KR830006328A - 신규 선택적 용매화 분해방법 - Google Patents
신규 선택적 용매화 분해방법 Download PDFInfo
- Publication number
- KR830006328A KR830006328A KR1019810001857A KR810001857A KR830006328A KR 830006328 A KR830006328 A KR 830006328A KR 1019810001857 A KR1019810001857 A KR 1019810001857A KR 810001857 A KR810001857 A KR 810001857A KR 830006328 A KR830006328 A KR 830006328A
- Authority
- KR
- South Korea
- Prior art keywords
- decomposition
- formula
- selective solvation
- solvation decomposition
- trifluoroacetyl
- Prior art date
Links
- 238000000354 decomposition reaction Methods 0.000 title claims 4
- 238000007614 solvation Methods 0.000 title claims 4
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- -1 cyclic orthoester Chemical class 0.000 claims 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 claims 2
- PDVFSPNIEOYOQL-UHFFFAOYSA-N (4-methylphenyl)sulfonyl 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)OS(=O)(=O)C1=CC=C(C)C=C1 PDVFSPNIEOYOQL-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims 1
- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- NBTOZLQBSIZIKS-UHFFFAOYSA-N methoxide Chemical compound [O-]C NBTOZLQBSIZIKS-UHFFFAOYSA-N 0.000 claims 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
- C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 본문에 상술한 바와 같이, 일반식(1)의 화합물을 저급알코올을 함유하는 무수 매체에서; 촉매로서 무수파라-톨루엔 설폰산, 메탄설폰산, 과염소산 또는 염화수소의 존재하에 21-위치에서 선택적 용매화 분해하여 R1이 수소일때 11β-트리플루오로아세틸-17α-모노에스테르를 얻고;촉매량의 나트륨 메톡사이드의 존재하에 11β-위치에서 선택적 용매화 분해하여 R2및 R3가 에스테르화되고 함께 환식 오르토에스테르를 형성하지 않는 경우에는 17α,21-디에스테르, 및 R3가 에스테르화되지 않거나, 또는 화합물이 일반식(2)인 경우에는 17α-모노에스테를 얻고; 촉매량의 나트륨 메톡사이드의 존재하에 R1이 트리플루오로아세틸이고 R2및 R3가 함께 환식 오르토에스테르를 형성하는 경우에는 11β-및 21-위치에서 선택적 용매화 분해함을 특징으로 하는, 다음 일반식의 16-메틸코티코스테로이드에스테르류를 고선택도 및 고수율로 용매화분해하는 신규 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT71309 | 1980-05-27 | ||
| PT71309A PT71309A (en) | 1980-05-27 | 1980-05-27 | Process of selective |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830006328A true KR830006328A (ko) | 1983-09-24 |
| KR840001809B1 KR840001809B1 (ko) | 1984-10-20 |
Family
ID=20082722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810001857A KR840001809B1 (ko) | 1980-05-27 | 1981-05-27 | 신규 선택적 용매화 분해방법 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4343739A (ko) |
| JP (1) | JPS5767598A (ko) |
| KR (1) | KR840001809B1 (ko) |
| CH (1) | CH655320A5 (ko) |
| GB (1) | GB2079754B (ko) |
| HK (1) | HK52186A (ko) |
| IL (1) | IL62948A (ko) |
| NL (1) | NL182963C (ko) |
| PT (1) | PT71309A (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2510582B1 (fr) | 1981-07-30 | 1986-05-30 | Sipsy | Steroides esterifies en la position 17 et thio-esterifies en la position 21, leur procede de preparation et leur application comme medicament |
| IL66432A0 (en) * | 1981-08-04 | 1982-12-31 | Plurichemie Anstalt | Process for the preparation of steroidal esters |
| KR890000664B1 (ko) * | 1981-10-19 | 1989-03-22 | 바리 안소니 뉴우샘 | 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법 |
