MA40920A - Vaccins de la main, du pied et de la bouche, et procédés de fabrication et d'utilisation de ceux-ci - Google Patents

Vaccins de la main, du pied et de la bouche, et procédés de fabrication et d'utilisation de ceux-ci

Info

Publication number
MA40920A
MA40920A MA040920A MA40920A MA40920A MA 40920 A MA40920 A MA 40920A MA 040920 A MA040920 A MA 040920A MA 40920 A MA40920 A MA 40920A MA 40920 A MA40920 A MA 40920A
Authority
MA
Morocco
Prior art keywords
vaccines
foot
mouth
manufacturing
methods
Prior art date
Application number
MA040920A
Other languages
English (en)
Inventor
Subash Chandra Das
Jorge E Osorio
Joseph David Santangelo
Dan Thomas Stinchcomb
Original Assignee
Takeda Vaccines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Vaccines Inc filed Critical Takeda Vaccines Inc
Publication of MA40920A publication Critical patent/MA40920A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/00051—Methods of production or purification of viral material
    • C12N2770/00052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32151—Methods of production or purification of viral material
    • C12N2770/32152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32171—Demonstrated in vivo effect
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32361—Methods of inactivation or attenuation
    • C12N2770/32363—Methods of inactivation or attenuation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32371—Demonstrated in vivo effect
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
MA040920A 2014-11-07 2015-11-05 Vaccins de la main, du pied et de la bouche, et procédés de fabrication et d'utilisation de ceux-ci MA40920A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462077139P 2014-11-07 2014-11-07

Publications (1)

Publication Number Publication Date
MA40920A true MA40920A (fr) 2017-09-12

Family

ID=55909911

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040920A MA40920A (fr) 2014-11-07 2015-11-05 Vaccins de la main, du pied et de la bouche, et procédés de fabrication et d'utilisation de ceux-ci

Country Status (14)

