ATE538080T1 - Curcuminsynthese - Google Patents
CurcuminsyntheseInfo
- Publication number
- ATE538080T1 ATE538080T1 AT07723370T AT07723370T ATE538080T1 AT E538080 T1 ATE538080 T1 AT E538080T1 AT 07723370 T AT07723370 T AT 07723370T AT 07723370 T AT07723370 T AT 07723370T AT E538080 T1 ATE538080 T1 AT E538080T1
- Authority
- AT
- Austria
- Prior art keywords
- curcumin
- synthesis
- curcumin synthesis
- vanillin
- acetylacetone
- Prior art date
Links
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 title abstract 4
- 235000012754 curcumin Nutrition 0.000 title abstract 2
- 229940109262 curcumin Drugs 0.000 title abstract 2
- 239000004148 curcumin Substances 0.000 title abstract 2
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 abstract 1
- 239000004327 boric acid Substances 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 235000012141 vanillin Nutrition 0.000 abstract 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 abstract 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
- C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
- C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06006519 | 2006-03-29 | ||
| PCT/EP2007/002403 WO2007110168A1 (en) | 2006-03-29 | 2007-03-19 | Curcumin synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE538080T1 true ATE538080T1 (de) | 2012-01-15 |
Family
ID=38093544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07723370T ATE538080T1 (de) | 2006-03-29 | 2007-03-19 | Curcuminsynthese |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7964755B2 (de) |
| EP (1) | EP1999097B1 (de) |
| JP (1) | JP5341747B2 (de) |
| KR (1) | KR20080112340A (de) |
| CN (1) | CN101454267B (de) |
| AT (1) | ATE538080T1 (de) |
| WO (1) | WO2007110168A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011507919A (ja) | 2007-12-27 | 2011-03-10 | バクスター・インターナショナル・インコーポレイテッド | 修飾第ｉｘ因子 |
| AU2009269530A1 (en) * | 2008-07-07 | 2010-01-14 | Laila Pharmaceuticals Pvt. Ltd. | Orally active curcuminoid compounds |
| ES2837014T3 (es) * | 2012-05-08 | 2021-06-29 | Asac Compania De Biotecnologia E Investig Sa | Procedimiento para la síntesis de curcumina |
| CN102701933A (zh) * | 2012-05-30 | 2012-10-03 | 江南大学 | 一种采用氧化铝负载氟化钾固体碱催化合成姜黄素的方法 |
| CN102701934A (zh) * | 2012-05-30 | 2012-10-03 | 江南大学 | 一种以氧化锌负载氧化镁为催化剂催化合成姜黄素的方法 |
| CN102911022B (zh) * | 2012-10-25 | 2015-12-09 | 山东鲁诺动物药业有限公司 | 一种天然姜黄素类物的人工合成方法 |
| CN103910615A (zh) * | 2014-04-09 | 2014-07-09 | 西安雅森生物技术有限公司 | 一种合成姜黄素的方法 |
| CN108101761B (zh) * | 2017-12-08 | 2021-08-03 | 陕西嘉禾生物科技股份有限公司 | 一种姜黄素的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL255427A (de) * | 1959-08-31 | |||
| DE3821197A1 (de) * | 1988-06-23 | 1989-12-28 | Basf Ag | Verfahren zur herstellung von (alpha),(beta)-ungesaettigten ketonen |
| US5679864A (en) * | 1995-11-03 | 1997-10-21 | Gene Print Inc. | Process for the synthesis of curcumin-related compounds |
-
2007
- 2007-03-19 WO PCT/EP2007/002403 patent/WO2007110168A1/en not_active Ceased
- 2007-03-19 JP JP2009501908A patent/JP5341747B2/ja not_active Expired - Fee Related
- 2007-03-19 US US12/295,010 patent/US7964755B2/en not_active Expired - Fee Related
- 2007-03-19 AT AT07723370T patent/ATE538080T1/de active
- 2007-03-19 EP EP07723370A patent/EP1999097B1/de not_active Not-in-force
- 2007-03-19 CN CN2007800198805A patent/CN101454267B/zh not_active Expired - Fee Related
- 2007-03-19 KR KR1020087026287A patent/KR20080112340A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007110168A1 (en) | 2007-10-04 |
| EP1999097A1 (de) | 2008-12-10 |
| JP2009531353A (ja) | 2009-09-03 |
| US20100312015A1 (en) | 2010-12-09 |
| US7964755B2 (en) | 2011-06-21 |
| EP1999097B1 (de) | 2011-12-21 |
| KR20080112340A (ko) | 2008-12-24 |
| CN101454267A (zh) | 2009-06-10 |
| CN101454267B (zh) | 2012-09-26 |
| JP5341747B2 (ja) | 2013-11-13 |
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