RU2004129324A - Применения бисфосфоновых кислот для лечения и профилактики остеопороза - Google Patents
Применения бисфосфоновых кислот для лечения и профилактики остеопороза Download PDFInfo
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- RU2004129324A RU2004129324A RU2004129324/15A RU2004129324A RU2004129324A RU 2004129324 A RU2004129324 A RU 2004129324A RU 2004129324/15 A RU2004129324/15 A RU 2004129324/15A RU 2004129324 A RU2004129324 A RU 2004129324A RU 2004129324 A RU2004129324 A RU 2004129324A
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- RU
- Russia
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- bisphosphonic acid
- use according
- acid
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Organic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
Claims (14)
1. Применение бисфосфоновой кислоты или ее фармацевтически приемлемой соли для приготовления лекарственного средства для профилактики или лечения заболеваний, характеризующихся паталогически повышенной костной резорбцией, которое
а) содержит по крайней мере 120% ожидаемой эффективной суточной дозы бисфосфоновой кислоты или ее фармацевтически приемлемой соли и один или несколько фармацевтически приемлемых эксципиентов и
б) лекарственное средство вводят орально в течение одних, двух или трех суток подряд в месяц.
2. Применение по п.1, где заболевание является остеопорозом.
3. Применение по п.1 или 2, где эффективная доза составляет примерно от 100 до 150 мг бисфосфоновой кислоты или ее фармацевтически приемлемой соли.
4. Применение по п.1, где бисфосфоновой кислотой является ибандроновая кислота или ее фармацевтически приемлемые соли.
5. Применение по п.1, где эффективная доза составляет примерно 100 мг бисфосфоновой кислоты или ее фармацевтически приемлемой соли.
6. Применение по п.1, где эффективная доза составляет примерно 150 мг бисфосфоновой кислоты или ее фармацевтически приемлемой соли.
7. Применение по п.1 или 5, где бисфосфоновая кислота или ее фармацевтически приемлемая соль представлена моногидратом мононатриевой соли ибандроновой кислоты.
8. Применение по п.1 или 6, где бисфосфоновая кислота или ее фармацевтически приемлемая соль представлена моногидратом мононатриевой соли ибандроновой кислоты.
9. Применение по п.1, где лекарственное средство является таблеткой с пленочным покрытием, в которой ядро таблетки содержит от 50 до 250 мг бисфосфоновой кислоты или ее фармацевтически приемлемой соли, как указано в пп.1-7, и один или более фармацевтически приемлемый эксципиент, выбранный из группы, включающей лактозу, поливинилпирролидон, микрокристаллическую целлюлозу, кросповидон, стеариновую кислоту, диоксид кремния, также ядро таблетки содержит один или более фармацевтически приемлемый эксципиент, выбранный из группы, включающей гидроксипропилметилцеллюлозу, диоксид титана, тальк и полиэтиленгликоль 6000.
10. Применение по п.1, где лекарственное средство вводится как разовая доза.
11. Применение по п.1, где лекарственное средство вводится в виде нескольких суб-доз.
12. Способ лечения или профилактики заболеваний, характеризующихся паталогически повышенной костной резорбцией, включающий оральное введение эффективного количества бисфосфоновой кислоты или ее фармацевтически приемлемой соли, по которому от 50 до 250 мг бисфосфоновой кислоты или ее фармацевтически приемлемой соли вводится в течение месяца за одни сутки или двое суток подряд.
13. Способ по п.12, в где бисфосфоновая кислота является ибандроновой кислотой или ее фармацевтически приемлемой солью.
14. Способ по п.12 или 13, где бисфосфоновая кислота или ее фармацевтически приемлемая соль вводится как указано в п.1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02010136.6 | 2002-05-10 | ||
EP02010136 | 2002-05-10 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2008103617/14A Division RU2387451C2 (ru) | 2002-05-10 | 2003-05-02 | Бисфосфоновые кислоты, предназначенные для лечения и профилактики остеопороза |
Publications (2)
Publication Number | Publication Date |
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RU2004129324A true RU2004129324A (ru) | 2006-01-27 |
RU2329809C2 RU2329809C2 (ru) | 2008-07-27 |
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Application Number | Title | Priority Date | Filing Date |
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RU2008103617/14A RU2387451C2 (ru) | 2002-05-10 | 2003-05-02 | Бисфосфоновые кислоты, предназначенные для лечения и профилактики остеопороза |
RU2004129324/15A RU2329809C2 (ru) | 2002-05-10 | 2003-05-02 | Применения бисфосфоновых кислот для лечения и профилактики остеопороза |
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RU2008103617/14A RU2387451C2 (ru) | 2002-05-10 | 2003-05-02 | Бисфосфоновые кислоты, предназначенные для лечения и профилактики остеопороза |
Country Status (33)
Country | Link |
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US (5) | US7410957B2 (ru) |
EP (4) | EP1880744B1 (ru) |
JP (5) | JP2005522526A (ru) |
KR (7) | KR20150053811A (ru) |
CN (2) | CN1939314A (ru) |
AR (2) | AR039978A1 (ru) |
AT (1) | ATE376444T1 (ru) |
AU (2) | AU2003229770B2 (ru) |
BR (1) | BR0308901A (ru) |
CA (2) | CA2763775C (ru) |
CY (2) | CY1108105T1 (ru) |
DE (1) | DE60317061T2 (ru) |
DK (2) | DK1506041T3 (ru) |
EC (1) | ECSP045335A (ru) |
ES (2) | ES2294277T3 (ru) |
GT (1) | GT200300107A (ru) |
HK (1) | HK1080409A1 (ru) |
HR (1) | HRP20040906B1 (ru) |
IL (3) | IL164371A0 (ru) |
MX (1) | MXPA04009586A (ru) |
MY (2) | MY140080A (ru) |
NO (2) | NO328734B1 (ru) |
NZ (2) | NZ535705A (ru) |
PA (1) | PA8573101A1 (ru) |
PE (1) | PE20040440A1 (ru) |
PL (2) | PL371346A1 (ru) |
PT (2) | PT1880744E (ru) |
RU (2) | RU2387451C2 (ru) |
SI (2) | SI1880744T1 (ru) |
TW (1) | TWI347188B (ru) |
UY (1) | UY27802A1 (ru) |
WO (1) | WO2003095029A1 (ru) |
ZA (1) | ZA200407950B (ru) |
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