JP5933544B2 - 外界温度で出荷および貯蔵中の血中ｄｎａ、ｒｎａおよびタンパク質ならびに他の生体試料を安定化させるための組成物 - Google Patents

外界温度で出荷および貯蔵中の血中ｄｎａ、ｒｎａおよびタンパク質ならびに他の生体試料を安定化させるための組成物 Download PDF

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JP5933544B2
JP5933544B2 JP2013521912A JP2013521912A JP5933544B2 JP 5933544 B2 JP5933544 B2 JP 5933544B2 JP 2013521912 A JP2013521912 A JP 2013521912A JP 2013521912 A JP2013521912 A JP 2013521912A JP 5933544 B2 JP5933544 B2 JP 5933544B2
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acid
sample
blood
composition
stored
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ウイットニー，スコット，イー．
ウイルキンソン，スティーブン
ムラー，ロルフ
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バイオマトリカ， インコーポレーテッド
バイオマトリカ， インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013521912A 2010-07-26 2011-07-26 外界温度で出荷および貯蔵中の血中ｄｎａ、ｒｎａおよびタンパク質ならびに他の生体試料を安定化させるための組成物 Active JP5933544B2 (ja)

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Application Number Priority Date Filing Date Title
US36778610P 2010-07-26 2010-07-26
US61/367,786 2010-07-26
PCT/US2011/045404 WO2012018638A2 (en) 2010-07-26 2011-07-26 Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures

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JP2013537628A JP2013537628A (ja) 2013-10-03
JP2013537628A5 JP2013537628A5 (https=) 2014-09-11
JP5933544B2 true JP5933544B2 (ja) 2016-06-08

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US (2) US9376709B2 (https=)
EP (1) EP2598660B1 (https=)
JP (1) JP5933544B2 (https=)
CA (1) CA2806670A1 (https=)
WO (1) WO2012018638A2 (https=)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080176209A1 (en) * 2004-04-08 2008-07-24 Biomatrica, Inc. Integration of sample storage and sample management for life science
US20060099567A1 (en) * 2004-04-08 2006-05-11 Biomatrica, Inc. Integration of sample storage and sample management for life science
CA2560513A1 (en) * 2004-04-08 2005-12-01 Biomatrica, Inc. Integration of sample storage and sample management for life science
US9683256B2 (en) * 2007-10-01 2017-06-20 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system
US8583380B2 (en) 2008-09-05 2013-11-12 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
WO2011034864A1 (en) * 2009-09-16 2011-03-24 Life Technologies Corporation Lysis buffers for extracting nucleic acids
CA2806670A1 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
US9845489B2 (en) 2010-07-26 2017-12-19 Biomatrica, Inc. Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
RU2565550C2 (ru) 2010-09-24 2015-10-20 Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити Прямой захват, амплификация и секвенирование днк-мишени с использованием иммобилизированных праймеров
CN106442039B (zh) 2011-06-19 2020-08-07 阿博根公司 用于样品采集的装置、溶液和方法
AP2014007466A0 (en) * 2011-08-04 2014-02-28 Univ California Salvia collection, processing, stabilization, and storage method
US9808798B2 (en) 2012-04-20 2017-11-07 California Institute Of Technology Fluidic devices for biospecimen preservation
EP2839260B1 (en) 2012-04-20 2018-07-18 Talis Biomedical Corporation Fluidic devices and systems for sample preparation or autonomous analysis
US9044738B2 (en) 2012-04-30 2015-06-02 General Electric Company Methods and compositions for extraction and storage of nucleic acids
US9040679B2 (en) 2012-04-30 2015-05-26 General Electric Company Methods and compositions for extraction and storage of nucleic acids
US9480966B2 (en) 2012-04-30 2016-11-01 General Electric Company Substrates and methods for collection, stabilization and elution of biomolecules
US9040675B2 (en) 2012-04-30 2015-05-26 General Electric Company Formulations for nucleic acid stabilization on solid substrates
US20150224144A1 (en) * 2012-08-31 2015-08-13 The Uab Research Foundation Anti-complement therapy compositions and methods for preserving stored blood
ES2692726T3 (es) * 2012-12-20 2018-12-04 General Electric Company Formulaciones para la estabilización de ácidos nucleicos en sustratos sólidos
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
CN105491883B (zh) * 2013-06-13 2018-11-02 生物马特里卡公司 细胞稳定化
WO2015022410A1 (en) * 2013-08-16 2015-02-19 General Electric Company Methods and compositions for extraction and storage of nucleic acids
CA2941764C (en) 2014-03-07 2023-10-24 Dna Genotek Inc. Composition and method for stabilizing nucleic acids in biological samples
JP6478775B2 (ja) * 2014-05-15 2019-03-06 キヤノン株式会社 アミン化合物及びイオン導電剤、導電性樹脂組成物
ES2812201T3 (es) 2014-06-10 2021-03-16 Biomatrica Inc Estabilización de células metabólicamente activas en una muestra de sangre a temperaturas ambiente
CN106572650B (zh) 2014-06-10 2021-08-31 生物马特里卡公司 在环境温度下稳定凝血细胞
JP6669672B2 (ja) 2014-06-10 2020-03-18 バイオマトリカ，インク． 周囲温度における血液サンプル中の変性されていないポリペプチド、核酸、およびエキソソームの安定化
WO2016011798A1 (zh) * 2015-01-27 2016-01-28 深圳华大基因研究院 用于保存生物样品的稳定剂
WO2016144891A1 (en) 2015-03-06 2016-09-15 Bio-Rad Laboratories, Inc. Stabilized rna solutions
CN108473932B (zh) 2015-09-09 2022-07-15 集联健康有限公司 用于样品收集、稳定化和保存的系统、方法和装置
US10905113B2 (en) 2015-11-12 2021-02-02 Regents Of The University Of Minnesota Compositions and method for storing liquid biospecimens
CN108603225A (zh) * 2015-12-08 2018-09-28 生物马特里卡公司 Pcr试剂的稳定化及测定
SG11201804776SA (en) 2015-12-08 2018-07-30 Biomatrica Inc Reduction of erythrocyte sedimentation rate
WO2018081161A1 (en) * 2016-10-24 2018-05-03 Biomatrica, Inc. Stabilization of nucleic acids on paper
EP3551212A4 (en) 2016-11-22 2020-11-04 Klotho Therapeutics, Inc. NEW RECOMBINATED KLOTHO PROTEINS AND COMPOSITIONS AND METHODS INCLUDING THEM
JP6355149B1 (ja) * 2016-12-19 2018-07-11 株式会社ユカシカド 尿検査装置および尿検査方法
US10793901B2 (en) 2016-12-28 2020-10-06 Roche Molecular Systems, Inc. Reversibly protected nucleotide reagents with high thermal stability
TWI882519B (zh) 2017-01-10 2025-05-01 美商集聯健康有限公司 用於收集和儲存來自受試者之血液的裝置
