ES8601692A1 - Un procedimiento para la obtencion de preparados del bifonazol con elevada liberacion del producto activo - Google Patents
Un procedimiento para la obtencion de preparados del bifonazol con elevada liberacion del producto activoInfo
- Publication number
- ES8601692A1 ES8601692A1 ES539289A ES539289A ES8601692A1 ES 8601692 A1 ES8601692 A1 ES 8601692A1 ES 539289 A ES539289 A ES 539289A ES 539289 A ES539289 A ES 539289A ES 8601692 A1 ES8601692 A1 ES 8601692A1
- Authority
- ES
- Spain
- Prior art keywords
- cream
- active compounds
- high release
- antimycotic agent
- antimycotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
METODO DE PREPARACION PARA EL BIFONAZOL DE FORMULA (I). SE HACE REACCIONAR EL HALOGENO METANO DE FORMULA (II) CON IMIDAZOL EN PRESENCIA DE UN AGENTE ACEPTOR DE ACIDO Y DE UN DILUYENTE O CON LAS SALES DE PLATA O ALCALINAS DEL IMIDAZOL EN PRESENCIA DE UN DILUYENTE. EL AZOLIL-(1)-METANO OBTENIDO SE HACE REACCIONAR CON ACIDOS FISIOLOGICAMENTE TOLERABLES. SE MEZCLA CON 10 A 60 UNIDADES DE AGENTE EXTENDEDOR Y DE 20 A 80 UNIDADES EN PESO DE DISOLVENTE. SE PUEDE ADICIONAR UN PROPULSOR PARA UTILIZARLO COMO SPRAY. APLICABLE COMO ANTIMICOTICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833311701 DE3311701A1 (de) | 1983-03-30 | 1983-03-30 | Antimykotische mittel mit hoher wirkstoff-freisetzung in form von creme |
Publications (2)
Publication Number | Publication Date |
---|---|
ES539289A0 ES539289A0 (es) | 1985-11-16 |
ES8601692A1 true ES8601692A1 (es) | 1985-11-16 |
Family
ID=6195162
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530846A Expired ES8503947A1 (es) | 1983-03-30 | 1984-03-22 | Agentes antimicoticos con elevada liberacion del producto activo |
ES539290A Expired ES8601693A1 (es) | 1983-03-30 | 1984-12-31 | Un procedimiento para la obtencion de preparados del bifonazol con elevada liberacion del producto activo |
ES539289A Expired ES8601692A1 (es) | 1983-03-30 | 1984-12-31 | Un procedimiento para la obtencion de preparados del bifonazol con elevada liberacion del producto activo |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530846A Expired ES8503947A1 (es) | 1983-03-30 | 1984-03-22 | Agentes antimicoticos con elevada liberacion del producto activo |
ES539290A Expired ES8601693A1 (es) | 1983-03-30 | 1984-12-31 | Un procedimiento para la obtencion de preparados del bifonazol con elevada liberacion del producto activo |
Country Status (19)
Country | Link |
---|---|
JP (1) | JPS59184106A (es) |
KR (1) | KR840008284A (es) |
AU (1) | AU564956B2 (es) |
BE (1) | BE899278A (es) |
CA (1) | CA1212327A (es) |
CH (1) | CH660126A5 (es) |
CY (1) | CY1358A (es) |
DE (1) | DE3311701A1 (es) |
ES (3) | ES8503947A1 (es) |
FR (1) | FR2543435B1 (es) |
GB (1) | GB2137091B (es) |
GR (1) | GR81485B (es) |
IT (1) | IT1173761B (es) |
KE (1) | KE3704A (es) |
LU (1) | LU85271A1 (es) |
PH (1) | PH20420A (es) |
PT (1) | PT78313B (es) |
SE (1) | SE8401748L (es) |
ZA (1) | ZA842337B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5087620A (en) * | 1990-05-17 | 1992-02-11 | Bristol-Myers Squibb Co. | Controlled dermal penetration enhancement using imidazoles |
