IT1237518B - Eparine supersolfatate - Google Patents
Eparine supersolfatateInfo
- Publication number
- IT1237518B IT1237518B IT02250489A IT2250489A IT1237518B IT 1237518 B IT1237518 B IT 1237518B IT 02250489 A IT02250489 A IT 02250489A IT 2250489 A IT2250489 A IT 2250489A IT 1237518 B IT1237518 B IT 1237518B
- Authority
- IT
- Italy
- Prior art keywords
- heparins
- super
- heparin
- sulfated
- sulfated heparins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT02250489A IT1237518B (it) | 1989-11-24 | 1989-11-24 | Eparine supersolfatate |
EP90122309A EP0432537B1 (en) | 1989-11-24 | 1990-11-22 | Supersulfated heparins |
JP2315683A JPH03210302A (ja) | 1989-11-24 | 1990-11-22 | 過硫酸化ヘパリン |
AT90122309T ATE117697T1 (de) | 1989-11-24 | 1990-11-22 | Supersulfatierte heparine. |
IE422590A IE904225A1 (en) | 1989-11-24 | 1990-11-22 | Supersulfated heparins |
DE69016383T DE69016383T2 (de) | 1989-11-24 | 1990-11-22 | Supersulfatierte Heparine. |
ES90122309T ES2068969T3 (es) | 1989-11-24 | 1990-11-22 | Heparinas supersulfatadas. |
PT95961A PT95961B (pt) | 1989-11-24 | 1990-11-22 | Processo para a preparacao de heparinas supersulfatadas |
US07/618,051 US5164378A (en) | 1989-11-24 | 1990-11-26 | Supersulfated heparins |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT02250489A IT1237518B (it) | 1989-11-24 | 1989-11-24 | Eparine supersolfatate |
Publications (3)
Publication Number | Publication Date |
---|---|
IT8922504A0 IT8922504A0 (it) | 1989-11-24 |
IT8922504A1 IT8922504A1 (it) | 1991-05-24 |
IT1237518B true IT1237518B (it) | 1993-06-08 |
Family
ID=11197161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT02250489A IT1237518B (it) | 1989-11-24 | 1989-11-24 | Eparine supersolfatate |
Country Status (9)
Country | Link |
---|---|
US (1) | US5164378A (it) |
EP (1) | EP0432537B1 (it) |
JP (1) | JPH03210302A (it) |
AT (1) | ATE117697T1 (it) |
DE (1) | DE69016383T2 (it) |
ES (1) | ES2068969T3 (it) |
IE (1) | IE904225A1 (it) |
IT (1) | IT1237518B (it) |
PT (1) | PT95961B (it) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1244373B (it) * | 1991-01-18 | 1994-07-08 | Sclavo Spa | Composizioni farmaceutiche per uso orale contenenti eparina a basso peso molecolare, loro preparazione ed uso |
SE9101155D0 (sv) * | 1991-04-18 | 1991-04-18 | Kabi Pharmacia Ab | Novel heparin derivatives |
US5514665A (en) * | 1993-12-30 | 1996-05-07 | University Of British Columbia | Method of preventing or reducing the risk of infection by bacterial pathogens utilizing simple and conjugated dextrans |
US5783568A (en) * | 1994-06-10 | 1998-07-21 | Sugen, Inc. | Methods for treating cancer and other cell proliferative diseases |
CA2235223A1 (en) | 1995-10-30 | 1997-05-09 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from heparinase i |
IT1285546B1 (it) * | 1996-01-16 | 1998-06-18 | Alfa Wassermann Spa | Uso del dermatano solfato a basso peso molecolare e delle specialita' medicinali che lo contengono nella terapia e nella prevenzione della |
IT1290814B1 (it) * | 1997-03-24 | 1998-12-11 | Istituto Scient Di Chimica E B | Glicosaminoglicani aventi elevata attivita' antitrombotica |
US7056504B1 (en) | 1998-08-27 | 2006-06-06 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase I and II |
WO2000012726A2 (en) | 1998-08-27 | 2000-03-09 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase i and ii |
US7412332B1 (en) * | 1999-04-23 | 2008-08-12 | Massachusetts Institute Of Technology | Method for analyzing polysaccharides |
WO2001066772A2 (en) * | 2000-03-08 | 2001-09-13 | Massachusetts Institute Of Technology | Heparinase iii and uses thereof |
EP1319183B1 (en) * | 2000-09-12 | 2009-03-25 | Massachusetts Institute Of Technology | Methods and products related to low molecular weight heparin |
AU2440802A (en) | 2000-10-18 | 2002-04-29 | Massachusetts Inst Technology | Methods and products related to pulmonary delivery of polysaccharides |
EP1238670A1 (en) * | 2001-03-07 | 2002-09-11 | Bruce Daniels | Composition and method for treating and preventing cardiovascular disease and hypertension. |
US7575886B2 (en) | 2002-03-11 | 2009-08-18 | Momenta Pharmaceuticals, Inc. | Analysis of sulfated polysaccharides |
AU2003225182B2 (en) * | 2002-04-25 | 2009-02-26 | Momenta Pharmaceuticals, Inc. | Methods and products for mucosal delivery |
