KR830005250A - 빈크리스틴의 제조방법 - Google Patents
빈크리스틴의 제조방법 Download PDFInfo
- Publication number
- KR830005250A KR830005250A KR1019810001096A KR810001096A KR830005250A KR 830005250 A KR830005250 A KR 830005250A KR 1019810001096 A KR1019810001096 A KR 1019810001096A KR 810001096 A KR810001096 A KR 810001096A KR 830005250 A KR830005250 A KR 830005250A
- Authority
- KR
- South Korea
- Prior art keywords
- vincristine
- manufacturing
- formula
- compound
- epoxide
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title 1
- 229960004528 vincristine Drugs 0.000 title 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 title 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/02—Ergot alkaloids of the cyclic peptide type
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 다음 구조식(Ⅰ)의 화합물(R1,R2및 R3가 후술한 바와 같고 R4가 CH3임)을 테트라하이드로푸란 존재하에 -50℃ 이하에서 크로메이트-황산 수용액과 반응시킴을 특징으로 하여 다음 구조식(Ⅰ)의 화합물을 제조하는 방법.상기 구조식에서R1,R2및 R3가 각각일 경우, R1및 R2중 하나는 H 또는 OH이고 다른 하나는 C2H5이며 R3는 H이고,R1,R2및 R3가 함께일 경우 R2및 R3는 α-에폭사이드이고, R1은 C2H5이며,R4는 CHO이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13661780A | 1980-04-02 | 1980-04-02 | |
US136617 | 1980-04-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830005250A true KR830005250A (ko) | 1983-08-03 |
KR850000242B1 KR850000242B1 (ko) | 1985-03-12 |
Family
ID=22473610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019810001096A KR850000242B1 (ko) | 1980-04-02 | 1981-04-01 | 빈크리스틴의 제조 방법 |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0037290B1 (ko) |
JP (1) | JPS56154488A (ko) |
KR (1) | KR850000242B1 (ko) |
CA (1) | CA1169857A (ko) |
DE (1) | DE3162739D1 (ko) |
GB (1) | GB2073195B (ko) |
HU (1) | HU183385B (ko) |
IE (1) | IE51082B1 (ko) |
IL (1) | IL62490A (ko) |
MY (1) | MY8500572A (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4375432A (en) * | 1981-05-12 | 1983-03-01 | Eli Lilly And Company | Method of preparing vincristine |
LU84640A1 (fr) * | 1983-02-10 | 1984-11-08 | Onmichem S A | Nouveau procede d'obtention de la vincristine et du sulfate de vincristine |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3354163A (en) * | 1966-12-15 | 1967-11-21 | Eli Lillty And Company | Nu-desmethylvinblastine |
US3899493A (en) * | 1972-12-29 | 1975-08-12 | Richter Gedeon Vegyeszet | Chromic acid oxidation of vinblastine sulfate to form vincristine |
HU168433B (ko) * | 1973-12-20 | 1976-04-28 | ||
HU178706B (en) * | 1979-04-23 | 1982-06-28 | Richter Gedeon Vegyeszet | Process for preparing bis-indole alkaloids and acid addition salts thereof |
-
1981
- 1981-03-01 HU HU81848A patent/HU183385B/hu unknown
- 1981-03-26 IL IL62490A patent/IL62490A/xx not_active IP Right Cessation
- 1981-03-26 CA CA000373921A patent/CA1169857A/en not_active Expired
- 1981-04-01 IE IE747/81A patent/IE51082B1/en not_active IP Right Cessation
- 1981-04-01 JP JP5002481A patent/JPS56154488A/ja active Granted
- 1981-04-01 KR KR1019810001096A patent/KR850000242B1/ko active
- 1981-04-02 EP EP81301438A patent/EP0037290B1/en not_active Expired
- 1981-04-02 GB GB8110427A patent/GB2073195B/en not_active Expired
- 1981-04-02 DE DE8181301438T patent/DE3162739D1/de not_active Expired
-
1985
- 1985-12-30 MY MY572/85A patent/MY8500572A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
GB2073195B (en) | 1983-09-07 |
MY8500572A (en) | 1985-12-31 |
EP0037290B1 (en) | 1984-03-21 |
IE51082B1 (en) | 1986-10-01 |
KR850000242B1 (ko) | 1985-03-12 |
IE810747L (en) | 1981-10-02 |
CA1169857A (en) | 1984-06-26 |
IL62490A0 (en) | 1981-05-20 |
GB2073195A (en) | 1981-10-14 |
IL62490A (en) | 1984-03-30 |
JPS56154488A (en) | 1981-11-30 |
EP0037290A1 (en) | 1981-10-07 |
HU183385B (en) | 1984-04-28 |
JPH0125756B2 (ko) | 1989-05-19 |
DE3162739D1 (de) | 1984-04-26 |
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