WO1993025238A1 (en) * | 1992-06-08 | 1993-12-23 | Schering-Plough Healthcare Products, Inc. | Stable imidazole anti-fungal powder compositions |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2461406C2 (de) * | 1974-12-24 | 1984-06-14 | Bayer Ag, 5090 Leverkusen | Azolyl-(1)-methane und deren Salze, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel |
DE3045914A1 (de) * | 1980-12-05 | 1982-07-22 | Bayer Ag, 5090 Leverkusen | Antimykotische mittel mit hoher wirkstoff-freisetzung in form von elastischen fluessig-pflastern |
DE3045913A1 (de) * | 1980-12-05 | 1982-07-08 | Bayer Ag, 5090 Leverkusen | Antimykotische mittel mit hoher wirkstoff-freisetzung |
DE3045915A1 (de) * | 1980-12-05 | 1982-07-08 | Bayer Ag, 5090 Leverkusen | Antimykotische mittel mit hoher wirkstoff-freisetzung in form von elastischen fluessig-pflastern |
DE3106635A1 (de) * | 1981-02-23 | 1982-09-09 | Bayer Ag | Antimykotisches mittel mit hoher wirkstoff-freisetzung in form von stiften |
-
1983
- 1983-03-30 DE DE19833311701 patent/DE3311701A1/de not_active Withdrawn
-
1984
- 1984-03-22 ES ES530846A patent/ES8503947A1/es not_active Expired
- 1984-03-26 PT PT78313A patent/PT78313B/pt unknown
- 1984-03-26 JP JP59056374A patent/JPS59184106A/ja active Pending
- 1984-03-27 PH PH30446A patent/PH20420A/en unknown
- 1984-03-28 LU LU85271A patent/LU85271A1/de unknown
- 1984-03-28 CA CA000450707A patent/CA1212327A/en not_active Expired
- 1984-03-28 GR GR74236A patent/GR81485B/el unknown
- 1984-03-29 IT IT20303/84A patent/IT1173761B/it active
- 1984-03-29 CY CY135884A patent/CY1358A/xx unknown
- 1984-03-29 CH CH1598/84A patent/CH660126A5/de not_active IP Right Cessation
- 1984-03-29 GB GB08408067A patent/GB2137091B/en not_active Expired
- 1984-03-29 ZA ZA842337A patent/ZA842337B/xx unknown
- 1984-03-29 BE BE0/212659A patent/BE899278A/fr not_active IP Right Cessation
- 1984-03-29 AU AU26236/84A patent/AU564956B2/en not_active Expired
- 1984-03-29 SE SE8401748A patent/SE8401748L/xx unknown
- 1984-03-29 FR FR8404906A patent/FR2543435B1/fr not_active Expired
- 1984-03-30 KR KR1019840001659A patent/KR840008284A/ko not_active Application Discontinuation
- 1984-12-31 ES ES539290A patent/ES8601693A1/es not_active Expired
- 1984-12-31 ES ES539289A patent/ES8601692A1/es not_active Expired
-
1987
- 1987-03-09 KE KE3704A patent/KE3704A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
PT78313B (en) | 1986-06-02 |
KE3704A (en) | 1987-03-27 |
CY1358A (en) | 1987-08-07 |
ES539290A0 (es) | 1985-11-16 |
SE8401748L (sv) | 1984-10-01 |
ZA842337B (en) | 1984-11-28 |
ES530846A0 (es) | 1985-04-16 |
PH20420A (en) | 1987-01-05 |
GB2137091B (en) | 1986-10-01 |
AU2623684A (en) | 1984-10-04 |
GB2137091A (en) | 1984-10-03 |
IT8420303A0 (it) | 1984-03-29 |
BE899278A (fr) | 1984-10-01 |
SE8401748D0 (sv) | 1984-03-29 |
LU85271A1 (de) | 1984-11-14 |
CH660126A5 (de) | 1987-03-31 |
AU564956B2 (en) | 1987-09-03 |
ES8601693A1 (es) | 1985-11-16 |
CA1212327A (en) | 1986-10-07 |
ES539289A0 (es) | 1985-11-16 |
PT78313A (en) | 1984-04-01 |
GB8408067D0 (en) | 1984-05-10 |
IT1173761B (it) | 1987-06-24 |
ES8503947A1 (es) | 1985-04-16 |
KR840008284A (ko) | 1984-12-14 |
FR2543435B1 (fr) | 1988-06-17 |
GR81485B (es) | 1984-12-11 |
FR2543435A1 (fr) | 1984-10-05 |
JPS59184106A (ja) | 1984-10-19 |
DE3311701A1 (de) | 1984-10-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20050723 |