FI3568475T3 (fi) 2017-01-16 2023-05-15 Spectrum Solutions L L C Nukleiinihapon säilytysliuos ja käyttömenetelmiä
JP7233669B2 (ja) * 2017-05-22 2023-03-07 国立大学法人金沢大学 双性イオンを含む難溶性物質溶解剤
CA3101100A1 (en) * 2017-12-06 2019-06-13 Klotho Therapeutics, Inc. Products and methods for assessing and increasing klotho protein levels
US10046322B1 (en) 2018-03-22 2018-08-14 Talis Biomedical Corporation Reaction well for assay device
JP6854553B2 (ja) * 2018-08-17 2021-04-07 国立大学法人大阪大学 粒子の分配方法
CN109321523A (zh) * 2018-10-16 2019-02-12 厦门艾德生物医药科技股份有限公司 一种血液添加剂
US11968975B2 (en) 2019-04-30 2024-04-30 Regents Of The University Of Minnesota Compositions and methods for storing liquid biospecimens
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
CN110760567A (zh) * 2019-11-12 2020-02-07 杭州昱鼎生物科技有限公司 尿液样本rna稳定液及制备方法
CN112176029B (zh) * 2020-06-12 2021-05-14 中山大学达安基因股份有限公司 一种拭子核酸样本释放剂及其应用
CN111690640B (zh) * 2020-06-22 2023-10-03 广州东盛生物科技有限公司 一种高度兼容磁珠法病毒核酸提取试剂盒的病毒保存液
CN111778242A (zh) * 2020-07-23 2020-10-16 德州学院 一种口腔液病毒dna保护剂及其制备方法与应用
WO2022150283A1 (en) * 2021-01-05 2022-07-14 Nuclease Probe Technologies, Inc. Sars-cov-2 detection
WO2022187115A1 (en) * 2021-03-02 2022-09-09 Idexx Laboratories, Inc. Biochemical probes attached to epoxy-based resins
JP2024514211A (ja) * 2021-04-16 2024-03-28 グリフォルス ダイアグノステック ソリューションズ インコーポレーテッド 生物学的サンプルを保管するための組成物及び方法
US20230235275A1 (en) * 2022-01-25 2023-07-27 Delta Electronics Int'l (Singapore) Pte Ltd Transport medium for microorganism
JP7671943B1 (ja) * 2024-06-19 2025-05-07 株式会社メタジェン 情報処理システム、情報処理方法、および物品

Family Cites Families (361)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3673158A (en) 1970-08-14 1972-06-27 Celanese Corp Sulfobetaine glycol modified poly(ethylene terephthalate)
US3700555A (en) * 1970-10-12 1972-10-24 Technicon Instr Method and apparatus for lymphocyte separation from blood
IT983328B (it) 1973-06-12 1974-10-31 Gasbarro L Attrezzatura per analisi biologi che ad esempio sul siero di sangue ed altro con contenitori e mezzi di prelevamento di campioni multi pli atti ad assicurare uniformita di prelevamenti
US4024548A (en) 1976-06-07 1977-05-17 International Business Machines Corporation Liquid absorbing assembly with two porosities
US4040785A (en) 1976-10-18 1977-08-09 Technicon Instruments Corporation Lysable blood preservative composition
US4185964A (en) 1977-02-08 1980-01-29 Central Laboratories of Associated Maryland Pathologists, Ltd. Lysing reagent
US4127502A (en) 1977-06-10 1978-11-28 Eastman Kodak Company Stabilizers for reconstituted, lyophilized samples
US4257958A (en) 1979-05-25 1981-03-24 Texaco Inc. Stabilized acid anhydrides
US4264560A (en) 1979-12-26 1981-04-28 Samuel Natelson Clinical analytical system
US4342740A (en) 1980-08-18 1982-08-03 E. R. Squibb & Sons, Inc. Method and kit for labeling red blood cells with technetium-99m
US4473552A (en) 1981-03-16 1984-09-25 Jost Leonora I Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells
JPS589688A (ja) 1981-07-06 1983-01-20 Toyobo Co Ltd 安定な酵素組成物
JPS58189558A (ja) 1982-04-28 1983-11-05 Mochida Pharmaceut Co Ltd 免疫学的測定用容器
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
JPH0687062B2 (ja) 1985-05-10 1994-11-02 株式会社京都医科学研究所 血液中の解糖阻止方法
GB8514288D0 (en) 1985-06-06 1985-07-10 Amersham Int Plc Enzyme assay of body fluids
ATE68524T1 (de) 1985-07-09 1991-11-15 Quadrant Bioresources Ltd Beschuetzung von proteinen und aehnlichem.
WO1987001206A1 (en) 1985-08-21 1987-02-26 William Rudolph Hargreaves Methods and devices for separating, mixing, and detecting components in specific binding assays
US5684045A (en) 1985-09-12 1997-11-04 Brigham And Women's Hospital Method of treating pancreatic atrophy
US5039704A (en) 1985-09-12 1991-08-13 Brigham And Women's Hospital Method of treating catabolic dysfunction
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
CA1339653C (en) 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US4806343A (en) 1986-03-13 1989-02-21 University Of Southwestern Louisiana Cryogenic protectant for proteins
US4898813A (en) 1986-04-04 1990-02-06 Albarella James P Catalytic test composition intended to produce a range of colors
WO1992006200A1 (en) 1990-09-28 1992-04-16 F. Hoffmann-La-Roche Ag 5' to 3' exonuclease mutations of thermostable dna polymerases
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US5079352A (en) 1986-08-22 1992-01-07 Cetus Corporation Purified thermostable enzyme
US6127155A (en) 1986-08-22 2000-10-03 Roche Molecular Systems, Inc. Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents
US5374553A (en) 1986-08-22 1994-12-20 Hoffmann-La Roche Inc. DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima
US4962022A (en) 1986-09-22 1990-10-09 Becton Dickinson And Company Storage and use of liposomes
US4801428A (en) 1986-10-27 1989-01-31 Becton, Dickinson And Company Blood sample sedimentation test kit
GR871619B (en) 1986-10-31 1988-03-03 Genetic Systems Corp Automated patient sample analysis instrument
US4842758A (en) 1986-10-31 1989-06-27 Colgate-Palmolive Company Stabilized enzyme system for use in aqueous liquid built detergent compositions
GB8715238D0 (en) 1987-06-29 1987-08-05 Quadrant Bioresources Ltd Food process
US5315505A (en) 1987-08-12 1994-05-24 Micro Chemical, Inc. Method and system for providing animal health histories and tracking inventory of drugs
GB8816443D0 (en) 1988-07-11 1988-08-17 Albright & Wilson Liquid enzymatic detergents
US5089407A (en) 1987-12-11 1992-02-18 Monsanto Company Encapsulation of biological material in non-ionic polymer beads
IL88923A (en) 1988-01-12 1995-07-31 Hoffmann La Roche Gene encoding a thermostable dna polymerase from thermus aquaticus said dna polymerase and its purification
GB8801338D0 (en) 1988-01-21 1988-02-17 Quadrant Bioresources Ltd Preservation of viruses
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5498523A (en) 1988-07-12 1996-03-12 President And Fellows Of Harvard College DNA sequencing with pyrophosphatase