GB0306615D0 (en) * | 2003-03-22 | 2003-04-30 | Astrazeneca Ab | New use |
WO2007019554A2 (en) * | 2005-08-08 | 2007-02-15 | Momenta Pharmaceuticals, Inc. | Polysaccharides for delivery of active agents |
US9139876B1 (en) | 2007-05-03 | 2015-09-22 | Momenta Pharmacueticals, Inc. | Method of analyzing a preparation of a low molecular weight heparin |
EP2526122B1 (en) * | 2010-01-19 | 2020-06-10 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
US9068957B2 (en) | 2011-02-21 | 2015-06-30 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
EP3398971A4 (en) * | 2015-12-30 | 2019-09-25 | Shenzhen Hepalink Pharmaceutical Group Co., Ltd. | OLIGOSACCHARIDE OF SULPHATED HEPARIN AND PREPARATION METHOD AND APPLICATION THEREOF |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2599172A (en) * | 1948-11-29 | 1952-06-03 | Searle & Co | Sulfuric acid esters of hyaluronic acid and processes for the production thereof |
FR1714M (fr) * | 1960-12-29 | 1963-02-25 | Chugai Pharmaceutical Co Ltd | Sulfates de polysaccharides faiblement polymérisés. |
DE1418844A1 (de) * | 1961-05-24 | 1969-05-08 | Hoechst Ag | Verfahren zur Herstellung von gegebenenfalls Phosphatgruppen enthaltenden Polysacchariden |
US3454560A (en) * | 1966-03-01 | 1969-07-08 | Seikagaku Kogyo Co Ltd | Process for the production of chondroitin polysulfate |
US3506642A (en) * | 1967-07-03 | 1970-04-14 | Canada Packers Ltd | Stable orally active heparinoid complexes |
IT1083903B (it) * | 1977-08-09 | 1985-05-25 | Lobo Srl | Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche |
SE7811306L (sv) * | 1978-11-01 | 1980-05-02 | Rothman Gunnvor | Antikoagulationsmedel samt sett for dess framstellning |
JPS57134419A (en) * | 1981-02-12 | 1982-08-19 | Eisai Co Ltd | Stable anticoagulant of blood |
DE3244214A1 (de) * | 1982-11-30 | 1984-05-30 | B. Braun Melsungen Ag, 3508 Melsungen | Verfahren zur reinigung und fraktionierung von heparin |
US4948881A (en) * | 1982-12-28 | 1990-08-14 | Sanofi | Process for the depolymerization and sulfation of polysaccharides |
IL70511A (en) * | 1982-12-28 | 1990-01-18 | Anic Spa | Process for the concurrent depolymerization and sulfation of polysaccharides at hydroxyl groups |
FR2538404B1 (it) * | 1982-12-28 | 1985-08-23 | Anic Spa | |
FR2548672A1 (fr) * | 1983-07-04 | 1985-01-11 | Pharmuka Lab | Oligosaccharides sulfates et leur utilisation comme medicaments |
JPS6049001A (ja) * | 1983-08-30 | 1985-03-18 | Eisai Co Ltd | アンチトロンビン3低親和性ヘパリン |
FR2584728B1 (fr) * | 1985-07-12 | 1987-11-20 | Choay Sa | Procede de sulfatation de glycosaminoglycanes et de leurs fragments |
FR2614026B1 (fr) * | 1987-04-16 | 1992-04-17 | Sanofi Sa | Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques |
DE3734815A1 (de) * | 1987-10-14 | 1989-04-27 | Luitpold Werk Chem Pharm | Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel |
DE3744119A1 (de) * | 1987-12-24 | 1989-07-06 | Basf Ag | Verwendung von polysulfatierten heparinen |
HU208029B (en) * | 1988-06-03 | 1993-07-28 | Italfarmaco Spa | Process for producing glycose-amino-glycane salts and pharmaceutical compositions containing them |
-
1989
- 1989-11-24 IT IT02250489A patent/IT1237518B/it active IP Right Grant
-
1990
- 1990-11-22 ES ES90122309T patent/ES2068969T3/es not_active Expired - Lifetime
- 1990-11-22 PT PT95961A patent/PT95961B/pt not_active IP Right Cessation
- 1990-11-22 EP EP90122309A patent/EP0432537B1/en not_active Expired - Lifetime
- 1990-11-22 JP JP2315683A patent/JPH03210302A/ja active Pending
- 1990-11-22 AT AT90122309T patent/ATE117697T1/de active
- 1990-11-22 IE IE422590A patent/IE904225A1/en unknown
- 1990-11-22 DE DE69016383T patent/DE69016383T2/de not_active Expired - Fee Related
- 1990-11-26 US US07/618,051 patent/US5164378A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0432537B1 (en) | 1995-01-25 |
US5164378A (en) | 1992-11-17 |
IE904225A1 (en) | 1991-06-05 |
ATE117697T1 (de) | 1995-02-15 |
PT95961B (pt) | 1996-12-31 |
DE69016383T2 (de) | 1995-07-13 |
EP0432537A3 (en) | 1991-11-13 |
IT8922504A1 (it) | 1991-05-24 |
DE69016383D1 (de) | 1995-03-09 |
EP0432537A2 (en) | 1991-06-19 |
JPH03210302A (ja) | 1991-09-13 |
PT95961A (pt) | 1991-09-13 |
ES2068969T3 (es) | 1995-05-01 |
IT8922504A0 (it) | 1989-11-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19951219 |