RU2020129844A - Синтетические глюкопиранозиллипидные адъюванты - Google Patents
Синтетические глюкопиранозиллипидные адъюванты Download PDFInfo
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- RU2020129844A RU2020129844A RU2020129844A RU2020129844A RU2020129844A RU 2020129844 A RU2020129844 A RU 2020129844A RU 2020129844 A RU2020129844 A RU 2020129844A RU 2020129844 A RU2020129844 A RU 2020129844A RU 2020129844 A RU2020129844 A RU 2020129844A
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- Prior art keywords
- gla
- gla compound
- vector
- compound according
- alkyl
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- 239000002671 adjuvant Substances 0.000 title 1
- -1 GLA compound Chemical class 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 239000013603 viral vector Substances 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000003259 recombinant expression Methods 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000015788 innate immune response Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/235—Adenoviridae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C07H11/04—Phosphates; Phosphites; Polyphosphates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
Claims (33)
1. GLA соединение, имеющее следующую структуру (I):
или его фармацевтически приемлемая соль, где:
L1, L2, L3, L4, L5 и L6 являются одинаковыми или различными и независимо представляют собой -O-, -NH- или -(CH2)-;
L7, L8, L9 и L10 являются одинаковыми или различными и независимо отсутствуют или представляют собой -(=O)-;
Y1 представляет собой кислотную функциональную группу;
Y2 и Y3 являются одинаковыми или различными и независимо представляют собой -OH, -SH или кислотную функциональную группу;
Y4 представляет собой -OH или -SH;
R1, R3, R5 и R6 являются одинаковыми или различными и независимо представляют собой C8-13алкил; и
R2 и R4 являются одинаковыми или различными и независимо представляют собой C6-11алкил.
2. GLA соединение по п. 1, где L5 и L6 оба представляют собой -O-, а каждый из L7, L8, L9 и L10 представляет собой -C(=O)-, и GLA соединение имеет следующую формулу (II):
3. GLA соединение по п. 2, где каждый из R1, R3, R5 и R6 представляет собой Cxалкил, где x является постоянной и выбран из целых чисел от 8 до 13, а R2 и R4 оба представляют собой Cx-2алкил, и GLA соединение имеет следующую формулу (III):
4. GLA соединение по п. 3, где x выбирают из целых чисел от 10 до 12.
5. GLA соединение по п. 4, где x равен 11 и GLA соединение имеет следующую структуру (IV):
6. GLA соединение по п. 2, где Y1 представляет собой -OP(=O)(OH)2, а каждый из Y2, Y3 и Y4 представляет собой -OH, и GLA соединения имеют следующую формулу (V):
7. GLA соединение по п. 2, где L1 и L3 оба представляют собой -O-, а L2 и L4 оба представляют собой -NH-, и GLA соединение имеет следующую формулу (VI):
8. GLA соединение по п. 2, где Y1 представляет собой -OP(O)(OH)2, каждый из Y2, Y3 и Y4 представляет собой -OH, L1 и L3 оба представляют собой -O-, и L2 и L4 оба представляют собой -NH-, и GLA соединение имеет следующую формулу (VII):
9. GLA соединение по п. 2, где Y1 представляет собой -OP(O)(OH)2, каждый из Y2, Y3 и Y4 представляет собой -OH, L1 и L3 представляют собой -O-, L2 и L4 оба представляют собой -NH-, каждый из R1, R3, R5 и R6 представляет собой Cxалкил, где x является постоянной и выбирают из целых чисел от 8 до 13, и R2 и R4 оба представляют собой Cx-2алкил, и GLA соединение имеет следующую формулу (VIII):
10. GLA соединение по п. 9, где x равен 11 и GLA соединение имеет следующую структуру (IX):
11. Вакцинная композиция, содержащая соединение по любому из пп. 1-10 в сочетании с антигеном или с рекомбинантным экспрессирующим вектором, кодирующим антиген.
12. Вакцинная композиция по п. 11, где рекомбинантный экспрессирующий конструкт представляет собой вирусный вектор.
13. Вакцинная композиция по п. 12, где вирусный вектор выбирают из группы, состоящей из аденовирусного вектора, адено-ассоциированного вирусного вектора, герпесвирусного вектора, лентивирусного вектора, поксивирусного вектора и ретровирусного вектора.
14. Способ индукции или усиления антиген-специфического иммунного ответа у субъекта, включающий введение субъекту вакцинной композиции по п. 11.
15. Фармацевтическая композиция, содержащая соединение по любому из пп. 1-10 и фармацевтически приемлемый носитель или наполнитель.
16. Способ стимуляции неспецифического иммунного ответа у субъекта, включающий введение субъекту фармацевтической композиции по п. 15.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US18470309P | 2009-06-05 | 2009-06-05 | |
US61/184,703 | 2009-06-05 |
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RU2015129468A Division RU2732574C2 (ru) | 2009-06-05 | 2010-06-04 | Синтетические глюкопиранозиллипидные адъюванты |
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RU2020129844A true RU2020129844A (ru) | 2022-03-10 |
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RU2011152602/04A RU2560182C2 (ru) | 2009-06-05 | 2010-06-04 | Синтетические глюкопиранозиллипидные адъюванты |
RU2015129468A RU2732574C2 (ru) | 2009-06-05 | 2010-06-04 | Синтетические глюкопиранозиллипидные адъюванты |
RU2020129844A RU2020129844A (ru) | 2009-06-05 | 2020-09-10 | Синтетические глюкопиранозиллипидные адъюванты |
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RU2011152602/04A RU2560182C2 (ru) | 2009-06-05 | 2010-06-04 | Синтетические глюкопиранозиллипидные адъюванты |
RU2015129468A RU2732574C2 (ru) | 2009-06-05 | 2010-06-04 | Синтетические глюкопиранозиллипидные адъюванты |
Country Status (22)
Country | Link |
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US (4) | US8722064B2 (ru) |
EP (2) | EP3124491B1 (ru) |
JP (3) | JP5830015B2 (ru) |
CN (2) | CN102481312B (ru) |