US4962020A (en) 1988-07-12 1990-10-09 President And Fellows Of Harvard College DNA sequencing
US5078997A (en) 1988-07-13 1992-01-07 Cetus Corporation Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers
DE3826055A1 (de) 1988-07-30 1990-02-01 Boehringer Mannheim Gmbh Mit reagenz abloesbar impraegnierte traegermatrix
US5985327A (en) 1988-10-05 1999-11-16 Flinders Technologies Pty. Ltd. Solid medium and method for DNA storage
US6627226B2 (en) 1988-10-05 2003-09-30 Whatman, Inc. Dry solid medium for storage and analysis of genetic material
US5756126A (en) 1991-05-29 1998-05-26 Flinders Technologies Pty. Ltd. Dry solid medium for storage and analysis of genetic material
US20040014068A1 (en) 1988-10-05 2004-01-22 Whatman, Inc. Solid medium and method for DNA storage
US5496562A (en) 1988-10-05 1996-03-05 Flinders Technologies Pty Ltd Solid medium and method for DNA storage
US6447804B1 (en) 1988-10-05 2002-09-10 Whatman, Plc Dry solid medium for storage and analysis of genetic material
GB8826429D0 (en) 1988-11-11 1988-12-14 Univ Leeds Ind Service Ltd Enzyme stabilisation systems
USRE38385E1 (en) 1989-02-16 2004-01-13 Nektar Therapeutics Storage of materials
GB8903593D0 (en) 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
US4978688A (en) 1989-03-24 1990-12-18 Louderback Allan Lee Method of treating white blood cells
US5071648A (en) 1989-04-06 1991-12-10 Merocel Corporation Polymeric broad-spectrum antimicrobial materials
JP3031923B2 (ja) 1989-07-07 2000-04-10 フロイント産業株式会社 造粒コーティング装置およびそれを用いた造粒コーティング方法
US5047342A (en) 1989-08-10 1991-09-10 Life Technologies, Inc. Cloning and expression of T5 DNA polymerase
US5270179A (en) 1989-08-10 1993-12-14 Life Technologies, Inc. Cloning and expression of T5 DNA polymerase reduced in 3'- to-5' exonuclease activity
IE64738B1 (en) 1990-03-20 1995-09-06 Akzo Nv Stabilized gonadotropin containing preparations
GB9006642D0 (en) 1990-03-24 1990-05-23 Gibson Timothy D Enzyme stabilisation
NZ237570A (en) 1990-04-13 1993-09-27 Colgate Palmolive Co Enzyme stabilising composition and stabilised enzyme-containing built detergent compositions
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5200399A (en) 1990-09-14 1993-04-06 Boyce Thompson Institute For Plant Research, Inc. Method of protecting biological materials from destructive reactions in the dry state
DE553264T1 (de) 1990-10-05 1994-04-28 Wayne M Barnes Thermostabile dna polymerase.
WO1992009300A1 (en) 1990-11-21 1992-06-11 Iterex Pharmaceuticals Ltd. Partnership Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures
IL100626A0 (en) 1991-01-11 1992-09-06 Cryopharm Corp A method of forming dry cells,diagnostic panels containing the same and diagnostic methods utilizing the same
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5242792A (en) 1991-02-25 1993-09-07 The United States Of America As Represented By The Secretary Of The Navy Method for the preservation of red blood cells by lyophilization using glycerol or inositol with disaccharides
AU659645B2 (en) 1991-06-26 1995-05-25 Inhale Therapeutic Systems Storage of materials
EP0525723B1 (en) 1991-07-29 1997-05-14 Mochida Pharmaceutical Co., Ltd. Process and device for specific binding assay
IL100810A (en) 1992-01-30 1996-12-05 Yeda Res & Dev Pharmaceutical preparations including 2 - methyl - carboxy - 5 - hydroxy - tetrahydropyrimidine and / or 2 - methyl - 4 - carboxy - tetrahydropyrimidine, plywood methods
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
DE4244580A1 (de) 1992-12-31 1994-07-07 Galinski Erwin A Verfahren zur in vivo Gewinnung von Inhaltsstoffen aus Zellen
WO1994018156A1 (en) 1993-02-01 1994-08-18 University Of Iowa Research Foundation Quartenary amine surfactants and methods of using same in isolation of rna
US5436149A (en) 1993-02-19 1995-07-25 Barnes; Wayne M. Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
CA2159649A1 (en) 1993-03-29 1994-10-13 Queen's University At Kingston Anticoagulant compounds
DE4311252A1 (de) 1993-04-06 1994-10-13 Boehringer Mannheim Gmbh Bestimmung eines Analyten in einer Probeflüssigkeit
US5351801A (en) 1993-06-07 1994-10-04 Board Of Regents - Univ. Of Nebraska Automated laboratory conveyor system
US5541290A (en) 1993-06-24 1996-07-30 Harbeson; Scott L. Optically pure calpain inhibitor compounds
DE59405534D1 (de) 1993-07-02 1998-04-30 Inst Molekulare Biolog E V Probenträger und seine verwendung
US5840677A (en) 1993-07-09 1998-11-24 Novo Nordisk A/S Boronic acid or borinic acid derivatives as enzyme stabilizers
DE4326342A1 (de) 1993-08-05 1995-02-09 Boehringer Mannheim Gmbh Verfahren zur Analyse von Probenflüssigkeiten
US5837546A (en) 1993-08-24 1998-11-17 Metrika, Inc. Electronic assay device and method
GB9320782D0 (en) 1993-10-08 1993-12-01 Univ Leeds Innovations Ltd Stabilising of proteins on solution
DE4336266A1 (de) 1993-10-23 1995-04-27 Boehringer Mannheim Gmbh Stabilisierte flüssige Mischungen für die Markierung von Nukleinsäuren
GB9325189D0 (en) 1993-12-08 1994-02-09 Unilever Plc Methods and apparatus for electrochemical measurements
US5695928A (en) 1993-12-10 1997-12-09 Novartis Corporation Rapid immunoassay for detection of antibodies or antigens incorporating simultaneous sample extraction and immunogenic reaction
US5512462A (en) 1994-02-25 1996-04-30 Hoffmann-La Roche Inc. Methods and reagents for the polymerase chain reaction amplification of long DNA sequences
US5428063A (en) 1994-04-11 1995-06-27 Board Of Regents Of The University Of Nebraska Use of betaine as a hepatic generator of S-adenosylmethionine and as a protective agent against hepatotoxicity
US5955448A (en) 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US5418141A (en) 1994-05-06 1995-05-23 Avocet Medical, Inc. Test articles for performing dry reagent prothrombin time assays