| DE19741874A1 (de) | 1997-09-23 | 1999-04-01 | Henkel Ecolab Gmbh & Co Ohg | Alkoholathaltiger Reiniger |
| FR2800635B1 (fr) * | 1999-11-05 | 2002-07-26 | Bio Merieux | Nanospheres composites, conjugues derives, procede de preparation et leurs utilisations |
| CN105646630A (zh) * | 2015-08-10 | 2016-06-08 | 山东泰华生物科技有限公司 | 一锅法制备丙酸氯倍他索中间体 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE418294B (sv) * | 1974-03-27 | 1981-05-18 | Plurichemie Anstalt | Sett att framstella en 16alfa- eller 16beta-9alfa-klor eller -fluorsteroidester |
| JPS50157357A (ko) * | 1974-06-10 | 1975-12-19 |
-
1980
- 1980-05-27 PT PT71309A patent/PT71309A/pt unknown
-
1981
- 1981-05-19 GB GB8115317A patent/GB2079754B/en not_active Expired
- 1981-05-25 IL IL62948A patent/IL62948A/xx unknown
- 1981-05-26 JP JP56078794A patent/JPS5767598A/ja active Granted
- 1981-05-26 CH CH3452/81A patent/CH655320A5/de not_active IP Right Cessation
- 1981-05-27 NL NLAANVRAGE8102602,A patent/NL182963C/xx not_active IP Right Cessation
- 1981-05-27 KR KR1019810001857A patent/KR840001809B1/ko active
- 1981-05-27 US US06/267,553 patent/US4343739A/en not_active Expired - Fee Related
-
1986
- 1986-07-10 HK HK521/86A patent/HK52186A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6411038B2 (ko) | 1989-02-23 |
| NL182963B (nl) | 1988-01-18 |
| NL182963C (nl) | 1988-06-16 |
| JPS5767598A (en) | 1982-04-24 |
| GB2079754A (en) | 1982-01-27 |
| CH655320A5 (de) | 1986-04-15 |
| HK52186A (en) | 1986-07-18 |
| GB2079754B (en) | 1984-11-07 |
| NL8102602A (nl) | 1981-12-16 |
| PT71309A (en) | 1980-06-01 |
| US4343739A (en) | 1982-08-10 |
| KR840001809B1 (ko) | 1984-10-20 |
| IL62948A (en) | 1984-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR850005452A (ko) | 항생물질 화합물의 제조방법 | |
| KR830005092A (ko) | 시클로프로판 카르복실산의 새로운 유도체 | |
| KR830006328A (ko) | 신규 선택적 용매화 분해방법 | |
| KR850008678A (ko) | 2-아미노-3-에톡시카보닐아미노-6-cP-플루오로-벤질아미노)-피리딘 글루코노이트의 제조방법 | |
| KR900016190A (ko) | 2-페닐피리딘 | |
| KR860008144A (ko) | 1,3- 디알킬 -2- 이미다졸리디논의 제조방법 | |
| KR830006324A (ko) | 루틴 데카 또는 노나(수소-황산염)나트륨염의 제조방법 | |
| KR830001952A (ko) | 세펄옥심(Cefuroxim)의 제조방법 | |
| KR830006302A (ko) | 신규 피리미딘 유도체의 제조방법 | |
| KR830007693A (ko) | 7-아미노 세펨 화합물을 제조하는 개량방법 | |
| KR840002766A (ko) | 디플루니잘 및 관현 화합물의 1-(알콕시 또는 아르옥시) 카보닐옥시알킬 에스테르의 제조방법 | |
| KR830007580A (ko) | 신규 피리미딘 유도체의 제조방법 | |
| KR860002959A (ko) | 제초제 중간화합물의 제법 | |
| KR880013872A (ko) | 이성화에 의한 4-펜터노에이트의 제조방법 | |
| KR880013860A (ko) | 알킬 스티렌의 제조방법 | |
| KR870000276A (ko) | (+)6-메톡시-α-메틸-2-나프탈렌 아세트산의 에스테르 제조방법 | |
| KR880011188A (ko) | N-아세틸-3-플루오로-뉴라민산 유도체 및 이의 제조방법 | |
| KR840008356A (ko) | 이속사졸릴 이미다졸리다논의 제조방법 | |
| KR850006428A (ko) | 에리드로마이신 아세트산염의 제조방법 | |
| KR840006227A (ko) | 5-티오-1,2,3-티아디아졸의 합성법 | |
| ES377089A1 (es) | Procedimiento para la obtencion de derivados de imidazo (2,1-a) isoindol. | |
| KR830007545A (ko) | 프로스타글란딘의 제조방법 | |
| KR840000593A (ko) | Tpa와 eg 혼합물의 유동성을 개선하는 방법 | |
| KR840000571A (ko) | 유기 게르마늄 화합물의 제조방법 | |
| KR840009099A (ko) | 사이클릭 디티오디아세트아미드의 제조방법 |