AU (1) | AU2010256461B2 (ru) |
BR (1) | BRPI1011072B1 (ru) |
CA (1) | CA2764374C (ru) |
CY (1) | CY1118347T1 (ru) |
DK (1) | DK2437753T3 (ru) |
ES (1) | ES2606563T3 (ru) |
HR (1) | HRP20161585T1 (ru) |
HU (1) | HUE031051T2 (ru) |
IL (2) | IL216669A (ru) |
LT (1) | LT2437753T (ru) |
MX (2) | MX2011012836A (ru) |
PL (1) | PL2437753T3 (ru) |
PT (1) | PT2437753T (ru) |
RU (3) | RU2560182C2 (ru) |
SI (1) | SI2437753T1 (ru) |
SM (1) | SMT201600437B (ru) |
TW (2) | TWI494125B (ru) |
WO (1) | WO2010141861A1 (ru) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
AU2007354917B2 (en) | 2006-09-26 | 2013-06-06 | Access To Advanced Health Institute | Vaccine composition containing synthetic adjuvant |
ES2616051T3 (es) | 2008-12-02 | 2017-06-09 | Wave Life Sciences Japan, Inc. | Método para la síntesis de ácidos nucleicos modificados en el átomo de fósforo |
CA2764374C (en) | 2009-06-05 | 2019-11-19 | Infectious Disease Research Institute | Synthetic glucopyranosyl lipid adjuvants |
US9744183B2 (en) | 2009-07-06 | 2017-08-29 | Wave Life Sciences Ltd. | Nucleic acid prodrugs and methods of use thereof |
EA201290897A1 (ru) | 2010-03-11 | 2013-03-29 | Иммьюн Дизайн Корп. | Вакцины для пандемического гриппа |
JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
BR112013020875A2 (pt) | 2011-02-15 | 2019-09-24 | Immune Design Corp | método para indução de uma resposta imune específica para um imunógeno em um indivíduo. |
NZ616304A (en) | 2011-04-08 | 2016-01-29 | Immune Design Corp | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
US20120288515A1 (en) | 2011-04-27 | 2012-11-15 | Immune Design Corp. | Synthetic long peptide (slp)-based vaccines |
SG10201700554VA (en) | 2011-07-19 | 2017-03-30 | Wave Life Sciences Pte Ltd | Methods for the synthesis of functionalized nucleic acids |
US20140328876A1 (en) | 2011-11-18 | 2014-11-06 | Variation Biotechnologies Inc. | Synthetic derivatives of mpl and uses thereof |
EP2785370B1 (en) * | 2011-12-02 | 2021-07-21 | Rhode Island Hospital | Vaccine for falciparum malaria |
TR201908003T4 (tr) * | 2012-02-07 | 2019-06-21 | Infectious Disease Res Inst | TLR4 agonistleri içeren gelişmiş adjuvan formülasyonları ve bunların kullanım metotları. |
JP5650780B2 (ja) * | 2012-04-04 | 2015-01-07 | 日東電工株式会社 | ワクチン組成物 |
SI2850431T1 (en) | 2012-05-16 | 2018-08-31 | Immune Design Corp. | Vaccine against HSV-2 |
WO2013185052A1 (en) | 2012-06-08 | 2013-12-12 | Aduro Biotech | Compostions and methods for cancer immunotherapy |
CA2878945A1 (en) | 2012-07-13 | 2014-01-16 | Wave Life Sciences Pte. Ltd. | Chiral control |
AU2013288048A1 (en) | 2012-07-13 | 2015-01-22 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
WO2014010718A1 (ja) * | 2012-07-13 | 2014-01-16 | 株式会社新日本科学 | キラル核酸アジュバント |
ES2718910T3 (es) | 2012-12-13 | 2019-07-05 | Aduro Biotech Inc | Composiciones que comprenden dinucleótidos cíclicos de purina que tienen estereoquímicas definidas y métodos para su preparación y uso |
EA032326B1 (ru) | 2013-04-18 | 2019-05-31 | Иммьюн Дизайн Корп. | Монотерапия gla для применения в лечении рака |
CA2908154C (en) | 2013-04-29 | 2023-11-28 | Memorial Sloan Kettering Cancer Center | Compositions and methods for altering second messenger signaling |
JP2016518140A (ja) | 2013-05-03 | 2016-06-23 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | I型インターフェロンの環状ジヌクレオチド誘導法 |
US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
DK2996473T3 (da) | 2013-05-18 | 2019-11-04 | Aduro Biotech Inc | Sammensætninger og fremgangsmåder til aktivering af "stimulator af interferon-gen"-afhængig signalering |
US9463198B2 (en) * | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
US10176292B2 (en) | 2013-07-31 | 2019-01-08 | Memorial Sloan-Kettering Cancer Center | STING crystals and modulators |
EA032441B1 (ru) * | 2013-09-05 | 2019-05-31 | Иммьюн Дизайн Корп. | Вакцинные композиции против никотиновой зависимости |
US9017698B2 (en) | 2013-09-25 | 2015-04-28 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
US9149521B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
US9149522B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
US9504743B2 (en) * | 2013-09-25 | 2016-11-29 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
EP3053593A4 (en) | 2013-10-03 | 2017-07-05 | Nitto Denko Corporation | Nasal mucosal vaccine composition |
WO2015050180A1 (ja) | 2013-10-03 | 2015-04-09 | 日東電工株式会社 | 粘膜ワクチン組成物 |
EP3053596B1 (en) | 2013-10-03 | 2020-05-06 | Nitto Denko Corporation | Mucosal vaccine composition |
CN105530953A (zh) | 2013-10-03 | 2016-04-27 | 日东电工株式会社 | 注射疫苗组合物 |
BR112016015422A2 (pt) | 2013-12-31 | 2017-10-24 | Infectious Disease Res Inst | formulações de vacina de frasco único |
WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
KR20220106232A (ko) | 2014-01-16 | 2022-07-28 | 웨이브 라이프 사이언시스 리미티드 | 키랄 디자인 |
US20160030459A1 (en) * | 2014-01-21 | 2016-02-04 | Immune Design Corp. | Compositions and methods for treating allergic conditions |
AU2015218365A1 (en) | 2014-02-14 | 2016-09-01 | Immune Design Corp. | Immunotherapy of cancer through combination of local and systemic immune stimulation |
AU2015289773A1 (en) | 2014-07-15 | 2017-02-02 | Immune Design Corp. | Prime-boost regimens with a TLR4 agonist adjuvant and a lentiviral vector |
SG11201706756VA (en) | 2015-03-10 | 2017-09-28 | Aduro Biotech Inc | Compositions and methods for activating "stimulator of interferon gene" -dependent signalling |
TW201722472A (zh) | 2015-11-27 | 2017-07-01 | Nitto Denko Corp | 口腔內投與用疫苗醫藥組合物及口腔內投與用疫苗醫藥組合物之製造方法 |
EP4112638A1 (en) | 2016-05-16 | 2023-01-04 | Access to Advanced Health Institute | Formulation containing tlr agonist and methods of use |
BR112018073676B1 (pt) | 2016-05-16 | 2023-10-03 | University Of Virginia Patent Foundation | Lipossomas peguilados e métodos de uso |
