BR9915927A - Uso de ácido ibandrÈnico ou seus sais ou ésteres fisiologicamente compatìveis - Google Patents

Uso de ácido ibandrÈnico ou seus sais ou ésteres fisiologicamente compatìveis

Info

Publication number
BR9915927A
BR9915927A BR9915927-9A BR9915927A BR9915927A BR 9915927 A BR9915927 A BR 9915927A BR 9915927 A BR9915927 A BR 9915927A BR 9915927 A BR9915927 A BR 9915927A
Authority
BR
Brazil
Prior art keywords
esters
physiologically compatible
compatible salts
ibandronic acid
acid
Prior art date
Application number
BR9915927-9A
Other languages
English (en)
Inventor
Frieder Bauss
Andreas A Kurth
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of BR9915927A publication Critical patent/BR9915927A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

<B><MU>USO DE áCIDO IBANDRÈNICO OU SEUS SAIS OU éSTERES FISIOLOGICAMENTE COMPATìVEIS<MV><D> A invenção refere-se ao uso de ácido ibandrónico (ácido 1-hidróxi-3-(N-metil-N-pentil)aminopropil-1,1-difosfónico) ou seus sais ou ésteres fisiologicamente compatíveis, para aperfeiçoar a osseintegração de endopróteses amarradas isentas de cimento. O ibandronato ou os seus sais são aplicados durante um curto período imediatamente após a inserção de uma endoprótese, com o resultado surpreendente de que se obtém estabilidade secundária do implante em apenas 5 semanas ou menos depois da operação.
BR9915927-9A 1998-12-04 1999-11-29 Uso de ácido ibandrÈnico ou seus sais ou ésteres fisiologicamente compatìveis BR9915927A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19855976 1998-12-04
PCT/EP1999/009252 WO2000033849A1 (en) 1998-12-04 1999-11-29 Use of ibandronate for promoting osseointegration of endoprostheses

Publications (1)

Publication Number Publication Date
BR9915927A true BR9915927A (pt) 2001-08-21

Family

ID=7889968

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915927-9A BR9915927A (pt) 1998-12-04 1999-11-29 Uso de ácido ibandrÈnico ou seus sais ou ésteres fisiologicamente compatìveis

Country Status (17)

Country Link
US (1) US6680307B1 (pt)
EP (2) EP1135140B1 (pt)
JP (1) JP3793023B2 (pt)
KR (1) KR100453779B1 (pt)
CN (1) CN1173704C (pt)
AR (1) AR020017A1 (pt)
AT (1) ATE303153T1 (pt)
AU (1) AU756540B2 (pt)
BR (1) BR9915927A (pt)
CA (1) CA2353528C (pt)
DE (1) DE69927048T2 (pt)
DK (1) DK1135140T3 (pt)
ES (1) ES2247842T3 (pt)
PT (1) PT1135140E (pt)
TR (1) TR200101546T2 (pt)
WO (1) WO2000033849A1 (pt)
ZA (1) ZA200104140B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004038A1 (en) * 2000-07-12 2002-01-17 Hopital Orthopedique De La Suisse Romande Active biocoating for bone implant
EP1228761A3 (en) * 2001-02-01 2003-01-15 Riderway Corporation Liquid pharmaceutical composition for treating bone diseases
TWI349553B (en) * 2001-12-21 2011-10-01 Procter & Gamble Kit and use of bisphosphonate for treating high bone turnover
MXPA04009586A (es) * 2002-05-10 2005-01-11 Hoffmann La Roche Acidos bisfosfonicos para el tratamiento y prevencion de la osteoporosis.
SI1596870T2 (sl) * 2002-12-20 2011-07-29 Hoffmann La Roche Formulacija z visokim odmerkom ibandronata
EP1508343B1 (en) * 2003-08-21 2015-11-04 AddBIO AB Bisphosponate coated implant device and method therefor
CA2594717C (en) * 2005-02-01 2015-01-20 F. Hoffmann-La Roche Ag Ibandronate polymorph b
BRPI0607092A2 (pt) * 2005-02-01 2009-08-04 Hoffmann La Roche polimorfo cristalino de monoidrato de sal monossódico de ácido 3-(n-metil-n-pentil) amino-1-hidroxipropano-1, 1-difosfÈnico, ibandronato, processo para a preparação de um polimorfo de ibandronato cristalino, e composição farmacêutica que o compreende
US8071574B2 (en) * 2005-02-22 2011-12-06 John Dennis Bobyn Implant improving local bone formation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3623397A1 (de) 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
WO1994014455A1 (en) 1992-12-23 1994-07-07 Merck & Co., Inc. Bisphosphonate/estrogen therapy for treating and preventing bone loss
US5403829A (en) 1993-03-24 1995-04-04 Leiras Oy Use of bisphosphonates in endo-osteal bone surgery
FI92465C (fi) * 1993-04-14 1994-11-25 Risto Tapani Lehtinen Menetelmä endo-osteaalisten materiaalien käsittelemiseksi
US5646134A (en) 1994-04-21 1997-07-08 Merck & Co., Inc. Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices
GB9408775D0 (en) 1994-05-04 1994-06-22 Ciba Geigy Ag Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration
WO1996039107A1 (en) * 1995-06-06 1996-12-12 Merck & Co., Inc. Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices
CA2274789A1 (en) * 1996-12-13 1998-06-18 Zymogenetics, Inc. Compositions and methods for stimulating bone growth

Also Published As

Publication number Publication date
ES2247842T3 (es) 2006-03-01
WO2000033849A1 (en) 2000-06-15
KR20010093137A (ko) 2001-10-27
DE69927048D1 (de) 2005-10-06
CA2353528C (en) 2007-04-24
DE69927048T2 (de) 2006-06-08
ATE303153T1 (de) 2005-09-15
DK1135140T3 (da) 2005-12-19
EP1135140A1 (en) 2001-09-26
KR100453779B1 (ko) 2004-10-20
ZA200104140B (en) 2002-08-21
US6680307B1 (en) 2004-01-20
JP3793023B2 (ja) 2006-07-05
EP1614422A2 (en) 2006-01-11
AU1557700A (en) 2000-06-26
EP1614422A3 (en) 2009-02-18
CN1329495A (zh) 2002-01-02
CN1173704C (zh) 2004-11-03
EP1135140B1 (en) 2005-08-31
JP2002531509A (ja) 2002-09-24
CA2353528A1 (en) 2000-06-15
AR020017A1 (es) 2002-03-27
TR200101546T2 (tr) 2001-11-21
PT1135140E (pt) 2005-10-31
AU756540B2 (en) 2003-01-16

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Legal Events

Date Code Title Description
B65X Notification of requirement for priority examination of patent application
B65Y Grant of priority examination of the patent application (request complies with dec. 132/06 of 20061117)
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AOS ARTIGOS 8O E 11 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]