CA3010977A1 - Novel cross protective vaccine compositions for porcine epidemic diarrhea virus - Google Patents

Novel cross protective vaccine compositions for porcine epidemic diarrhea virus Download PDF

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Publication number
CA3010977A1
CA3010977A1 CA3010977A CA3010977A CA3010977A1 CA 3010977 A1 CA3010977 A1 CA 3010977A1 CA 3010977 A CA3010977 A CA 3010977A CA 3010977 A CA3010977 A CA 3010977A CA 3010977 A1 CA3010977 A1 CA 3010977A1
Authority
CA
Canada
Prior art keywords
vaccine compositions
epidemic diarrhea
porcine epidemic
diarrhea virus
cross protective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3010977A
Other languages
French (fr)
Inventor
Marta Cabana Sumsi
Monica Balasch Sanuy
Laia Plaja Dilme
Alicia Urniza Hostench
Paul J. Dominowski
Jay Gregory Calvert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zoetis Services LLC
Original Assignee
Zoetis Services LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Services LLC filed Critical Zoetis Services LLC
Publication of CA3010977A1 publication Critical patent/CA3010977A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20061—Methods of inactivation or attenuation
    • C12N2770/20064—Methods of inactivation or attenuation by serial passage

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention is directed to novel isolates of porcine epidemic diarrhea virus (PEDV) and vaccine compositions made therefrom. The vaccine compositions protect swine from PED disease, and are cross protective against a wide variety of strains, whether variant or prototype, that currently circulate throughout the world. The vaccines are provided in both killed and live virus forms, as derived from strain Calaf14, and suggest specific amino acid modifications to the encoding sequences of all other PEDV strains that may improve their performance as vaccines.. Novel culture methods are also employed to increase reproducible yield of cultured viruses.
CA3010977A 2016-01-11 2016-01-11 Novel cross protective vaccine compositions for porcine epidemic diarrhea virus Abandoned CA3010977A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2016/012899 WO2017123201A1 (en) 2016-01-11 2016-01-11 Novel cross protective vaccine compositions for porcine epidemic diarrhea virus

Publications (1)

Publication Number Publication Date
CA3010977A1 true CA3010977A1 (en) 2017-07-20

Family

ID=55358111

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3010977A Abandoned CA3010977A1 (en) 2016-01-11 2016-01-11 Novel cross protective vaccine compositions for porcine epidemic diarrhea virus

Country Status (3)

Country Link
EP (1) EP3402878A1 (en)
CA (1) CA3010977A1 (en)
WO (1) WO2017123201A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108060139B (en) * 2017-08-31 2021-07-20 浙江美保龙生物技术有限公司 Isolation culture method of porcine epidemic diarrhea virus
CN107446894A (en) * 2017-09-15 2017-12-08 天津瑞普生物技术股份有限公司 A kind of Porcine epidemic diarrhea virus preparation method
KR20210062015A (en) * 2018-09-20 2021-05-28 베링거잉겔하임베트메디카게엠베하 Modified PEDV Spike Protein
CN110894216B (en) * 2019-11-21 2022-03-08 河北农业大学 Porcine epidemic diarrhea virus epitope peptide, monoclonal antibody and application
CN114438040A (en) * 2020-11-04 2022-05-06 中山大学 Monoclonal cell strain secreting antibody with PEDV (porcine epidemic diarrhea Virus) neutralizing activity and application thereof
CN115074334B (en) * 2021-03-15 2024-01-19 夏津新希望六和农牧有限公司 Porcine epidemic diarrhea virus strain, amplification culture method, vaccine composition prepared from porcine epidemic diarrhea virus strain, preparation method and application of porcine epidemic diarrhea virus strain and amplification culture method
CN114931648B (en) * 2022-06-15 2024-02-27 金宇保灵生物药品有限公司 Heat-resistant protective agent for combined live vaccine against porcine epidemic diarrhea and transmissible gastroenteritis, and preparation method and application thereof
CN117286162B (en) * 2023-04-14 2024-08-23 扬州大学 Recombinant porcine delta coronavirus infectious clone and construction method and application thereof

Family Cites Families (22)

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US5078996A (en) 1985-08-16 1992-01-07 Immunex Corporation Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor
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US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
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IL101715A (en) 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs
WO1993013302A1 (en) 1991-12-23 1993-07-08 Michael Zoche Engine with oil separator
US5571515A (en) 1994-04-18 1996-11-05 The Wistar Institute Of Anatomy & Biology Compositions and methods for use of IL-12 as an adjuvant
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
GB9518220D0 (en) 1995-09-06 1995-11-08 Medical Res Council Checkpoint gene
AU729579B2 (en) 1996-10-23 2001-02-01 Trustees Of The University Of Pennsylvania, The Immunotherapy and improved vaccines
US6113918A (en) 1997-05-08 2000-09-05 Ribi Immunochem Research, Inc. Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
MXPA00008352A (en) 1998-02-27 2002-10-17 Univ Pennsylvania Vaccines, immunotherapeutics and methods for using the same.
AU770333B2 (en) 1998-09-30 2004-02-19 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Mutant cholera holotoxin as an adjuvant
AU769539B2 (en) 1999-01-29 2004-01-29 Zoetis Services Llc Adjuvants for use in vaccines
JP2004535187A (en) 2001-06-07 2004-11-25 ワイス・ホールデイングス・コーポレーシヨン Mutant forms of cholera holotoxin as adjuvants
KR100877258B1 (en) 2001-06-07 2009-01-12 와이어쓰 홀딩스 코포레이션 Mutant forms of cholera holotoxin as an adjuvant
PL216541B1 (en) 2002-08-26 2014-04-30 Pfizer Prod Inc Vaccine for respiratory and reproductive system infections in cattle
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HUE028921T2 (en) 2008-06-27 2017-01-30 Zoetis Services Llc Novel adjuvant compositions
CN104152578B (en) * 2013-06-03 2016-03-30 中国农业科学院上海兽医研究所 Porcine epidemic diarrhea virus RT-PCR differential diagnosis kit and application thereof
EP3046580A2 (en) 2013-09-19 2016-07-27 Zoetis Services LLC Oil-based adjuvants
RS62414B1 (en) * 2014-07-11 2021-10-29 Zoetis Services Llc Novel vaccine compositions for porcine epidemic diarrhea virus

Also Published As

Publication number Publication date
WO2017123201A1 (en) 2017-07-20
EP3402878A1 (en) 2018-11-21

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EEER Examination request

Effective date: 20180710

FZDE Dead

Effective date: 20201112