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US5593824A (en) 1994-09-02 1997-01-14 Pharmacia Biotech, Inc. Biological reagent spheres
US5777303A (en) 1994-09-09 1998-07-07 Gay Freres, Vente Et Exportation S.A. Device for associating test tube samples with electronic labels for storage of identifying data
US5705366A (en) 1994-09-15 1998-01-06 Johnson & Johnson Clinical Diagnostics, Inc. Coamplification of target nucleic acids using volume exclusion agent in reaction composition, test kit and test device useful therefor
US6015668A (en) 1994-09-30 2000-01-18 Life Technologies, Inc. Cloned DNA polymerases from thermotoga and mutants thereof
US5912155A (en) 1994-09-30 1999-06-15 Life Technologies, Inc. Cloned DNA polymerases from Thermotoga neapolitana
DE9416270U1 (de) 1994-10-10 1994-12-08 Grieb, Reinhard, 63633 Birstein Laborprobenbehälter
US5614365A (en) 1994-10-17 1997-03-25 President & Fellow Of Harvard College DNA polymerase having modified nucleotide binding site for DNA sequencing
US5556771A (en) 1995-02-10 1996-09-17 Gen-Probe Incorporated Stabilized compositions of reverse transcriptase and RNA polymerase for nucleic acid amplification
US5777099A (en) 1995-02-24 1998-07-07 Biotecx Laboratories, Inc. RNA separation
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
WO1996036436A1 (en) 1995-04-25 1996-11-21 Irori Remotely programmable matrices with memories and uses thereof
US6284459B1 (en) 1995-04-25 2001-09-04 Discovery Partners International Solid support matrices with memories and combinatorial libraries therefrom
US5741462A (en) 1995-04-25 1998-04-21 Irori Remotely programmable matrices with memories
US6352854B1 (en) 1995-04-25 2002-03-05 Discovery Partners International, Inc. Remotely programmable matrices with memories
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6025129A (en) 1995-04-25 2000-02-15 Irori Remotely programmable matrices with memories and uses thereof
GB9508691D0 (en) 1995-04-28 1995-06-14 Pafra Ltd Stable compositions
US5827874A (en) 1995-05-05 1998-10-27 Meyer; Hans Methods of treating pain and inflammation with proline
US6964771B1 (en) 1995-06-07 2005-11-15 Elan Drug Delivery Limited Method for stably incorporating substances within dry, foamed glass matrices
SE9502244D0 (sv) 1995-06-20 1995-06-20 Bioglan Ab A composition and a process for the preparation thereof
EP0755654B1 (en) 1995-07-21 2000-03-22 Becton, Dickinson and Company A test tube for determining the erythrocyte sedimentation rate and a surfactant for use therein
US5945515A (en) 1995-07-31 1999-08-31 Chomczynski; Piotr Product and process for isolating DNA, RNA and proteins
EP0871775A4 (en) 1995-09-08 2002-07-31 Life Technologies Inc CLONED DNA POLYMERASES FROM THERMOTOGA AND MUTANTS THEREOF
US5888822A (en) 1995-10-04 1999-03-30 Hycor Biomedical Inc. Erythrocyte sedimentation rate control
ATE272058T1 (de) 1995-10-17 2004-08-15 Combichem Inc Matrize für die synthese kombinatorischer bibliotheken in lösung
GB9521775D0 (en) 1995-10-24 1996-01-03 Pa Consulting Services Microwell plates
DE19539574A1 (de) 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
JP3647000B2 (ja) 1995-10-27 2005-05-11 アークレイ株式会社 液体試料分析用具及び分析方法
US6057117A (en) 1996-04-04 2000-05-02 Chiron Corporation Identification and use of selective inhibitors of glycogen synthase kinase 3
US5928916A (en) 1996-04-25 1999-07-27 Medtronic, Inc. Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces
TW518219B (en) 1996-04-26 2003-01-21 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
US5914272A (en) 1996-06-19 1999-06-22 Becton Dickinson And Company Test method for determining the erythrocyte sedimentation rate and a surfactant for use therein
US5876992A (en) 1996-07-03 1999-03-02 Molecular Biology Resources, Inc. Method and formulation for stabilization of enzymes
US5800784A (en) 1996-07-09 1998-09-01 Horn; Marcus J. Chemical sample treatment system and cassette, and methods for effecting multistep treatment process
US20020039771A1 (en) 1996-07-16 2002-04-04 Lars-Erik Peters Method for producing complex multienzymatical, storage resistant reaction mixtures and use thereof
US6013488A (en) 1996-07-25 2000-01-11 The Institute Of Physical And Chemical Research Method for reverse transcription
US6458556B1 (en) 1996-07-25 2002-10-01 The Institute Of Physical & Chemical Research Method for enhancing enzyme activity at elevated temperature
JP2000516468A (ja) 1996-08-14 2000-12-12 ライフ テクノロジーズ，インコーポレイテッド 核酸増幅および配列決定のための安定な組成物
US5798035A (en) 1996-10-03 1998-08-25 Pharmacopeia, Inc. High throughput solid phase chemical synthesis utilizing thin cylindrical reaction vessels useable for biological assay
EP1011862A4 (en) 1996-10-10 2000-06-28 Corning Inc TOOL FOR TRANSPORTING LIQUID DROPS AND METHOD FOR TRANSFERRING SUCH DROPS USING THE SAME
AU4920397A (en) 1996-10-11 1998-05-11 Chiron Corporation Purine inhibitors of glycogen synthase kinase 3 (gsk3)
US5861251A (en) 1996-10-15 1999-01-19 Bioneer Corporation Lyophilized reagent for polymerase chain reaction
US6054325A (en) 1996-12-02 2000-04-25 Glaxo Wellcom Inc. Method and apparatus for transferring and combining distinct chemical compositions with reagents
US20020182258A1 (en) 1997-01-22 2002-12-05 Zycos Inc., A Delaware Corporation Microparticles for delivery of nucleic acid
US5856102A (en) 1997-02-26 1999-01-05 Bierke-Nelson; Diane Lynn Home/self-storage to improve DNA banking
JPH10248828A (ja) 1997-03-10 1998-09-22 Nissho Corp 溶血管
EP0973875B1 (en) 1997-03-12 2006-06-14 Novozymes A/S Storage-stable liquid formulation comprising a laccase
US5939259A (en) 1997-04-09 1999-08-17 Schleicher & Schuell, Inc. Methods and devices for collecting and storing clinical samples for genetic analysis
NL1005914C2 (nl) 1997-04-28 1998-10-29 Sgt Exploitatie Bv Inrichting voor het opslaan en/of behandelen van chemicaliën.
