority
MX
Mexico
Prior art keywords
glucopyranosyl lipid
compounds
provided
lipid adjuvants
synthetic glucopyranosyl
Prior art date
Application number
MX2014009221A
Other languages
English (en)
Inventor
G Reed Steven
Carter Darrick
Original Assignee
Infectious Disease Res Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US18470309P priority Critical
Application filed by Infectious Disease Res Institute filed Critical Infectious Disease Res Institute
Priority to PCT/US2010/037466 priority patent/WO2010141861A1/en
Publication of MX360448B publication Critical patent/MX360448B/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/665Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016Disaccharides, e.g. lactose, lactulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/04Mycobacterium, e.g. Mycobacterium tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/21Retroviridae, e.g. equine infectious anemia virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/235Adenoviridae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/245Herpetoviridae, e.g. herpes simplex virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/275Poxviridae, e.g. avipoxvirus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02Acyclic radicals, not substituted by cyclic structures
    • C07H15/04Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02Acyclic radicals, not substituted by cyclic structures
    • C07H15/12Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55572Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response

Abstract

Se proporcionan compuestos, particularmente compuestos de adyuvantes de glucopiranosil-lípido (GLA), que tienen la siguiente estructura (I): (I) o una sal farmacéuticamente aceptable de los mismos, en donde L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, Y1, Y2, Y3, Y4, R1, R2, R3, R4, R5, R6, son como se define en este documento. También se proporcionan composiciones farmacéuticas, composiciones de vacunas y métodos relacionados para inducir o mejorar las respuestas inmunológicas.
MX2014009221A 2009-06-05 2010-06-04 Adyuvantes sinteticos de glucopiranosil-lipido. MX360448B (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US18470309P true 2009-06-05 2009-06-05
PCT/US2010/037466 WO2010141861A1 (en) 2009-06-05 2010-06-04 Synthetic glucopyranosyl lipid adjuvants

Publications (1)

Publication Number Publication Date
MX360448B true MX360448B (es) 2018-11-01

Family

ID=43298190

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014009221A MX360448B (es) 2009-06-05 2010-06-04 Adyuvantes sinteticos de glucopiranosil-lipido.
MX2011012836A MX2011012836A (es) 2009-06-05 2010-06-04 Adyuvantes sinteticos de glucopiranosil-lipido.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2011012836A MX2011012836A (es) 2009-06-05 2010-06-04 Adyuvantes sinteticos de glucopiranosil-lipido.

Country Status (22)

Country Link
US (4) US8722064B2 (es)
EP (2) EP3124491B1 (es)
JP (3) JP5830015B2 (es)
CN (2) CN105131051A (es)
AU (1) AU2010256461B2 (es)
BR (1) BRPI1011072A2 (es)
CA (1) CA2764374A1 (es)
CY (1) CY1118347T1 (es)
DK (1) DK2437753T3 (es)
ES (1) ES2606563T3 (es)
HR (1) HRP20161585T1 (es)
HU (1) HUE031051T2 (es)
IL (2) IL216669A (es)
LT (1) LT2437753T (es)
MX (2) MX360448B (es)
PL (1) PL2437753T3 (es)
PT (1) PT2437753T (es)
RU (2) RU2560182C2 (es)
SI (1) SI2437753T1 (es)
SM (1) SMT201600437B (es)
TW (2) TWI549688B (es)
WO (1) WO2010141861A1 (es)

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CA2764374A1 (en) 2010-12-09
TWI549688B (zh) 2016-09-21
JP2012528892A (ja) 2012-11-15
TWI494125B (zh) 2015-08-01
US20100310602A1 (en) 2010-12-09
SMT201600437B (it) 2017-01-10
EP3124491B1 (en) 2019-10-30
HUE031051T2 (en) 2017-06-28
ES2606563T3 (es) 2017-03-24
LT2437753T (lt) 2016-12-12
IL216669D0 (en) 2012-02-29
EP2437753A1 (en) 2012-04-11
CN102481312B (zh) 2015-07-15
MX2011012836A (es) 2012-04-20
AU2010256461B2 (en) 2016-03-17
PL2437753T3 (pl) 2017-03-31
RU2560182C2 (ru) 2015-08-20
WO2010141861A1 (en) 2010-12-09
AU2010256461A1 (en) 2012-01-12
US20170182155A1 (en) 2017-06-29
EP2437753B1 (en) 2016-08-31
DK2437753T3 (en) 2016-12-19
IL216669A (en) 2016-04-21

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