KR840007730A - 고결정성 나트륨 세포페라존의 제조방법 - Google Patents

고결정성 나트륨 세포페라존의 제조방법 Download PDF

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Publication number
KR840007730A
KR840007730A KR1019840000544A KR840000544A KR840007730A KR 840007730 A KR840007730 A KR 840007730A KR 1019840000544 A KR1019840000544 A KR 1019840000544A KR 840000544 A KR840000544 A KR 840000544A KR 840007730 A KR840007730 A KR 840007730A
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KR
South Korea
Prior art keywords
acetone
sodium
water
volumetric
solution containing
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Application number
KR1019840000544A
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English (en)
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KR870001071B1 (ko
Inventor
조셉오브린 Ii 다니엘
Original Assignee
테렌스 제이. 감라거
화이자 인코포레이티드
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Publication of KR840007730A publication Critical patent/KR840007730A/ko
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Publication of KR870001071B1 publication Critical patent/KR870001071B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

내용 없음.

Description

고결정성 나트륨 세포페라존의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. (a) 1.0내지 1.5용적비의 물, 2.0내지 5.0용적비의 아세톤, 및 1중량비의 나트륨 세포페라존을 함유하는 물/아세톤/나트륨 세포페라존 용액을 충분한 아세톤과 결합시켜서 약 5내지 25℃의 온도에서 약 14% 내지 17% 아세톤 기준의 용적비의 물을 함유하는 물/아세톤 용액을 만들고 (b) 생성된 슬러리에 충분한 아세톤을 가하여 아세톤 기준 약 3%내지 5%물을 함유하는 물/아세톤 용액을 만들며 (c) 생성되 결정성 나트륨 세포 페라존을 상기의 슬러리에서 분리하는 단계를 특징으로하는 고결성 나트륨 세포페라존을 제조하는 방법.
  2. 제1항에 있어서, 상기의 온도가 18내지 25℃인 방법.
  3. 제1항에 있어서, 상기의 물/아세톤/나트륨 세포페라존 용액을, 세포 페라존유리산의 아세톤 용액과 중탄산나트륨, 탄산나트륨 및 나트륨 2-에틸 헥사노에이트 그룹에서 선택된 염기 약1당량을 함유하는 수용성 용액과 결합시켜 제조하는 방법.
  4. 제1항에 있어서, 상기의 결정성 나트륨 세포페라존을 진공하에서 약 25내지 50℃에서 건조시키는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840000544A 1983-02-07 1984-02-06 고 결정성 나트륨 세포페라존의 제조방법 KR870001071B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/464,223 US4456753A (en) 1983-02-07 1983-02-07 Process for the manufacture of highly crystalline sodium cefoperazone
US464223 1983-02-07
US464,223 1983-02-07

Publications (2)

Publication Number Publication Date
KR840007730A true KR840007730A (ko) 1984-12-10
KR870001071B1 KR870001071B1 (ko) 1987-05-27

Family

ID=23843028

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840000544A KR870001071B1 (ko) 1983-02-07 1984-02-06 고 결정성 나트륨 세포페라존의 제조방법

Country Status (22)

