KR840002766A - 디플루니잘 및 관현 화합물의 1-(알콕시 또는 아르옥시) 카보닐옥시알킬 에스테르의 제조방법 - Google Patents
디플루니잘 및 관현 화합물의 1-(알콕시 또는 아르옥시) 카보닐옥시알킬 에스테르의 제조방법 Download PDFInfo
- Publication number
- KR840002766A KR840002766A KR1019820005700A KR820005700A KR840002766A KR 840002766 A KR840002766 A KR 840002766A KR 1019820005700 A KR1019820005700 A KR 1019820005700A KR 820005700 A KR820005700 A KR 820005700A KR 840002766 A KR840002766 A KR 840002766A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- hydrogen
- preparing
- treated
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 6
- 150000002148 esters Chemical class 0.000 title claims 3
- 238000004519 manufacturing process Methods 0.000 title claims 3
- 125000003545 alkoxy group Chemical group 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- GOYDNIKZWGIXJT-UHFFFAOYSA-N 1,2-difluorobenzene Chemical compound FC1=CC=CC=C1F GOYDNIKZWGIXJT-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 239000002841 Lewis acid Substances 0.000 claims 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 1
- WRYNUJYAXVDTCB-UHFFFAOYSA-M acetyloxymercury Chemical compound CC(=O)O[Hg] WRYNUJYAXVDTCB-UHFFFAOYSA-M 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 150000007517 lewis acids Chemical class 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- 229960004889 salicylic acid Drugs 0.000 claims 1
- AFQCYAJUSXIRJO-UHFFFAOYSA-M sodium;ethyl carbonate Chemical compound [Na+].CCOC([O-])=O AFQCYAJUSXIRJO-UHFFFAOYSA-M 0.000 claims 1
- 229920001567 vinyl ester resin Polymers 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C68/00—Preparation of esters of carbonic or haloformic acids
- C07C68/06—Preparation of esters of carbonic or haloformic acids from organic carbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
- C07C67/287—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Polyurethanes Or Polyureas (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Dental Preparations (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 다음 일반식(I°)의 화합물을 염기 및 다음 일반식(II)의 α-할로카보네이트로 처리함을 특징으로 하는, 다음 일반식(I)의 화합물의 제조방법.상기식에서 R은 (a) 저급 알킬; (b) 저급 사이클알킬; (c) 비치환된 또는 치환된 아릴; 또는 (d) 아르알킬이고; R1은 (a) 수소; (b) 저급 알킬; (c) 저급 사이클로알킬; 또는 (d) 아릴이며; R2는 (a) 수소; (b) 저급 알카노일; (c) 저급 알콕시카보닐이고; R3는 (a) 수소; 또는 (b) 저급 알킬이며; X 및 X1은 할로이다.
- 제1항에 있어서, (a) 살리실산을 염기 및 다음 일반식(II)의 α-할로카보네이트로 처리하고, (b) 생성된 다음 일반식(II')의 에스테르를 팔라듐 촉매계의 존재하에서 m-디플루오로벤젠과 커플링함을 특징으로 하는, 일반식(I)의 화합물의 제조방법.상기식에서 X1은 할로이고 R은 저급 알킬, 저급 사이클로알킬, 비치환된 또는 치환된 아릴 또는 아르알킬이며, R1은 수소, 저급알킬, 저급 사이클로알킬 또는 아릴이다.
