KR840008284A - 바이픈아졸 조성물의 제조방법 - Google Patents

바이픈아졸 조성물의 제조방법 Download PDF

Info

Publication number
KR840008284A
KR840008284A KR1019840001659A KR840001659A KR840008284A KR 840008284 A KR840008284 A KR 840008284A KR 1019840001659 A KR1019840001659 A KR 1019840001659A KR 840001659 A KR840001659 A KR 840001659A KR 840008284 A KR840008284 A KR 840008284A
Authority
KR
South Korea
Prior art keywords
formula
diluent
suitably
imidazole
composition
Prior art date
Application number
KR1019840001659A
Other languages
English (en)
Inventor
아담스 카를하인츠
Original Assignee
요하임 그렘, 귄터 페터스
바이엘 아크티엔 게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 요하임 그렘, 귄터 페터스, 바이엘 아크티엔 게젤샤프트 filed Critical 요하임 그렘, 귄터 페터스
Publication of KR840008284A publication Critical patent/KR840008284A/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용 없음.

Description

바이픈아졸 조성물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 구조식(II)의 카빈올을 적절하게는 희석제의 존재하에서 티오닐-비스-이미다졸과 반응시키거나; 일반식(III)의 할로게노-메탄을 적절하게는 산결합제 및 희석제의 존재하에서 이미다졸과 반응시키거나, 적절하게는 희석제의 존재하에서 이미다졸의 은염 또는 알카리 금속염과 반응시키거나, 적절하게는 희석제의 존재하에서 구조식(IV)의 트리메틸실릴 이미다졸과 반응시키고, 이렇게 하여 수득된 구조식(I)의 아졸-l-일 메탄올 경우에 따라 생리적으로 허용되는 산과 반응시킨후, 그 생성물을 5 내지 25%의 확산제, 통상의 제형화보조제 및 용매와 혼합함을 특징으로 하여 바이픈아졸 조성물을 제조하는 방법.
    상기 식에서, Hal은 할로겐을 나타낸다.
  2. 제1항에 있어서, 0.05 내지 1.5%, 바람직하게는 0.1 내지 1%의 바이픈아졸을 함유함을 특징으로 하는 조성물의 제조방법.
  3. 제1항에 있어서, 1.0%의 바이픈아졸을 함유함을 특징으로 하는 조성물의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840001659A 1983-03-30 1984-03-30 바이픈아졸 조성물의 제조방법 KR840008284A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833311701 DE3311701A1 (de) 1983-03-30 1983-03-30 Antimykotische mittel mit hoher wirkstoff-freisetzung in form von creme
DEP3311701.2 1983-03-30

Publications (1)

Publication Number Publication Date
KR840008284A true KR840008284A (ko) 1984-12-14

Family

ID=6195162

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840001659A KR840008284A (ko) 1983-03-30 1984-03-30 바이픈아졸 조성물의 제조방법

Country Status (19)

Country Link
JP (1) JPS59184106A (ko)
KR (1) KR840008284A (ko)
AU (1) AU564956B2 (ko)
BE (1) BE899278A (ko)
CA (1) CA1212327A (ko)
CH (1) CH660126A5 (ko)
CY (1) CY1358A (ko)
DE (1) DE3311701A1 (ko)
ES (3) ES8503947A1 (ko)
FR (1) FR2543435B1 (ko)
GB (1) GB2137091B (ko)
GR (1) GR81485B (ko)
IT (1) IT1173761B (ko)
KE (1) KE3704A (ko)
LU (1) LU85271A1 (ko)
PH (1) PH20420A (ko)
PT (1) PT78313B (ko)
SE (1) SE8401748L (ko)
ZA (1) ZA842337B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087620A (en) * 1990-05-17 1992-02-11 Bristol-Myers Squibb Co. Controlled dermal penetration enhancement using imidazoles
WO1993025238A1 (en) * 1992-06-08 1993-12-23 Schering-Plough Healthcare Products, Inc. Stable imidazole anti-fungal powder compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2461406C2 (de) * 1974-12-24 1984-06-14 Bayer Ag, 5090 Leverkusen Azolyl-(1)-methane und deren Salze, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
DE3045914A1 (de) * 1980-12-05 1982-07-22 Bayer Ag, 5090 Leverkusen Antimykotische mittel mit hoher wirkstoff-freisetzung in form von elastischen fluessig-pflastern
DE3045913A1 (de) * 1980-12-05 1982-07-08 Bayer Ag, 5090 Leverkusen Antimykotische mittel mit hoher wirkstoff-freisetzung
DE3045915A1 (de) * 1980-12-05 1982-07-08 Bayer Ag, 5090 Leverkusen Antimykotische mittel mit hoher wirkstoff-freisetzung in form von elastischen fluessig-pflastern
DE3106635A1 (de) * 1981-02-23 1982-09-09 Bayer Ag Antimykotisches mittel mit hoher wirkstoff-freisetzung in form von stiften

