ATE360366T1 - Plasmidstabilisierungssystem für die verabreichung von antigenen - Google Patents
Plasmidstabilisierungssystem für die verabreichung von antigenenInfo
- Publication number
- ATE360366T1 ATE360366T1 AT99964042T AT99964042T ATE360366T1 AT E360366 T1 ATE360366 T1 AT E360366T1 AT 99964042 T AT99964042 T AT 99964042T AT 99964042 T AT99964042 T AT 99964042T AT E360366 T1 ATE360366 T1 AT E360366T1
- Authority
- AT
- Austria
- Prior art keywords
- plasmid
- expression plasmids
- maintenance system
- maintenance
- stabilization system
- Prior art date
Links
- 239000013612 plasmid Substances 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 230000006641 stabilisation Effects 0.000 title abstract 2
- 238000011105 stabilization Methods 0.000 title abstract 2
- 239000013613 expression plasmid Substances 0.000 abstract 3
- 230000027086 plasmid maintenance Effects 0.000 abstract 3
- 238000012423 maintenance Methods 0.000 abstract 2
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 231100000518 lethal Toxicity 0.000 abstract 1
- 230000001665 lethal effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000005192 partition Methods 0.000 abstract 1
- 238000005204 segregation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0283—Shigella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/25—Shigella (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/255—Salmonella (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/204,117 US6413768B1 (en) | 1998-12-02 | 1998-12-02 | Expression plasmids |
| US15873899P | 1999-10-12 | 1999-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE360366T1 true ATE360366T1 (de) | 2007-05-15 |
Family
ID=26855335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99964042T ATE360366T1 (de) | 1998-12-02 | 1999-12-02 | Plasmidstabilisierungssystem für die verabreichung von antigenen |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US6703233B1 (de) |
| EP (1) | EP1135025B1 (de) |
| JP (1) | JP2003506007A (de) |
| AT (1) | ATE360366T1 (de) |
| AU (1) | AU776562B2 (de) |
| CA (1) | CA2352457A1 (de) |
| CZ (1) | CZ20011538A3 (de) |
| DE (1) | DE69935927T2 (de) |
| DK (1) | DK1135025T3 (de) |
| ES (1) | ES2286905T3 (de) |
| HU (1) | HUP0104609A2 (de) |
| NO (1) | NO20012721L (de) |
| NZ (2) | NZ511449A (de) |
| PL (1) | PL349041A1 (de) |
| WO (1) | WO2000032047A1 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU776562B2 (en) * | 1998-12-02 | 2004-09-16 | University Of Maryland At Baltimore | Plasmid maintenance system for antigen delivery |
| US8076130B2 (en) * | 1998-12-02 | 2011-12-13 | University Of Maryland, Baltimore | Plasmid maintenance system for antigen delivery |
| US7081244B2 (en) * | 1999-02-22 | 2006-07-25 | Health Protection Agency | Neisserial vaccine compositions and methods |
| ES2298128T3 (es) * | 1999-02-22 | 2008-05-16 | Health Protection Agency | Composiciones de vacuna neisseriana y metodos. |
| EP1210445B1 (de) * | 1999-09-10 | 2007-03-07 | The Secretary of State for Defence | Rekombinante mikroorganismen |
| GB0024203D0 (en) * | 2000-10-03 | 2000-11-15 | Peptide Therapeutics Ltd | Stabilisation of plasmid inheritance in bacteria |
| EP1917975A1 (de) | 2001-11-30 | 2008-05-07 | University of Maryland, Baltimore | Neuartige Proteine in Enteroaggregativen Escherichia Coli (EAEC) zur Diagnose und Therapie von EAEC-Infektionen |
| GB0325494D0 (en) * | 2003-10-31 | 2003-12-03 | Sbl Vaccin Ab | Expression system |
| GB0327056D0 (en) * | 2003-11-20 | 2003-12-24 | Cobra Biolog Ltd | Plasmid maintenance |
| CA2549263A1 (en) * | 2003-12-12 | 2005-08-11 | Conjugon, Inc. | Systems for tightly regulated gene expression |
| US8137930B2 (en) | 2005-10-28 | 2012-03-20 | University Of Maryland, Baltimore | Attenuated Salmonella enterica serovar paratyphi A and uses thereof |
| EP1941024B1 (de) * | 2005-10-28 | 2013-07-31 | University of Maryland, Baltimore | Gedämpfte enterische salmonellen-paratyphi a und verwendungen davon |
| US20080124355A1 (en) * | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| WO2009011940A2 (en) * | 2007-04-06 | 2009-01-22 | University Of Maryland, Baltimore | Microcin h47 plasmid selection system |
| US20100317084A1 (en) * | 2007-05-10 | 2010-12-16 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacteria comprising vectors for expression of nucleic acid sequences encoding antigens |