US20200148729A1 (en) | 2016-05-21 | 2020-05-14 | Infectious Disease Research Institute | Compositions and Methods for Treating Secondary Tuberculosis and Nontuberculosis Mycobacterium Infections |
CN109195587A (zh) | 2016-06-01 | 2019-01-11 | 传染病研究所 | 含上胶剂的纳米明矾颗粒 |
US11098077B2 (en) | 2016-07-05 | 2021-08-24 | Chinook Therapeutics, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
US11633411B2 (en) | 2016-10-04 | 2023-04-25 | University Of Maryland, Baltimore | Methods of treating sepsis using anti-sepsis lipid A (ASLA) based therapeutics |
KR102028463B1 (ko) * | 2016-11-25 | 2019-10-04 | 재단법인 목암생명과학연구소 | 바리셀라 조스터 바이러스 백신 |
CA3048608C (en) | 2016-12-26 | 2021-11-23 | Mogam Institute For Biomedical Research | Herpes zoster vaccine composition |
UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
US11141377B2 (en) | 2017-06-15 | 2021-10-12 | Infectious Disease Research Institute | Nanostructured lipid carriers and stable emulsions and uses thereof |
US20200276299A1 (en) | 2017-09-08 | 2020-09-03 | Infectious Disease Research Institute | Liposomal formulations comprising saponin and methods of use |
WO2019052975A1 (en) | 2017-09-13 | 2019-03-21 | Sanofi Pasteur | IMMUNOGENIC COMPOSITION AGAINST HUMAN CYTOMEGALOVIRUS |
AU2019218978A1 (en) | 2018-02-12 | 2020-09-03 | Inimmune Corporation | Toll-like receptor ligands |
US20190275135A1 (en) | 2018-03-12 | 2019-09-12 | Janssen Pharmaceuticals, Inc | Vaccines against intra-abdominal infections |
WO2020191088A1 (en) | 2019-03-18 | 2020-09-24 | Janssen Pharmaceuticals, Inc. | Methods of producing bioconjugates of e. coli o-antigen polysaccharides, compositions thereof, and methods of use thereof |
CN113924112A (zh) | 2019-03-18 | 2022-01-11 | 杨森制药公司 | 大肠杆菌o-抗原多糖的生物缀合物、其生产方法及其使用方法 |
WO2020243115A1 (en) | 2019-05-25 | 2020-12-03 | Infectious Disease Research Institute | Composition and method for spray drying an adjuvant vaccine emulsion |
US11679163B2 (en) | 2019-09-20 | 2023-06-20 | Hdt Bio Corp. | Compositions and methods for delivery of RNA |
MX2022004061A (es) | 2019-10-02 | 2022-07-19 | Janssen Vaccines & Prevention Bv | Peptidos de estafilococo y metodos de uso. |
WO2021097347A1 (en) | 2019-11-15 | 2021-05-20 | Infectious Disease Research Institute | Rig-i agonist and adjuvant formulation for tumor treatment |
WO2021144369A1 (en) | 2020-01-16 | 2021-07-22 | Janssen Pharmaceuticals, Inc. | Fimh mutant, compositions therewith and use thereof |
GB2605538A (en) | 2020-03-23 | 2022-10-05 | Hdt Bio Corp | Compositions and methods for delivery of RNA |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
US20230310323A1 (en) | 2020-09-04 | 2023-10-05 | Access To Advanced Health Institute | Co-lyophilized rna and nanostructured lipid carrier |
IL308201A (en) | 2020-09-17 | 2024-01-01 | Janssen Pharmaceuticals Inc | Multivalent vaccine compositions and uses thereof |
CA3200234A1 (en) | 2020-11-25 | 2022-06-02 | Daryl C. Drummond | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
CN117120087A (zh) | 2020-12-23 | 2023-11-24 | 高级健康研究所 | 茄尼醇疫苗助剂及其制备方法 |
KR20230125842A (ko) | 2021-01-12 | 2023-08-29 | 얀센 파마슈티칼즈, 인코포레이티드 | FimH 돌연변이체, 이를 포함하는 조성물 및 이의 용도 |
TW202304504A (zh) | 2021-04-01 | 2023-02-01 | 美商詹森藥物公司 | 大腸桿菌o18生物軛合物之生產 |
WO2022256740A1 (en) | 2021-06-04 | 2022-12-08 | Curia Ip Holdings, Llc | Polymeric fusion proteins and compositions for inducing an immune response against infection |
Family Cites Families (244)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3238190A (en) | 1963-10-23 | 1966-03-01 | Madaus & Co K G Fa Dr | Aescin recovery |
US3598122A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US4029762A (en) | 1971-11-17 | 1977-06-14 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Lipid A-preparation |
US4286592A (en) | 1980-02-04 | 1981-09-01 | Alza Corporation | Therapeutic system for administering drugs to the skin |
US4314557A (en) | 1980-05-19 | 1982-02-09 | Alza Corporation | Dissolution controlled active agent dispenser |
US4420558A (en) | 1981-02-12 | 1983-12-13 | Janssen Pharmaceutica N.V. | Bright field light microscopic method of enumerating and characterizing subtypes of white blood cells and their precursors |
US4379454A (en) | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
US4420461A (en) | 1982-05-26 | 1983-12-13 | Ortho Diagnostic Systems Inc. | Agglutination-inhibition test kit for detecting immune complexes |
SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
US4987237A (en) | 1983-08-26 | 1991-01-22 | Ribi Immunochem Research, Inc. | Derivatives of monophosphoryl lipid A |
US4743540A (en) | 1983-09-27 | 1988-05-10 | Memorial Sloan-Kettering Cancer Center | Method for diagnosis of subclassifications of common varied immunodeficiency disease group |
US5147785A (en) | 1983-11-01 | 1992-09-15 | Amtl Corporation | Method and apparatus for measuring the degree of reaction between a foreign entity and white blood cells |
US4614722A (en) | 1983-11-01 | 1986-09-30 | Pasula Mark J | Method and apparatus for measuring the degree of reaction between antigens and leukocyte cellular antibodies |
US4595654A (en) | 1983-11-07 | 1986-06-17 | Immunomedics Inc. | Method for detecting immune complexes in serum |
US4855238A (en) | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
US4844894A (en) | 1984-07-12 | 1989-07-04 | Ribi Immunochem Research Inc. | Method of inhibiting the onset of septicemia and endotoxemia |
US4629722A (en) | 1984-07-12 | 1986-12-16 | Ribi Immunochem Research, Inc. | Method of inhibiting the onset of acute radiation syndrome |
US5612041A (en) | 1984-07-17 | 1997-03-18 | Chiron Corporation | Recombinant herpes simplex gD vaccine |