US5985214A (en) 1997-05-16 1999-11-16 Aurora Biosciences Corporation Systems and methods for rapidly identifying useful chemicals in liquid samples
US6099832A (en) 1997-05-28 2000-08-08 Genzyme Corporation Transplants for myocardial scars
EP0884352B1 (en) 1997-06-11 2001-09-05 Kuraray Co., Ltd. Water-soluble film
US5991729A (en) 1997-06-28 1999-11-23 Barry; James T. Methods for generating patient-specific medical reports
US6821963B2 (en) 1997-07-01 2004-11-23 Warner-Lambert Company 4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
US6310060B1 (en) 1998-06-24 2001-10-30 Warner-Lambert Company 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
WO1999014321A1 (en) 1997-09-17 1999-03-25 The Walter And Eliza Hall Institute Of Medical Research Novel therapeutic molecules
US6057159A (en) 1997-12-12 2000-05-02 Vertex Pharmaceuticals Incorporated Processes for identifying a solvent condition suitable for determining a biophysical property of a protein
US6197229B1 (en) 1997-12-12 2001-03-06 Massachusetts Institute Of Technology Method for high supercoiled DNA content microspheres
US6037168A (en) 1997-12-31 2000-03-14 Cytonix Corporation Microbiological assembly comprising resealable closure means
IL123256A0 (en) 1998-02-10 1998-09-24 Yeda Res & Dev Methods for dna amplification and sequencing
US6787305B1 (en) 1998-03-13 2004-09-07 Invitrogen Corporation Compositions and methods for enhanced synthesis of nucleic acid molecules
EP1555033A3 (en) 1998-03-13 2005-08-17 Wyeth Polynucleotide composition, method of preparation, and use thereof
US6410044B1 (en) 1998-03-19 2002-06-25 Surmodics, Inc. Crosslinkable macromers
US6007833A (en) 1998-03-19 1999-12-28 Surmodics, Inc. Crosslinkable macromers bearing initiator groups
US20040228794A1 (en) 1998-04-10 2004-11-18 Battelle Memorial Institute Therapeutic agent carrier compositions
US6139878A (en) 1998-04-27 2000-10-31 Aventis Behring, Llc Method for preparing a diafiltered stabilized blood product
EP1100888A2 (en) 1998-05-26 2001-05-23 University Of Medicine And Dentistry Of New Jersey System for reproducing and modulating stability and turnover of rna molecules
JP2002516254A (ja) 1998-05-26 2002-06-04 ライフセル コーポレイション ヒト赤血球の低温保存
EP0969090A1 (en) * 1998-05-27 2000-01-05 QIAGEN GmbH Rapid and simple process for isolation of circular nucleic acids
KR100581199B1 (ko) 1998-06-19 2006-05-17 카이론 코포레이션 글리코겐 신타제 키나제 3의 억제제
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US20020055118A1 (en) 1998-06-24 2002-05-09 Yong-Bin Eym Method of preparing objects containing DNA
US6242235B1 (en) 1998-06-24 2001-06-05 Promega Corp. Polymerase stabilization by polyethoxylated amine surfactants
US6750059B1 (en) 1998-07-16 2004-06-15 Whatman, Inc. Archiving of vectors
US6204375B1 (en) 1998-07-31 2001-03-20 Ambion, Inc. Methods and reagents for preserving RNA in cell and tissue samples
DE19834816A1 (de) 1998-08-01 2000-02-03 Merck Patent Gmbh Verwendung von Ectoin oder Ectoin-Derivaten in kosmetischen Formulierungen
US6447726B1 (en) 1998-08-10 2002-09-10 Uab Research Foundation High density protein crystal growth
DE19836559A1 (de) 1998-08-12 2000-03-23 Antigen Gmbh Gefäß zur Entnahme von Blut
WO2000009086A2 (en) 1998-08-14 2000-02-24 Valentis, Inc. Protected one-vial formulation for nucleic acid molecules, methods of making the same by in-line mixing, and related products and methods
US20010039010A1 (en) 1998-09-03 2001-11-08 Leigh Alexander Burgoyne Sample collection medium incorporating material for sample visualization
US6610531B1 (en) 1998-09-24 2003-08-26 The United States Of America As Represented By The Secretary Of The Navy Viable dried bacteria produced by drying in the presence of trehalose and divalent cation
GB9821573D0 (en) 1998-10-02 1998-11-25 Central Research Lab Ltd Method and apparatus for removing a substance from a container
US6143817A (en) 1998-10-07 2000-11-07 National Starch & Chemical Co. Use of derivatives of polyamino acids as emulsifiers stabilizers in aqueous free radical emulsion polymerization
US6746841B1 (en) 1999-04-14 2004-06-08 Whatman Inc. FTA- coated media for use as a molecular diagnostic tool
US7001770B1 (en) 1998-10-15 2006-02-21 Canji, Inc. Calpain inhibitors and their applications
US6251599B1 (en) 1998-11-06 2001-06-26 Selective Genetics, Inc. Stabilized nucleic acid compositions and methods of preparation and use thereof
US6153412A (en) 1998-12-07 2000-11-28 Bioneer Corporation Lyophilized reagent for polymerase chain reaction
FR2787042B1 (fr) 1998-12-09 2001-03-09 Central Labo Europ Systeme d'analyse biologique comprenant un moyen de controle de l'appariement entre un equipement d'analyse biologique et un recipient complementaire.
CA2349832A1 (en) 1999-01-13 2000-07-20 Warner-Lambert Company Benzenesulfonamide derivatives and their use as mek inhibitors
EP1033566B1 (de) 1999-03-04 2005-08-24 F. KURT RETSCH GmbH & Co. KG Verfahren und Vorrichtung zum Aufschluss von biologischem Material
AU6048199A (en) 1999-03-11 2000-09-28 Whatman, Inc. Solid medium and process for the storage and rapid purification of nucleic acid
EP1177420B1 (en) 1999-04-14 2007-08-15 Whatman, Inc. Fta-coated media for use as a molecular diagnostic tool
US6124089A (en) 1999-04-30 2000-09-26 Streck Laboratories, Inc. Blood control and system for erythrocyte sedimentation measurement
US6664099B1 (en) 1999-05-04 2003-12-16 Anhydro Limited Method for the preservation of viruses and mycoplasma
GB9910580D0 (en) 1999-05-08 1999-07-07 Zeneca Ltd Chemical compounds
ES2163356B1 (es) 1999-06-16 2003-04-16 Univ Granada Equipo autonomo para recogida, almacenamiento y envio de muestras bio logicas humanas, animales y vegetales.
US6323039B1 (en) 1999-06-22 2001-11-27 Mitokor Compositions and methods for assaying subcellular conditions and processes using energy transfer
US6942964B1 (en) 1999-07-09 2005-09-13 Sigma-Aldrich Co. Tracer reagents that enhance reaction-product analysis
AU781570B2 (en) 1999-07-23 2005-06-02 Gen-Probe Incorporated Polynucleotide amplification method
JP2001050872A (ja) 1999-08-12 2001-02-23 Arkray Inc 検体保持用具およびそれを用いた検体回収方法
DE19953475A1 (de) 1999-11-05 2001-05-10 Alfa Laval Lkm As Kolding Montagewerkzeug
IL149778A0 (en) 1999-11-22 2002-11-10 Universal Preservation Technologies Inc Preservation of sensitive biological material
US6649406B1 (en) 1999-11-23 2003-11-18 3M Innovative Properties Company Device for propagation and storage of microorganisms
CN100335479C (zh) 1999-12-17 2007-09-05 希龙公司 糖元合成酶激酶3的双环抑制剂
EP1237880B1 (en) 1999-12-17 2008-01-23 Novartis Vaccines and Diagnostics, Inc. Pyrazine based inhibitors of glycogen synthase kinase 3
US6294999B1 (en) 1999-12-29 2001-09-25 Becton, Dickinson And Company Systems and methods for monitoring patient compliance with medication regimens
CN1302006A (zh) 1999-12-29 2001-07-04 仁宝电脑工业股份有限公司 便携式电脑用的磁控式启闭装置
US20070048726A1 (en) 2000-01-14 2007-03-01 Biolife Solutions, Inc. Methods and Compositions for the Control of Molecular-Based Cell Death During Preservation of Cells, Tissues or Organs in a Gel-Like State
US6746851B1 (en) 2000-01-14 2004-06-08 Lab Vision Corporation Method for automated staining of specimen slides
DE10006662A1 (de) 2000-02-15 2001-08-23 Antigen Produktions Gmbh Gefäß zur Nukleinsäureanalytik
WO2001061015A2 (en) 2000-02-17 2001-08-23 Qiagen Gmbh Thermostable chimeric nucleic acid polymerases and uses thereof
EP1339702A1 (en) 2000-03-15 2003-09-03 Warner-Lambert Company 5-amide substituted diarylamines as mek inhibitors
US20050196824A1 (en) 2000-03-15 2005-09-08 Fisher Mark T. Chaperonin and osmolyte protein folding and related screening methods
JP3668091B2 (ja) * 2000-03-15 2005-07-06 独立行政法人食品総合研究所 人工シャペロン用キット
AU2001259817A1 (en) 2000-05-04 2001-11-12 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health Methods of and compounds for inhibiting calpains
US20040142475A1 (en) 2000-06-02 2004-07-22 Barman Shikha P. Delivery systems for bioactive agents
GB0013619D0 (en) 2000-06-06 2000-07-26 Glaxo Group Ltd Sample container
US6608632B2 (en) 2000-06-12 2003-08-19 Sharp Laboratories Of America, Inc. Methods and systems for improving display resolution in images using sub-pixel sampling and visual error filtering
DE10031236A1 (de) 2000-06-27 2002-01-10 Qiagen Gmbh Verwendung von Carbonsäuren und anderen Additiven in Kombination mit kationischen Verbindungen zur Stabilisierung von Nukleinsäuren in biologischen Materialien
US6689353B1 (en) 2000-06-28 2004-02-10 Bayer Pharmaceuticals Corporation Stabilized interleukin 2
US6617123B1 (en) 2000-06-29 2003-09-09 Jack V. Smith Method for detection of 4-hydroxybutyric acid and its precursor(s) in fluids
US6653062B1 (en) 2000-07-26 2003-11-25 Wisconsin Alumni Research Foundation Preservation and storage medium for biological materials
ES2295191T3 (es) 2000-07-27 2008-04-16 Novartis Vaccines And Diagnostics, Inc. Polipeptidos de gsk3.
