JP5837552B2 - 骨粗鬆症の治療および予防用のビスホスホン酸 - Google Patents
骨粗鬆症の治療および予防用のビスホスホン酸 Download PDFInfo
- Publication number
- JP5837552B2 JP5837552B2 JP2013249105A JP2013249105A JP5837552B2 JP 5837552 B2 JP5837552 B2 JP 5837552B2 JP 2013249105 A JP2013249105 A JP 2013249105A JP 2013249105 A JP2013249105 A JP 2013249105A JP 5837552 B2 JP5837552 B2 JP 5837552B2
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- Prior art keywords
- pharmaceutically acceptable
- pharmaceutical composition
- acceptable salt
- osteoporosis
- dose
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- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Description
a)ビスホスホン酸または許容され得るその塩を約50〜250mg、好ましくは約100〜150mg含み、そして
b)その医薬は、1ヶ月当たり1、2、または3日間連日投与される。
a)イバンドロン酸または薬学的に許容され得るその塩約100〜約150mgを含み、
b)1ヶ月当たり1、2、または3日間連日経口投与される。
実施例は、50mg錠剤の組成物を示す。これらの錠剤の組成および調製は当業界で既知であり、例えば米国特許第6,143,326号および第6,294,196号に記載されている。
Claims (3)
- 骨粗鬆症の予防または治療のための医薬組成物であって、その医薬が、
a)100mgのイバンドロン酸または薬学的に許容され得るその塩の有効用量および1以上の薬学的に許容され得るその添加剤を含み;そして
b)その医薬が1ヶ月当たり1日で単回投与量として経口投与される、
医薬組成物。 - イバンドロン酸が、モノナトリウム塩、モノヒドレートの形態である、請求項1記載の医薬組成物。
- 請求項1または2記載の医薬組成物であって、その医薬組成物がフィルムコーティング錠であり、錠剤核が請求項1または2記載の100mgのイバンドロン酸または薬学的に許容され得るその塩と、ラクトース、ポリビニルピロリドン、微結晶性セルロース、クロスポビドン、ステアリン酸、二酸化ケイ素から成る群より選択される1種以上の薬学的に許容され得る添加剤とを含み、そして錠剤被膜がヒドロキシプロピルメチルセルロース、二酸化チタン、タルク、およびポリエチレングリコール6000から成る群より選択される1種以上の薬学的に許容され得る添加剤を含む、医薬組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02010136 | 2002-05-10 | ||
EP02010136.6 | 2002-05-10 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008293614A Division JP5813911B2 (ja) | 2002-05-10 | 2008-11-17 | 骨粗鬆症の治療および予防用のビスホスホン酸 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2014058554A JP2014058554A (ja) | 2014-04-03 |
JP5837552B2 true JP5837552B2 (ja) | 2015-12-24 |
Family
ID=29414669
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004503108A Pending JP2005522526A (ja) | 2002-05-10 | 2003-05-02 | 骨粗鬆症の治療および予防用のビスホスホン酸 |
JP2008293614A Expired - Fee Related JP5813911B2 (ja) | 2002-05-10 | 2008-11-17 | 骨粗鬆症の治療および予防用のビスホスホン酸 |
JP2013088493A Expired - Lifetime JP6067466B2 (ja) | 2002-05-10 | 2013-04-19 | 骨粗鬆症の治療および予防用のビスホスホン酸 |
JP2013249105A Expired - Lifetime JP5837552B2 (ja) | 2002-05-10 | 2013-12-02 | 骨粗鬆症の治療および予防用のビスホスホン酸 |
JP2014258163A Pending JP2015083592A (ja) | 2002-05-10 | 2014-12-22 | 骨粗鬆症の治療および予防用のビスホスホン酸 |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004503108A Pending JP2005522526A (ja) | 2002-05-10 | 2003-05-02 | 骨粗鬆症の治療および予防用のビスホスホン酸 |
JP2008293614A Expired - Fee Related JP5813911B2 (ja) | 2002-05-10 | 2008-11-17 | 骨粗鬆症の治療および予防用のビスホスホン酸 |
JP2013088493A Expired - Lifetime JP6067466B2 (ja) | 2002-05-10 | 2013-04-19 | 骨粗鬆症の治療および予防用のビスホスホン酸 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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JP2014258163A Pending JP2015083592A (ja) | 2002-05-10 | 2014-12-22 | 骨粗鬆症の治療および予防用のビスホスホン酸 |
Country Status (33)
Country | Link |
---|---|
US (5) | US7410957B2 (ja) |
EP (4) | EP1880744B1 (ja) |
JP (5) | JP2005522526A (ja) |
KR (7) | KR20090106663A (ja) |
CN (2) | CN100551377C (ja) |
AR (2) | AR039978A1 (ja) |
AT (1) | ATE376444T1 (ja) |
AU (2) | AU2003229770B2 (ja) |
BR (1) | BR0308901A (ja) |
CA (2) | CA2763775C (ja) |
CY (2) | CY1108105T1 (ja) |
DE (1) | DE60317061T2 (ja) |
DK (2) | DK1506041T3 (ja) |
EC (1) | ECSP045335A (ja) |
ES (2) | ES2294277T3 (ja) |
GT (1) | GT200300107A (ja) |
HK (1) | HK1080409A1 (ja) |
HR (1) | HRP20040906B1 (ja) |
IL (3) | IL164371A0 (ja) |
MX (1) | MXPA04009586A (ja) |
MY (2) | MY140080A (ja) |
NO (2) | NO328734B1 (ja) |
NZ (2) | NZ556278A (ja) |
PA (1) | PA8573101A1 (ja) |
PE (1) | PE20040440A1 (ja) |
PL (2) | PL399493A1 (ja) |
PT (2) | PT1880744E (ja) |
RU (2) | RU2329809C2 (ja) |
SI (2) | SI1880744T1 (ja) |
TW (1) | TWI347188B (ja) |
UY (1) | UY27802A1 (ja) |
WO (1) | WO2003095029A1 (ja) |
ZA (1) | ZA200407950B (ja) |
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