US5066794A (en) | 1984-08-24 | 1991-11-19 | Daiichi Pharmaceutical Co., Ltd. | Process for preparing a disaccharide derivative |
JPS6153295A (ja) * | 1984-08-24 | 1986-03-17 | Dai Ichi Seiyaku Co Ltd | ジサツカライド誘導体 |
US4568343A (en) | 1984-10-09 | 1986-02-04 | Alza Corporation | Skin permeation enhancer compositions |
US4659659A (en) | 1985-01-22 | 1987-04-21 | Monsanto Company | Diagnostic method for diseases having an arthritic component |
GB8508845D0 (en) | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
FI861417A0 (fi) | 1985-04-15 | 1986-04-01 | Endotronics Inc | Hepatitis b ytantigen framstaelld med rekombinant-dna-teknik, vaccin, diagnostiskt medel och cellinjer samt foerfaranden foer framstaellning daerav. |
US4746742A (en) | 1985-11-28 | 1988-05-24 | Toho Yakuhin Kogyo Kabushiki Kaisha | Analogs of nonreducing monosaccharide moiety of lipid A |
US5310651A (en) | 1986-01-22 | 1994-05-10 | Institut Pasteur | DNA probes of human immunodeficiency virus type 2 (HIV-2), and methods employing these probes for dectecting the presence of HIV-2 |
US6514691B1 (en) | 1986-01-22 | 2003-02-04 | Institut Pasteur | Peptides of human immunodeficiency virus type 2 (HIV-2), antibodies against peptides of HIV-2, and methods and kits for detecting HIV-2 |
US5976785A (en) | 1986-01-22 | 1999-11-02 | Institut Pasteur | Competitive assays for determining the effectiveness of a human immunodeficiency virus type 2 (HIV-2) antiviral agent, employing peptides and proteins of HIV-2 |
US6054565A (en) | 1986-03-03 | 2000-04-25 | Institut Pasteur | Nucleic Acids of HIV-2, Diagnostic Test Kit and Method using Nucleic Acid Probes of HIV-2 |
US5169763A (en) | 1986-04-08 | 1992-12-08 | Transgene S.A., Institut Pasteur | Viral vector coding glycoprotein of HIV-1 |
US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
JPH0755906B2 (ja) | 1986-07-01 | 1995-06-14 | 第一製薬株式会社 | ジサツカライド誘導体含有鎮痛剤 |
US4948587A (en) | 1986-07-08 | 1990-08-14 | Massachusetts Institute Of Technology | Ultrasound enhancement of transbuccal drug delivery |
US4767402A (en) | 1986-07-08 | 1988-08-30 | Massachusetts Institute Of Technology | Ultrasound enhancement of transdermal drug delivery |
US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
FR2672290B1 (fr) | 1991-02-05 | 1995-04-21 | Pasteur Institut | Sequences peptidiques specifiques des stades hepatiques de p. falciparum porteuses d'epitopes capables de stimuler les lymphocytes t. |
US5565209A (en) | 1987-03-17 | 1996-10-15 | Akzo Nobel N.V. | Adjuvant mixture |
CA1331443C (en) | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Saponin adjuvant |
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
EP0304578B1 (en) | 1987-06-22 | 2001-10-24 | Medeva Holdings Bv | Peptide comprising hepatitis B surface antigen |
US4780212A (en) | 1987-07-31 | 1988-10-25 | Massachusetts Institute Of Technology | Ultrasound enchancement of membrane permeability |
US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
WO1989001973A2 (en) | 1987-09-02 | 1989-03-09 | Applied Biotechnology, Inc. | Recombinant pox virus for immunization against tumor-associated antigens |
EP0324455A3 (en) | 1988-01-15 | 1991-03-27 | Hans O. Ribi | Novel polymeric immunological adjuvants |
GB2232892B (en) | 1988-02-23 | 1991-07-24 | John Mark Tucker | Occlusive body for administering a physiologically active substance |
US5278302A (en) | 1988-05-26 | 1994-01-11 | University Patents, Inc. | Polynucleotide phosphorodithioates |
US5888519A (en) | 1988-06-02 | 1999-03-30 | The United States Of America As Represented By The Secretary Of The Army | Encapsulated high-concentration lipid a compositions as immunogenic agents to produce human antibodies to prevent or treat gram-negative bacterial infections |
US4912094B1 (en) * | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
GB8819209D0 (en) | 1988-08-12 | 1988-09-14 | Research Corp Ltd | Polypeptide & dna encoding same |
US5231168A (en) | 1988-09-16 | 1993-07-27 | Statens Seruminstitut | Malaria antigen |
US4999403A (en) | 1988-10-28 | 1991-03-12 | Exxon Chemical Patents Inc. | Graft polymers of functionalized ethylene-alpha-olefin copolymer with polypropylene, methods of preparation, and use in polypropylene compositions |
EP0449856B1 (en) | 1988-12-16 | 2001-09-12 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | Pneumolysin mutants and pneumococcal vaccines made therefrom |
EP0832980B1 (en) | 1989-01-23 | 2002-06-19 | Chiron Corporation | Recombinant therapies for infection and hyperproliferative disorders |
DE69015222T2 (de) | 1989-02-04 | 1995-05-04 | Akzo Nv | Tocole als Impfstoffadjuvans. |
JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
FR2649012B1 (fr) | 1989-07-03 | 1991-10-25 | Seppic Sa | Emulsions multiphasiques injectables |
FR2649013B1 (fr) | 1989-07-03 | 1991-10-25 | Seppic Sa | Vaccins et vecteurs de principes actifs fluides contenant une huile metabolisable |
ES2109921T3 (es) | 1989-07-25 | 1998-02-01 | Smithkline Beecham Biolog | Nuevos antigenos y procedimientos para su preparacion. |
AU648261B2 (en) | 1989-08-18 | 1994-04-21 | Novartis Vaccines And Diagnostics, Inc. | Recombinant retroviruses delivering vector constructs to target cells |
US4981684A (en) | 1989-10-24 | 1991-01-01 | Coopers Animal Health Limited | Formation of adjuvant complexes |
US6120769A (en) | 1989-11-03 | 2000-09-19 | Immulogic Pharmaceutical Corporation | Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor |
US5298396A (en) | 1989-11-15 | 1994-03-29 | National Jewish Center For Immunology And Respiratory Medicine | Method for identifying T cells disease involved in autoimmune disease |
US5256643A (en) | 1990-05-29 | 1993-10-26 | The Government Of The United States | Human cripto protein |
US5124141A (en) | 1990-06-14 | 1992-06-23 | Flow Incorporated | Method for diagnosing malaria |
