HUP9901894A2 - Eljárás kurkuminnal rokon vegyületek előállítására - Google Patents

Eljárás kurkuminnal rokon vegyületek előállítására

Info

Publication number
HUP9901894A2
HUP9901894A2 HU9901894A HUP9901894A HUP9901894A2 HU P9901894 A2 HUP9901894 A2 HU P9901894A2 HU 9901894 A HU9901894 A HU 9901894A HU P9901894 A HUP9901894 A HU P9901894A HU P9901894 A2 HUP9901894 A2 HU P9901894A2
Authority
HU
Hungary
Prior art keywords
curcumin
synthesis
related compounds
cumene
solvent
Prior art date
Application number
HU9901894A
Other languages
English (en)
Inventor
Harold Edward Bellis
Mark Harry Krackov
Original Assignee
Geneprint, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geneprint, Inc. filed Critical Geneprint, Inc.
Publication of HUP9901894A2 publication Critical patent/HUP9901894A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány tárgya eljárás kűrkűmin és kűrkűminnal rőkőn vegyületekelőállítására, a 2,4-diketőn enől alakjának és egy mőnőkarbőciklikűsaldehid szerves amin katalizátőr jelenlétében történő reagál-tatásával. A reagenseket erősen pőlárős, aprőtikűs szerves őldószerbenfelőldják. A kűrkűminnal rőkőn terméket a reakcióelegyből kicsapvakristályős főrmában kinyerik, és az őldószert újra kristályősítják. ŕ
HU9901894A 1995-11-03 1996-11-01 Eljárás kurkuminnal rokon vegyületek előállítására HUP9901894A2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/552,904 US5679864A (en) 1995-11-03 1995-11-03 Process for the synthesis of curcumin-related compounds

Publications (1)

Publication Number Publication Date
HUP9901894A2 true HUP9901894A2 (hu) 1999-09-28

Family

ID=24207300

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901894A HUP9901894A2 (hu) 1995-11-03 1996-11-01 Eljárás kurkuminnal rokon vegyületek előállítására

Country Status (16)

Country Link
US (1) US5679864A (hu)
EP (1) EP0861223B1 (hu)
JP (1) JP3346576B2 (hu)
KR (1) KR19990067279A (hu)
AT (1) ATE256652T1 (hu)
AU (1) AU7551096A (hu)
BR (1) BR9611412A (hu)
CA (1) CA2236600A1 (hu)
DE (1) DE69631155T2 (hu)
DK (1) DK0861223T3 (hu)
ES (1) ES2213183T3 (hu)
HU (1) HUP9901894A2 (hu)
MX (1) MX9803546A (hu)
NO (1) NO981974L (hu)
PL (1) PL326452A1 (hu)
WO (1) WO1997016403A1 (hu)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU768189B2 (en) * 1999-06-15 2003-12-04 Nutri-Logics, Inc. Nutrient formulations for disease reduction, and related treatment and component screening methods
US20030149113A1 (en) * 2001-10-12 2003-08-07 Caplan Michael J. Conductance of improperly folded proteins through the secretory pathway and related methods for treating disease
US20030236300A1 (en) * 1999-10-27 2003-12-25 Yale University Conductance of improperly folded proteins through the secretory pathway and related methods for treating disease
DE10029770A1 (de) * 2000-06-16 2001-12-20 Transmit Technologietransfer Verwendung von Curcuminen zur Behandlung von soliden Tumoren,insbesondere von Hirntumoren
WO2002083614A1 (en) * 2001-04-18 2002-10-24 Laila, Impex Novel polyhydroxy curcumins having antioxidant activity
US7355081B2 (en) 2002-04-17 2008-04-08 The University Of North Carolina At Chapel Hill Curcumin analogues and uses thereof
US6790979B2 (en) * 2002-04-17 2004-09-14 University Of North Carolina At Chapel Hill Curcumin analogues and uses thereof
WO2003105751A2 (en) * 2002-06-17 2003-12-24 Ho-Jeong Kwon Novel curcumin derivatives
DE102005008262A1 (de) * 2005-02-22 2006-08-24 Basf Ag Verfahren zur Herstellung von Curcumin
ATE538080T1 (de) * 2006-03-29 2012-01-15 Dsm Ip Assets Bv Curcuminsynthese
WO2007143635A1 (en) * 2006-06-05 2007-12-13 Kim Darrick S Method to prepare pure curcumin
US7507864B2 (en) * 2006-08-01 2009-03-24 Salisbury University Method for the synthesis of curcumin analogues
WO2008066151A1 (en) 2006-11-30 2008-06-05 Tokyo Institute Of Technology Novel curcumin derivative
WO2008085984A1 (en) 2007-01-08 2008-07-17 Androscience Corporation Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and uses thereof
US8710272B2 (en) 2007-01-08 2014-04-29 Androscience Corporation Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
US9000222B2 (en) 2007-01-08 2015-04-07 Androscience Corporation Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
EP2749552B1 (en) * 2007-04-17 2015-11-18 Codman & Shurtleff, Inc. Curcumin-resveratrol hybrids
US8383865B2 (en) * 2007-04-17 2013-02-26 Codman & Shurtleff, Inc. Curcumin derivatives
MX2010001125A (es) 2007-07-31 2010-09-30 Androscience Corp Composiciones incluyendo receptor androgeno de degradacion (ard) ponteciadores y metodos de tratamiento profilactico o terapeutico de trastornos de la piel y la caida de cabello.
US7745670B2 (en) * 2008-06-27 2010-06-29 Codman & Shurtleff, Inc. Curcumin-Resveratrol hybrid molecule
US7985776B2 (en) * 2008-06-27 2011-07-26 Codman & Shurtleff, Inc. Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's Disease
US7723515B1 (en) * 2009-01-26 2010-05-25 Codman & Shurtleff, Inc. Methylene blue—curcumin analog for the treatment of alzheimer's disease
US20100286585A1 (en) * 2009-01-26 2010-11-11 Codman & Shurtleff, Inc. Shunt Delivery of Curcumin
EP3206488B1 (en) 2009-05-15 2019-08-21 The Research Foundation for The State University of New York Curcumin analogues as zinc chelators and their uses
US9393198B2 (en) * 2010-03-22 2016-07-19 Signpath Pharma Inc. Intravenous curcumin and derivatives for treatment of neurodegenerative and stress disorders
US10117881B2 (en) 2011-06-03 2018-11-06 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies
ES2896105T3 (es) 2011-06-03 2022-02-23 Signpath Pharma Inc Mitigación liposomal del síndrome de QT largo inducido por un fármaco y corriente rectificadora retardada de potasio
US12004868B2 (en) 2011-06-03 2024-06-11 Signpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel
US10238602B2 (en) 2011-06-03 2019-03-26 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LysoPG and LysoPC against drugs that cause channelopathies
US8753674B2 (en) 2011-06-03 2014-06-17 Signpath Pharma Inc. Liposomal mitigation of drug-induced long QT syndrome and potassium delayed-rectifier current
US10449193B2 (en) 2011-06-03 2019-10-22 Signpath Pharma Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, lysoPG and lysoPC against drugs that cause channelopathies
US10349884B2 (en) 2011-06-03 2019-07-16 Sighpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel
ES2837014T3 (es) 2012-05-08 2021-06-29 Asac Compania De Biotecnologia E Investig Sa Procedimiento para la síntesis de curcumina
AU2013274105A1 (en) 2012-06-14 2014-12-18 Signpath Pharma, Inc. Method and system for measuring the pharmacokinetics of liposomal curcumin and its metabolite tetrahydrocurcumin
CA2882978A1 (en) 2012-08-31 2014-03-06 University Of North Texas Health Science Center Curcumin-er, a liposomal-plga sustained release nanocurcumin for minimizing qt prolongation for cancer therapy
WO2015095576A1 (en) 2013-12-18 2015-06-25 Signpath Pharma, Inc. Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel
CN108884112B (zh) 2016-03-22 2021-03-02 国立研究开发法人科学技术振兴机构 姜黄素硼配合物和含有该姜黄素硼配合物的药物
KR102181659B1 (ko) 2016-04-27 2020-11-24 사인패스 파마 인코포레이티드 약물 유발된 방실 차단의 방지
CN110551026B (zh) * 2018-06-04 2022-02-15 永胜光学股份有限公司 改质姜黄素及其制备方法
US11434189B1 (en) * 2021-10-20 2022-09-06 I-Mei Foods Co., Ltd. Method for isolating curcuminoids from turmeric rhizome

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE859145C (de) * 1944-04-22 1952-12-11 Hoechst Ag Verfahren zur Herstellung von symmetrischen 1, 3-Diketonen
NL255427A (hu) * 1959-08-31
DE1280849B (de) * 1967-06-10 1968-10-24 Ludwig Heumann & Co Chem Pharm Verfahren zur Herstellung von Curcumin aus Vanillin und Acetylaceton
DE1282642B (de) * 1967-12-09 1968-11-14 Ludwig Heumann & Co Chemisch P Verfahren zur Herstellung von Curcumin aus Vanillin und Acetylaceton

Also Published As

Publication number Publication date
MX9803546A (es) 1998-11-29
WO1997016403A1 (en) 1997-05-09
PL326452A1 (en) 1998-09-28
US5679864A (en) 1997-10-21
ES2213183T3 (es) 2004-08-16
EP0861223A1 (en) 1998-09-02
AU7551096A (en) 1997-05-22
DE69631155D1 (de) 2004-01-29
JP3346576B2 (ja) 2002-11-18
ATE256652T1 (de) 2004-01-15
NO981974L (no) 1998-06-03
BR9611412A (pt) 1999-12-28
DE69631155T2 (de) 2004-09-02
CA2236600A1 (en) 1997-05-09
JPH11502232A (ja) 1999-02-23
KR19990067279A (ko) 1999-08-16
DK0861223T3 (da) 2004-04-05
EP0861223B1 (en) 2003-12-17
NO981974D0 (no) 1998-04-30

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