DE69632989D1 - Matrize für die Synthese kombinatorischer Bibliotheken in Lösung - Google Patents

Matrize für die Synthese kombinatorischer Bibliotheken in Lösung

Info

Publication number
DE69632989D1
DE69632989D1 DE69632989T DE69632989T DE69632989D1 DE 69632989 D1 DE69632989 D1 DE 69632989D1 DE 69632989 T DE69632989 T DE 69632989T DE 69632989 T DE69632989 T DE 69632989T DE 69632989 D1 DE69632989 D1 DE 69632989D1
Authority
DE
Germany
Prior art keywords
combinatorial libraries
template
synthesis
solution
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69632989T
Other languages
English (en)
Other versions
DE69632989T2 (de
Inventor
Dale L Boger
Soan Cheng
Peter L Myers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Deltagen Research Laboratories LLC
Original Assignee
Scripps Research Institute
CombiChem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute, CombiChem Inc filed Critical Scripps Research Institute
Application granted granted Critical
Publication of DE69632989D1 publication Critical patent/DE69632989D1/de
Publication of DE69632989T2 publication Critical patent/DE69632989T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C07D265/33—Two oxygen atoms, in positions 3 and 5
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00599—Solution-phase processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE69632989T 1995-10-17 1996-10-16 Matrize für die Synthese kombinatorischer Bibliotheken in Lösung Expired - Lifetime DE69632989T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US689195P 1995-10-17 1995-10-17
US6891 1995-10-17

Publications (2)

Publication Number Publication Date
DE69632989D1 true DE69632989D1 (de) 2004-09-02
DE69632989T2 DE69632989T2 (de) 2005-08-25

Family

ID=21723130

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69632989T Expired - Lifetime DE69632989T2 (de) 1995-10-17 1996-10-16 Matrize für die Synthese kombinatorischer Bibliotheken in Lösung

Country Status (7)

Country Link
US (1) US6194612B1 (de)
EP (1) EP0774464B1 (de)
JP (2) JP3819092B2 (de)
AT (1) ATE272058T1 (de)
AU (1) AU729646B2 (de)
CA (1) CA2187969C (de)
DE (1) DE69632989T2 (de)

