JP6831777B2 - Cd33キメラ抗原受容体を使用する癌の処置 - Google Patents
Cd33キメラ抗原受容体を使用する癌の処置 Download PDFInfo
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- JP6831777B2 JP6831777B2 JP2017503497A JP2017503497A JP6831777B2 JP 6831777 B2 JP6831777 B2 JP 6831777B2 JP 2017503497 A JP2017503497 A JP 2017503497A JP 2017503497 A JP2017503497 A JP 2017503497A JP 6831777 B2 JP6831777 B2 JP 6831777B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Cell Biology (AREA)
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- Molecular Biology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2014/082589 | 2014-07-21 | ||
| CN2014082589 | 2014-07-21 | ||
| CN2014090504 | 2014-11-06 | ||
| CNPCT/CN2014/090504 | 2014-11-06 | ||
| PCT/US2015/041390 WO2016014576A1 (en) | 2014-07-21 | 2015-07-21 | Treatment of cancer using a cd33 chimeric antigen receptor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021012629A Division JP2021087430A (ja) | 2014-07-21 | 2021-01-29 | Cd33キメラ抗原受容体を使用する癌の処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017522880A JP2017522880A (ja) | 2017-08-17 |
| JP2017522880A5 JP2017522880A5 (enExample) | 2018-08-30 |
| JP6831777B2 true JP6831777B2 (ja) | 2021-02-17 |
Family
ID=53765585
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017503497A Active JP6831777B2 (ja) | 2014-07-21 | 2015-07-21 | Cd33キメラ抗原受容体を使用する癌の処置 |
| JP2021012629A Pending JP2021087430A (ja) | 2014-07-21 | 2021-01-29 | Cd33キメラ抗原受容体を使用する癌の処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021012629A Pending JP2021087430A (ja) | 2014-07-21 | 2021-01-29 | Cd33キメラ抗原受容体を使用する癌の処置 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US9777061B2 (enExample) |
| EP (2) | EP3172234B1 (enExample) |
| JP (2) | JP6831777B2 (enExample) |
| KR (1) | KR102594343B1 (enExample) |
| CN (2) | CN107109419B (enExample) |
| AU (2) | AU2015292755B2 (enExample) |
| BR (1) | BR112017001242A2 (enExample) |
| CA (1) | CA2955154C (enExample) |
| CO (1) | CO2017000510A2 (enExample) |
| ES (1) | ES2805475T3 (enExample) |
| IL (1) | IL250138B (enExample) |
| MX (1) | MX390943B (enExample) |
| RU (1) | RU2747384C2 (enExample) |
| SG (2) | SG11201700416TA (enExample) |
| TW (1) | TWI719942B (enExample) |
| WO (1) | WO2016014576A1 (enExample) |
| ZA (1) | ZA201700157B (enExample) |
Families Citing this family (204)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104136458A (zh) | 2012-02-22 | 2014-11-05 | 宾夕法尼亚大学董事会 | 在第二代嵌合抗原受体中cd2信号传导结构域的使用 |
| ES2949648T3 (es) | 2012-12-20 | 2023-10-02 | Purdue Research Foundation | Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer |
| US9573988B2 (en) | 2013-02-20 | 2017-02-21 | Novartis Ag | Effective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells |
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