- 제1항에 있어서, (a) 다음 일반식(III')의 화합물을 수은 아세테이트 및 황산의 존재하에서 비닐아세테이트로 처리하고; (b) 단계(a)로부터 생성된 비닐에스테르를 루이스 산의 존재하에서 무수 염화 수소로 염화수소화한후; (c) 단계(b)로부터 생성된 할로저급알킬 에스테르를 나트륨 에틸카보네이트로 처리함을 특징으로 하는 일반식(I)의 화합물의 제조방법.상기식에서 X는 할로이고 n은 1 내지 5이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33242681A | 1981-12-21 | 1981-12-21 | |
| US332426 | 1981-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR840002766A true KR840002766A (ko) | 1984-07-16 |
Family
ID=23298179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019820005700A KR840002766A (ko) | 1981-12-21 | 1982-12-20 | 디플루니잘 및 관현 화합물의 1-(알콕시 또는 아르옥시) 카보닐옥시알킬 에스테르의 제조방법 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0082404B1 (ko) |
| JP (1) | JPS58116440A (ko) |
| KR (1) | KR840002766A (ko) |
| AT (1) | ATE17941T1 (ko) |
| AU (1) | AU563270B2 (ko) |
| CA (1) | CA1191153A (ko) |
| DE (1) | DE3269109D1 (ko) |
| DK (1) | DK562482A (ko) |
| ES (1) | ES518359A0 (ko) |
| FI (1) | FI824202L (ko) |
| GR (1) | GR77835B (ko) |
| NO (1) | NO156200C (ko) |
| NZ (1) | NZ202721A (ko) |
| PT (1) | PT76003B (ko) |
| ZA (1) | ZA829334B (ko) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2482587A1 (fr) * | 1980-05-14 | 1981-11-20 | Poudres & Explosifs Ste Nale | Procede de synthese de chloroformiates a-chlores et nouveaux chloroformiates a-chlores |
| IL67445A (en) * | 1982-12-09 | 1985-11-29 | Teva Pharma | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids |
| IL67623A (en) * | 1983-01-05 | 1984-09-30 | Teva Pharma | 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it |
| FR2551058B1 (fr) * | 1983-08-26 | 1986-09-26 | Poudres & Explosifs Ste Nale | Procede de preparation de chloroformiates a-chlores |
| FR2574075B1 (fr) * | 1984-12-04 | 1987-09-18 | Poudres & Explosifs Ste Nale | Procede de synthese d'esters actifs d'acides carboxyliques, nouveaux carbonates alpha-halogenes utiles pour cette synthese et leur mode d'obtention |
| EP1679299A1 (en) * | 2003-10-08 | 2006-07-12 | Innovaprotean, S.L. | Compounds for the treatment of diseases associated with the formation of amyloid fibrils |
| US7423818B2 (en) * | 2005-07-15 | 2008-09-09 | Electro Scientific Industries, Inc. | Method of suppressing distortion of a working laser beam of a laser link processing system |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1175212A (en) * | 1967-03-09 | 1969-12-23 | Merck & Co Inc | Halo-Substituted 5-Phenylbenzoic Acids and their Derivatives |
-
1982
- 1982-12-06 NZ NZ202721A patent/NZ202721A/en unknown
- 1982-12-06 CA CA000417037A patent/CA1191153A/en not_active Expired
- 1982-12-07 AT AT82111313T patent/ATE17941T1/de not_active IP Right Cessation
- 1982-12-07 EP EP82111313A patent/EP0082404B1/en not_active Expired
- 1982-12-07 DE DE8282111313T patent/DE3269109D1/de not_active Expired
- 1982-12-07 FI FI824202A patent/FI824202L/fi not_active Application Discontinuation
- 1982-12-08 AU AU91331/82A patent/AU563270B2/en not_active Expired - Fee Related
- 1982-12-16 GR GR70094A patent/GR77835B/el unknown
- 1982-12-20 NO NO824280A patent/NO156200C/no unknown
- 1982-12-20 ZA ZA829334A patent/ZA829334B/xx unknown
- 1982-12-20 PT PT76003A patent/PT76003B/pt unknown
- 1982-12-20 KR KR1019820005700A patent/KR840002766A/ko unknown
- 1982-12-20 ES ES518359A patent/ES518359A0/es active Granted
- 1982-12-20 DK DK562482A patent/DK562482A/da not_active Application Discontinuation
- 1982-12-21 JP JP57223114A patent/JPS58116440A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PT76003A (en) | 1983-01-01 |
| CA1191153A (en) | 1985-07-30 |
| ES8401924A1 (es) | 1984-01-16 |
| PT76003B (en) | 1985-12-03 |
| ATE17941T1 (de) | 1986-02-15 |
| ES518359A0 (es) | 1984-01-16 |
| ZA829334B (en) | 1984-07-25 |
| GR77835B (ko) | 1984-09-25 |
| NO156200B (no) | 1987-05-04 |
| JPS58116440A (ja) | 1983-07-11 |
| AU9133182A (en) | 1983-06-30 |
| FI824202L (fi) | 1983-06-22 |
| NZ202721A (en) | 1985-12-13 |
| EP0082404A1 (en) | 1983-06-29 |
| AU563270B2 (en) | 1987-07-02 |
| FI824202A0 (fi) | 1982-12-07 |
| NO824280L (no) | 1983-06-22 |
| DK562482A (da) | 1983-06-22 |
| DE3269109D1 (en) | 1986-03-27 |
| NO156200C (no) | 1987-08-12 |
| EP0082404B1 (en) | 1986-02-12 |
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