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WO2003062390A2 (en) 2002-01-17 2003-07-31 Children's Hospital & Research Center At Oakland Compositions and methods for the modulation of sphingolipid metabolism and/or signaling
AU2003257109A1 (en) * 2002-08-05 2004-02-23 Invitrogen Corporation Compositions and methods for molecular biology
US20050233473A1 (en) * 2002-08-16 2005-10-20 Zyomyx, Inc. Methods and reagents for surface functionalization
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US20040248323A1 (en) * 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
US20040254285A1 (en) * 2003-06-12 2004-12-16 Rodrigues Klein A. Fiberglass nonwoven binder
AU2004263896A1 (en) 2003-08-08 2005-02-17 Genenews Inc. Osteoarthritis biomarkers and uses thereof
RU2418633C2 (ru) 2004-04-08 2011-05-20 Байоматрика, Инк. Объединение процессов хранения образцов и управление образцами в медико-биологических науках
RU2402548C2 (ru) * 2004-05-19 2010-10-27 Медарекс, Инк. Химические линкеры и их конъюгаты
BRPI0510909A2 (pt) * 2004-05-19 2008-12-16 Medarex Inc composto de ligaÇço fÁrmaco-ligante citotàxico, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula e mÉtodo para retardar ou interromper o crescimento de tumor
CN103497993A (zh) 2005-02-07 2014-01-08 基因信息公司 轻度骨关节炎生物标志物及其用途
NZ556661A (en) * 2005-02-18 2010-10-29 Medarex Inc Human monoclonal antibodies to prostate specific membrance antigen (PSMA)
EP3354265A1 (de) 2005-03-22 2018-08-01 President and Fellows of Harvard College Behandlung von proteinabbaustörungen
US7714016B2 (en) * 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
WO2007038658A2 (en) * 2005-09-26 2007-04-05 Medarex, Inc. Antibody-drug conjugates and methods of use
US8249814B2 (en) 2005-10-21 2012-08-21 Genenews Inc. Method, computer readable medium, and system for determining a probability of colorectal cancer in a test subject
CN101365679B (zh) 2005-10-26 2012-11-14 梅达莱克斯公司 制备cc-1065类似物的方法和化合物
WO2007059404A2 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
US8377448B2 (en) 2006-05-15 2013-02-19 The Board Of Trustees Of The Leland Standford Junior University CD47 related compositions and methods for treating immunological diseases and disorders
WO2008067196A2 (en) 2006-11-16 2008-06-05 The Regents Of The University Of California Methods for identifying inhibitors of solute transporters
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
CL2008000510A1 (es) 2007-02-21 2008-08-22 Medarex Inc Compuestos conjugados farmaco-ligandos, que se unen a citotoxinas potentes; composicion farmaceutica; y uso para retardar o detener el crecimiento de un tumor en un mamifero.
EP2142923A2 (de) 2007-03-23 2010-01-13 King's College London Veränderte mitochondriale aktivität bei durch oxidativen stress hervorgerufenen krankheiten
WO2009079373A2 (en) 2007-12-14 2009-06-25 The Regents Of The University Of California Inhibitors of calcium-activated chloride channels
JP2012518001A (ja) 2009-02-13 2012-08-09 インディアナ ユニバーシティ リサーチ アンド テクノロジー コーポレイション Ｍｍｐ２およびｍｍｐ９を阻害する化合物および方法
US8716344B2 (en) 2009-08-11 2014-05-06 President And Fellows Of Harvard College Class- and isoform-specific HDAC inhibitors and uses thereof
US9376709B2 (en) 2010-07-26 2016-06-28 Biomatrica, Inc. Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures
CA2806734A1 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
CN108744262A (zh) 2010-11-23 2018-11-06 普莱萨格生命科学公司 用于实体递送的治疗方法和组合物
CN104023760A (zh) 2011-10-28 2014-09-03 普莱萨格生命科学公司 药物递送方法
JP6133431B2 (ja) 2012-11-24 2017-05-24 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
US9682123B2 (en) 2013-12-20 2017-06-20 The Trustees Of Columbia University In The City Of New York Methods of treating metabolic disease
WO2015127685A1 (en) 2014-02-28 2015-09-03 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
EP3656215B1 (de) 2014-06-10 2021-08-04 Biomatrica, INC. Stabilisierung von thrombozyten bei umgebungstemperatur
WO2015151081A2 (en) 2015-07-12 2015-10-08 Suzhou M-Conj Biotech Co., Ltd Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
KR102589056B1 (ko) 2015-12-08 2023-10-12 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
AU2016429272A1 (en) 2016-11-14 2019-05-02 Hangzhou Dac Biotech Co., Ltd. Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
KR20200138714A (ko) 2018-02-21 2020-12-10 에이아이 테라퓨틱스, 인코포레이티드 아필리모드 및 글루타메이트성 작용제를 사용한 병용 요법
AU2021421391A1 (en) 2021-01-24 2023-07-20 Michael David FORREST Inhibitors of atp synthase - cosmetic and therapeutic uses

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Also Published As

Publication number Publication date
CA2187969A1 (en) 1997-04-18
AU729646B2 (en) 2001-02-08
DE69632989T2 (de) 2005-08-25
JPH09278763A (ja) 1997-10-28
US6194612B1 (en) 2001-02-27
ATE272058T1 (de) 2004-08-15
JP2004196813A (ja) 2004-07-15
JP3819092B2 (ja) 2006-09-06
EP0774464B1 (de) 2004-07-28
EP0774464A2 (de) 1997-05-21
EP0774464A3 (de) 1997-08-13
CA2187969C (en) 2006-05-30
AU7026496A (en) 1997-04-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DELTAGEN RESEARCH LABORATORIES,L.L.C., SAN DIEGO,

Owner name: THE SCRIPPS RESEARCH INSTITUTE, LA JOLLA, CALIF.,