ATE272058T1 - Matrize für die synthese kombinatorischer bibliotheken in lösung - Google Patents

Matrize für die synthese kombinatorischer bibliotheken in lösung

Info

Publication number
ATE272058T1
ATE272058T1 AT96307509T AT96307509T ATE272058T1 AT E272058 T1 ATE272058 T1 AT E272058T1 AT 96307509 T AT96307509 T AT 96307509T AT 96307509 T AT96307509 T AT 96307509T AT E272058 T1 ATE272058 T1 AT E272058T1
Authority
AT
Austria
Prior art keywords
combinatorial libraries
matrize
synthesis
solution
image
Prior art date
Application number
AT96307509T
Other languages
English (en)
Inventor
Dale L Boger
Soan Cheng
Peter L Myers
Original Assignee
Combichem Inc
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combichem Inc, Scripps Research Inst filed Critical Combichem Inc
Application granted granted Critical
Publication of ATE272058T1 publication Critical patent/ATE272058T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C07D265/33—Two oxygen atoms, in positions 3 and 5
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00599—Solution-phase processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Indole Compounds (AREA)
AT96307509T 1995-10-17 1996-10-16 Matrize für die synthese kombinatorischer bibliotheken in lösung ATE272058T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US689195P 1995-10-17 1995-10-17

Publications (1)

Publication Number Publication Date
ATE272058T1 true ATE272058T1 (de) 2004-08-15

Family

ID=21723130

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96307509T ATE272058T1 (de) 1995-10-17 1996-10-16 Matrize für die synthese kombinatorischer bibliotheken in lösung

Country Status (7)

Country Link
US (1) US6194612B1 (de)
EP (1) EP0774464B1 (de)
JP (2) JP3819092B2 (de)
AT (1) ATE272058T1 (de)
AU (1) AU729646B2 (de)
CA (1) CA2187969C (de)
DE (1) DE69632989T2 (de)

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US20040248323A1 (en) * 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
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RU2402548C2 (ru) * 2004-05-19 2010-10-27 Медарекс, Инк. Химические линкеры и их конъюгаты
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US7714016B2 (en) * 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
US20080279868A1 (en) * 2005-09-26 2008-11-13 Medarex, Inc. Antibody-Drug Conjugates and Methods of Use
CN102260742A (zh) 2005-10-21 2011-11-30 基因信息股份有限公司 用于使生物标志产物水平与疾病相关联的方法和装置
ES2375843T3 (es) 2005-10-26 2012-03-06 Medarex, Inc. Procedimientos y compuestos para la preparación de an�?logos de cc-1065.
CA2627190A1 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
US8377448B2 (en) 2006-05-15 2013-02-19 The Board Of Trustees Of The Leland Standford Junior University CD47 related compositions and methods for treating immunological diseases and disorders
WO2008067196A2 (en) 2006-11-16 2008-06-05 The Regents Of The University Of California Methods for identifying inhibitors of solute transporters
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US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
US9682123B2 (en) 2013-12-20 2017-06-20 The Trustees Of Columbia University In The City Of New York Methods of treating metabolic disease
US10464955B2 (en) 2014-02-28 2019-11-05 Hangzhou Dac Biotech Co., Ltd. Charged linkers and their uses for conjugation
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US5767238A (en) * 1995-06-07 1998-06-16 Combichem, Inc. Inverse solid phase synthesis

Also Published As

Publication number Publication date
CA2187969A1 (en) 1997-04-18
JP2004196813A (ja) 2004-07-15
JPH09278763A (ja) 1997-10-28
DE69632989D1 (de) 2004-09-02
JP3819092B2 (ja) 2006-09-06
CA2187969C (en) 2006-05-30
AU729646B2 (en) 2001-02-08
AU7026496A (en) 1997-04-24
DE69632989T2 (de) 2005-08-25
EP0774464A3 (de) 1997-08-13
EP0774464A2 (de) 1997-05-21
US6194612B1 (en) 2001-02-27
EP0774464B1 (de) 2004-07-28

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