KR840006813A - 다당류의 해중합 및 황산염화를 위한 방법 - Google Patents

다당류의 해중합 및 황산염화를 위한 방법 Download PDF

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Publication number
KR840006813A
KR840006813A KR1019830006213A KR830006213A KR840006813A KR 840006813 A KR840006813 A KR 840006813A KR 1019830006213 A KR1019830006213 A KR 1019830006213A KR 830006213 A KR830006213 A KR 830006213A KR 840006813 A KR840006813 A KR 840006813A
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KR
South Korea
Prior art keywords
polysaccharides
depolymerized
process according
depolymerization
sulfuric acid
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KR1019830006213A
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English (en)
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KR920003692B1 (ko
Inventor
나지 안나마리아 (외 1)
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아니크 에스·피·에이 (외 1)
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Priority claimed from FR8221934A external-priority patent/FR2538404B1/fr
Priority claimed from FR8319506A external-priority patent/FR2555993B1/fr
Application filed by 아니크 에스·피·에이 (외 1) filed Critical 아니크 에스·피·에이 (외 1)
Publication of KR840006813A publication Critical patent/KR840006813A/ko
Application granted granted Critical
Publication of KR920003692B1 publication Critical patent/KR920003692B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

다당류의 해중합 및 황산염화를 위한 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 출발 헤파린(D-212)과 해중합되고 고황산화된 헤파린(AH-16)을 염산에서 전기영동시킨 그래프이고,
제2도는 D-212와 AH-16의 초산바륨 전기영동그래프이고,
제3도는 D-212와 AH-16의 13C-NMR 스펙트럼이고,
제4도는 D-212/B와 AH-18의 초산바륨 전기영동그래프이고,
제5도는 D-212와 AH-19의 초산바륨 전기영동 그래프이고,
제6도는 D-212/A와 AH-17의 초산바륨 전기영동의 그래프.

Claims (9)

  1. 다당류와 황산 및 클로로술폰산의 혼합물을 반응시킴을 특징으로 하는 다당류의 해중합 및 황산염화를 위한 방법.
  2. 제1항에 있어서, 반응이 -20∼40℃의 온도에서 수행됨을 특징으로 하는 방법.
  3. 제1항과 2항의 어느 한항에 따라, 두가지 산의 농도가 95무게% 이상임을 특징으로 하는 방법.
  4. 제1∼3항중 어느 한항에 따라, 황산 : 클로로술폰산의 비가 약 4 : 1∼1 : 1임을 특징으로 하는 방법.
  5. 제1∼4항중 어느 한항에 따라, 황산 : 클로로술폰산의 비가 약 2 : 1임을 특징으로 하는 방법.
  6. 제1∼5항중 어느 한항에 따라, 해중합되고 황산염화된 다당류를 나트륨염으로서 분리시킴을 특징으로 하는 방법.
  7. 제1∼5항중 어느 한항에 따라, 해중합되고 황산염화된 다당류를 그 염들중 어느 하나의 형태로 전확시킴을 특징으로 하는 방법.
  8. 제6항에 있어서, 나트륨염이 적당한 염과의 교확 반응을 통해 해중합되고 황산염화된 다당류의 또다른 염으로 전환함을 특징으로 하는 방법.
  9. 제1∼8항중 어느 한항에 따라, 출발물질인 다당류를 미리 해중합시킴을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830006213A 1982-12-28 1983-12-27 다당류의 해중합 및 황산염화 방법 KR920003692B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
FR8221934A FR2538404B1 (ko) 1982-12-28 1982-12-28
FR8221934 1982-12-28
FR21,934 1982-12-28
FR8319506A FR2555993B1 (fr) 1983-12-06 1983-12-06 Chitosanes 6-sulfates et procede pour leur preparation
FR19,506 1983-12-06
FR8319506 1983-12-06

Publications (2)

Publication Number Publication Date
KR840006813A true KR840006813A (ko) 1984-12-03
KR920003692B1 KR920003692B1 (ko) 1992-05-09

Family

ID=26223212

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830006213A KR920003692B1 (ko) 1982-12-28 1983-12-27 다당류의 해중합 및 황산염화 방법

Country Status (9)

Country Link
EP (1) EP0116251B1 (ko)
KR (1) KR920003692B1 (ko)
AU (1) AU563377B2 (ko)
CA (1) CA1218986A (ko)
DE (1) DE3374935D1 (ko)
DK (1) DK598083A (ko)
IE (1) IE56783B1 (ko)
IL (1) IL70511A (ko)
NZ (1) NZ206698A (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538404B1 (ko) 1982-12-28 1985-08-23 Anic Spa
FR2555993B1 (fr) * 1983-12-06 1986-11-07 Anic Spa Chitosanes 6-sulfates et procede pour leur preparation
DE3422407A1 (de) * 1984-06-16 1986-03-06 B. Braun Melsungen Ag, 3508 Melsungen Verwendung von heparinderivaten zur selektiven extrakorporalen praezipitation von low-density-lipoproteinen aus vollserum oder plasma
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
US5145841A (en) * 1987-03-19 1992-09-08 Arthropharm Pty. Limited Anti-inflammatory compounds and compositions
FR2623396B1 (fr) * 1987-11-25 1990-03-30 Sanofi Sa Utilisation de l'ademetionine contre le vieillissement de la peau
DE3744119A1 (de) * 1987-12-24 1989-07-06 Basf Ag Verwendung von polysulfatierten heparinen
IT1237518B (it) * 1989-11-24 1993-06-08 Renato Conti Eparine supersolfatate
US6063773A (en) * 1995-09-29 2000-05-16 Polydex Pharmaceuticals Ltd. Cellulose sulfate for use as antimicrobial and contraceptive agent
US7078392B2 (en) 2000-06-30 2006-07-18 Polydex Pharmaceuticals Limited Cellulose sulfate and other sulfated polysaccharides to prevent and treat papilloma virus infection and other infections
EP2025687A1 (en) * 2007-07-23 2009-02-18 Istituto Scientifico di Chimica E Biochimica "G Ronzoni Process for the preparation of heparanase-inhibiting sulfated hyaluronates and products obtained thereby

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2025073A (en) * 1934-01-09 1935-12-24 Du Pont Cellulose derivative and method of making the same
US2755275A (en) * 1952-08-29 1956-07-17 Abbott Lab Process for sulfating chitin
FR1093999A (fr) * 1952-10-15 1955-05-11 Upjohn Co Procédé de préparation de chitosane sulfaté
US3454560A (en) * 1966-03-01 1969-07-08 Seikagaku Kogyo Co Ltd Process for the production of chondroitin polysulfate

Also Published As

Publication number Publication date
AU2285683A (en) 1984-07-05
EP0116251A1 (fr) 1984-08-22
IL70511A (en) 1990-01-18
IE56783B1 (en) 1991-12-18
IL70511A0 (en) 1984-03-30
DK598083D0 (da) 1983-12-23
NZ206698A (en) 1986-11-12
IE833063L (en) 1984-06-28
DK598083A (da) 1984-06-29
CA1218986A (en) 1987-03-10
KR920003692B1 (ko) 1992-05-09
AU563377B2 (en) 1987-07-09
EP0116251B1 (fr) 1987-12-16
DE3374935D1 (en) 1988-01-28

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