| WO2009025888A2 (en) | 2007-05-10 | 2009-02-26 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Regulated synthesis of antigen and/or regulated attentuation to enhance vaccine immunogenics and/or safety |
| JP2010533000A (ja) * | 2007-07-12 | 2010-10-21 | ユニヴァーシティ オブ メディシン アンド デンティストリ オブ ニュージャーシィ | 抗毒素不安定化技術 |
| WO2009046449A1 (en) * | 2007-10-05 | 2009-04-09 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting an immune response against enteric pathogens |
| JP5210675B2 (ja) * | 2008-03-19 | 2013-06-12 | 株式会社東芝 | 不揮発性半導体記憶装置及びその製造方法 |
| ES2473605T3 (es) | 2008-06-03 | 2014-07-07 | University Of Maryland, Baltimore | ClyA no hemol�tica para la excreci�n de proteínas |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| WO2010045620A1 (en) | 2008-10-17 | 2010-04-22 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae |
| US9163219B2 (en) * | 2009-04-14 | 2015-10-20 | Arizona Board Of Regents On Behalf Of Arizona State University | Single expression vector for generation of a virus with a segmented genome |
| WO2010135563A1 (en) | 2009-05-22 | 2010-11-25 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium and methods of antigen and nucleic acid delivery |
| US9045742B2 (en) * | 2009-05-29 | 2015-06-02 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant Edwardsiella bacterium |
| WO2011060431A2 (en) | 2009-11-16 | 2011-05-19 | University Of Maryland Baltimore | Multivalent live vector vaccine against clostridium difficile-associated disease |
| US9062297B2 (en) | 2010-01-13 | 2015-06-23 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Yersinia pestis vaccine |
| EP2526185A4 (de) | 2010-01-22 | 2013-07-24 | Univ Arizona | Bakterium mit einer regulierten rfah-nukleinsäure |
| US9598697B2 (en) | 2010-05-28 | 2017-03-21 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium to decrease tumor growth |
| WO2012069551A1 (en) | 2010-11-23 | 2012-05-31 | Oslo Universitetssykehus Hf | Dinq-srna type i toxin-antitoxin system for plasmid maintenance |
| US9198950B2 (en) | 2010-11-24 | 2015-12-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Recombinant bacterium comprising a toxin/antitoxin system |
| US9303264B2 (en) | 2012-05-18 | 2016-04-05 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Photosynthetic microorganisms expressing thermostable lipase |
| WO2014062580A1 (en) | 2012-10-15 | 2014-04-24 | University Of Maryland, Baltimore | Bacterial live vector vaccines expressing chromosomally-integrated foreign antigens |
| US9580718B2 (en) | 2013-06-17 | 2017-02-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Attenuated live bacteria with increased acid resistance and methods of use thereof |
| WO2015118146A1 (en) | 2014-02-10 | 2015-08-13 | Univercells Nv | System, apparatus and method for biomolecules production |
| AR102547A1 (es) | 2014-11-07 | 2017-03-08 | Takeda Vaccines Inc | Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y su uso |
| AU2015252119A1 (en) | 2014-11-07 | 2016-05-26 | Takeda Vaccines, Inc. | Hand, foot, and mouth vaccines and methods of manufacture and use thereof |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| CA3081581A1 (en) | 2017-11-03 | 2019-05-09 | Takeda Vaccines, Inc. | Method for inactivating zika virus and for determining the completeness of inactivation |
| CN109321591B (zh) * | 2018-10-22 | 2021-07-13 | 上海海洋大学 | 一种重组质粒及其构建方法 |
| JP2023516420A (ja) * | 2020-03-05 | 2023-04-19 | ユニヴァーシティー オブ メリーランド バルチモア | がんタンパク質抗原を発現するように操作された生チフス菌ベクターおよびその使用方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4735801A (en) | 1982-09-07 | 1988-04-05 | Board Of Trustees Of Leland Stanford Jr. University | Novel non-reverting salmonella live vaccines |
| US5643771A (en) | 1980-05-19 | 1997-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Non-reverting live bacterial vaccines |
| DK410783D0 (da) * | 1982-09-16 | 1983-09-09 | Benzon A Salfred | Fremgangsmade til stabilisering af plasmider |
| US4764370A (en) * | 1984-09-12 | 1988-08-16 | Scripps Clinic And Research Foundation | Vaccine utilizing an avirulent strain of Salmonella typhimurium |
| DK275685D0 (da) | 1985-06-18 | 1985-06-18 | Benzon As Alfred | Stabilisering af biologiske systemer |
| AU7232087A (en) | 1986-03-26 | 1987-10-20 | Genexpress Aps | Biological containment |
