JP4485608B2 - アミノアルキルグルコサミンフォスフェート化合物ならびにアジュバントおよびイムノエフェクターとしてのそれらの用途 - Google Patents
アミノアルキルグルコサミンフォスフェート化合物ならびにアジュバントおよびイムノエフェクターとしてのそれらの用途 Download PDFInfo
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- JP4485608B2 JP4485608B2 JP54851298A JP54851298A JP4485608B2 JP 4485608 B2 JP4485608 B2 JP 4485608B2 JP 54851298 A JP54851298 A JP 54851298A JP 54851298 A JP54851298 A JP 54851298A JP 4485608 B2 JP4485608 B2 JP 4485608B2
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- compound
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- phosphono
- stereogenic center
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- 125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 252
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- 229960005486 vaccine Drugs 0.000 claims description 33
- 125000004432 carbon atom Chemical group C* 0.000 claims description 23
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims description 21
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 14
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/853,826 | 1997-05-08 | ||
| US08/853,826 US6113918A (en) | 1997-05-08 | 1997-05-08 | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| PCT/US1998/009385 WO1998050399A1 (en) | 1997-05-08 | 1998-05-07 | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009276135A Division JP5266192B2 (ja) | 1997-05-08 | 2009-12-04 | アミノアルキルグルコサミンフォスフェート化合物ならびにアジュバントおよびイムノエフェクターとしてのそれらの用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002512623A JP2002512623A (ja) | 2002-04-23 |
| JP2002512623A5 JP2002512623A5 (enExample) | 2005-12-02 |
| JP4485608B2 true JP4485608B2 (ja) | 2010-06-23 |
Family
ID=25317008
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54851298A Expired - Lifetime JP4485608B2 (ja) | 1997-05-08 | 1998-05-07 | アミノアルキルグルコサミンフォスフェート化合物ならびにアジュバントおよびイムノエフェクターとしてのそれらの用途 |
| JP2009276135A Expired - Lifetime JP5266192B2 (ja) | 1997-05-08 | 2009-12-04 | アミノアルキルグルコサミンフォスフェート化合物ならびにアジュバントおよびイムノエフェクターとしてのそれらの用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009276135A Expired - Lifetime JP5266192B2 (ja) | 1997-05-08 | 2009-12-04 | アミノアルキルグルコサミンフォスフェート化合物ならびにアジュバントおよびイムノエフェクターとしてのそれらの用途 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6113918A (enExample) |
| EP (1) | EP0983286B1 (enExample) |
| JP (2) | JP4485608B2 (enExample) |
| KR (1) | KR100553641B1 (enExample) |
| CN (1) | CN1181086C (enExample) |
| AP (1) | AP1181A (enExample) |
| AT (1) | ATE272067T1 (enExample) |
| AU (1) | AU740663B2 (enExample) |
| BR (1) | BRPI9809791B8 (enExample) |
| CA (1) | CA2288601C (enExample) |
| DE (1) | DE69825271T2 (enExample) |
| DK (1) | DK0983286T3 (enExample) |
| ES (1) | ES2224397T3 (enExample) |
| HU (1) | HU228667B1 (enExample) |
| ID (1) | ID22994A (enExample) |
| IL (2) | IL132739A0 (enExample) |
| NZ (1) | NZ500938A (enExample) |
| OA (1) | OA11214A (enExample) |
| PL (1) | PL188046B1 (enExample) |
| PT (1) | PT983286E (enExample) |
| WO (1) | WO1998050399A1 (enExample) |
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| JPS6344588A (ja) * | 1986-08-11 | 1988-02-25 | Toho Yakuhin Kogyo Kk | リピドａ単糖類縁体のレクタス型異性体 |
| JPS62129292A (ja) * | 1985-11-28 | 1987-06-11 | Toho Yakuhin Kogyo Kk | 生物活性を発現するリピドａ単糖類縁体 |
| JPS6330495A (ja) * | 1986-07-24 | 1988-02-09 | Toho Yakuhin Kogyo Kk | リピドａ単糖類縁体の立体異性体 |
| US4746742A (en) * | 1985-11-28 | 1988-05-24 | Toho Yakuhin Kogyo Kabushiki Kaisha | Analogs of nonreducing monosaccharide moiety of lipid A |
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