US5162990A (en) | 1990-06-15 | 1992-11-10 | The United States Of America As Represented By The United States Navy | System and method for quantifying macrophage phagocytosis by computer image analysis |
EP0468520A3 (en) | 1990-07-27 | 1992-07-01 | Mitsui Toatsu Chemicals, Inc. | Immunostimulatory remedies containing palindromic dna sequences |
US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
GB9105992D0 (en) | 1991-03-21 | 1991-05-08 | Smithkline Beecham Biolog | Vaccine |
DE122007000084I1 (de) | 1991-07-19 | 2008-03-27 | Univ Queensland St Lucia | Impfstoff gegen Humanes Papillomavirus (Typ 18) |
US5464387A (en) | 1991-07-24 | 1995-11-07 | Alza Corporation | Transdermal delivery device |
US6197311B1 (en) | 1991-07-25 | 2001-03-06 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
DE69225710T3 (de) | 1991-07-25 | 2004-10-14 | Idec Pharmaceuticals Corp., San Diego | Anregung von antworten zytotoxischer t-lymphozyten |
WO1993003709A1 (en) | 1991-08-16 | 1993-03-04 | Vical, Inc. | Composition and method for treating cystic fibrosis |
AU660325B2 (en) | 1991-10-11 | 1995-06-22 | Eisai Co. Ltd. | Anti-endotoxin compounds and related molecules and methods |
US5530113A (en) | 1991-10-11 | 1996-06-25 | Eisai Co., Ltd. | Anti-endotoxin compounds |
WO1993010152A1 (en) | 1991-11-16 | 1993-05-27 | Smithkline Beecham Biologicals S.A. | HYBRID PROTEIN BETWEEN CS FROM PLASMODIUM AND HBsAG |
US6057427A (en) | 1991-11-20 | 2000-05-02 | Trustees Of Dartmouth College | Antibody to cytokine response gene 2(CR2) polypeptide |
JP3723231B2 (ja) | 1991-12-23 | 2005-12-07 | ディミナコ アクチェンゲゼルシャフト | アジュバント |
US5286718A (en) | 1991-12-31 | 1994-02-15 | Ribi Immunochem Research, Inc. | Method and composition for ameliorating tissue damage due to ischemia and reperfusion |
JPH05328975A (ja) | 1992-06-02 | 1993-12-14 | Takara Shuzo Co Ltd | E1a−f遺伝子 |
WO1993025234A1 (en) | 1992-06-08 | 1993-12-23 | The Regents Of The University Of California | Methods and compositions for targeting specific tissue |
EP0644946A4 (en) | 1992-06-10 | 1997-03-12 | Us Health | VECTOR PARTICLES RESISTANT TO HUMAN SERUM INACTIVATION. |
SG49909A1 (en) | 1992-06-25 | 1998-06-15 | Smithkline Beecham Biolog | Vaccine composition containing adjuvants |
ATE380871T1 (de) | 1992-06-25 | 2007-12-15 | Univ Georgetown | Papillomavirus vakzine |
US5786148A (en) | 1996-11-05 | 1998-07-28 | Incyte Pharmaceuticals, Inc. | Polynucleotides encoding a novel prostate-specific kallikrein |
GB2269175A (en) | 1992-07-31 | 1994-02-02 | Imperial College | Retroviral vectors |
US5437951A (en) | 1992-09-03 | 1995-08-01 | The United States Of America As Represented By The Department Of Health And Human Services | Self-assembling recombinant papillomavirus capsid proteins |
US5411865A (en) | 1993-01-15 | 1995-05-02 | Iasys Corporation | Method of detecting anti-leishmania parasite antibodies |
DE122011100018I1 (de) | 1993-03-09 | 2011-11-17 | Univ Rochester | Herstellung von menschlichem Papilloma-Virus-Capsid-Protein und virusahnlichen Teilchen. |
DE69405551T3 (de) | 1993-03-23 | 2005-10-20 | Smithkline Beecham Biologicals S.A. | 3-0-deazylierte monophosphoryl lipid a enthaltende impfstoff-zusammensetzungen |
US5532133A (en) | 1993-06-02 | 1996-07-02 | New York University | Plasmodium vivax blood stage antigens, PvESP-1, antibodies, and diagnostic assays |
US6106824A (en) | 1993-08-13 | 2000-08-22 | The Rockefeller University | Expression of growth associated protein B-50/GAP-43 in vitro and in vivo |
US5961970A (en) | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
DE69434767T2 (de) | 1993-11-02 | 2006-11-09 | Matsushita Electric Industrial Co., Ltd., Kadoma | Halbleiterbauelement mit Aggregat von Mikro-Nadeln aus Halbleitermaterial |
US5814599A (en) | 1995-08-04 | 1998-09-29 | Massachusetts Insitiute Of Technology | Transdermal delivery of encapsulated drugs |
US5885211A (en) | 1993-11-15 | 1999-03-23 | Spectrix, Inc. | Microporation of human skin for monitoring the concentration of an analyte |
US5458140A (en) | 1993-11-15 | 1995-10-17 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers |
SI0729473T1 (en) | 1993-11-17 | 2001-02-28 | Om Pharma | Glucosamine disaccharides, method for their preparation, pharmaceutical composition comprising same, and their use |
US5693531A (en) | 1993-11-24 | 1997-12-02 | The United States Of America As Represented By The Department Of Health And Human Services | Vector systems for the generation of adeno-associated virus particles |
GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
US5688506A (en) | 1994-01-27 | 1997-11-18 | Aphton Corp. | Immunogens against gonadotropin releasing hormone |
WO1995026204A1 (en) | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
US5457041A (en) | 1994-03-25 | 1995-10-10 | Science Applications International Corporation | Needle array and method of introducing biological substances into living cells using the needle array |
US5591139A (en) | 1994-06-06 | 1997-01-07 | The Regents Of The University Of California | IC-processed microneedles |
EP0772619B2 (en) | 1994-07-15 | 2010-12-08 | The University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
US7037712B2 (en) | 1994-07-26 | 2006-05-02 | Commonwealth Scientific And Industrial Research Organisation | DNA encoding ovine adenovirus (OAV287) and its use as a viral vector |
GB9415319D0 (en) | 1994-07-29 | 1994-09-21 | Medical Res Council | HSV viral vector |
SE9403137D0 (sv) | 1994-09-20 | 1994-09-20 | Perstorp Ab | Derivatives of carbohydrates and compositions containing them |
WO1996011272A2 (de) | 1994-10-07 | 1996-04-18 | Medigene Gesellschaft Für Molekularbiologische Diagnostik, Theraphie Und Technologie Mbh | Papillomavirusähnliche partikel, fusionsproteine sowie verfahren zu deren herstellung |
AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
FR2727689A1 (fr) | 1994-12-01 | 1996-06-07 | Transgene Sa | Nouveau procede de preparation d'un vecteur viral |
DE69633272T2 (de) | 1995-02-08 | 2005-09-08 | Takara Bio Inc., Otsu | Methoden zur Krebsbehandlung und -kontrolle |
JP3958360B2 (ja) | 1995-02-24 | 2007-08-15 | キャンタブ ファーマシューティカルズ リサーチ リミティド | 免疫治療剤として役立つポリペプチド及びポリペプチド調製の方法 |
US5912166A (en) | 1995-04-21 | 1999-06-15 | Corixa Corporation | Compounds and methods for diagnosis of leishmaniasis |
US6846489B1 (en) | 1995-04-25 | 2005-01-25 | Smithkline Beecham Biologicals S.A. | Vaccines containing a saponin and a sterol |
UA56132C2 (ru) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиция вакцины (варианты), способ стабилизации qs21 по отношению к гидролизу (варианты), способ приготовления вакцины |
US5843464A (en) | 1995-06-02 | 1998-12-01 | The Ohio State University | Synthetic chimeric fimbrin peptides |
US5718904A (en) | 1995-06-02 | 1998-02-17 | American Home Products Corporation | Adjuvants for viral vaccines |
US6417172B1 (en) | 1995-06-05 | 2002-07-09 | Eisai Co., Ltd. | Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs |
US5993800A (en) | 1995-06-05 | 1999-11-30 | Bristol-Myers Squibb Company | Methods for prolonging the expression of a heterologous gene of interest using soluble CTLA4 molecules and an antiCD40 ligand |
US5981215A (en) | 1995-06-06 | 1999-11-09 | Human Genome Sciences, Inc. | Human criptin growth factor |
US6309847B1 (en) | 1995-07-05 | 2001-10-30 | Yeda Research And Development Co. Ltd. | Method for detecting or monitoring the effectiveness of treatment of T cell mediated diseases |
US6458366B1 (en) | 1995-09-01 | 2002-10-01 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
AU7254396A (en) | 1995-09-29 | 1997-04-17 | Eisai Research Institute | Method for treating alcoholic liver disease |
US5666153A (en) | 1995-10-03 | 1997-09-09 | Virtual Shopping, Inc. | Retractable teleconferencing apparatus |
US5618275A (en) | 1995-10-27 | 1997-04-08 | Sonex International Corporation | Ultrasonic method and apparatus for cosmetic and dermatological applications |
US5846758A (en) | 1995-11-30 | 1998-12-08 | His Excellency Ghassan I. Shaker | Method for diagnosing autoimmune diseases |
US5843462A (en) | 1995-11-30 | 1998-12-01 | Regents Of The University Of Minnesota | Diphtheria toxin epitopes |
SE9600648D0 (sv) | 1996-02-21 | 1996-02-21 | Bror Morein | Receptorbimdande enhet |
US5656016A (en) | 1996-03-18 | 1997-08-12 | Abbott Laboratories | Sonophoretic drug delivery system |
EP0909562B1 (en) | 1996-07-03 | 2005-06-29 | Eisai Co., Ltd. | Injections containing lipid a analogues and process for the preparation thereof |
ATE229073T1 (de) | 1996-09-06 | 2002-12-15 | Univ California | Protein e25a, methoden zu dessen herstellung und anwendung |
US5955306A (en) | 1996-09-17 | 1999-09-21 | Millenium Pharmaceuticals, Inc. | Genes encoding proteins that interact with the tub protein |
JP4111403B2 (ja) | 1996-10-11 | 2008-07-02 | ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | 免疫刺激ポリヌクレオチド/免疫調節分子複合体 |
JPH10131046A (ja) | 1996-10-29 | 1998-05-19 | Nikka Chem Co Ltd | 繊維の耐久性pH緩衝加工方法 |
US6797276B1 (en) | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
US7033598B2 (en) | 1996-11-19 | 2006-04-25 | Intrabrain International N.V. | Methods and apparatus for enhanced and controlled delivery of a biologically active agent into the central nervous system of a mammal |
DE19654221B4 (de) | 1996-12-23 | 2005-11-24 | Telefonaktiebolaget Lm Ericsson (Publ) | Leitungsanschlußschaltkreis |
US5840871A (en) | 1997-01-29 | 1998-11-24 | Incyte Pharmaceuticals, Inc. | Prostate-associated kallikrein |
US6977073B1 (en) | 1997-02-07 | 2005-12-20 | Cem Cezayirli | Method for stimulating an immune response |
CO4870792A1 (es) | 1997-02-25 | 1999-12-27 | Corixa Corp | Compuestos y conjunto de medios de diagnostico para detectar y vigilar la progresion de cancer de prostata |
US6541212B2 (en) | 1997-03-10 | 2003-04-01 | The Regents Of The University Of California | Methods for detecting prostate stem cell antigen protein |
JP5019494B2 (ja) | 1997-04-01 | 2012-09-05 | コリクサ コーポレーション | モノホスホリルリピドaの水性免疫アジュバント組成物 |
US6491919B2 (en) | 1997-04-01 | 2002-12-10 | Corixa Corporation | Aqueous immunologic adjuvant compostions of monophosphoryl lipid A |
US7037510B2 (en) | 1997-04-18 | 2006-05-02 | Statens Serum Institut | Hybrids of M. tuberculosis antigens |
US6555653B2 (en) | 1997-05-20 | 2003-04-29 | Corixa Corporation | Compounds for diagnosis of tuberculosis and methods for their use |
GB9711990D0 (en) | 1997-06-11 | 1997-08-06 | Smithkline Beecham Biolog | Vaccine |
US6358508B1 (en) | 1997-06-11 | 2002-03-19 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor TR9 |
AU7983198A (en) | 1997-06-23 | 1999-01-04 | Ludwig Institute For Cancer Research | Improved methods for inducing an immune response |
US6764686B2 (en) | 1997-07-21 | 2004-07-20 | Baxter International Inc. | Modified immunogenic pneumolysin compositions as vaccines |
GB9717953D0 (en) | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
WO1999010008A1 (en) | 1997-08-29 | 1999-03-04 | Aquila Biopharmaceuticals, Inc. | Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient |
GB9718901D0 (en) | 1997-09-05 | 1997-11-12 | Smithkline Beecham Biolog | Vaccine |
WO1999011241A1 (en) | 1997-09-05 | 1999-03-11 | Smithkline Beecham Biologicals S.A. | Oil in water emulsions containing saponins |
US6749856B1 (en) | 1997-09-11 | 2004-06-15 | The United States Of America, As Represented By The Department Of Health And Human Services | Mucosal cytotoxic T lymphocyte responses |
US6368604B1 (en) | 1997-09-26 | 2002-04-09 | University Of Maryland Biotechnology Institute | Non-pyrogenic derivatives of lipid A |
US7459524B1 (en) | 1997-10-02 | 2008-12-02 | Emergent Product Development Gaithersburg Inc. | Chlamydia protein, sequence and uses thereof |
EP1032676A2 (en) | 1997-11-28 | 2000-09-06 | Genset | $i(CHLAMYDIA TRACHOMATIS) GENOMIC SEQUENCE AND POLYPEPTIDES, FRAGMENTS THEREOF AND USES THEREOF, IN PARTICULAR FOR THE DIAGNOSIS, PREVENTION AND TREATMENT OF INFECTION |
US7012134B2 (en) | 1998-01-26 | 2006-03-14 | Human Genome Sciences, Inc. | Dendritic enriched secreted lymphocyte activation molecule |
DE19803453A1 (de) | 1998-01-30 | 1999-08-12 | Boehringer Ingelheim Int | Vakzine |
ES2255248T3 (es) | 1998-02-05 | 2006-06-16 | Glaxosmithkline Biologicals S.A. | Derivados de antigenos asociados a tumor de la familia mage, y secuencias de acidos nucleicos que los codifican, usados para la preparacion de proteinas de fusion y de composiciones para vacunas. |
WO1999040938A2 (en) | 1998-02-12 | 1999-08-19 | American Cyanamid Company | Vaccines comprising interleukin-12 and herpes simplex viral antigen |
US6596501B2 (en) | 1998-02-23 | 2003-07-22 | Fred Hutchinson Cancer Research Center | Method of diagnosing autoimmune disease |
FR2775601B1 (fr) | 1998-03-03 | 2001-09-21 | Merial Sas | Vaccins vivants recombines et adjuves |
PL343429A1 (en) | 1998-03-09 | 2001-08-13 | Smithkline Beecham Biolog | Combined vaccine compositions |
CA2326598C (en) | 1998-04-07 | 2014-06-10 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis antigens and their uses |
GB2336310B (en) | 1998-04-14 | 2003-09-10 | Stowic Resources Ltd | Method of manufacturing transdermal patches |
JP2002511266A (ja) | 1998-04-15 | 2002-04-16 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | 腫瘍関連核酸及びその使用 |
US6680175B2 (en) | 1998-05-05 | 2004-01-20 | Adherex Technologies, Inc. | Methods for diagnosing and evaluating cancer |
DE69937343T2 (de) | 1998-05-07 | 2008-07-24 | Corixa Corp., Seattle | Adjuvanszusammensetzung und methoden zu deren verwendung |
US6322532B1 (en) | 1998-06-24 | 2001-11-27 | 3M Innovative Properties Company | Sonophoresis method and apparatus |
TW200532020A (en) | 1998-07-14 | 2005-10-01 | Corixa Corp | Compositions and methods for therapy and diagnosis of prostate cancer |
AU766994B2 (en) | 1998-08-25 | 2003-10-30 | Ronald J. Gallenberg | Beach cleaning apparatus and method |
JP3943334B2 (ja) | 1998-09-01 | 2007-07-11 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | リピッドa類縁体含有注射剤の評価方法 |
US6692752B1 (en) | 1999-09-08 | 2004-02-17 | Smithkline Beecham Biologicals S.A. | Methods of treating human females susceptible to HSV infection |
JP2000095694A (ja) * | 1998-09-24 | 2000-04-04 | Sankyo Co Ltd | 新規な医療用薬剤 |
WO2000018929A2 (en) | 1998-09-25 | 2000-04-06 | Smithkline Beecham Biologicals S.A. | Paramyxovirus vaccines |
US6375944B1 (en) | 1998-09-25 | 2002-04-23 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for enhancing the immunostimulatory effect of interleukin-12 |
US7001770B1 (en) | 1998-10-15 | 2006-02-21 | Canji, Inc. | Calpain inhibitors and their applications |
US7357936B1 (en) | 1998-10-16 | 2008-04-15 | Smithkline Beecham Biologicals, Sa | Adjuvant systems and vaccines |
US6261573B1 (en) | 1998-10-30 | 2001-07-17 | Avant Immunotherapeutics, Inc. | Immunoadjuvants |
US6734172B2 (en) | 1998-11-18 | 2004-05-11 | Pacific Northwest Research Institute | Surface receptor antigen vaccines |
US6512102B1 (en) | 1998-12-31 | 2003-01-28 | Chiron Corporation | Compositions and methods of diagnosis and treatment using casein kinase I |
WO2000042994A2 (en) | 1999-01-21 | 2000-07-27 | North Shore-Long Island Jewish Research Institute | Inhibition of bacterial dissemination |
AU769539B2 (en) | 1999-01-29 | 2004-01-29 | Zoetis Services Llc | Adjuvants for use in vaccines |
US20030170249A1 (en) | 1999-02-19 | 2003-09-11 | Hakomori Sen-Itiroh | Vaccines directed to cancer-associated carbohydrate antigens |
US6770445B1 (en) | 1999-02-26 | 2004-08-03 | Pacific Northwest Research Institute | Methods and compositions for diagnosing carcinomas |
US6599710B1 (en) | 1999-03-10 | 2003-07-29 | The General Hospital Corporation | Treatment of autoimmune disease |
GB9906177D0 (en) | 1999-03-17 | 1999-05-12 | Oxford Biomedica Ltd | Anti-viral vectors |
EP1167974B1 (en) | 1999-04-07 | 2006-09-13 | Hiroshi Okamoto | METHOD FOR JUDGING AUTOIMMUNE DISEASE, METHOD FOR DETECTING ANTI-Reg PROTEIN AUTOANTIBODY AND DIAGNOSTICS FOR AUTOIMMUNE DISEASES |
IL145982A0 (en) | 1999-04-19 | 2002-07-25 | Smithkline Beecham Biolog | Vaccines |
US6685699B1 (en) | 1999-06-09 | 2004-02-03 | Spectrx, Inc. | Self-removing energy absorbing structure for thermal tissue ablation |
EP1206533A1 (en) | 1999-08-26 | 2002-05-22 | Pharmacia AB | Novel response element |
GB9921146D0 (en) | 1999-09-07 | 1999-11-10 | Smithkline Beecham Biolog | Novel composition |
US7084256B2 (en) | 1999-09-24 | 2006-08-01 | Large Scale Biology Corporation | Self antigen vaccines for treating B cell lymphomas and other cancers |
JP4162813B2 (ja) | 1999-10-28 | 2008-10-08 | 久光製薬株式会社 | イオントフォレーシス装置 |
US6218186B1 (en) | 1999-11-12 | 2001-04-17 | Trustees Of The University Of Pennsylvania | HIV-MSCV hybrid viral vector for gene transfer |
JP2003514824A (ja) | 1999-11-15 | 2003-04-22 | ビオミラ,インコーポレーテッド | 合成脂質−a類似体およびその使用 |
US20020064801A1 (en) | 1999-12-01 | 2002-05-30 | Ryan Jeffrey R. | Novel and practical serological assay for the clinical diagnosis of leishmaniasis |
US6974588B1 (en) | 1999-12-07 | 2005-12-13 | Elan Pharma International Limited | Transdermal patch for delivering volatile liquid drugs |
US6587792B1 (en) | 2000-01-11 | 2003-07-01 | Richard A. Thomas | Nuclear packing efficiency |
GB0000891D0 (en) | 2000-01-14 | 2000-03-08 | Allergy Therapeutics Ltd | Formulation |