ATE344834T1 (de) 2000-08-25 2006-11-15 Riken Methode zur herstellung von genormten und/oder subtrahierten cdna
US7144729B2 (en) 2000-09-01 2006-12-05 Dfb Pharmaceuticals, Inc. Methods and compositions for tissue regeneration
DE10043456A1 (de) 2000-09-04 2002-03-14 Merck Patent Gmbh Verwendung von Ectoin oder Ectoin-Derivaten zur Stabilisierung von p53
US6858634B2 (en) 2000-09-15 2005-02-22 Monsanto Technology Llc Controlled release formulations and methods for their production and use
US6716629B2 (en) 2000-10-10 2004-04-06 Biotrove, Inc. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
US20020081565A1 (en) 2000-10-30 2002-06-27 Sigma-Aldrich Co. Process for producing freeze dried competent cells and use thereof in cloning
ATE384954T1 (de) 2000-11-08 2008-02-15 Becton Dickinson Co Verfahren und vorrichtung zum sammeln und zum stabilisieren einer biologischen probe
US6602718B1 (en) 2000-11-08 2003-08-05 Becton, Dickinson And Company Method and device for collecting and stabilizing a biological sample
US6535129B1 (en) 2000-11-17 2003-03-18 Moore North America, Inc. Chain of custody business form with automated wireless data logging feature
US6872357B1 (en) 2000-11-22 2005-03-29 Quadrant Drug Delivery Limited Formulation of preservation mixtures containing sensitive biologicals to be stabilized for ambient temperature storage by drying
US7129242B2 (en) 2000-12-06 2006-10-31 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto
US6803200B2 (en) 2000-12-12 2004-10-12 Invitrogen Corporation Compositions and methods for the release of nucleic acid molecules from solid matrices
US20020076819A1 (en) 2000-12-14 2002-06-20 Bowman Danny Charles Paperless chain of custody evidence for lab samples
US20040110267A1 (en) 2000-12-15 2004-06-10 Stratagene Room temperature stable competent cells
AU2002248192A1 (en) 2000-12-15 2002-08-12 Stratagene Room temperature stable competent cells
US6475716B1 (en) 2001-03-06 2002-11-05 Biobank Co., Ltd. Method for preserving mammalian organs
ES2180416B1 (es) 2001-03-12 2004-06-01 BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES, S.A. Procedimiento para la preparacion de mezclas de reaccion estabilizadas, total o parcialmente desecadas, que comprenden, al menos, una enzima, mezclas de reaccion y kits que las contienen.
US6528309B2 (en) 2001-03-19 2003-03-04 The Regents Of The University Of California Vacuum-mediated desiccation protection of cells
EP1373257B9 (en) 2001-03-29 2008-10-15 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
DE10117275B4 (de) 2001-04-06 2005-02-24 Hte Ag The High Throughput Experimentation Company Vorrichtung zur Archivierung und Analyse von Materialien
US6950757B2 (en) * 2001-04-11 2005-09-27 Emerald Biostructures, Inc. Screening methods for identifying ligands
US6821479B1 (en) 2001-06-12 2004-11-23 The University Of Akron Preservation of biological materials using fiber-forming techniques
US20030032203A1 (en) 2001-07-10 2003-02-13 Sabatini David M. Small molecule microarrays
RU2206575C2 (ru) 2001-07-25 2003-06-20 Институт молекулярной биологии им. В.А. Энгельгардта РАН Композиция для иммобилизации биологических макромолекул в гидрогелях, способ приготовления композиции, биочип, способ проведения пцр на биочипе
WO2003020924A2 (en) 2001-09-05 2003-03-13 Whatman Plc Stable storage of proteins
EP1428008B1 (en) 2001-09-06 2012-01-18 Core Dynamics Limited Improved method for freezing viable cells
US7101693B2 (en) 2001-09-07 2006-09-05 Brigham Young University Plasticized hydrophilic glasses for improved stabilization of biological agents
US20030091971A1 (en) 2001-09-14 2003-05-15 Invitrogen Corporation Composition for stabilizing biological materials
US20040058349A1 (en) 2001-10-01 2004-03-25 Jeffrey Van Ness Methods for identifying nucleotides at defined positions in target nucleic acids
US7148343B2 (en) * 2001-10-12 2006-12-12 Gentra Systems, Inc. Compositions and methods for using a solid support to purify RNA
US6896894B2 (en) 2001-10-30 2005-05-24 Battelle Memorial Institute Proteins stabilized with polysaccharide gums
AU2002340776A1 (en) 2001-10-30 2003-05-12 Novozymes A/S High throughput isolation of proteins by charge induction chromatography
AU2002353997A1 (en) 2001-11-01 2003-05-12 Rensselaer Polytechnic Institute In vitro metabolic engineering on microscale devices
US7142987B2 (en) 2001-11-07 2006-11-28 Genvault Corporation Apparatus, system, and method of archival and retrieval of samples
US20030129755A1 (en) 2001-11-07 2003-07-10 Genvault Corporation System and method of storing and retrieving storage elements
TWI229696B (en) 2001-11-09 2005-03-21 Yeastern Biotech Co Ltd A fast method of transforming competent cells
WO2003041667A2 (en) 2001-11-13 2003-05-22 The Procter & Gamble Company Compositions containing enzymes stabilized with certain osmo-protectants and methods for using such compositions in personal care
MXPA04004479A (es) 2001-11-13 2004-08-11 Procter & Gamble Composiciones topicas que contienen enzimas estabilizadas con inhibidores.
