DE69930940D1 - Synthese von verbindungen die zur herstellung von ketorolac dienen - Google Patents
Synthese von verbindungen die zur herstellung von ketorolac dienenInfo
- Publication number
- DE69930940D1 DE69930940D1 DE69930940T DE69930940T DE69930940D1 DE 69930940 D1 DE69930940 D1 DE 69930940D1 DE 69930940 T DE69930940 T DE 69930940T DE 69930940 T DE69930940 T DE 69930940T DE 69930940 D1 DE69930940 D1 DE 69930940D1
- Authority
- DE
- Germany
- Prior art keywords
- ketorolac
- compounds
- synthesis
- preparation
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9240898P | 1998-07-10 | 1998-07-10 | |
US92408P | 1998-07-10 | ||
PCT/US1999/015496 WO2000002855A2 (en) | 1998-07-10 | 1999-07-08 | Synthesis of compounds useful in the manufacture of ketorolac |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69930940D1 true DE69930940D1 (de) | 2006-05-24 |
DE69930940T2 DE69930940T2 (de) | 2006-12-14 |
Family
ID=22233070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69930940T Expired - Fee Related DE69930940T2 (de) | 1998-07-10 | 1999-07-08 | Synthese von verbindungen die zur herstellung von ketorolac dienen |
Country Status (8)
Country | Link |
---|---|
US (3) | US6376681B1 (de) |
EP (1) | EP1097152B1 (de) |
JP (1) | JP2002520313A (de) |
AT (1) | ATE323703T1 (de) |
AU (1) | AU5209699A (de) |
DE (1) | DE69930940T2 (de) |
ES (1) | ES2259475T3 (de) |
WO (1) | WO2000002855A2 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050070906A1 (en) * | 1999-11-30 | 2005-03-31 | Ron Clark | Endosteal tibial ligament fixation with adjustable tensioning |
GB0000569D0 (en) | 2000-01-12 | 2000-03-01 | Ici Plc | Organometallic compositions |
GB0112901D0 (en) | 2001-05-29 | 2001-07-18 | Ici Plc | Organometallic compositions |
US7341502B2 (en) * | 2002-07-18 | 2008-03-11 | Micron Technology, Inc. | Methods and systems for planarizing workpieces, e.g., microelectronic workpieces |
LU91605B1 (fr) | 2009-09-07 | 2011-03-08 | Terra Nobilis S A | Procédé de sécurisation du stockage de déchets radioactifs de longue vie. |
CN113087626A (zh) * | 2020-01-09 | 2021-07-09 | 鲁南制药集团股份有限公司 | 一种酮咯酸氨丁三醇中间体化合物ⅵ |
CN113087710A (zh) * | 2020-01-09 | 2021-07-09 | 鲁南制药集团股份有限公司 | 一种酮咯酸氨丁三醇中间体的制备方法 |
CN113087619A (zh) * | 2020-01-09 | 2021-07-09 | 鲁南制药集团股份有限公司 | 一种酮咯酸氨丁三醇中间体化合物 |
CN112898307A (zh) * | 2021-02-07 | 2021-06-04 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 一种酮咯酸杂质c及其制备方法与应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4089969A (en) * | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
US4140698A (en) * | 1977-07-25 | 1979-02-20 | Syntex (Usa) Inc. | 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles |
CH616808B (fr) * | 1978-06-14 | Piquerez Sa Ervin | Procede de fabrication d'une boite de montre et boite de montre obtenue par ce procede. | |
US4458081A (en) * | 1980-10-20 | 1984-07-03 | Syntex (U.S.A.) Inc. | 5-Aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-decarboxylates |
US5082951A (en) * | 1990-10-12 | 1992-01-21 | Syntex (U.S.A.) Inc. | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor |
KR0140134B1 (ko) * | 1994-11-16 | 1998-06-01 | 강재헌 | 피롤리진 유도체의 제조방법 |
-
1999
- 1999-07-08 EP EP99937220A patent/EP1097152B1/de not_active Expired - Lifetime
- 1999-07-08 AT AT99937220T patent/ATE323703T1/de not_active IP Right Cessation
- 1999-07-08 JP JP2000559086A patent/JP2002520313A/ja not_active Withdrawn
- 1999-07-08 WO PCT/US1999/015496 patent/WO2000002855A2/en active IP Right Grant
- 1999-07-08 AU AU52096/99A patent/AU5209699A/en not_active Abandoned
- 1999-07-08 DE DE69930940T patent/DE69930940T2/de not_active Expired - Fee Related
- 1999-07-08 ES ES99937220T patent/ES2259475T3/es not_active Expired - Lifetime
- 1999-07-08 US US09/719,033 patent/US6376681B1/en not_active Expired - Fee Related
-
2002
- 2002-02-05 US US10/072,649 patent/US6489491B2/en not_active Expired - Fee Related
- 2002-09-03 US US10/233,809 patent/US6559319B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2259475T3 (es) | 2006-10-01 |
DE69930940T2 (de) | 2006-12-14 |
WO2000002855A3 (en) | 2000-02-24 |
US6489491B2 (en) | 2002-12-03 |
EP1097152A2 (de) | 2001-05-09 |
US6559319B2 (en) | 2003-05-06 |
EP1097152B1 (de) | 2006-04-19 |
ATE323703T1 (de) | 2006-05-15 |
AU5209699A (en) | 2000-02-01 |
JP2002520313A (ja) | 2002-07-09 |
US20030036660A1 (en) | 2003-02-20 |
US6376681B1 (en) | 2002-04-23 |
US20020137945A1 (en) | 2002-09-26 |
WO2000002855A2 (en) | 2000-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |