KR850006182A - 시스-3,3,5-트리메틸사이클로헥실-D,L-α-(3-피리딘카복시)-페닐아세테이트의 제조방법 - Google Patents
시스-3,3,5-트리메틸사이클로헥실-D,L-α-(3-피리딘카복시)-페닐아세테이트의 제조방법 Download PDFInfo
- Publication number
- KR850006182A KR850006182A KR1019850001404A KR850001404A KR850006182A KR 850006182 A KR850006182 A KR 850006182A KR 1019850001404 A KR1019850001404 A KR 1019850001404A KR 850001404 A KR850001404 A KR 850001404A KR 850006182 A KR850006182 A KR 850006182A
- Authority
- KR
- South Korea
- Prior art keywords
- pyridinecarboxy
- trimethylcyclohexyl
- phenylacetate
- water
- cis
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 6
- 229940049953 phenylacetate Drugs 0.000 title claims 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical group ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- BRRVXFOKWJKTGG-SFYZADRCSA-N (1s,5s)-3,3,5-trimethylcyclohexan-1-ol Chemical compound C[C@@H]1C[C@H](O)CC(C)(C)C1 BRRVXFOKWJKTGG-SFYZADRCSA-N 0.000 claims 1
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- QQVDYSUDFZZPSU-UHFFFAOYSA-M chloromethylidene(dimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)=CCl QQVDYSUDFZZPSU-UHFFFAOYSA-M 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- KJIFKLIQANRMOU-UHFFFAOYSA-N oxidanium;4-methylbenzenesulfonate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1 KJIFKLIQANRMOU-UHFFFAOYSA-N 0.000 claims 1
- 229960003424 phenylacetic acid Drugs 0.000 claims 1
- 239000003279 phenylacetic acid Substances 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 238000010586 diagram Methods 0.000 description 3
- 241000786363 Rhampholeon spectrum Species 0.000 description 1
- 241001342522 Vampyrum spectrum Species 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 생성물의 I.R.스펙트럼에 관한 도이다.
제2도는 생성물의 U.V.스펙트럼에 관한 도이다.
제3도는 생성물의 NMR스펙트럼에 관한 도이다.
Claims (6)
- D,L-α-(3-피리딘카복시)-페닐아세트산의 염산염을 시스-3,3,5-트리메틸사이클로 헥산올과 반응시킴을 특징으로 하여 시스-3,3,5-트리메틸사이클로헥실-D,L-α-(3-피리딘카복시)-페닐아세테이트(I)을 제조하는 방법.
- 제1항에 있어서, 반응을 디메틸렌클로라이드 중의 클로로메틸렌 디메틸암모늄클로라이드로 구성된 매질중에서 수행하는 방법.
- 제2항에 있어서, 반응을 20°내지 30℃의 온도에서 수행하는 방법.
- 제2항에 있어서, 두 시약을 1:1.1내지 1:1.2의 몰비로 반응시키는 방법.
- 제1항에 있어서, 생성물(I)을 아세톤중의 P톨루엔 설폰산으로 침전시킨 다음 물 및 수-불혼화성 유기 용매로 구성된 매질중에서 탄산 나트륨으로 처리함으로써 정제시키는 방법.
- 제5항에 있어서, 수-불혼화성 유기용매가 메틸렌 클로라이드인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19931A/84 | 1984-03-07 | ||
| IT19931/84A IT1175810B (it) | 1984-03-07 | 1984-03-07 | Processo per la preparazione di cis-3,3,5-trimetilcicloesil-d,l-(3-piridin-carbossi)-fenilacetato |
| IT19,931A/84 | 1984-03-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR850006182A true KR850006182A (ko) | 1985-10-02 |
| KR910003614B1 KR910003614B1 (ko) | 1991-06-07 |
Family
ID=11162441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850001404A KR910003614B1 (ko) | 1984-03-07 | 1985-03-06 | 시스-3,3,5-트리메틸사이클로헥실-D,L-α-(3-피리딘카복시)-페닐아세테이트의 제조방법 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0157151B1 (ko) |
| KR (1) | KR910003614B1 (ko) |
| AT (1) | ATE35679T1 (ko) |
| DE (1) | DE3563743D1 (ko) |
| ES (1) | ES8601895A1 (ko) |
| IT (1) | IT1175810B (ko) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108997202A (zh) * | 2018-07-10 | 2018-12-14 | 湖南华腾制药有限公司 | 一种（5-三氟甲基-吡啶-2-基）-乙酸盐的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7416232L (ko) * | 1974-01-03 | 1975-07-04 | Gaver Sa |
-
1984
- 1984-03-07 IT IT19931/84A patent/IT1175810B/it active
-
1985
- 1985-02-22 EP EP85101944A patent/EP0157151B1/en not_active Expired
- 1985-02-22 AT AT85101944T patent/ATE35679T1/de active
- 1985-02-22 DE DE8585101944T patent/DE3563743D1/de not_active Expired
- 1985-03-06 ES ES540982A patent/ES8601895A1/es not_active Expired
- 1985-03-06 KR KR1019850001404A patent/KR910003614B1/ko active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IT1175810B (it) | 1987-07-15 |
| DE3563743D1 (en) | 1988-08-18 |
| ES540982A0 (es) | 1985-11-16 |
| IT8419931A0 (it) | 1984-03-07 |
| ES8601895A1 (es) | 1985-11-16 |
| ATE35679T1 (de) | 1988-07-15 |
| EP0157151B1 (en) | 1988-07-13 |
| KR910003614B1 (ko) | 1991-06-07 |
| EP0157151A1 (en) | 1985-10-09 |
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