CA2467563A1 (en) 2001-11-20 2003-05-30 Genentech, Inc. Cell and tissue arrays and microarrays and methods of use
US20030163608A1 (en) 2002-02-21 2003-08-28 Ashutosh Tiwary Instrumentation and workload recording for a system for performance testing of N-tiered computer systems using recording and playback of workloads
CA2484052C (en) 2002-04-11 2011-06-14 Medimmune Vaccines, Inc. Preservation of bioactive materials by spray drying
US20030215369A1 (en) 2002-05-17 2003-11-20 Eggers Mitchell D. Sample carrier receiver
GB0218800D0 (en) 2002-08-13 2002-09-18 Celltech R&D Ltd Chemical compounds
EP2395073B1 (en) 2002-11-01 2017-09-06 GlaxoSmithKline Biologicals S.A. Drying process
US7718442B2 (en) 2002-11-22 2010-05-18 Genvault Corporation Sealed sample storage element system and method
EP1608952B1 (en) 2002-12-20 2016-08-10 Life Technologies Corporation Assay apparatus and method using microfluidic arrays
US20050112610A1 (en) 2003-04-16 2005-05-26 Applied Dna Sciences, Inc. System and method for marking textiles with nucleic acids
US20050026181A1 (en) 2003-04-29 2005-02-03 Genvault Corporation Bio bar-code
EP1641804A1 (en) 2003-06-20 2006-04-05 Celltech R & D Limited Thienopyridone derivatives as kinase inhibitors
GB0314607D0 (en) 2003-06-23 2003-07-30 Univ Cambridge Tech Preservation method
AU2004203373A1 (en) 2003-07-25 2005-02-10 University Of Chicago Identification of novel factors that block programmed cell death or apoptosis by targeting JNK
GB0318182D0 (en) 2003-08-04 2003-09-03 Univ Liverpool Porous material and method of production thereof
US7083106B2 (en) 2003-09-05 2006-08-01 Cytyc Corporation Locally storing biological specimen data to a slide
US7314755B2 (en) 2003-10-15 2008-01-01 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Preservation of eukaryotic cells using reversible pore formation
BRPI0415850A (pt) 2003-10-23 2007-01-02 Alza Corp composição de dna estabilizado para o revestimento de micro projeções
AU2004285752A1 (en) 2003-10-24 2005-05-12 Ucb Pharma S.A. Thieno-pyridinone derivatives as kinase inhibitors
JP2007515956A (ja) 2003-12-10 2007-06-21 バイオトローブ， インコーポレイテッド 改良された選択的ライゲーションおよび増幅アッセイ
WO2005070968A1 (ja) * 2004-01-21 2005-08-04 Wako Pure Chemical Industries, Ltd. 蛋白質の固定化方法及び定量方法
US20070196826A1 (en) * 2004-03-23 2007-08-23 Hiroyuki Ohno Solvent For Dissolving Nucleic Acid, Nucleic Acid-Containing Solution And Method Of Preserving Nucleic Acid
US20080176209A1 (en) 2004-04-08 2008-07-24 Biomatrica, Inc. Integration of sample storage and sample management for life science
CA2560513A1 (en) 2004-04-08 2005-12-01 Biomatrica, Inc. Integration of sample storage and sample management for life science
US20060099567A1 (en) 2004-04-08 2006-05-11 Biomatrica, Inc. Integration of sample storage and sample management for life science
CN1980738A (zh) 2004-04-09 2007-06-13 科研智囊团有限公司 用于收集、储存和运输生物样本的设备和方法
US20050251501A1 (en) 2004-05-07 2005-11-10 Mark Phillips System and method for integrating disparate data sources
ES2243131B1 (es) 2004-05-07 2007-02-01 Consejo Sup. Investig. Cientificas Tiamidas derivadas de bifenilo como inhibidores de calpaina.
EP1758937B1 (en) 2004-05-24 2009-09-02 Genvault Corporation Stable protein storage and stable nucleic acid storage in recoverable form
AR049938A1 (es) 2004-06-25 2006-09-13 Takeda Pharmaceutical Derivados de metastina y utilizacion de los mismos
MY144232A (en) 2004-07-26 2011-08-15 Chugai Pharmaceutical Co Ltd 5-substituted-2-phenylamino benzamides as mek inhibitors
CA2577068C (en) 2004-08-12 2016-05-17 Adlyfe, Inc. Methods for preparing freeze-dried platelets, compositions comprising freeze-dried platelets, and methods of use
WO2006023471A2 (en) 2004-08-18 2006-03-02 Preanalytix Gmbh Additive, method, and article for dna collection, stabilization, and purification
US20060198891A1 (en) 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
ES2255848B1 (es) 2004-12-16 2007-07-01 Consejo Superior Investig. Cientificas Derivados de isoquinolina como inhibidores de calpaina.
US7727718B2 (en) 2005-01-04 2010-06-01 Molecular Research Center, Inc. Reagents for storage and preparation of samples for DNA analysis
US7964380B2 (en) 2005-01-21 2011-06-21 Argylia Technologies Nanoparticles for manipulation of biopolymers and methods of thereof
US7419832B2 (en) 2005-03-10 2008-09-02 Streck, Inc. Blood collection tube with surfactant
DE102005015005A1 (de) 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
US20060293212A1 (en) 2005-05-05 2006-12-28 Ecolab Inc. Stable solid compositions of spores, bacteria, fungi and/or enzyme
ES2524922T3 (es) 2005-05-10 2014-12-15 Intermune, Inc. Derivados de piridona para modular el sistema de proteína cinasa activada por estrés
CN102206216B (zh) 2005-06-22 2014-11-12 普莱希科公司 作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物
US7931919B2 (en) 2005-08-12 2011-04-26 The United States Of America As Represented By The Secretary Of The Army Method of producing glycine-stabilized, lyophilized plasma
JP2009510122A (ja) 2005-09-29 2009-03-12 ザ スクリプス リサーチ インスティテュート ウイルスペプチドおよびフラビウイルス科のウイルスに対してウイルス感染を阻害するためのその使用
HRP20110498T1 (hr) 2005-10-07 2011-08-31 Exelixis Azetidini kao inhibitori mek za liječenje proliferativnih bolesti
GB0601962D0 (en) 2006-01-31 2006-03-15 Ucb Sa Therapeutic agents
KR100777249B1 (ko) 2006-02-14 2007-11-28 (주)바이오니아 건조 올리고뉴클레오티드 조성물 및 이의 제조 방법
MX2008013097A (es) 2006-04-18 2008-10-27 Ardea Biosciences Inc Piridona sulfonamidas y piridona sulfamidas como inhibidores de metiletilcetona.