WO2001055362A2 (en) | 2000-01-31 | 2001-08-02 | The Governement Of The United States Of America, As Represented By The Secretary, Departement Of Health & Human Services, The National Institutes Of Health | Hybrid adeno-retroviral vector for the transfection of cells |
EP1122542A1 (en) | 2000-02-01 | 2001-08-08 | Anda Biologicals S.A. | Method for the rapid detection of whole microorganisms on retaining membranes by use of chaotropic agents |
WO2001062893A2 (en) | 2000-02-25 | 2001-08-30 | Corixa Corporation | Compounds and methods for diagnosis and immunotherapy of tuberculosis |
DE60134134D1 (de) | 2000-05-19 | 2008-07-03 | Corixa Corp | Prophylaktische und therapeutische behandlung von ten mit verbindungen, die auf monosacchariden basieren |
DE60140052D1 (de) | 2000-05-31 | 2009-11-12 | Human Gene Therapy Res Inst | Methode und zusammensetzungen für effizienten gentransfer durch transcomplementierende vektoren |
DE10041515A1 (de) | 2000-08-24 | 2002-03-14 | Gerold Schuler | Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen |
US6969704B1 (en) | 2000-08-25 | 2005-11-29 | The Trustees Of Columbia University In The City Of New York | Methods for suppressing early growth response—1protein (Egr-1) to reduce vascular injury in a subject |
US7060802B1 (en) | 2000-09-18 | 2006-06-13 | The Trustees Of Columbia University In The City Of New York | Tumor-associated marker |
CA2436107C (en) | 2000-10-06 | 2012-05-22 | H. Henrich Paradies | Kyberdrug as autovaccines with immune-regulating effects |
CA2425358C (en) | 2000-10-18 | 2012-08-21 | Glaxosmithkline Biologicals S.A. | A vaccine composition comprising qs21, mpl, a cpg oligonucleotide and a cancer antigen |
WO2003004525A2 (en) | 2001-01-26 | 2003-01-16 | Walter Reed Army Institute Of Research | Isolation and purification of plasmodium falciparum merozoite protein-142 |
US6893820B1 (en) | 2001-01-31 | 2005-05-17 | The Ohio State University Research Foundation | Detection of methylated CpG rich sequences diagnostic for malignant cells |
US7029685B2 (en) | 2001-03-26 | 2006-04-18 | The United States Of America As Represented By The Secretary Of The Army | Plasmodium falciparum AMA-1 protein and uses thereof |
US7060276B2 (en) | 2001-03-26 | 2006-06-13 | The United States Of America As Represented By The Secretary Of The Army | Plasmodium falciparum AMA-1 protein and uses thereof |
US6933123B2 (en) | 2001-04-05 | 2005-08-23 | Yao Xiong Hu | Peptides from the E2, E6, and E7 proteins of human papilloma viruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers |
US6844192B2 (en) | 2001-06-29 | 2005-01-18 | Wake Forest University | Adenovirus E4 protein variants for virus production |
US7727974B2 (en) | 2001-08-10 | 2010-06-01 | Eisai R & D Management Co., Ltd. | Methods of reducing the severity of mucositis |
AU2002339865A1 (en) | 2001-09-05 | 2003-03-18 | The Children's Hospital Of Philadelphia | Methods and compositions useful for diagnosis, staging, and treatment of cancers and tumors |
US20040161776A1 (en) | 2001-10-23 | 2004-08-19 | Maddon Paul J. | PSMA formulations and uses thereof |
US6752995B2 (en) | 2002-04-15 | 2004-06-22 | Board Of Regents, The University Of Texas System | Nucleic acid and polypeptide sequences useful as adjuvants |
US6908453B2 (en) | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
IL163305A (en) | 2002-02-04 | 2010-10-31 | Corixa Corp | Azacycloalkyl glucosaminide phosphate as immunoeffector compounds and pharmaceutical compositions for propylactic and therapeutic treatment of infectious and therapeutic treatment of infectious and other diseases comprising the same |
US6911434B2 (en) | 2002-02-04 | 2005-06-28 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds |
RU2288723C2 (ru) * | 2002-02-04 | 2006-12-10 | Корикса Корпорейшн | Профилактическое и терапевтическое лечение инфекционных и других заболеваний с помощью иммуноэффективных соединений |
US6676961B1 (en) | 2002-03-06 | 2004-01-13 | Automated Carrier Technologies, Inc. | Transdermal patch assembly |
AU2003228966C1 (en) | 2002-05-09 | 2010-05-13 | Oncothyreon Inc. | Lipid A and other carbohydrate ligand analogs |
US7018345B2 (en) | 2002-12-06 | 2006-03-28 | Hisamitsu Pharmaceutical Co., Inc. | Iontophoresis system |
US20050123550A1 (en) | 2003-05-12 | 2005-06-09 | Laurent Philippe E. | Molecules enhancing dermal delivery of influenza vaccines |
FR2862062B1 (fr) | 2003-11-06 | 2005-12-23 | Oreal | Lipide a et composition topique, notamment cosmetique, le comprenant |
AU2007354917B2 (en) | 2006-09-26 | 2013-06-06 | Access To Advanced Health Institute | Vaccine composition containing synthetic adjuvant |
US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
US8563523B2 (en) * | 2007-09-07 | 2013-10-22 | University Of Georgia Research Foundation, Inc. | Synthetic lipid A derivative |
KR101064518B1 (ko) | 2007-09-21 | 2011-09-19 | 주식회사 운화 | 저장근을 가지는 초본식물의 형성층 유래 식물줄기세포주 및 이의 분리방법 |
US9930541B2 (en) | 2007-12-27 | 2018-03-27 | Nokia Technologies Oy | Maintaining the integrity of configuration information of a network of access points for use in positioning an apparatus |
CA2764374C (en) | 2009-06-05 | 2019-11-19 | Infectious Disease Research Institute | Synthetic glucopyranosyl lipid adjuvants |
TR201908003T4 (tr) | 2012-02-07 | 2019-06-21 | Infectious Disease Res Inst | TLR4 agonistleri içeren gelişmiş adjuvan formülasyonları ve bunların kullanım metotları. |
JP5328975B2 (ja) | 2012-12-19 | 2013-10-30 | ルネサスエレクトロニクス株式会社 | Rfパワーモジュール |
EA032326B1 (ru) * | 2013-04-18 | 2019-05-31 | Иммьюн Дизайн Корп. | Монотерапия gla для применения в лечении рака |
US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
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