| ATE121785T1 (de) | 1987-10-07 | 1995-05-15 | Univ Washington | Verfahren zur erhaltung eines erwünschten rekombinanten gens in einer genetischen zellpopulation. |
| US5811105A (en) | 1987-12-23 | 1998-09-22 | Glaxo Wellcome, Inc. | Vaccines containing bacteria attenuated by mutations in two genes of the aromatic amino acid biosynthetic pathway |
| GB8912330D0 (en) * | 1989-05-30 | 1989-07-12 | Wellcome Found | Live vaccines |
| GB9007194D0 (en) | 1990-03-30 | 1990-05-30 | Wellcome Found | Live vaccines |
| US5695983A (en) | 1990-12-18 | 1997-12-09 | The General Hospital Corporation | Salmonella vaccines |
| US5459072A (en) | 1992-02-25 | 1995-10-17 | Regents Of The University Of Minnesota | Food-grade integration vectors for industrial bacterial strains |
| WO1994012629A1 (en) | 1992-12-02 | 1994-06-09 | Baylor College Of Medicine | Episomal vectors for gene therapy |
| US5763270A (en) | 1995-06-07 | 1998-06-09 | Genemedicine, Inc. | Plasmid for delivery of nucleic acids to cells and methods of use |
| US5824538A (en) * | 1995-09-06 | 1998-10-20 | The United States Of America As Represented By The Secretary Of The Army | Shigella vector for delivering DNA to a mammalian cell |
| US5922583A (en) | 1995-10-17 | 1999-07-13 | Biostar Inc. | Methods for production of recombinant plasmids |
| GB9621091D0 (en) * | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| AU776562B2 (en) * | 1998-12-02 | 2004-09-16 | University Of Maryland At Baltimore | Plasmid maintenance system for antigen delivery |
-
1999
- 1999-12-02 AU AU20364/00A patent/AU776562B2/en not_active Ceased
- 1999-12-02 DK DK99964042T patent/DK1135025T3/da active
- 1999-12-02 US US09/453,313 patent/US6703233B1/en not_active Expired - Fee Related
- 1999-12-02 EP EP99964042A patent/EP1135025B1/de not_active Expired - Lifetime
- 1999-12-02 PL PL99349041A patent/PL349041A1/xx not_active Application Discontinuation
- 1999-12-02 WO PCT/US1999/028499 patent/WO2000032047A1/en not_active Ceased
- 1999-12-02 JP JP2000584755A patent/JP2003506007A/ja not_active Withdrawn
- 1999-12-02 NZ NZ511449A patent/NZ511449A/en active IP Right Revival
- 1999-12-02 ES ES99964042T patent/ES2286905T3/es not_active Expired - Lifetime
- 1999-12-02 HU HU0104609A patent/HUP0104609A2/hu unknown
- 1999-12-02 CA CA002352457A patent/CA2352457A1/en not_active Abandoned
- 1999-12-02 CZ CZ20011538A patent/CZ20011538A3/cs unknown
- 1999-12-02 DE DE69935927T patent/DE69935927T2/de not_active Expired - Fee Related
- 1999-12-02 NZ NZ529507A patent/NZ529507A/en unknown
- 1999-12-02 AT AT99964042T patent/ATE360366T1/de not_active IP Right Cessation
-
2001
- 2001-06-01 NO NO20012721A patent/NO20012721L/no not_active Application Discontinuation
-
2004
- 2004-01-05 US US10/750,976 patent/US6977176B2/en not_active Expired - Fee Related
- 2004-01-05 US US10/750,965 patent/US6969513B2/en not_active Expired - Fee Related
-
2005
- 2005-09-19 US US11/229,069 patent/US7141408B2/en not_active Expired - Lifetime
- 2005-09-19 US US11/229,306 patent/US7138112B2/en not_active Expired - Lifetime
- 2005-09-19 US US11/229,073 patent/US7125720B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6969513B2 (en) | 2005-11-29 |
| WO2000032047A9 (en) | 2001-04-19 |
| ES2286905T3 (es) | 2007-12-01 |
| HUP0104609A2 (hu) | 2002-03-28 |
| AU776562B2 (en) | 2004-09-16 |
| US6977176B2 (en) | 2005-12-20 |
| CA2352457A1 (en) | 2000-06-08 |
| PL349041A1 (en) | 2002-07-01 |
| US7141408B2 (en) | 2006-11-28 |
| EP1135025A4 (de) | 2004-11-17 |
| NO20012721L (no) | 2001-07-31 |
| US7125720B2 (en) | 2006-10-24 |
| DK1135025T3 (da) | 2007-08-13 |
| EP1135025B1 (de) | 2007-04-25 |
| US7138112B2 (en) | 2006-11-21 |
| DE69935927D1 (de) | 2007-06-06 |
| US20050003539A1 (en) | 2005-01-06 |
| NO20012721D0 (no) | 2001-06-01 |
| DE69935927T2 (de) | 2008-01-10 |
| EP1135025A1 (de) | 2001-09-26 |
| US20060029616A1 (en) | 2006-02-09 |
| NZ511449A (en) | 2004-05-28 |
| WO2000032047A1 (en) | 2000-06-08 |
| US20060030048A1 (en) | 2006-02-09 |
| CZ20011538A3 (cs) | 2001-11-14 |
| US20060030047A1 (en) | 2006-02-09 |
| NZ529507A (en) | 2005-05-27 |
| JP2003506007A (ja) | 2003-02-18 |
| US20040161420A1 (en) | 2004-08-19 |
| AU2036400A (en) | 2000-06-19 |
| US6703233B1 (en) | 2004-03-09 |
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