CA2653454A1 (en) 2006-05-23 2007-11-29 Molecular Detection, Inc. Ambient temperature stable kits for molecular diagnostics
WO2008007463A1 (fr) 2006-07-12 2008-01-17 Nippon Zenyaku Kogyo Co., Ltd. Composition de dilution et de stockage de sperme
WO2008013885A2 (en) 2006-07-25 2008-01-31 Stratagene California Zwitterionic detergents for the storage and use of dna polymerases
CN101528231A (zh) 2006-08-16 2009-09-09 埃克塞利希斯股份有限公司 在癌症的治疗中使用pi3k和mek调控剂
US7846703B2 (en) 2006-10-02 2010-12-07 Takara Bio Inc. Method for enhancing polymerase activity
US20100099149A1 (en) 2006-10-06 2010-04-22 Dna Genotek Inc. Stabilizing compositions and methods for extraction of ribonucleic acid
US7972828B2 (en) 2006-12-19 2011-07-05 Sigma-Aldrich Co. Stabilized compositions of thermostable DNA polymerase and anionic or zwitterionic detergent
EP2118260A2 (en) 2007-01-16 2009-11-18 Genvault Corporation Nanoparticles useful for biomolecule storage
WO2008108549A1 (en) 2007-03-05 2008-09-12 Jootae Kim Method on long-term structural preservation of hemocyte utilizing cellular lyophilization technique
EP1970440A1 (en) 2007-03-06 2008-09-17 Qiagen GmbH Polymerase stabilization by ionic detergents
BRPI0810516A2 (pt) 2007-04-24 2014-10-07 Biomatrica Inc Armazenamento de amostra para ciência da vida
BRPI0813342A2 (pt) 2007-06-13 2014-10-14 Ge Healthcare Bio Sciences " composição de dna polimerase termoestável, e, métodos para estabilizar e ou realçar a atividade de dna polimerase e para realizar pcr ".
US20110014676A1 (en) 2007-06-29 2011-01-20 Battelle Memorial Institute Protein stabilization
US20090010858A1 (en) 2007-07-02 2009-01-08 Hirofumi Asano Oral cavity disinfectant and oral cavity disinfecting method
US8530480B2 (en) 2007-09-04 2013-09-10 The Scripps Research Institute Substituted pyrimidinyl-amines as protein kinase inhibitors
CA2861667C (en) * 2007-10-01 2017-06-13 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system and methods of use
US20100292447A1 (en) * 2007-10-12 2010-11-18 Merck Patent Gesellschaft Method and agent for refolding proteins
JP4761265B2 (ja) 2007-10-17 2011-08-31 学校法人甲南学園 核酸合成を促進する化合物を含む組成物およびその利用、並びに当該化合物の製造方法
US8871434B2 (en) 2008-03-21 2014-10-28 Fenwal, Inc. Red blood cell storage medium for extended storage
BRPI0911048A2 (pt) 2008-04-14 2015-12-29 Atrm Llc formulações líquidas tamponadas de gdf-5
US8178555B2 (en) 2008-06-24 2012-05-15 Takeda Pharmaceutical Company Limited Apoptosis signal-regulating kinase 1 inhibitors
MX2010014565A (es) 2008-07-01 2011-03-04 Genentech Inc Isoindolona y metodos de uso.
DE102008039734A1 (de) * 2008-08-26 2010-03-04 Universität Rostock Stabilisierung von Zellen durch ionische Flüssigkeiten
JP2012506424A (ja) 2008-10-22 2012-03-15 デ スタート デル ネダーランデン、フェルト．ドール デ ミニスター ファン フォルクスヘーゾンドハイド、フェルジイン アン スポルト 保存混合物及びその使用
EP2373804B1 (en) 2008-12-05 2014-11-12 DNA Polymerase Technology, Inc. Compositions for improving gene amplification
CA2688174C (en) 2008-12-19 2018-08-07 F. Hoffmann-La Roche Ag Dry composition of reaction compounds with stabilized polymerase
TW201040266A (en) * 2009-04-10 2010-11-16 Biomarin Pharm Inc Methods of enhancing yield of active IgA protease
EP2430195B1 (en) 2009-05-11 2019-01-23 Biomatrica, INC. Compositions and methods for biological sample storage
WO2010138522A2 (en) 2009-05-26 2010-12-02 Advanced Bionutrition Corporation Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making
WO2010144682A1 (en) 2009-06-12 2010-12-16 Micronics, Inc. Rehydratable matrices for dry storage of taq polymerase in a microfluidic device
WO2011008553A1 (en) 2009-06-29 2011-01-20 Life Technologies Corporation Rna sample stabilization in the presence of a transitional metal
TWI491606B (zh) 2009-07-13 2015-07-11 Gilead Sciences Inc 調節細胞凋亡信號之激酶的抑制劑
GB0915796D0 (en) 2009-09-09 2009-10-07 Fermentas Uab Polymerase compositions and uses
US20110152384A1 (en) * 2009-12-17 2011-06-23 Gunn Euen T Mild leave-on skin care compositions
EP2345719A1 (en) 2010-01-18 2011-07-20 Qiagen GmbH Method for isolating small RNA
EP2555918A1 (en) 2010-04-06 2013-02-13 Genvault Corporation Stabilized chemical dehydration of biological material
SI2588475T1 (sl) 2010-07-02 2015-12-31 Gilead Sciences, Inc. Kinazni inhibitorji za regulacijo apoptoznega signala
CA2806670A1 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
US9845489B2 (en) * 2010-07-26 2017-12-19 Biomatrica, Inc. Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
US20120028933A1 (en) 2010-07-28 2012-02-02 Baust John M Cell Culture Media Supplement and Method of Molecular Stress Control
US8664244B2 (en) 2010-09-12 2014-03-04 Advenchen Pharmaceuticals, LLC Compounds as c-Met kinase inhibitors
US10299714B2 (en) 2010-12-02 2019-05-28 Becton, Dickinson And Company Blood collection devices containing blood stabilization agent including variegin or analog thereof and/or a polysulfated disaccharide
US10191038B2 (en) 2011-03-28 2019-01-29 Lsi Medience Corporation Immunological measuring method and measuring kit for whole blood sample
BR112013021963A2 (pt) 2011-04-22 2016-08-09 Polymer Technology Systems Inc sistema e método de separação de sangue para uma tira de teste seca
WO2012170907A2 (en) 2011-06-08 2012-12-13 Life Technologies Corporation Polymerization of nucleic acids using proteins having low isoelectric points
JP5822683B2 (ja) 2011-11-25 2015-11-24 株式会社日立国際電気 電源回路
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
WO2014150245A1 (en) 2013-03-15 2014-09-25 Aradigm Corporation Methods for inhalation of smoke-free nicotine
CN105491883B (zh) 2013-06-13 2018-11-02 生物马特里卡公司 细胞稳定化
ES2812201T3 (es) 2014-06-10 2021-03-16 Biomatrica Inc Estabilización de células metabólicamente activas en una muestra de sangre a temperaturas ambiente
JP6669672B2 (ja) 2014-06-10 2020-03-18 バイオマトリカ，インク． 周囲温度における血液サンプル中の変性されていないポリペプチド、核酸、およびエキソソームの安定化
CN106572650B (zh) 2014-06-10 2021-08-31 生物马特里卡公司 在环境温度下稳定凝血细胞
CN108603225A (zh) 2015-12-08 2018-09-28 生物马特里卡公司 Pcr试剂的稳定化及测定

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