Country Link
US (1) US4456753A (ko)
EP (1) EP0118196B1 (ko)
JP (1) JPH0643429B2 (ko)
KR (1) KR870001071B1 (ko)
AU (1) AU541675B2 (ko)
CA (1) CA1190220A (ko)
DE (1) DE3461802D1 (ko)
DK (1) DK152757C (ko)
ES (1) ES529485A0 (ko)
FI (1) FI75571C (ko)
GR (1) GR81694B (ko)
HK (1) HK99687A (ko)
HU (1) HU190544B (ko)
IE (1) IE56752B1 (ko)
IL (1) IL70872A (ko)
NZ (1) NZ207038A (ko)
PH (1) PH19052A (ko)
PL (1) PL146540B1 (ko)
PT (1) PT78058B (ko)
SG (1) SG70087G (ko)
YU (1) YU43562B (ko)
ZA (1) ZA84853B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9609872A (pt) 1995-07-17 1999-03-23 Warner Lambert Co Hemi sal de cálcio de ácido (R-(R*R*)]-2-(4-fluorfenil-)-beta delta-diidróxi-5-(1-metiletil)-3-fenil-4- [(fenilamino) carbonil]-1H- pirrol-1heptanóico (atorvasta-tina)c ristalino
WO1999024441A1 (en) * 1997-11-10 1999-05-20 Dsm N.V. Crystallization of beta-lactam compounds
TR200102771T2 (tr) * 1999-04-01 2002-04-22 Dsm N. V. Kristalleştirme ile elde edilen aglomeralar
IT1318467B1 (it) * 2000-04-14 2003-08-25 Antibioticos Spa Processo per la sintesi di cefoperazone sodico ad elevatacristallinita'.
US20090221989A1 (en) * 2005-09-21 2009-09-03 Novabay Pharmaceuticals Inc System and method for the prevention and treatment of bacterial and fungal infections including urinary tract infections (uti) using a hypohalous acid composition
CN101863907B (zh) * 2010-07-07 2012-05-23 福建省福抗药业股份有限公司 一种头孢哌酮钠的结晶方法
CN104470933A (zh) * 2012-07-17 2015-03-25 中化帝斯曼制药有限公司荷兰公司 头孢哌酮钠新晶型
CN103951679B (zh) * 2014-04-29 2016-04-27 悦康药业集团有限公司 一种头孢哌酮钠化合物及其药物组合物
CN104327099A (zh) * 2014-09-29 2015-02-04 联合康兴（北京）医药科技有限公司 头孢哌酮钠化合物实体及组合物和用途
CN105440057B (zh) * 2015-11-25 2017-10-17 华北制药河北华民药业有限责任公司 一种制备头孢哌酮钠的方法
CN112442048B (zh) * 2020-11-10 2022-04-08 华北制药河北华民药业有限责任公司 一种头孢匹胺钠的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087424A (en) * 1974-05-09 1978-05-02 Toyama Chemical Co., Ltd. Novel penicillins and cephalosporins and process for producing the same
GB1508071A (en) * 1976-01-19 1978-04-19 Toyama Chemical Co Ltd Cephalosporins and process for producing the same
DE2600880C2 (de) * 1976-01-12 1984-09-13 Toyama Chemical Co. Ltd., Tokio / Tokyo Cephalosporinverbindungen
IL53427A0 (en) * 1976-11-24 1978-01-31 Lilly Co Eli Method of preparing a rapidly dissolving powder of sterile crystalline cefozolin sodium for parenteral administration

Also Published As

Publication number Publication date
EP0118196B1 (en) 1986-12-30
HK99687A (en) 1987-12-31
SG70087G (en) 1988-02-19
IE840273L (en) 1984-08-07
FI840475A (fi) 1984-08-08
AU541675B2 (en) 1985-01-17
DK152757C (da) 1988-09-26
NZ207038A (en) 1986-05-09
HUT34208A (en) 1985-02-28
IE56752B1 (en) 1991-12-04
EP0118196A1 (en) 1984-09-12
CA1190220A (en) 1985-07-09
AU2420984A (en) 1984-08-16
YU43562B (en) 1989-08-31
KR870001071B1 (ko) 1987-05-27
HU190544B (en) 1986-09-29
PH19052A (en) 1985-12-11
IL70872A (en) 1987-08-31
ES8504700A1 (es) 1985-05-01
YU20684A (en) 1986-06-30
PL246090A1 (en) 1985-02-13
PT78058B (en) 1986-06-02
DK51784A (da) 1984-08-08
GR81694B (ko) 1984-12-12
JPH0643429B2 (ja) 1994-06-08
FI840475A0 (fi) 1984-02-06
ES529485A0 (es) 1985-05-01
US4456753A (en) 1984-06-26
PT78058A (en) 1984-03-01
FI75571B (fi) 1988-03-31
FI75571C (fi) 1988-07-11
DE3461802D1 (en) 1987-02-05
DK152757B (da) 1988-05-09
ZA84853B (en) 1985-09-25
DK51784D0 (da) 1984-02-06
IL70872A0 (en) 1984-05-31
JPS59148789A (ja) 1984-08-25
PL146540B1 (en) 1989-02-28

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