Country Link
US (1) US10806782B2 (fr)
EP (1) EP3215621A4 (fr)
JP (1) JP6839088B2 (fr)
KR (1) KR20170082584A (fr)
CN (1) CN107406856B (fr)
AR (1) AR102547A1 (fr)
AU (2) AU2015342829A1 (fr)
CA (1) CA2965994A1 (fr)
HK (1) HK1244508A1 (fr)
MA (1) MA40920A (fr)
SG (1) SG11201703711RA (fr)
TW (1) TWI737584B (fr)
UY (1) UY36395A (fr)
WO (1) WO2016073929A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR102547A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y su uso
AR102548A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y uso
CN106520789B (zh) * 2015-09-09 2019-05-10 中国人民解放军军事医学科学院微生物流行病研究所 一种dna分子与重组病毒及它们的制备方法和用途
CN106636001B (zh) * 2016-12-29 2020-07-31 汕头大学医学院 一种重组肠道病毒表型混合系统的构建方法和应用
SG11201913826QA (en) * 2017-07-03 2020-01-30 Bharat Biotech Int Ltd A synthetic polypeptide epitope based vaccine composition
US11730802B2 (en) 2017-11-03 2023-08-22 Takeda Vaccines, Inc. Zika vaccines and immunogenic compositions, and methods of using the same
EP3717511A4 (fr) * 2017-11-30 2021-09-15 Takeda Vaccines, Inc. Vaccins contre le virus zika, compositions immunogènes et leurs procédés d'utilisation
CN109182496A (zh) * 2018-09-20 2019-01-11 西安交通大学医学院第二附属医院 一种ev71感染和重症化风险检测试剂盒及其应用
SG11202106394PA (en) 2018-12-29 2021-07-29 Bharat Biotech Int Ltd Adaptation of enterovirus to vero cells and vaccine formulations thereof
CN110184242B (zh) * 2019-06-11 2021-08-20 武汉生物制品研究所有限责任公司 柯萨奇病毒a组6型(cva6)的小鼠强毒力攻毒株及其应用
US20240076631A2 (en) * 2020-02-27 2024-03-07 Takeda Vaccines, Inc. Method for removing host cell dna from virus preparation
WO2022070210A1 (fr) * 2020-09-29 2022-04-07 Bharat Biotech International Limited Formulations stables de vaccins contre des entérovirus à faible abondance et leur procédé de fabrication
CN114807060B (zh) * 2022-06-23 2022-09-30 北京民海生物科技有限公司 柯萨奇病毒a6型毒株及其免疫原性组合物和应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3238190A (en) 1963-10-23 1966-03-01 Madaus & Co K G Fa Dr Aescin recovery
FR2475572A1 (fr) 1980-02-11 1981-08-14 Pasteur Institut Procede pour l'obtention de fragments de virus a enveloppe lipidique, en particulier d'antigenes utilisables comme vaccins, produits obtenus et applications
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
CA1331443C (fr) 1987-05-29 1994-08-16 Charlotte A. Kensil Adjuvant a saponine
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US5278302A (en) 1988-05-26 1994-01-11 University Patents, Inc. Polynucleotide phosphorodithioates
DK0382271T3 (da) 1989-02-04 1995-05-01 Akzo Nobel Nv Tocoler som adjuvanser i vacciner
JPH0832638B2 (ja) 1989-05-25 1996-03-29 カイロン コーポレイション サブミクロン油滴乳剤を含んで成るアジュバント製剤
FR2649012B1 (fr) 1989-07-03 1991-10-25 Seppic Sa Emulsions multiphasiques injectables
FR2649013B1 (fr) 1989-07-03 1991-10-25 Seppic Sa Vaccins et vecteurs de principes actifs fluides contenant une huile metabolisable
EP0468520A3 (en) 1990-07-27 1992-07-01 Mitsui Toatsu Chemicals, Inc. Immunostimulatory remedies containing palindromic dna sequences
DE69405551T3 (de) 1993-03-23 2005-10-20 Smithkline Beecham Biologicals S.A. 3-0-deazylierte monophosphoryl lipid a enthaltende impfstoff-zusammensetzungen
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
WO1995026204A1 (fr) 1994-03-25 1995-10-05 Isis Pharmaceuticals, Inc. Stimulation immunitaire par des analogues d'oligonucleotides de phosphorothioate
CA2194761C (fr) 1994-07-15 2006-12-19 Arthur M. Krieg Oligonucleotides immunomodulateurs
US5666153A (en) 1995-10-03 1997-09-09 Virtual Shopping, Inc. Retractable teleconferencing apparatus
DE19612967A1 (de) 1996-04-01 1997-10-02 Behringwerke Ag Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren
DE19612966B4 (de) 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
US6230051B1 (en) 1996-06-18 2001-05-08 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US5856462A (en) 1996-09-10 1999-01-05 Hybridon Incorporated Oligonucleotides having modified CpG dinucleosides
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
CN1133472C (zh) 1996-12-20 2004-01-07 阿尔萨公司 增加经皮样剂流量的装置
US6113918A (en) 1997-05-08 2000-09-05 Ribi Immunochem Research, Inc. Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
US6355257B1 (en) 1997-05-08 2002-03-12 Corixa Corporation Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
US5993412A (en) 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
GB9711990D0 (en) 1997-06-11 1997-08-06 Smithkline Beecham Biolog Vaccine
GB9718901D0 (en) 1997-09-05 1997-11-12 Smithkline Beecham Biolog Vaccine
EP1009382B1 (fr) 1997-09-05 2003-06-18 GlaxoSmithKline Biologicals S.A. Emulsions huile-dans-l'eau contenant des saponines
JP2001519162A (ja) 1997-10-07 2001-10-23 ユニバーシティ・オブ・メリーランド・バイオテクノロジー・インスティチュート 動物細胞にｒｎａを導入して発現させる方法
CN1285753A (zh) 1997-12-02 2001-02-28 鲍德杰克特疫苗公司 透皮给药微粒疫苗组合物
GB9727262D0 (en) 1997-12-24 1998-02-25 Smithkline Beecham Biolog Vaccine
WO1999052549A1 (fr) 1998-04-09 1999-10-21 Smithkline Beecham Biologicals S.A. Compositions adjuvantes
JP4620251B2 (ja) 1998-08-10 2011-01-26 アンチジェニックス・インコーポレイテッド Ｃｐｇおよびサポニンアジュバントの組成物並びにその方法
HUP0104609A2 (hu) 1998-12-02 2002-03-28 University Of Maryland, Baltimore Plazmidfenntartó rendszer antigén-bejuttatásra
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
EP1103610A1 (fr) 1999-11-26 2001-05-30 Introgene B.V. Production de vaccins de lignées de cellules mammifère immortalisées
FR2810888B1 (fr) 2000-06-29 2004-07-30 Merial Sas Vaccin contre la fievre aphteuse
DE60142646D1 (en) 2000-11-22 2010-09-02 Univ Maryland Fusionprotein
KR100401423B1 (ko) * 2001-01-10 2003-10-17 주식회사 엘지생명과학 혼합 백신의 제조 방법
CA2890962A1 (fr) 2004-09-09 2006-03-16 Novartis Vaccines And Diagnostics Gmbh & Co. Kg Reduction de risques iatrogenes potentiels associes aux vaccins contre la grippe
CN101575593B (zh) 2009-06-03 2012-07-04 北京科兴生物制品有限公司 手足口病疫苗及其制备方法和应用
CN101897963B (zh) 2010-03-18 2012-07-25 北京绿竹生物技术有限责任公司 一种手足口病病毒疫苗
CN102220288B (zh) 2011-05-04 2013-07-17 中国科学院上海巴斯德研究所 一种肠道病毒ev71型鼠适应株573及其应用
US20150044257A1 (en) * 2012-03-23 2015-02-12 Fred Hutchinson Cancer Research Center Baculovirus-based enterovirus 71 vlp as a vaccine
CN103834618B (zh) 2012-11-28 2016-09-14 中国科学院上海巴斯德研究所 一种能有效感染小鼠的柯萨奇a16型病毒突变株
WO2014112945A1 (fr) 2013-01-18 2014-07-24 Temasek Life Sciences Laboratory Limited Souches d'entérovirus 71 sensibles à la température, adaptées au froid, et procédés de développement de souches virales sensibles à la température, adaptées au froid
KR102276405B1 (ko) 2013-03-15 2021-07-12 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 구제역 바이러스 (fmdv) 공통 단백질, 그에 대한 코딩 서열 및 그로부터 제조된 백신
AR102548A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y uso
AR102547A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y su uso