Also Published As

Publication number Publication date
PT78313B (en) 1986-06-02
KE3704A (en) 1987-03-27
CY1358A (en) 1987-08-07
ES539290A0 (es) 1985-11-16
SE8401748L (sv) 1984-10-01
ZA842337B (en) 1984-11-28
ES530846A0 (es) 1985-04-16
PH20420A (en) 1987-01-05
GB2137091B (en) 1986-10-01
AU2623684A (en) 1984-10-04
GB2137091A (en) 1984-10-03
IT8420303A0 (it) 1984-03-29
BE899278A (fr) 1984-10-01
SE8401748D0 (sv) 1984-03-29
LU85271A1 (de) 1984-11-14
CH660126A5 (de) 1987-03-31
AU564956B2 (en) 1987-09-03
ES8601693A1 (es) 1985-11-16
CA1212327A (en) 1986-10-07
ES539289A0 (es) 1985-11-16
PT78313A (en) 1984-04-01
ES8601692A1 (es) 1985-11-16
GB8408067D0 (en) 1984-05-10
IT1173761B (it) 1987-06-24
ES8503947A1 (es) 1985-04-16
FR2543435B1 (fr) 1988-06-17
GR81485B (ko) 1984-12-11
FR2543435A1 (fr) 1984-10-05
JPS59184106A (ja) 1984-10-19
DE3311701A1 (de) 1984-10-04

Similar Documents

Publication Publication Date Title
KR840000528A (ko) 비스-트리아졸 유도체의 제조방법
KR850004246A (ko) 헤테로-폴리사이클 방향족 화합물의 제법
KR830009089A (ko) 2-펜옥시알킬-1,2,4-트리아졸-3-원 항우울제의 제조방법
KR850003414A (ko) (2-니트록시메틸-6-클로로피리딘)과 (β-사이클로덱스트린)의 교합화합물의 제조방법
KR830009084A (ko) 퀴놀린 카복실산 유도체의 제조방법
EP0692486A3 (de) Bisindenyl-Derivat und Verfahren zu seiner Herstellung
KR830007648A (ko) 크산틴산염의 제조방법
KR840004756A (ko) 항 정신질환제의 제조방법
KR830008684A (ko) 면역 글로불린 접합체의 제조방법
KR850008678A (ko) 2-아미노-3-에톡시카보닐아미노-6-cP-플루오로-벤질아미노)-피리딘 글루코노이트의 제조방법
KR840008283A (ko) 바이폰아졸 조성물의 제조방법
KR840008284A (ko) 바이픈아졸 조성물의 제조방법
KR880005145A (ko) N-글리코릴네우라민산 함유 당지질 및 그 제조방법
ES8207527A1 (es) Un metodo de preparacion de derivados de imidazolidinonas
KR840005146A (ko) N-(2-메톡시에틸)-노르옥시모르폰의 제조방법
ATE57530T1 (de) Verfahren zur herstellung von triazolylalkoholen.
KR840004720A (ko) 살충제 조성물 및 이의 제조방법
KR840006657A (ko) 이소퀴놀린 화합물의 제조방법
KR880000411A (ko) 벤조구아나민 유도체의 제법
EP0109817A3 (en) Process for preparing oxazolinoazetidinones
KR830001644A (ko) 아릴알킬-및 아릴옥시알킬포스포네이트의 제조방법
KR840007422A (ko) 디아조 화합물의 제조방법
KR840000503A (ko) 4-벤조일-5-히드록시 피라졸계 화합물의 제조방법
KR840005318A (ko) 살균제 조성물
KR860002473A (ko) 4-메틸-5-티오포름아미디노메틸이미다졸 디하이드로클로라이드의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application