KR840005146A - N-(2-메톡시에틸)-노르옥시모르폰의 제조방법 - Google Patents

N-(2-메톡시에틸)-노르옥시모르폰의 제조방법 Download PDF

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Publication number
KR840005146A
KR840005146A KR1019830002440A KR830002440A KR840005146A KR 840005146 A KR840005146 A KR 840005146A KR 1019830002440 A KR1019830002440 A KR 1019830002440A KR 830002440 A KR830002440 A KR 830002440A KR 840005146 A KR840005146 A KR 840005146A
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KR
South Korea
Prior art keywords
methoxyethyl
noroxymorphone
formula
preparing
following structural
Prior art date
Application number
KR1019830002440A
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English (en)
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KR900006754B1 (ko
Inventor
메르쯔 허버트
Original Assignee
벨만 페르호프
베링거 인겔하임 케이지
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Application filed by 벨만 페르호프, 베링거 인겔하임 케이지 filed Critical 벨만 페르호프
Publication of KR840005146A publication Critical patent/KR840005146A/ko
Application granted granted Critical
Publication of KR900006754B1 publication Critical patent/KR900006754B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

N-(2-메톡시에틸)-노르옥시모르폰의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. a)하기 구조식(Ⅳ)의 노르옥시모르폰을 하기 일반식(Ⅴ)의 2-메톡시에틸 할라이드와 반응시키거나, b)하기 구조식(Ⅵ)의 N-(2-메톡시에틸)-노르옥시모르폰 에틸렌 케탈을 희(稀)산과 반응시켜 케탈분해하고, 필요하면, 수득된 구조식(I)의 염기를 산부가염으로 전환시킴을 특징으로 하여 하기 구조식(I)의 N-(2-메톡시-에틸)노르옥시모르폰을 제조하는 방법.
    (상기식에서 X는 염소, 브롬 또는 요오드 원자임.)
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830002440A 1982-06-03 1983-06-01 N-(2-메톡시에틸)-노르옥시모르폰의 제조방법 KR900006754B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823220831 DE3220831A1 (de) 1982-06-03 1982-06-03 N-(2-methoxyethyl)-noroxymorphon, dessen saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
DE3220831.6 1982-06-03

Publications (2)

Publication Number Publication Date
KR840005146A true KR840005146A (ko) 1984-11-03
KR900006754B1 KR900006754B1 (ko) 1990-09-20

Family

ID=6165151

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830002440A KR900006754B1 (ko) 1982-06-03 1983-06-01 N-(2-메톡시에틸)-노르옥시모르폰의 제조방법

Country Status (27)

Country Link
US (1) US4473573A (ko)
EP (1) EP0096279B1 (ko)
JP (1) JPS591487A (ko)
KR (1) KR900006754B1 (ko)
AU (1) AU558319B2 (ko)
CA (1) CA1196633A (ko)
CS (1) CS236882B2 (ko)
CZ (1) CZ410691A3 (ko)
DD (1) DD209834A5 (ko)
DE (2) DE3220831A1 (ko)
DK (1) DK156068C (ko)
ES (1) ES8403487A1 (ko)
FI (1) FI78101C (ko)
GB (1) GB2121041B (ko)
GR (1) GR78273B (ko)
HK (1) HK1389A (ko)
HU (1) HU185832B (ko)
IE (1) IE55232B1 (ko)
IL (1) IL68872A0 (ko)
NO (1) NO158579C (ko)
NZ (1) NZ204451A (ko)
PH (1) PH19518A (ko)
PL (1) PL139569B1 (ko)
PT (1) PT76805B (ko)
SG (1) SG58788G (ko)
SU (1) SU1195909A3 (ko)
ZA (1) ZA833981B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4132159A1 (de) * 1991-09-27 1993-04-01 Boehringer Ingelheim Kg 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel
SI2506712T1 (sl) 2009-12-04 2019-06-28 Alkermes Pharma Ireland Limited, Derivati morfinana za zdravljenje prevelikega odmerka mamil
HUE041981T2 (hu) 2010-08-23 2019-06-28 Alkermes Pharma Ireland Ltd Eljárások antipszichotikum által kiváltott súlygyarapodás kezelésére
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
US9656961B2 (en) 2013-05-24 2017-05-23 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
CA2911231C (en) 2013-05-24 2021-12-07 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
WO2022101444A1 (en) 2020-11-12 2022-05-19 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
DE2538075A1 (de) * 1975-08-27 1977-03-17 Boehringer Sohn Ingelheim N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
FI78101B (fi) 1989-02-28
CS236882B2 (en) 1985-05-15
GB2121041A (en) 1983-12-14
CA1196633A (en) 1985-11-12
IL68872A0 (en) 1983-10-31
CZ410691A3 (en) 1993-02-17
KR900006754B1 (ko) 1990-09-20
AU1531483A (en) 1983-12-08
DK156068C (da) 1989-11-06
ES522897A0 (es) 1984-03-16
PL139569B1 (en) 1987-02-28
DE3220831A1 (de) 1983-12-08
DK250783A (da) 1983-12-04
NZ204451A (en) 1986-07-11
DE3361165D1 (en) 1985-12-12
SU1195909A3 (ru) 1985-11-30
DD209834A5 (de) 1984-05-23
IE831299L (en) 1983-12-03
ES8403487A1 (es) 1984-03-16
FI831941L (fi) 1983-12-04
AU558319B2 (en) 1987-01-29
PL242312A1 (en) 1985-04-09
EP0096279B1 (de) 1985-11-06
IE55232B1 (en) 1990-07-04
US4473573A (en) 1984-09-25
GR78273B (ko) 1984-09-26
FI831941A0 (fi) 1983-05-31
DK250783D0 (da) 1983-06-02
FI78101C (fi) 1989-06-12
JPS591487A (ja) 1984-01-06
PT76805B (de) 1986-04-09
ZA833981B (en) 1985-01-30
NO158579C (no) 1988-10-05
PT76805A (de) 1983-07-01
SG58788G (en) 1989-03-10
NO158579B (no) 1988-06-27
JPH0373552B2 (ko) 1991-11-22
NO831995L (no) 1983-12-05
HK1389A (en) 1989-01-13
HU185832B (en) 1985-04-28
GB8315292D0 (en) 1983-07-06
GB2121041B (en) 1985-09-11
EP0096279A1 (de) 1983-12-21
DK156068B (da) 1989-06-19
PH19518A (en) 1986-05-14

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