Also Published As

Publication number Publication date
EP3215621A4 (fr) 2018-06-27
AR102547A1 (es) 2017-03-08
CN107406856B (zh) 2022-02-11
JP6839088B2 (ja) 2021-03-03
UY36395A (es) 2016-06-30
EP3215621A1 (fr) 2017-09-13
SG11201703711RA (en) 2017-06-29
KR20170082584A (ko) 2017-07-14
TW201631159A (zh) 2016-09-01
CN107406856A (zh) 2017-11-28
AU2015342829A1 (en) 2017-05-25
HK1244508A1 (zh) 2018-08-10
CA2965994A1 (fr) 2016-05-12
WO2016073929A1 (fr) 2016-05-12
US10806782B2 (en) 2020-10-20
US20180125965A1 (en) 2018-05-10
TWI737584B (zh) 2021-09-01
JP2017535602A (ja) 2017-11-30
AU2022202779A1 (en) 2022-05-19

Similar Documents

Publication Publication Date Title
MA40920A (fr) Vaccins de la main, du pied et de la bouche, et procédés de fabrication et d'utilisation de ceux-ci
HK1243949A1 (zh) 包含大麻素的口腔護理組合物
IL260718B (en) Oral treatment compounds and methods of using the compounds
HUE050563T2 (hu) Endofiták, kapcsolódó kompozíciók, és eljárások az alkalmazásukra
IL251379A0 (en) Compositions for oral care containing zinc, arginine and serine
IL259239B (en) Oral care compounds and methods
DK3244920T3 (da) Mund- og klovsyge-vaccine
ZA201703470B (en) Oral care compositions having high water content and micro robustness
PL3157901T3 (pl) Preparaty, ich wytwarzanie i zastosowanie, oraz odpowiednie składniki
ZA201801015B (en) Oral care compositions and methods of using the compositions
ZA201902623B (en) Oral care composition
ZA201903378B (en) Oral care composition
ZA201902622B (en) Oral care composition
DK3253868T3 (da) Sammensætninger og fremgangsmåder, der omfatter anvendelsen af en bacillus agaradhaerens inulosucrase (inou)
IL258304A (en) Oral care compounds and methods for using the compounds
IL252447B (en) Compound for oral care
ES1127830Y (es) Cuna infantil
IL252994A0 (en) Compound for oral care
UA33980S (uk) Стілець дитячий
UA31200S (uk) Пляшка для ополіскувача роту «glister»
UA30547S (uk) Ходунки дитячі
TH1601003595A (th) องค์ประกอบดูแลช่องปาก
TH1601003347A (th) องค์ประกอบดูแลช่องปาก
UA30760S (uk) Стілець дитячий складаний
UA32540S (uk) Іграшковий набір «фрукти»