JP5307708B2 - ヒトｉｌ−６受容体に対する高親和性抗体 - Google Patents

ヒトｉｌ−６受容体に対する高親和性抗体 Download PDF

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Publication number
JP5307708B2
JP5307708B2 JP2009513324A JP2009513324A JP5307708B2 JP 5307708 B2 JP5307708 B2 JP 5307708B2 JP 2009513324 A JP2009513324 A JP 2009513324A JP 2009513324 A JP2009513324 A JP 2009513324A JP 5307708 B2 JP5307708 B2 JP 5307708B2
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Prior art keywords
antibody
hil
antigen
human
seq
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Japanese (ja)
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JP2009539349A (ja
JP2009539349A5 (OSRAM
Inventor
ショーン・スティーヴンス
タミー・ティー・フワーン
ジョウエル・エイチ・マーティン
ジャネット・エル・フェアハースト
アシク・ラフィク
エリク・スミス
ケヴィン・ジェイ・ポバースキ
ニコラス・ジェイ・パパドプーロス
ジェイムズ・ピー・ファンドル
ガン・チェン
マーガレット・カロウ
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
JP2009513324A 2006-06-02 2007-06-01 ヒトｉｌ−６受容体に対する高親和性抗体 Active JP5307708B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US81066406P 2006-06-02 2006-06-02
US60/810,664 2006-06-02
US84323206P 2006-09-08 2006-09-08
US60/843,232 2006-09-08
PCT/US2007/013062 WO2007143168A2 (en) 2006-06-02 2007-06-01 High affinity antibodies to human il-6 receptor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013102655A Division JP5805703B2 (ja) 2006-06-02 2013-05-15 ヒトｉｌ−６受容体に対する高親和性抗体

Publications (3)

Publication Number Publication Date
JP2009539349A JP2009539349A (ja) 2009-11-19
JP2009539349A5 JP2009539349A5 (OSRAM) 2010-07-22
JP5307708B2 true JP5307708B2 (ja) 2013-10-02

Family

ID=38792460

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009513324A Active JP5307708B2 (ja) 2006-06-02 2007-06-01 ヒトｉｌ−６受容体に対する高親和性抗体
JP2013102655A Active JP5805703B2 (ja) 2006-06-02 2013-05-15 ヒトｉｌ−６受容体に対する高親和性抗体
JP2015171640A Active JP6140777B2 (ja) 2006-06-02 2015-09-01 ヒトｉｌ−６受容体に対する高親和性抗体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013102655A Active JP5805703B2 (ja) 2006-06-02 2013-05-15 ヒトｉｌ−６受容体に対する高親和性抗体
JP2015171640A Active JP6140777B2 (ja) 2006-06-02 2015-09-01 ヒトｉｌ−６受容体に対する高親和性抗体

Country Status (33)

Country Link
US (10) US7582298B2 (OSRAM)
EP (2) EP2374818B1 (OSRAM)
JP (3) JP5307708B2 (OSRAM)
KR (1) KR101464502B1 (OSRAM)
CN (2) CN102585002A (OSRAM)
AT (1) ATE537190T1 (OSRAM)
AU (1) AU2007254831B2 (OSRAM)
BR (1) BRPI0712224B8 (OSRAM)
CA (1) CA2652976C (OSRAM)
CR (1) CR10462A (OSRAM)
CY (3) CY1112456T1 (OSRAM)
DK (2) DK2041177T3 (OSRAM)
ES (2) ES2398076T3 (OSRAM)
GT (1) GT200800272A (OSRAM)
HR (2) HRP20120175T1 (OSRAM)
HU (1) HUS1700050I1 (OSRAM)
IL (1) IL195393A (OSRAM)
LT (1) LTC2041177I2 (OSRAM)
LU (1) LUC00050I2 (OSRAM)
ME (1) ME00519B (OSRAM)
MX (1) MX2008014804A (OSRAM)
MY (2) MY147468A (OSRAM)
NL (1) NL300911I2 (OSRAM)
NO (2) NO340778B1 (OSRAM)
NZ (2) NZ573557A (OSRAM)
PL (2) PL2374818T3 (OSRAM)
PT (2) PT2374818E (OSRAM)
RS (2) RS52176B (OSRAM)
RU (1) RU2433138C2 (OSRAM)
SI (2) SI2041177T1 (OSRAM)
SV (1) SV2008003113A (OSRAM)
TN (1) TNSN08502A1 (OSRAM)
WO (1) WO2007143168A2 (OSRAM)

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