JP6809681B2 - ２−ヒドロキシ−６−（（２−（１−イソプロピル−１ｈ−ピラゾール−５−イル）ピリジン−３−イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形 - Google Patents

２−ヒドロキシ−６−（（２−（１−イソプロピル−１ｈ−ピラゾール−５−イル）ピリジン−３−イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形 Download PDF

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JP6809681B2
JP6809681B2 JP2016568465A JP2016568465A JP6809681B2 JP 6809681 B2 JP6809681 B2 JP 6809681B2 JP 2016568465 A JP2016568465 A JP 2016568465A JP 2016568465 A JP2016568465 A JP 2016568465A JP 6809681 B2 JP6809681 B2 JP 6809681B2
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free base
compound
crystalline
xrpd
solvate
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JP2017505347A5 (OSRAM
JP2017505347A (ja
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リ，チェ
ペアレント，ステファン，ディー
ヒューストン，トラビス
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グローバル ブラッド セラピューティクス インコーポレイテッド
グローバル ブラッド セラピューティクス インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2016568465A 2014-02-07 2015-02-05 ２−ヒドロキシ−６−（（２−（１−イソプロピル−１ｈ−ピラゾール−５−イル）ピリジン−３−イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形 Active JP6809681B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461937404P 2014-02-07 2014-02-07
US201461937393P 2014-02-07 2014-02-07
US61/937,393 2014-02-07
US61/937,404 2014-02-07
PCT/US2015/014589 WO2015120133A1 (en) 2014-02-07 2015-02-05 Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde

Related Child Applications (1)

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JP2019100577A Division JP2019137699A (ja) 2014-02-07 2019-05-29 ２−ヒドロキシ−６−（（２−（１−イソプロピル−１ｈ−ピラゾール−５−イル）ピリジン−３−イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形

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JP2017505347A JP2017505347A (ja) 2017-02-16
JP2017505347A5 JP2017505347A5 (OSRAM) 2018-03-15
JP6809681B2 true JP6809681B2 (ja) 2021-01-06

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JP2016568465A Active JP6809681B2 (ja) 2014-02-07 2015-02-05 ２−ヒドロキシ−６−（（２−（１−イソプロピル−１ｈ−ピラゾール−５−イル）ピリジン−３−イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形
JP2019100577A Pending JP2019137699A (ja) 2014-02-07 2019-05-29 ２−ヒドロキシ−６−（（２−（１−イソプロピル−１ｈ−ピラゾール−５−イル）ピリジン−３−イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形
JP2021078276A Pending JP2021113225A (ja) 2014-02-07 2021-05-06 ２−ヒドロキシ−６−（（２−（１−イソプロピル−１ｈ−ピラゾール−５−イル）ピリジン−３−イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形
JP2022195902A Active JP7444957B2 (ja) 2014-02-07 2022-12-07 ２－ヒドロキシ－６－（（２－（１－イソプロピル－１ｈ－ピラゾール－５－イル）ピリジン－３－イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形

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JP2019100577A Pending JP2019137699A (ja) 2014-02-07 2019-05-29 ２−ヒドロキシ−６−（（２−（１−イソプロピル−１ｈ−ピラゾール−５−イル）ピリジン−３−イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形
JP2021078276A Pending JP2021113225A (ja) 2014-02-07 2021-05-06 ２−ヒドロキシ−６−（（２−（１−イソプロピル−１ｈ−ピラゾール−５−イル）ピリジン−３−イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形
JP2022195902A Active JP7444957B2 (ja) 2014-02-07 2022-12-07 ２－ヒドロキシ－６－（（２－（１－イソプロピル－１ｈ－ピラゾール－５－イル）ピリジン－３－イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形

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US (7) US9447071B2 (OSRAM)
EP (2) EP3102208B2 (OSRAM)
JP (4) JP6809681B2 (OSRAM)
KR (2) KR102345380B1 (OSRAM)
CN (4) CN105431147A (OSRAM)
AP (1) AP2016009261A0 (OSRAM)
AU (3) AU2015214182B2 (OSRAM)
BR (1) BR112015032160B1 (OSRAM)
CA (1) CA2916564C (OSRAM)
CY (1) CY1124097T1 (OSRAM)
DK (1) DK3102208T4 (OSRAM)
EA (1) EA028529B1 (OSRAM)
ES (1) ES2860648T5 (OSRAM)
FI (1) FI3102208T4 (OSRAM)
HR (1) HRP20210388T4 (OSRAM)
HU (1) HUE053706T2 (OSRAM)
IL (2) IL243214B (OSRAM)
LT (1) LT3102208T (OSRAM)
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MY (1) MY189995A (OSRAM)
PE (2) PE20201444A1 (OSRAM)
PL (1) PL3102208T5 (OSRAM)
PT (1) PT3102208T (OSRAM)
RS (1) RS61653B2 (OSRAM)
SA (1) SA516370358B1 (OSRAM)
SG (4) SG10201911662YA (OSRAM)
SI (1) SI3102208T2 (OSRAM)
SM (1) SMT202100160T1 (OSRAM)
TW (4) TWI755952B (OSRAM)
WO (1) WO2015120133A1 (OSRAM)
ZA (1) ZA202401707B (OSRAM)

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